Wurst, Wolfgang
- Beaufort N, Ingendahl L, Merdanovic M, Schmidt A, Podlesainski D, Richter T, Neumann T, Kuszner M, Vetter IR, Stege P, Burston SG, Filipovic A, Ruiz-Blanco YB, Bravo-Rodriguez K, Mieres-Perez J, Beuck C, Uebel S, Zobawa M, Schillinger J, Malik R, Todorov-Völgyi K, Rey J, Roberti A, Hagemeier B, Wefers B, Müller SA, Wurst W, Sanchez-Garcia E, Zimmermann A, Hu XY, Clausen T, Huber R, Lichtenthaler SF, Schmuck C, Giese M, Kaiser M, Ehrmann M, Dichgans M. Rational correction of pathogenic conformational defects in HTRA1. Nat Commun. 2024 Jul 16;15(1):5944. doi: 10.1038/s41467-024-49982-8. PMID: 39013852; PMCID: PMC11252331.
Dunot J, Moreno S, Gandin C, Pousinha PA, Amici M, Dupuis J, Anisimova M, Winschel A, Uriot M, Petshow SJ, Mensch M, Bethus I, Giudici C, Hampel H, Wefers B, Wurst W, Naumann R, Ashby MC, Laube B, Zito K, Mellor JR, Groc L, Willem M, Marie H. APP fragment controls both ionotropic and non-ionotropic signaling of NMDA receptors. Neuron. 2024 Jun 7:S0896-6273(24)00404-5. doi: 10.1016/j.neuron.2024.05.027. Epub ahead of print. PMID: 38878768.
- Giusti SA, Pino NS, Pannunzio C, Ogando MB, Armando NG, Garrett L, Zimprich A, Becker L, Gimeno ML, Lukin J, Merino FL, Pardi MB, Pedroncini O, Di Mauro GC, Durner VG, Fuchs H, de Angelis MH, Patop IL, Turck CW, Deussing JM, Vogt Weisenhorn DM, Jahn O, Kadener S, Hölter SM, Brose N, Giesert F, Wurst W, Marin-Burgin A, Refojo D. A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli. Sci Adv. 2024 May 24;10(21):eadj8769. doi: 10.1126/sciadv.adj8769. Epub 2024 May 24. PMID: 38787942; PMCID: PMC11122670.
- Hembach S, Schmidt S, Orschmann T, Burtscher I, Lickert H, Giesert F, Weisenhorn DV, Wurst W. Engrailed 1 deficiency induces changes in ciliogenesis during human neuronal differentiation. Neurobiol Dis. 2024 Mar 20:106474. doi: 10.1016/j.nbd.2024.106474. Epub ahead of print. PMID: 38518837.
Leu CL, Lam DD, Salminen AV, Wefers B, Becker L, Garrett L, Rozman J, Wurst W, de Angelis MH, Hölter SM, Winkelmann J, Williams RH. A patient-enriched MEIS1 coding variant causes a restless legs syndrome-like phenotype in mice. Sleep. 2024 Feb 5:zsae015. doi: 10.1093/sleep/zsae015. Epub ahead of print. PMID: 38314840.
Sen P, Ortiz O, Brivio E, Menegaz D, Sotillos Elliott L, Du Y, Ries C, Chen A, Wurst W, Lopez JP, Eder M, Deussing JM. A bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior. Mol Psychiatry. 2024 Jul 13. doi: 10.1038/s41380-024-02663-w. Epub ahead of print. PMID: 39003412.
- Wang M, Flaswinkel H, Joshi A, Napoli M, Masgrau-Alsina S, Kamper JM, Henne A, Heinz A, Berouti M, Schmacke NA, Hiller K, Kremmer E, Wefers B, Wurst W, Sperandio M, Ruland J, Fröhlich T, Hornung V. Phosphorylation of PFKL regulates metabolic reprogramming in macrophages following pattern recognition receptor activation. Nat Commun. 2024 Jul 31;15(1):6438. doi: 10.1038/s41467-024-50104-7. PMID: 39085210; PMCID: PMC11291651.
- Xu M, Ito-Kureha T, Kang HS, Chernev A, Raj T, Hoefig KP, Hohn C, Giesert F, Wang Y, Pan W, Ziętara N, Straub T, Feederle R, Daniel C, Adler B, König J, Feske S, Tsokos GC, Wurst W, Urlaub H, Sattler M, Kisielow J, Wulczyn FG, Łyszkiewicz M, Heissmeyer V. The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression. Nat Commun. 2024 Mar 11;15(1):2194. doi: 10.1038/s41467-024-46371-z. PMID: 38467629; PMCID: PMC10928157.
- Garrett L, Trümbach D, Spielmann N, Wurst W, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Hölter SM. A rationale for considering heart/brain axis control in neuropsychiatric disease. Mamm Genome. 2023 Jun;34(2):331-350. doi: 10.1007/s00335-022-09974-9. Epub 2022 Dec 20. PMID: 36538124; PMCID: PMC10290621.
- González-García I, García-Clavé E, Cebrian-Serrano A, Le Thuc O, Contreras RE, Xu Y, Gruber T, Schriever SC, Legutko B, Lintelmann J, Adamski J, Wurst W, Müller TD, Woods SC, Pfluger PT, Tschöp MH, Fisette A, García-Cáceres C (2023). Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1. Cell Metab. 2023 Mar 7;35(3):438-455.e7. doi: 10.1016/j.cmet.2023.02.004. PMID: 36889283.
- Schmidt H, Raj T, O'Neill TJ, Muschaweckh A, Giesert F, Negraschus A, Hoefig KP, Behrens G, Esser L, Baumann C, Feederle R, Plaza-Sirvent C, Geerlof A, Gewies A, Isay SE, Ruland J, Schmitz I, Wurst W, Korn T, Krappmann D, Heissmeyer V (2023). Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity. Proc Natl Acad Sci U S A. 2023 Nov 28;120(48):e2309205120. doi: 10.1073/pnas.2309205120. Epub 2023 Nov 21. PMID: 37988467; PMCID: PMC10691344.
- Schmidt S, Stautner C, Vu DT, Heinz A, Regensburger M, Karayel O, Trümbach D, Artati A, Kaltenhäuser S, Nassef MZ, Hembach S, Steinert L, Winner B, Jürgen W, Jastroch M, Luecken MD, Theis FJ, Westmeyer GG, Adamski J, Mann M, Hiller K, Giesert F, Vogt Weisenhorn DM, Wurst W (2023). A reversible state of hypometabolism in a human cellular model of sporadic Parkinson's disease. Nat Commun. 2023 Nov 23;14(1):7674. doi: 10.1038/s41467-023-42862-7. PMID: 37996418; PMCID: PMC10667251.
- Stroo E, Janssen L, Sin O, Hogewerf W, Koster M, Harkema L, Youssef SA, Beschorner N, Wolters AH, Bakker B, Becker L, Garrett L, Marschall S, Hoelter SM, Wurst W, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Thathiah A, Foijer F, van de Sluis B, van Deursen J, Jucker M, de Bruin A, Nollen EA (2023). Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain. Life Sci Alliance. 2023 May 2;6(7):e202201730. doi: 0.26508/lsa.202201730. PMID: 37130781; PMCID: PMC10155860.
- Wefers B, Wurst W, Kühn R (2023). Gene Editing in Mouse Zygotes Using the CRISPR/Cas9 System. Methods Mol Biol. 2023;2631:207-230. doi: 10.1007/978-1-0716-2990-1_8. PMID: 36995669.
- Danileviciute E, Zeng N, Capelle CM, Paczia N, Gillespie MA, Kurniawan H, Benzarti M, Merz MP, Coowar D, Fritah S, Vogt Weisenhorn DM, Gomez Giro G, Grusdat M, Baron A, Guerin C, Franchina DG, Léonard C, Domingues O, Delhalle S, Wurst W, Turner JD, Schwamborn JC, Meiser J, Krüger R, Ranish J, Brenner D, Linster CL, Balling R, Ollert M, Hefeng FQ (2022). PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis during ageing. Nat Metab. 2022 May;4(5):589-607. doi: 10.1038/s42255-022-00576-y. Epub 2022 May 26. PMID: 35618940.
Dening Y, Straßl T, Ruf V, Dirscherl P, Chovsepian A, Stievenard A, Khairnar A, Schmidt F, Giesert F, Herms J, Levin J, Dieterich M, Falkai P, Weisenhorn DV, Wurst W, Giese A, Pan-Montojo F. Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein. Sci Rep. 2022 Dec 19;12(1):21951. doi: 10.1038/s41598-022-25790-2. PMID: 36535974; PMCID: PMC9763379.
- Giehrl-Schwab J, Giesert F, Rauser B, Lao CL, Hembach S, Lefort S, Ibarra IL, Koupourtidou C, Luecken MD, Truong DJ, Fischer-Sternjak J, Masserdotti G, Prakash N, Ninkovic J, Giehrl-Schwab J, Giesert F, Rauser B, Lao CL, Hembach S, Lefort S, Ibarra IL, Koupourtidou C, Luecken MD, Truong DJ, Fischer-Sternjak J, Masserdotti G, Prakash N, Ninkovic J, Hölter SM, Vogt Weisenhorn DM, Theis FJ, Götz M, Wurst W (2022). Parkinson's disease motor symptoms rescue by CRISPRa-reprogramming astrocytes into GABAergic neurons. EMBO Mol Med. 2022 Apr 4:e14797. doi: 10.15252/emmm.202114797. Epub ahead of print. PMID: 35373464.
- Klein-Rodewald T, Micklich K, Sanz-Moreno A, Tost M, Calzada-Wack J, Adler T, Klaften M, Sabrautzki S, Aigner B, Kraiger M, Gailus-Durner V, Fuchs H; German Mouse Clinic Consortium [i.a. Wurst W], Gründer A, Pahl H, Wolf E, Hrabe de Angelis M, Rathkolb B (2022). New C3H KitN824K/WT cancer mouse model develops late-onset malignant mammary tumors with high penetrance. Sci Rep. 2022 Nov 17;12(1):19793. doi: 10.1038/s41598-022-23218-5. PMID: 36396684; PMCID: PMC9671887.
- Maity-Kumar G, Ständer L, DeAngelis M, Lee S, Molenaar A, Becker L, Garrett L, Amerie OV, Hoelter SM, Wurst W, Fuchs H, Feuchtinger A, Gailus-Durner V, Garcia-Caceres C, Othman AE, Brockmann C, Schöffling VI, Beiser K, Krude H, Mroz PA, Hofmann S, Tuckermann J, DiMarchi RD, Hrabe de Angelis M, Tschöp MH, Pfluger PT, Müller TD (2022). Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome. Mol Metab. 2022 Oct 18:101616. doi: 10.1016/j.molmet.2022.101616. Epub ahead of print. PMID: 36270613.
- Sanchez-Gonzalez R, Koupourtidou C, Lepko T, Zambusi A, Novoselc KT, Durovic T, Aschenbroich S, Schwarz V, Breunig CT, Straka H, Huttner HB, Irmler M, Beckers J, Wurst W, Zwergal A, Schauer T, Straub T, Czopka T, Trümbach D, Götz M, Stricker SH, Ninkovic J (2022). Innate Immune Pathways Promote Oligodendrocyte Progenitor Cell Recruitment to the Injury Site in Adult Zebrafish Brain. Cells. 2022 Feb 2;11(3):520. doi: 10.3390/cells11030520. PMID: 35159329; PMCID: PMC8834209.
- Schmidt S, Vogt Weisenhorn DM, Wurst W (2022). Chapter 5 - "Parkinson's disease - A role of non-enzymatic posttranslational modifications in disease onset and progression?". Mol Aspects Med. 2022 Apr 1:101096. doi: 10.1016/j.mam.2022.101096. Epub ahead of print. PMID: 35370007.
- Schmidt S, Luecken MD, Trümbach D, Hembach S, Niedermeier KM, Wenck N, Pflügler K, Stautner C, Böttcher A, Lickert H, Ramirez-Suastegui C, Ahmad R, Ziller MJ, Fitzgerald JC, Ruf V, van de Berg WDJ, Jonker AJ, Gasser T, Winner B, Winkler J, Vogt Weisenhorn DM, Giesert F, Theis FJ, Wurst W (2022). Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease. Nat Commun. 2022 Aug 16;13(1):4819. doi: 10.1038/s41467-022-32229-9. PMID: 35974013; PMCID: PMC9380673.
- Xie K, Fuchs H, Scifo E, Liu D, Aziz A, Aguilar-Pimentel JA, Amarie OV, Becker L, da Silva-Buttkus P, Calzada-Wack J, Cho YL, Deng Y, Edwards AC, Garrett L, Georgopoulou C, Gerlini R, Hölter SM, Klein-Rodewald T, Kramer M, Leuchtenberger S, Lountzi D, Mayer-Kuckuk P, Nover LL, Oestereicher MA, Overkott C, Pearson BL, Rathkolb B, Rozman J, Russ J, Schaaf K, Spielmann N, Sanz-Moreno A, Stoeger C, Treise I, Bano D, Busch DH, Graw J, Klingenspor M, Klopstock T, Mock BA, Salomoni P, Schmidt-Weber C, Weiergräber M, Wolf E, Wurst W, Gailus-Durner V, Breteler MMB, Hrabě de Angelis M, Ehninger D (2022). Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice. Nat Commun. 2022 Nov 11;13(1):6830. doi: 10.1038/s41467-022-34515-y. PMID: 36369285; PMCID: PMC9652467.
- Biagosch CA, Vidali S, Faerberboeck M, Hensler SV, Becker L, Amarie OV, Aguilar-Pimentel A, Garrett L, Klein-Rodewald T, Rathkolb B, Zanuttigh E, Calzada-Wack J, da Silva-Buttkus P, Rozman J, Treise I, Fuchs H, Gailus-Durner V, de Angelis MH, Janik D, Wurst W, Mayr JA, Klopstock, eitinger T, Prokisch H, Iuso A (2021). A comprehensive phenotypic characterization of a whole-body Wdr45 knock-out mouse. Mamm Genome. 2021 May 27. doi: 10.1007/s00335-021-09875-3. Epub ahead of print. PMID: 34043061.
- Brandes RP, Dueck A, Engelhardt S, Kaulich M, Kupatt C, De Angelis MT, Leisegang MS, le Noble F, Moretti A, Müller OJ, Skryabin BV, Thum T, Wurst W (2021). DGK and DZHK position paper on genome editing: basic science applications and future perspective. Basic Res Cardiol. 2021 Jan 15;116(1):2. doi: 10.1007/s00395-020-00839-3. PMID: 33449167.
- Findeiss E, Schwarz SC, Evsyukov V, Rösler TW, Höllerhage M, Chakroun T, Nykänen NP, Shen Y, Wurst W, Kohl M, Tost J, Höglinger GU (2021). Comprehensive miRNome-Wide Profiling in a Neuronal Cell Model of Synucleinopathy Implies Involvement of Cell Cycle Genes. Front Cell Dev Biol. 2021 Mar 4;9:561086. doi: 10.3389/fcell.2021.561086. PMID: 33748099; PMCID: PMC7969723.
- Garrett L, Da Silva-Buttkus P, Rathkolb B, Gerlini R, Becker L, Sanz-Moreno A, Seisenberger C, Zimprich A, Aguilar-Pimentel A, Amarie OV, Cho YL, Kraiger M, Spielmann N, Calzada-Wack J, Marschall S, Busch D, Schmitt-Weber C, Wolf E, Wurst W, Fuchs H, Gailus-Durner V, Hölter SM, de Angelis MH (2021). Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk. Dis Model Mech. 2021 Dec 29:dmm.049205. doi: 10.1242/dmm.049205. Epub ahead of print. PMID: 34964047.
- Hansen J, von Melchner H, Wurst W (2021). Mutant non-coding RNA resource in mouse embryonic stem cells. Dis Model Mech. 2021 Feb 5;14(2):dmm047803. doi: 10.1242/dmm.047803. PMID: 33729986; PMCID: PMC7875499.
- Hsia HE, Tüshaus J, Feng X, Hofmann LI, Wefers B, Marciano DK, Wurst W, Lichtenthaler S (2021). Endoglycan (PODXL2) is proteolytically processed by ADAM10 (a disintegrin and metalloprotease 10) and controls neurite branching in primary neurons. FASEB J. 2021 Sep;35(9):e21813. doi: 10.1096/fj.202100475R. PMID: 34390512.
- Kupatt C, Windisch A, Moretti A, Wolf E, Wurst W, Walter MC (2021). Genome editing for Duchenne muscular dystrophy: a glimpse of the future? Gene Ther. 2021 Feb 2. doi: 10.1038/s41434-021-00222-4. Epub ahead of print. PMID: 33531685.
- O'Neill TJ, Seeholzer T, Gewies A, Gehring T, Giesert F, Hamp I, Graß C, Schmidt H, Kriegsmann K, Tofaute MJ, Demski K, Poth T, Rosenbaum M, Schnalzger T, Ruland J, Göttlicher M, Kriegsmann M, Naumann R, Heissmeyer V, Plettenburg O, Wurst W, Krappmann D (2021). TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease. Sci Immunol. 2021 Nov 12;6(65):eabh2095. doi: 10.1126/sciimmunol.abh2095. Epub 2021 Nov 12. PMID: 34767456.
- Schänzer A, Achleitner M, Trümbach D, Hubert L, Munnich A, Ahlemeyer B, AlAbdulrahim MM, Greif PA, Vosberg S, Hummer B, Feichtinger RG, Mayr JA, Wortmann SB, Aichner H, Rudnik-Schöneborn S, Ruiz A, Gabau E, Sánchez JP, Ellard S, Homfray T, Stals KL, Wurst W, Neubauer BA, Acker T, Bohlander SK, Asensio C, Besmond C, Alkuraya FS, AlSayed MD, Hahn A, Weber A (2021). Mutations in HID1 cause syndromic infantile encephalopathy and hypopituitarism. Ann Neurol. 2021 May 17. doi: 10.1002/ana.26127. Epub ahead of print. PMID: 33999436.
- Weisheit I, Kroeger JA, Malik R, Wefers B, Lichtner P, Wurst W, Dichgans M, Paquet D (2021). Simple and reliable detection of CRISPR-induced on-target effects by qgPCR and SNP genotyping. Nat Protoc. 2021 Feb 17. doi: 10.1038/s41596-020-00481-2. Epub ahead of print. PMID: 33597771.
- Baumann P, Schriever SC, Kullmann S, Zimprich A, Peter A, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Wurst W, Tschöp MH, Heni M, Hölter SM, Pfluger PT (2020). Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans. Brain Behav. 2020 Nov 1:e01928. doi: 10.1002/brb3.1928. Epub ahead of print. PMID: 33131190.
- Boussaad I, Obermaier CD, Hanss Z, Bobbili DR, Bolognin S, Glaab E, Wołyńska K, Weisschuh N, De Conti L, May C, Giesert F, Grossmann D, Lambert A, Kirchen S, Biryukov M, Burbulla LF, Massart F, Bohler J, Cruciani G, Schmid B, Kurz-Drexler A, May P, Duga S, Klein C, Schwamborn JC, Marcus K, Woitalla D, Vogt Weisenhorn DM, Wurst W, Baralle M, Krainc D, Gasser T, Wissinger B, Krüger R (2020). A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease. Sci Transl Med. 2020;12(560):eaau3960. doi:10.1126/scitranslmed.aau3960
- Cacheiro P, Muñoz-Fuentes V, Murray SA, Dickinson ME, Bucan M, Nutter LMJ, Peterson KA, Haselimashhadi H, Flenniken AM, Morgan H, Westerberg H, Konopka T, Hsu CW, Christiansen A, Lanza DG, Beaudet AL, Heaney JD, Fuchs H, Gailus-Durner V, Sorg T, Prochazka J, Novosadova V, Lelliott CJ, Wardle-Jones H, Wells S, Teboul L, Cater H, Stewart M, Hough T, Wurst W, Sedlacek R, Adams DJ, Seavitt JR, Tocchini-Valentini G, Mammano F, Braun RE, McKerlie C, Herault Y, de Angelis MH, Mallon AM, Lloyd KCK, Brown SDM, Parkinson H, Meehan TF, Smedley D; Genomics England Research Consortium; International Mouse Phenotyping Consortium (2020). Human and mouse essentiality screens as a resource for disease gene discovery. Nat Commun. 2020 Jan 31;11(1):655. doi: 10.1038/s41467-020-14284-2.
- Chakroun T, Evsyukov V, Nykänen NP, Höllerhage M, Schmidt A, Kamp F, Ruf VC, Wurst W, Rösler TW, Höglinger GU (2020). Alpha-synuclein fragments trigger distinct aggregation pathways. Cell Death Dis. 2020 Feb 3;11(2):84. doi: 10.1038/s41419-020-2285-7.
- Garrett L, Chang YJ, Niedermeier KM, Heermann T, Enard W, Fuchs H, Gailus-Durner V, Angelis MH, Huttner WB, Wurst W, Hölter SM (2020). A truncating Aspm allele leads to a complex cognitive phenotype and region-specific reductions in parvalbuminergic neurons. Transl Psychiatry. 2020 Feb 13;10(1):66. doi: 10.1038/s41398-020-0686-0.
Ignatova VV, Stolz P, Kaiser S, Gustafsson TH, Lastres PR, Sanz-Moreno A, Cho YL, Amarie OV, Aguilar-Pimentel A, Klein-Rodewald T, Calzada-Wack J, Becker L, Marschall S, Kraiger M, Garrett L, Seisenberger C, Hölter SM, Borland K, Van De Logt E, Jansen PWTC, Baltissen MP, Valenta M, Vermeulen M, Wurst W, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Rando OJ, Kellner SM, Bultmann S, Schneider R. The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs. Genes Dev. 2020 May 1;34(9-10):715-729. doi: 10.1101/gad.333369.119. Epub 2020 Mar 26. PMID: 32217665; PMCID: PMC7197354.
- Kollmus H, Fuchs H, Lengger C, Haselimashhadi H, Bogue MA, Östereicher MA, Horsch M, Adler T, Aguilar-Pimentel JA, Amarie OV, Becker L, Beckers J, Calzada-Wack J, Garrett L, Hans W, Hölter SM, Klein-Rodewald T, Maier H, Mayer-Kuckuk P, Miller G, Moreth K, Neff F, Rathkolb B, Rácz I, Rozman J, Spielmann N, Treise I, Busch D, Graw J, Klopstock T, Wolf E, Wurst W, Yildirim AÖ, Mason J, Torres A; Mouse Phenome Database Team, Balling R, Mehaan T, Gailus-Durner V, Schughart K, Hrabě de Angelis M (2020). A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. Mamm Genome. 2020 Feb 14. doi: 10.1007/s00335-020-09827-3. [Epub ahead of print]
- LaClair KD, Zhou Q, Michaelsen M, Wefers B, Brill MS, Janjic A, Rathkolb B, Farny D, Cygan M, de Angelis MH, Wurst W, Neumann M, Enard W, Misgeld T, Arzberger T, Edbauer D (2020). Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS. Acta Neuropathol. 2020;10.1007/s00401-020-02176-0. doi:10.1007/s00401-020-02176-0 [published online ahead of print, 2020 Jun 19].
- Lloyd KCK, Adams DJ, Baynam G, Beaudet AL, Bosch F, Boycott KM, Braun RE, Caulfield M, Cohn R, Dickinson ME, Dobbie MS, Flenniken AM, Flicek P, Galande S, Gao X, Grobler A, Heaney JD, Herault Y, de Angelis MH, Lupski JR, Lyonnet S, Mallon AM, Mammano F, MacRae CA, McInnes R, McKerlie C, Meehan TF, Murray SA, Nutter LMJ, Obata Y, Parkinson H, Pepper MS, Sedlacek R, Seong JK, Shiroishi T, Smedley D, Tocchini-Valentini G, Valle D, Wang CL, Wells S, White J, Wurst W, Xu Y, Brown SDM (2020). The Deep Genome Project. Genome Biol. 2020 Feb 3;21(1):18. doi: 10.1186/s13059-020-1931-9.
- Lüningschrör P, Werner G, Stroobants S, Kakuta S, Dombert B, Sinske D, Wanner R, Lüllmann-Rauch R, Wefers B, Wurst W, D'Hooge R, Uchiyama Y, Sendtner M, Haass C, Saftig P, Knöll B, Capell A, Damme M (2020). The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons. Cell Rep. 2020 Mar 10;30(10):3506-3519.e6. doi: 10.1016/j.celrep.2020.02.060.
- Moretti A, Fonteyne L, Giesert F, Hoppmann P, Meier AB, Bozoglu T, Baehr A, Schneider CM, Sinnecker D, Klett K, Fröhlich T, Rahman FA, Haufe T, Sun S, Jurisch V, Kessler B, Hinkel R, Dirschinger R, Martens E, Jilek C, Graf A, Krebs S, Santamaria G, Kurome M, Zakhartchenko V, Campbell B, Voelse K, Wolf A, Ziegler T, Reichert S, Lee S, Flenkenthaler F, Dorn T, Jeremias I, Blum H, Dendorfer A, Schnieke A, Krause S, Walter MC, Klymiuk N, Laugwitz KL, Wolf E, Wurst W, Kupatt C (2020). Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy. Nat Med. 2020 Jan 27. doi: 10.1038/s41591-019-0738-2. [Epub ahead of print]
- Nouri P, Götz S, Rauser B, Irmler M, Peng C, Trümbach D, Kempny C, Lechermeier CG, Bryniok A, Dlugos A, Euchner E, Beckers J, Brodski C, Klümper C, Wurst W, Prakash N (2020). Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling. Front Cell Dev Biol. 2020 Oct 26;8:587778. doi: 10.3389/fcell.2020.587778. PMID: 33195246; PMCID: PMC7649324.
- Russo GL, Sonsalla G, Natarajan P, Breunig CT, Bulli G, Merl-Pham J, Schmitt S, Giehrl-Schwab J, Giesert F, Jastroch M, Zischka H, Wurst W, Stricker SH, Hauck SM, Masserdotti G, Götz M (2020). CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion. Cell Stem Cell. 2020 Nov 9:S1934-5909(20)30509-9. doi: 10.1016/j.stem.2020.10.015. Epub ahead of print. PMID: 33202244.
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- Takalo M, Wittrahm R, Wefers B, Parhizkar S, Jokivarsi K, Kuulasmaa T, Mäkinen P, Martiskainen H, Wurst W, Xiang X, Marttinen M, Poutiainen P, Haapasalo A, Hiltunen M, Haass C (2020). The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions. Mol Neurodegener. 2020 Sep 11;15(1):52. doi: 10.1186/s13024-020-00402-7. PMID: 32917267.
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- Vogl AM, Phu L, Becerra R, Giusti SA, Verschueren E, Hinkle TB, Bordenave MD, Adrian M, Heidersbach A, Yankilevich P, Stefani FD, Wurst W, Hoogenraad CC, Kirkpatrick DS, Refojo D, Sheng M (2020). Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics. Nat Struct Mol Biol. 2020 Feb;27(2):210-220. doi: 10.1038/s41594-019-0370-3. Epub 2020 Feb 3.
- Werner G, Damme M, Schludi M, Gnörich J, Wind K, Fellerer K, Wefers B, Wurst W, Edbauer D, Brendel M, Haass C, Capell A (2020). Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice. EMBO Rep. 2020 Sep 14:e50241. doi: 10.15252/embr.202050241. Epub ahead of print. PMID: 32929860.
- Baumann P, Schriever SC, Kullmann S, Zimprich A, Feuchtinger A, Amarie O, Peter A, Walch A, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Wurst W, Tschöp MH, Heni M, Hölter SM, Pfluger PT (2019). Dusp8 affects hippocampal size and behavior in mice and humans. Sci Rep. 2019 Dec 20;9(1):19483. doi: 10.1038/s41598-019-55527-7.
- Castro Dias M, Coisne C, Baden P, Enzmann G, Garrett L, Becker L, Hölter SM; German Mouse Clinic Consortium [i.a. Wurst W], Hrabě de Angelis M, Deutsch U, Engelhardt B (2019). Claudin-12 is not required for blood-brain barrier tight junction function. Fluids Barriers CNS. 2019 Sep 12;16(1):30. doi: 10.1186/s12987-019-0150-9.
- Fecher C, Trovò L, Müller SA, Snaidero N, Wettmarshausen J, Heink S, Ortiz O, Wagner I, Kühn R, Hartmann J, Karl RM, Konnerth A, Korn T, Wurst W, Merkler D, Lichtenthaler SF, Perocchi F, Misgeld T (2019). Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity. Nat Neurosci. 2019 Sep 9. doi: 10.1038/s41593-019-0479-z. [Epub ahead of print]
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- Höllerhage M, Fussi N, Rösler TW, Wurst W, Behrends C, Höglinger GU (2019). Multiple molecular pathways stimulating macroautophagy protect from alpha-synuclein-induced toxicity in human neurons. Neuropharmacology. 2019 Feb 4;149:13-26. doi: 10.1016/j.neuropharm.2019.01.023. [Epub ahead of print]
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- Xiang X, Piers TM, Wefers B, Zhu K, Mallach A, Brunner B, Kleinberger G, Song W, Colonna M, Herms J, Wurst W, Pocock JM, Haass C (2018). The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans. Mol Neurodegener. 2018 Sep 6;13(1):49. doi: 10.1186/s13024-018-0280-6.
- Danner E, Bashir S, Yumlu S, Wurst W, Wefers B, Kühn R (2017). Control of gene editing by manipulation of DNA repair mechanisms. Mamm Genome. 2017 Apr 3. doi: 10.1007/s00335-017-9688-5. [Epub ahead of print]
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- Giesert F, Glasl L, Zimprich A, Ernst L, Piccoli G, Stautner C, Zerle J, Hölter SM, Vogt Weisenhorn DM, Wurst W (2017). The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse. Neurobiol Dis. 2017 May 31;105:179-193. doi: 10.1016/j.nbd.2017.05.013. [Epub ahead of print]
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- Trümbach D, Pfeiffer S, Poppe M, Scherb H, Doll S, Wurst W, Schick JA (2017). ENCoRE: an efficient software for CRISPR screens identifies new players in extrinsic apoptosis. BMC Genomics. 2017 Nov 25;18(1):905. doi: 10.1186/s12864-017-4285-2.
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- Wefers B, Bashir S, Rossius J, Wurst W, Kühn R (2017). Gene editing in mouse zygotes using the CRISPR/Cas9 system Methods. 2017 Mar 2. pii: S1046-2023(16)30469-8. doi: 10.1016/j.ymeth.2017.02.008. [Epub ahead of print]
- Xie K, Neff F, Markert A, Rozman J, Aguilar-Pimentel JA, Amarie OV, Becker L, Brommage R, Garrett L, Henzel KS, Hölter SM, Janik D, Lehmann I, Moreth K, Pearson BL, Racz I, Rathkolb B, Ryan DP, Schröder S, Treise I, Bekeredjian R, Busch DH, Graw J, Ehninger G, Klingenspor M, Klopstock T, Ollert M, Sandholzer M, Schmidt-Weber C, Weiergräber M, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Ehninger D (2017). Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice. Nat Commun. 2017 Jul 24;8(1):155. doi: 10.1038/s41467-017-00178-3.
- Zimprich A, Östereicher MA, Becker L, Dirscherl P, Ernst L, Fuchs H, Gailus-Durner V, Garrett L, Giesert F, Glasl L, Hummel A, Rozman J, de Angelis MH, Vogt-Weisenhorn D, Wurst W, Hölter SM (2017). Analysis of Locomotor Behavior in the German Mouse. Clinic J Neurosci Methods. 2017 May 5. pii: S0165-0270(17)30124-3. doi: 10.1016/j.jneumeth.2017.05.005. [Epub ahead of print]
- Deng T, Postnikov Y, Zhang S, Garrett L, Becker L, Rácz I, Hölter SM, Wurst W, Fuchs H, Gailus-Durner V, de Angelis MH, Bustin M (2016). Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation. Nucleic Acids Res. 2016 Dec 6. pii: gkw1222. [Epub ahead of print]
- Eden M, Meder B, Völkers M, Poomvanicha M, Domes K, Branchereau M, Marck P, Will R, Bernt A, Rangrez A, Busch M; German Mouse Clinic Consortium [i.a. Wurst W], Hrabě de Angelis M, Heymes C, Rottbauer W, Most P, Hofmann F, Frey N (2016). Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression. Nat Commun. 2016 Apr 28;7:11317. doi: 15.13155/ncomms11317.
- Fuchs H, Sabrautzki S, Przemeck GK, Leuchtenberger S, Lorenz-Depiereux B, Becker L, Rathkolb B, Horsch M, Garrett L, Östereicher MA, Hans W, Abe K, Sagawa N, Rozman J, Vargas-Panesso IL, Sandholzer M, Lisse TS, Adler T, Aguilar-Pimentel JA, Calzada-Wack J, Ehrhard N, Elvert R, Gau C, Hölter SM, Micklich K, Moreth K, Prehn C, Puk O, Racz I, Stoeger C, Vernaleken A, Michel D, Diener S, Wieland T, Adamski J, Bekeredjian R, Busch DH, Favor J, Graw J, Klingenspor M, Lengger C, Maier H, Neff F, Ollert M, Stoeger T, Yildirim AÖ, Strom TM, Zimmer A, Wolf E, Wurst W, Klopstock T, Beckers J, Gailus-Durner V, Hrabě de Angelis M (2016). The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations. G3 (Bethesda). 2016 Nov 4. pii: g3.116.033670. doi: 10.1534/g3.116.033670. [Epub ahead of print]
- Klafke R, Prem Anand AA, Wurst W, Prakash N, Wizenmann A (2016). Differences in the spatiotemporal expression and epistatic gene regulation of the mesodiencephalic dopaminergic precursor marker PITX3 during chicken and mouse development. Development. 2016 Jan 11. pii: dev.126748. [Epub ahead of print]
- Meiser J, Delcambre S, Wegner A, Jäger C, Ghelfi J, D'Herouel AF, Dong X, Weindl D, Stautner C, Nonnenmacher Y, Michelucci A, Popp O, Giesert F, Schildknecht S, Krämer L, Schneider JG, Woitalla D, Wurst W, Skupin A, Weisenhorn DM, Krüger R, Leist M, Hiller K (2016). Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism. Neurobiol Dis. 2016 Jan 30. pii: S0969-9961(16)30019-5. doi: 10.1016/j.nbd.2016.01.019. [Epub ahead of print]
- Metzger MW, Walser SM, Aprile-Garcia F, Dedic N, Chen A, Holsboer F, Arzt E, Wurst W, Deussing JM (2016). Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice. Purinergic Signal. 2016 Nov 17. [Epub ahead of print]
- Nechiporuk T, McGann J, Mullendorff K, Hsieh J, Wurst W, Floss T, Mandel G (2016). The REST remodeling complex protects genomic integrity during embryonic neurogenesis. Elife. 2016 Jan 8;5. pii: e09584. doi: 10.7554/eLife.09584.
- Sabrautzki S, Sandholzer MA, Lorenz-Depiereux B, Brommage R, Przemeck G, Vargas Panesso IL, Vernaleken A, Garrett L, Baron K, Yildirim AO, Rozman J, Rathkolb B, Gau C, Hans W, Hoelter SM, Marschall S, Stoeger C, Becker L, Fuchs H, Gailus-Durner V, Klingenspor M, Klopstock T, Lengger C, Stefanie L, Wolf E, Strom TM, Wurst W, de Angelis MH. Viable Ednra Y129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation. Mamm Genome. 2016 Dec;27(11-12):587-598. doi: 10.1007/s00335-016-9664-5. Epub 2016 Sep 26. PMID: 27671791; PMCID: PMC5110705.
- Schick JA, Seisenberger C, Beig J, Bürger A, Iyer V, Maier V, Perera S, Rosen B, Skarnes WC, Wurst W (2016). CRISPR-Cas9 enables conditional mutagenesis of challenging loci. Sci Rep. 2016 Sep 1;6:32326. doi: 10.1038/srep32326.
- Vogt Weisenhorn DM, Giesert F, Wurst W (2016). Diversity matters – heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease. Journal of Neurochemistry. 2016 May 21. DOI: 10.1111/jnc.13670. [Epub ahead of print]
- Weber T, Namikawa K, Winter B, Müller-Brown K, Kühn R, Wurst W, Köster RW (2016). Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons. Development. 2016 Oct 11. pii: dev.122721. [Epub ahead of print]
- Wurst W (2016). Animal models are valid to uncover disease mechanisms. Public Library of Science Genetics. 2016 May 26. 12(5): e1006013. DOI: 10.1371/journal.pgen.1006013
- Zimprich A, Mroz G, Meyer Zu Reckendorf C, Anastasiadou S, Förstner P, Garrett L, Hölter SM, Becker L, Rozman J, Prehn C, Rathkolb B, Moreth K, Wurst W, Klopstock T, Klingenspor M, Adamski J, Wolf E, Bekeredjian R, Fuchs H, Gailus-Durner V, de Angelis MH, Knöll B (2016). Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms. Mol Neurobiol. 2016 Dec 2. [Epub ahead of print]
- Arloth J, Bogdan R, Weber P, Frishman G, Menke A, Wagner KV, Balsevich G, Schmidt MV, Karbalai N, Czamara D, Altmann A, Trümbach D, Wurst W, Mehta D, Uhr M, Klengel T, Erhardt A, Carey CE, Conley ED; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC), Ruepp A, Müller-Myhsok B, Hariri AR, Binder EB; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium PGC (2015). Genetic differences in the immediate transcriptome response to stress predict risk-related brain function and psychiatric disorders. Neuron. 2015 Jun 3;86(5):1189-202. doi: 10.1016/j.neuron.2015.05.034.
- Chu VT, Weber T, Wefers B, Wurst W, Sander S, Rajewsky K, Kühn R (2015). Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. Nat Biotechnol. 2015 Mar 24. doi: 10.1038/nbt.3198. [Epub ahead of print]
- Fukusumi Y, Meier F, Götz S, Matheus F, Irmler M, Beckervordersandforth R, Faus-Kessler T, Minina E, Rauser B, Zhang J, Arenas E, Andersson E, Niehrs C, Beckers J, Simeone A, Wurst W, Prakash N (2015). Dickkopf 3 promotes the differentiation of a rostrolateral midbrain dopaminergic neuronal subset in vivo and from pluripotent stem cells in vitro in the mouse. J Neurosci. 2015 Sep 30;35(39):13385-401. doi: 10.1523/JNEUROSCI.1722-15.2015.
- Garrett L, Zhang J, Zimprich A, Niedermeier KM, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Vogt Weisenhorn D, Wurst W, Hölter SM (2015). Conditional reduction of adult born doublecortin-positive neurons reversibly impairs selective behaviors. Front Behav Neurosci. 2015 Nov 12;9:302.
- Hölter SM, Garrett L, Einicke J, Sperling B, Dirscherl P, Zimprich A, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Wurst W (2015). Assessing cognition in mice. Curr Protoc Mouse Biol. 2015 Dec 2;5(4):331-58. doi: 10.1002/9780470942390.mo150068.
- Hölter SM, Einicke J, Sperling B, Zimprich A, Garrett L, Fuchs H, Gailus-Durner V, Hrabé de Angelis M, Wurst W (2015). Tests for anxiety-related behavior in mice. Curr Protoc Mouse Biol. 2015 Dec 2;5(4):291-309. doi: 10.1002/9780470942390.mo150010.
- Ingold I, Aichler M, Yefremova E, Roveri A, Buday K, Doll S, Tasdemir A, Hoffard N, Wurst W, Walch A, Ursini F, Angeli JP, Conrad M (2015). Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility. J Biol Chem. 2015 Apr 28. pii: jbc.M115.656363. [Epub ahead of print]
- Rosen B, Schick J, Wurst W (2015). Beyond knockouts: the International Knockout Mouse Consortium delivers modular and evolving tools for investigating mammalian genes. Mamm Genome. 2015 Sep 4. [Epub ahead of print]
- Theodorou M, Rauser B, Zhang J, Prakash N, Wurst W, Schick JA. Limitations of In Vivo Reprogramming to Dopaminergic Neurons via a Tricistronic Strategy. Hum Gene Ther Methods. 2015 Aug;26(4):107-22. doi: 10.1089/hgtb.2014.152. Epub 2015 Jul 29. PMID: 26107288.
- Truong DJ, Kühner K, Kühn R, Werfel S, Engelhardt S, Wurst W, Ortiz O (2015). Development of an intein-mediated split-Cas9 system for gene therapy. Nucleic Acids Res. 2015 Jun 16. pii: gkv601. [Epub ahead of print]
- Washkowitz AJ, Schall C, Zhang K, Wurst W, Floss T, Mager J, Papaioannou VE (2015). Mga is essential for the survival of pluripotent cells during peri-implantation development. Development. 2015 Jan 1;142(1):31-40. doi: 10.1242/dev.111104.
- Wefers B, Brandl C, Ortiz O, Wurst W, Kühn R (2015). Genome editing in mice using TALE nucleases. Methods Mol Biol. 2016;1338:229-43. doi: 10.1007/978-1-4939-2932-0_17.
- Zhang J, Götz S, Vogt Weisenhorn DM, Simeone A, Wurst W, Prakash N (2015). A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1+/- mice. Neurobiol Dis. 2015 Jun 3;82:32-45. doi: 10.1016/j.nbd.2015.05.015. [Epub ahead of print]
- Brandl C, Ortiz O, Röttig B, Wefers B, Wurst W, Kühn R (2014). Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos. FEBS Open Bio. 2014 Dec 3;5:26-35. doi: 10.1016/j.fob.2014.11.009. eCollection 2015
- Dykes IM, Lammerts van Bueren K, Ashmore RJ, Floss T, Wurst W, Szumska D, Bhattacharya S, Scambler PJ (2014). HIC2 is a Novel Dosage-Dependent Regulator of Cardiac Development Located Within the Distal 22q11 Deletion Syndrome Region. Circ Res. 2014 Apr 18. [Epub ahead of print]
- Gewies A, Gorka O, Bergmann H, Pechloff K, Petermann F, Jeltsch KM, Rudelius M, Kriegsmann M, Weichert W, Horsch M, Beckers J, Wurst W, Heikenwalder M, Korn T, Heissmeyer V, Ruland J (2014). Uncoupling malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation. Cell Rep. 2014 Nov 20;9(4):1292-305. doi: 10.1016/j.celrep.2014.10.044. Epub 2014 Nov 13.
- Giusti SA, Vogl AM, Brockmann MM, Vercelli CA, Rein ML, Trümbach D, Wurst W, Cazalla D, Stein V, Deussing JM, Refojo D (2014). MicroRNA-9 controls dendritic development by targeting REST. Elife. 2014 Nov 18;3. doi: 10.7554/eLife.02755.
- Keeney JG, O'Bleness MS, Anderson N, Davis JM, Arevalo N, Busquet N, Chick W, Rozman J, Hölter SM, Garrett L, Horsch M, Beckers J, Wurst W, Klingenspor M, Restrepo D; German Mouse Clinic Consortium, Sikela JM, de Angelis MH (2014). Generation of Mice Lacking DUF1220 Protein Domains: Effects on Fecundity and Hyperactivity. Mamm Genome. 2014 Oct 12. [Epub ahead of print]
- Kraus P, V S, Yu HB, Xing X, Lim SL, Adler T, Pimentel JA, Becker L, Bohla A, Garrett L, Hans W, Hölter SM, Janas E, Moreth K, Prehn C, Puk O, Rathkolb B, Rozman J, Adamski J, Bekeredjian R, Busch DH, Graw J, Klingenspor M, Klopstock T, Neff F, Ollert M, Stoeger T, Yildrim AÖ, Eickelberg O, Wolf E, Wurst W, Fuchs H, Gailus-Durner V, de Angelis MH, Lufkin T, Stanton LW (2014). Pleiotropic functions for transcription factor zscan10. PLoS One. 2014 Aug 11;9(8):e104568. doi: 10.1371/journal.pone.0104568. eCollection 2014
- Matthes M, Preusse M, Zhang J, Schechter J, Mayer D, Lentes B, Theis F, Prakash N, Wurst W, Trümbach D (2014). Mouse IDGenes: a reference database for genetic interactions in the developing mouse brain. Database (Oxford). 2014 Aug 20;2014. pii: bau083. doi: 10.1093/database/bau083. Print 2014.
- Meier F, Giesert F, Delic S, Faus-Kessler T, Matheus F, Simeone A, Hölter SM, Kühn R, Weisenhorn DM, Wurst W, Prakash N (2014). FGF/FGFR2 Signaling Regulates the Generation and Correct Positioning of Bergmann Glia Cells in the Developing Mouse Cerebellum. PLoS One. 2014 Jul 1;9(7):e101124. doi: 10.1371/journal.pone.0101124. eCollection 2014.
- Pertek A, Meier F, Irmler M, Beckers J, Skylaki S, Endele M, Wurst W, Prakash N, Kühn R (2014). Simple Derivation of Transgene-Free iPS Cells by a Dual Recombinase Approach. Mol Biotechnol. 2014 Mar 28. [Epub ahead of print]
- Seyfarth K, Poschmann G, Rozman J, Fromme T, Rink N, Hofmann A, Wurst W, Stühler K, Klingenspor M (2014). The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice. J Nutr Biochem. 2014 Oct 2. pii: S0955-2863(14)00197-1. doi: 10.1016/j.jnutbio.2014.09.002. [Epub ahead of print]
- Spieler D, Kaffe M, Knauf F, Bessa J, Tena JJ, Giesert F, Schormair B, Tilch E, Lee H, Horsch M, Czamara D, Karbalai N, von Toerne C, Waldenberger M, Gieger C, Lichtner P, Claussnitzer M, Naumann R, Müller-Myhsok B, Torres M, Garrett L, Rozman J, Klingenspor M, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Beckers J, Hölter SM, Meitinger T, Hauck SM, Laumen H, Wurst W, Casares F, Gómez-Skarmeta JL, Winkelmann J (2014). Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome Res. 2014 Mar 18. [Epub ahead of print]
- Toyoda Y, Erkut C, Pan-Montojo F, Boland S, Stewart MP, Müller DJ, Wurst W, Hyman AA, Kurzchalia TV (2014). Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival. Biol Open. 2014 Jul 25. pii: BIO20149399. doi: 10.1242/bio.20149399. [Epub ahead of print]
- Wefers B, Ortiz O, Wurst W, Kühn R (2014). Generation of targeted mouse mutants by embryo microinjection of TALENs. Methods. 2014 Jan 10. pii: S1046-2023(14)00003-6. doi: 10.1016/j.ymeth.2014.01.002. [Epub ahead of print]
- Zimprich A, Garrett L, Deussing JM, Wotjak CT, Fuchs H, Gailus-Durner V, de Angelis MH, Wurst W, Hölter SM (2014). A robust and reliable non-invasive test for stress responsivity in mice. Front Behav Neurosci. 2014 Apr 15;8:125. doi: 10.3389/fnbeh.2014.00125. eCollection 2014
- Zumbrennen-Bullough KB, Becker L, Garrett L, Hölter SM, Calzada-Wack J, Mossbrugger I, Quintanilla-Fend L, Racz I, Rathkolb B, Klopstock T, Wurst W, Zimmer A, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Romney SJ, Leibold EA(2014). Abnormal brain iron metabolism in irp2 deficient mice is associated with mild neurological and behavioral impairments. PLoS One. 2014 Jun 4;9(6):e98072. doi: 10.1371/journal.pone.0098072. eCollection 2014
- Mueller-Rischart A-K, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, Peis R, Deinlein A, Schweimer C, Kuhn P-H, Lichtenthaler SF, Motori E, Hrelia S, Wurst W, Truembach D, Langer T, Krappmann D, Dittmar G, Tatzelt J, Winklhofer KF (2013). The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO. Molecular cell doi:10.1016/j.molcel.2013.01.036
- Panda SK, Wefers B, Ortiz O, Floss T, Schmid B, Haass C, Wurst W, Kühn R (2013). Highly Efficient Targeted Mutagenesis in Mice Using TALENs. Genetics. 2013 Aug 26. [Epub ahead of print]