Weber, Christian

2024

Döring Y, van der Vorst EPC, Weber C. Targeting immune cell recruitment in atherosclerosis. Nat Rev Cardiol. 2024 Apr 25. doi: 10.1038/s41569-024-01023-z. Epub ahead of print. PMID: 38664575.
Döring Y, van der Vorst EPC, Yan Y, Neideck C, Blanchet X, Jansen Y, Kemmerich M, Bayasgalan S, Peters LJF, Hristov M, Bidzhekov K, Yin C, Zhang X, Leberzammer J, Li Y, Park I, Kral M, Nitz K, Parma L, Gencer S, Habenicht AJR, Faussner A, Teupser D, Monaco C, Holdt L, Megens RTA, Atzler D, Santovito D, von Hundelshausen P, Weber C. Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis. Nat Cardiovasc Res 2024. https://doi.org/10.1038/s44161-023-00413-9
Hristov M, Weber C. Monocyte Subsets in Cardiovascular Disease: A Biomarker Perspective. Thromb Haemost. 2024 Jul 6. doi: 10.1055/a-2348-5697. Epub ahead of print. PMID: 38897222.
Kral M, van der Vorst EPC, Weber C, Döring Y. (Multi-) omics studies of ILC2s in inflammation and metabolic diseases. Front Cell Dev Biol. 2024 Oct 28;12:1473616. doi: 10.3389/fcell.2024.1473616. PMID: 39529633; PMCID: PMC11551558.
Mohanta SK, Santovito D, Weber C. Cortico-limbic restructuring and atherosclerosis: a stressful liaison. Eur Heart J. 2024 May 21;45(19):1765-1767. doi: 10.1093/eurheartj/ehae212. PMID: 38770964.
Parma L, Duchene J, Weber C. Breaking Point: How Intraplaque Hemorrhage Propels Plaque Rupture. Circ Res. 2024 Jul 5;135(2):317-319. doi: 10.1161/CIRCRESAHA.124.324795. Epub 2024 Jul 4. PMID: 38963871.

Santovito D, Henderson JM, Bidzhekov K, Triantafyllidou V, Jansen Y, Chen Z, Farina FM, Diagel A, Aslani M, Blanchet X, Schunkert H, Megens RTA, Döring Y, Sattler M, Weber C. Mex3a Protects Against Atherosclerosis: Evidence From Mice and Humans. Circulation. 2024 Oct 8;150(15):1213-1216. doi: 10.1161/CIRCULATIONAHA.124.069526. Epub 2024 Oct 7. PMID: 39374329.
Strohm L, Daiber A, Ubbens H, Krishnankutty R, Oelze M, Kuntic M, Hahad O, Klein V, Hoefer IE, von Kriegsheim A, Kleinert H, Atzler D, Lurz P, Weber C, Wild PS, Münzel T, Knosalla C, Lutgens E, Daub S. Role of inflammatory signaling pathways involving the CD40-CD40L-TRAF cascade in diabetes and hypertension-insights from animal and human studies. Basic Res Cardiol. 2024 Mar 30. doi: 10.1007/s00395-024-01045-1. Epub ahead of print. PMID: 38554187.
Vos WG, van Os BW, den Toom M, Beckers L, van Roomen CPAA, van Tiel CM, Mohapatra BC, Band H, Nitz K, Weber C, Atzler D, de Winther MPJ, Bosmans LA, Lutgens E, Seijkens TTP. T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation. Front Immunol. 2024 Mar 4;15:1297893. doi: 10.3389/fimmu.2024.1297893. PMID: 38504977; PMCID: PMC10949527.
Wang Y, Li G, Chen B, Shakir G, Volz M, van der Vorst EPC, Maas SL, Geiger M, Jethwa C, Bartelt A, Li Z, Wettich J, Sachs N, Maegdefessel L, Nazari Jahantigh M, Hristov M, Lacy M, Lutz B, Weber C, Herzig S, Guillamat Prats R, Steffens S. Myeloid cannabinoid CB1 receptor deletion confers atheroprotection in male mice by reducing macrophage proliferation in a sex-dependent manner. Cardiovasc Res. 2024 Jun 5:cvae125. doi: 10.1093/cvr/cvae125. Epub ahead of print. PMID: 38838211.

2023

Cimen I, Natarelli L, Abedi Kichi Z, Henderson JM, Farina FM, Briem E, Aslani M, Megens RTA, Jansen Y, Mann-Fallenbuchel E, Gencer S, Duchêne J, Nazari-Jahantigh M, van der Vorst EPC, Enard W, Döring Y, Schober A, Santovito D, Weber C (2023). Targeting a cell-specific microRNA repressor of CXCR4 ameliorates atherosclerosis in mice. Sci Transl Med. 2023 Nov;15(720):eadf3357. doi: 10.1126/scitranslmed.adf3357. Epub 2023 Nov 1. PMID: 37910599.
Ebert S, Zang L, Ismail N, Otabil M, Fröhlich A, Egea V, Ács S, Hoeberg M, Berres ML, Weber C, Moreira JMA, Ries C, Bernhagen J, El Bounkari O (2023). Tissue Inhibitor of Metalloproteinases-1 Interacts with CD74 to Promote AKT Signaling, Monocyte Recruitment Responses, and Vascular Smooth Muscle Cell Proliferation. Cells. 2023 Jul 20;12(14):1899. doi: 10.3390/cells12141899. PMID: 37508563; PMCID: PMC10378328.
Farina FM, Weber C, Santovito D (2023). The emerging landscape of non-conventional RNA functions in atherosclerosis. Atherosclerosis. 2023 Jan 20:S0021-9150(23)00010-2. doi: 10.1016/j.atherosclerosis.2023.01.009. Epub ahead of print. PMID: 36725418.
Kral M, van der Vorst EPC, Surnov A, Weber C, Döring Y. ILC2-mediated immune crosstalk in chronic (vascular) inflammation. Front Immunol. 2023 Dec 20;14:1326440. doi: 10.3389/fimmu.2023.1326440. PMID: 38179045; PMCID: PMC10765502.
Krammer C, Yang B, Reichl S, Besson-Girard S, Ji H, Bolini V, Schulte C, Noels H, Schlepckow K, Jocher G, Werner G, Willem M, El Bounkari O, Kapurniotu A, Gokce O, Weber C, Mohanta S, Bernhagen J (2023). Pathways linking aging and atheroprotection in Mif-deficient atherosclerotic mice. FASEB J. 2023 Mar;37(3):e22752. doi: 10.1096/fj.202200056R. PMID: 36794636.
Mohanta SK, Sun T, Lu S, Wang Z, Zhang X, Yin C, Weber C, Habenicht AJR (2023). The Impact of the Nervous System on Arteries and the Heart: The Neuroimmune Cardiovascular Circuit Hypothesis. Cells. 2023 Oct 19;12(20):2485. doi: 10.3390/cells12202485. PMID: 37887328; PMCID: PMC10605509.
Mohanta SK, Yin C, Weber C, Habenicht AJR (2023). Neuroimmune cardiovascular interfaces in atherosclerosis. Front Cell Dev Biol. 2023 Jan 30;11:1117368. doi: 10.3389/fcell.2023.1117368. PMID: 36793445; PMCID: PMC9923102.
Mohanta SK, Yin C, Weber C, Godinho-Silva C, Veiga-Fernandes H, Xu QJ, Chang RB, Habenicht AJR (2023). Cardiovascular Brain Circuits. Circ Res. 2023 May 26;132(11):1546-1565. doi: 10.1161/CIRCRESAHA.123.322791. Epub 2023 May 25. PMID: 37228235.
Pekayvaz K, Gold C, Hoseinpour P, Engel A, Martinez-Navarro A, Eivers L, Coletti R, Joppich M, Dionísio F, Kaiser R, Tomas L, Janjic A, Knott M, Mehari F, Polewka V, Kirschner M, Boda A, Nicolai L, Schulz H, Titova A, Kilani B, Lorenz M, Fingerle-Rowson G, Bucala R, Enard W, Zimmer R, Weber C, Libby P, Schulz C, Massberg S, Stark K (2023). Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation. Immunity. 2023 Aug 24:S1074-7613(23)00358-8. doi: 10.1016/j.immuni.2023.08.002. Epub ahead of print. PMID: 37652021.
Sachs S, Götz A, Finan B, Feuchtinger A, DiMarchi RD, Döring Y, Weber C, Tschöp MH, Müller TD, Hofmann SM (2023). GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease. Cardiovasc Diabetol. 2023 Aug 17;22(1):217. doi: 10.1186/s12933-023-01940-2. PMID: 37592302; PMCID: PMC10436634.
van Os BW, Vos WG, Bosmans LA, van Tiel CM, Lith SC, den Toom MS, Beckers L, Levels JHM, van Wouw SAE, Zelcer N, Zaal EA, Berkers CR, van der Lest CHA, Helms JB, Weber C, Atzler D, de Winther MPJ, Baardman J, Lutgens E (2023). Hyperlipidaemia elicits an atypical, T helper 1-like CD4+ T-cell response: a key role for very low-density lipoprotein. Eur Heart J Open. 2023 Mar 3;3(2):oead013. doi: 10.1093/ehjopen/oead013. PMID: 36969380; PMCID: PMC10032356.
Wagner JUG, Tombor LS, Malacarne PF, Kettenhausen LM, Panthel J,. Kujundzic H, Manickam N, Schmitz K, Cipca M, Stilz KA, Fischer A,. Muhly-Reinholz M, Abplanalp WT, John D, Mohanta SK, Weber C, Habenicht. AJR, Buchmann GK, Angendohr S, Amin E, Scherschel K, Klöcker N, Kelm M,. Schüttler D, Clauss S, Günther S, Boettger T, Braun T, Bär C, Pham MD,. Krishnan J, Hille S, Müller OJ, Bozoglu T, Kupatt C, Nardini E,. Osmanagic-Myers S, Meyer C, Zeiher AM, Brandes RP, Luxán G, Dimmeler S (2023). Aging impairs the neurovascular interface in the heart. Science. 2023. Aug 25;381(6660):897-906. doi: 10.1126/science.ade4961. Epub 2023 Aug. 24. PMID: 37616346.
Wang Z, Zhang X, Lu S, Zhang C, Ma Z, Su R, Li Y, Sun T, Li Y, Hong M, Deng X, Monjezi MR, Hristov M, Steffens S, Santovito D, Weber C, Mohanta SK, Habenicht AJR, Yin C (2023). Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis. Nat Cardiovasc Res 2023, 2, 290–306. https://doi.org/10.1038/s44161-023-00218-w
Weber C, Habenicht AJR, von Hundelshausen P (2023). Novel mechanisms and therapeutic targets in atherosclerosis: inflammation and beyond. Eur Heart J. 2023 May 20:ehad304. doi: 10.1093/eurheartj/ehad304. Epub ahead of print. PMID: 37210082.

2022

Asare Y, Shnipova M, Živković L, Schlegl C, Tosato F, Aronova A, Brandhofer M, Strohm L, Beaufort N, Malik R, Weber C, Bernhagen J, Dichgans M (2022). IKKβ binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responses. Signal Transduct Target Ther. 2022 Oct 19;7(1):355. doi: 10.1038/s41392-022-01189-3. PMID: 36257930; PMCID: PMC9579124.
Bosmans LA, van Tiel CM, Aarts SABM, Willemsen L, Baardman J, van Os BW, den Toom M, Beckers L, Ahern DJ, Levels JHM, Jongejan A, Moerland PD, Verberk SGS, van den Bossche J, de Winther MMPJ, Weber C, Atzler D, Monaco C, Gerdes N, Shami A, Lutgens E (2022). Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state. Cardiovasc Res. 2022 May 19:cvac084. doi: 10.1093/cvr/cvac084. Epub ahead of print. PMID: 35587037.
Brandhofer M, Hoffmann A, Blanchet X, Siminkovitch E, Rohlfing AK, El Bounkari O, Nestele JA, Bild A, Kontos C, Hille K, Rohde V, Fröhlich A, Golemi J, Gokce O, Krammer C, Scheiermann P, Tsilimparis N, Sachs N, Kempf WE, Maegdefessel L, Otabil MK, Megens RTA, Ippel H, Koenen RR, Luo J, Engelmann B, Mayo KH, Gawaz M, Kapurniotu A, Weber C, von Hundelshausen P, Bernhagen J (2022). Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation. Cell Mol Life Sci. 2022 Sep 12;79(10):512. doi: 10.1007/s00018-022-04539-0. PMID: 36094626; PMCID: PMC9468113.
Dening Y, Straßl T, Ruf V, Dirscherl P, Chovsepian A, Stievenard A, Khairnar A, Schmidt F, Giesert F, Herms J, Levin J, Dieterich M, Falkai P, Weisenhorn DV, Wurst W, Giese A, Pan-Montojo F. Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein. Sci Rep. 2022 Dec 19;12(1):21951. doi: 10.1038/s41598-022-25790-2. PMID: 36535974; PMCID: PMC9763379.
Egea V, Megens RTA, Santovito D, Wantha S, Brandl R, Siess W, Khani S, Soehnlein O, Bartelt A, Weber C, Ries C (2022). Properties and fate of human mesenchymal stem cells upon miRNA let-7f-promoted recruitment to atherosclerotic plaques. Cardiovasc Res. 2022 Mar 3:cvac022. doi: 10.1093/cvr/cvac022. Epub ahead of print. PMID: 35238350.
Evans PC, Davidson SM, Wojta J, Bäck M, Bollini S, Brittan M, Catapano AL, Chaudhry B, Cluitmans M, Gnecchi M, Guzik TJ, Hoefer I, Madonna R, Monteiro JP, Morawietz H, Osto E, Padró T, Sluimer JC, Tocchetti CG, Van der Heiden K, Vilahur G, Waltenberger J, Weber C (2022). From novel discovery tools and biomarkers to precision medicine - basic cardiovascular science highlights of 2021/2022. Cardiovasc Res. 2022 Jul 28:cvac114. doi: 10.1093/cvr/cvac114. Epub ahead of print. PMID: 35899362.
Farina FM, Santovito D, Weber C (2022). Two-Faced Janus: CCR2-Expressing Macrophages and Their Dual Role in Allograft Rejection of the Transplanted Heart. Circulation. 2022 Aug 23;146(8):639-642. doi: 10.1161/CIRCULATIONAHA.122.061088. Epub 2022 Aug 22. PMID: 35994560.
Ferdinandy P, Koller Á, Weber C, Wojta J, Waltenberger J (2022). Frontiers of CardioVascular Biomedicine 2022 Budapest is on in person! The excellent program proves that scientists won against Covid-19. Cardiovasc Res. 2022 Apr 19:cvac064. doi: 10.1093/cvr/cvac064. Epub ahead of print. PMID: 35438746.
Gencer S, Döring Y, Jansen Y, Bayasgalan S, Yan Y, Bianchini M, Cimen I, Müller M, Peters LJF, Megens RTA, von Hundelshausen P, Duchene J, Lemnitzer P, Soehnlein O, Weber C, van der Vorst EP (2022). Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium. Basic Res Cardiol. 2022 Jun 8;117(1):30. doi: 10.1007/s00395-022-00937-4. PMID: 35674847; PMCID: PMC9177477.
Georgakis MK, Malik R, Burgess S, Dichgans M (2022). Additive Effects of Genetic Interleukin-6 Signaling Downregulation and Low-Density Lipoprotein Cholesterol Lowering on
Georgakis MK, Bernhagen J, Heitman LH, Weber C, Dichgans M (2022). Targeting the CCL2-CCR2 axis for atheroprotection. Eur Heart J. 2022 Mar 7:ehac094. doi: 10.1093/eurheartj/ehac094. Epub ahead of print. PMID: 35253053.
Guillamat-Prats R, Hering D, Derle A, Rami M, Härdtner C, Santovito D, Rinne P, Bindila L, Hristov M, Pagano S, Vuilleumier N, Schmid S, Janjic A, Enard W, Weber C, Maegdefessel L, Faussner A, Hilgendorf I, Steffens S (2022). GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation. Nat Cardiovasc Res. 2022 Nov;1:1056-1071. doi: 10.1038/s44161-022-00155-0. Epub 2022 Nov 11. PMID: 36523570; PMCID: PMC7613934.
Habenicht LKL, Wang Z, Zhang X, Li Y, Mogler C, Huspenina JS, Schmid RM, Weber C, Mohanta SK, Ma Z, Yin C (2022). The C1q-ApoE complex: A new hallmark pathology of viral hepatitis and nonalcoholic fatty liver disease. Front Immunol. 2022 Oct 6;13:970938. doi: 10.3389/fimmu.2022.970938. PMID: 36304458; PMCID: PMC9592549.
Koenen RR, Weber C (2022). Jam-A Unleashed Incites Thromboinflammatory Coronary Artery Disease. JACC Basic Transl Sci. 2022 May 23;7(5):462-464. doi: 10.1016/j.jacbts.2022.03.014. PMID: 35663635; PMCID: PMC9156524.
Leberzammer J, Agten SM, Blanchet X, Duan R, Ippel H, Megens RTA, Schulz C, Aslani M, Duchene J, Döring Y, Jooss NJ, Zhang P, Brandl R, Stark K, Siess W, Jurk K, Heemskerk JWM, Hackeng TM, Mayo KH, Weber C, von Hundelshausen P (2022). Targeting platelet-derived CXCL12 impedes arterial thrombosis. Blood. 2022 Mar 21:blood.2020010140. doi: 10.1182/blood.2020010140. Epub ahead of print. PMID: 35313337.
Liu Y, Shi JZ, Jiang R, Liu SF, He YY, van der Vorst EPC, Weber C, Döring Y, Yan (2022). Regulatory T Cell-Related Gene Indicators in Pulmonary Hypertension. Front Pharmacol. 2022 May 31;13:908783. doi: 10.3389/fphar.2022.908783. PMID: 35712711; PMCID: PMC9197497.
Mohanta SK, Peng L, Li Y, Lu S, Sun T, Carnevale L, Perrotta M, Ma Z, Förstera B, Stanic K, Zhang C, Zhang X, Szczepaniak P, Bianchini M, Saeed BR, Carnevale R, Hu D, Nosalski R, Pallante F, Beer M, Santovito D, Ertürk A, Mettenleiter TC, Klupp BG, Megens RTA, Steffens S, Pelisek J, Eckstein HH, Kleemann R, Habenicht L, Mallat Z, Michel JB, Bernhagen J, Dichgans M, D'Agostino G, Guzik TJ, Olofsson PS, Yin C, Weber C, Lembo G, Carnevale D, Habenicht AJR (2022). Neuroimmune cardiovascular interfaces control atherosclerosis. Nature. 2022 May;605(7908):152-159. doi: 10.1038/s41586-022-04673-6. Epub 2022 Apr 27. PMID: 35477759.
Mohanta SK, Weber C, Yin C, Habenicht AJR (2022). The dawn has come for new therapeutics to treat atherosclerosis: Targeting neuroimmune cardiovascular interfaces in artery brain circuits. Clin Transl Med. 2022 Sep;12(9):e1040. doi: 10.1002/ctm2.1040. PMID: 36052959; PMCID: PMC9437971.
Peters LJF, Baaten CCFMJ, Maas SL, Lu C, Nagy M, Jooss NJ, Bidzhekov K, Santovito D, Moreno-Andrés D, Jankowski J, Biessen EAL, Döring Y, Heemskerk JWM, Weber C, Kuijpers MJE, van der Vorst EPC (2022). MicroRNA-26b Attenuates Platelet Adhesion and Aggregation in Mice. Biomedicines. 2022 Apr 23;10(5):983. doi: 10.3390/biomedicines10050983. PMID: 35625720; PMCID: PMC9138361.
Pichet Binette A, Franzmeier N, Spotorno N, Ewers M, Brendel M, Biel D; Alzheimer’s Disease Neuroimaging Initiative; Strandberg O, Janelidze S, Palmqvist S, Mattsson-Carlgren N, Smith R, Stomrud E, Ossenkoppele R, Hansson O. Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer's disease. Nat Commun. 2022 Nov 4;13(1):6635. doi: 10.1038/s41467-022-34129-4. PMID: 36333294; PMCID: PMC9636262.
Ramos-Vega M, Kjellman P, Todorov MI, Kylkilahti TM, Bäckström BT, Ertürk A, Madsen CD, Lundgaard I. Mapping of neuroinflammation-induced hypoxia in the spinal cord using optoacoustic imaging. Acta Neuropathol Commun. 2022 Apr 11;10(1):51. doi: 10.1186/s40478-022-01337-4. PMID: 35410629; PMCID: PMC8996517.
Rot A, Gutjahr JC, Biswas A, Aslani M, Hub E, Thiriot A, von Andrian UH, Megens RTA, Weber C, Duchene J (2022). Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1. Cell Stem Cell. 2022 Jul 7;29(7):1013-1015. doi: 10.1016/j.stem.2021.11.010. PMID: 35803222.
Santovito D, Weber C (2022). Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease. Nat Rev Cardiol. 2022 Mar 18. doi: 10.1038/s41569-022-00680-2. Epub ahead of print. PMID: 35304600.
Sun T, Li Y, Förstera B, Stanic K, Lu S, Steffens S, Yin C, Ertürk A, Megens RTA, Weber C, Habenicht A, Mohanta SK (2022). Tissue Clearing Approaches in Atherosclerosis. Methods Mol Biol. 2022;2419:747-763. doi: 10.1007/978-1-0716-1924-7_45. PMID: 35237999.
Taş K, Volta BD, Lindner C, El Bounkari O, Hille K, Tian Y, Puig-Bosch X, Ballmann M, Hornung S, Ortner M, Prem S, Meier L, Rammes G, Haslbeck M, Weber C, Megens RTA, Bernhagen J, Kapurniotu A (2022). Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly. Nat Commun. 2022 Aug 25;13(1):5004. doi: 10.1038/s41467-022-32688-0. PMID: 36008417; PMCID: PMC9411207.
Wang Z, Zhang X, Zhang C, Li Y, Lu S, Mohanta S, Weber C, Habenicht A, Yin C (2022). Combined Single-Cell RNA and Single-Cell α/β T Cell Receptor Sequencing of the Arterial Wall in Atherosclerosis. Methods Mol Biol. 2022;2419:727-746. doi: 10.1007/978-1-0716-1924-7_44. PMID: 35237998.
Zhang X, Wang Z, Zhang C, Li Y, Lu S, Steffens S, Mohanta S, Weber C, Habenicht A, Yin C (2022). Laser Capture Microdissection-Based mRNA Expression Microarrays and Single-Cell RNA Sequencing in Atherosclerosis Research. Methods Mol Biol. 2022;2419:715-726. doi: 10.1007/978-1-0716-1924-7_43. PMID: 35237997.

2021

Bonfiglio CA, Weber C, Atzler D, Lutgens E (2021). Immunotherapy and cardiovascular diseases (CVD): novel avenues for immunotherapeutic approaches. QJM. 2021 Jul 22:hcab207. doi: 10.1093/qjmed/hcab207. Epub ahead of print. PMID: 34293177.
Bosmans LA, Shami A, Atzler D, Weber C, Gonçalves I, Lutgens E (2021). Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis. Vascul Pharmacol. 2021 Jun 5:106884. doi: 10.1016/j.vph.2021.106884. Epub ahead of print. PMID: 34102305.
Davidson SM, Padró T, Bollini S, Vilahur G, Duncker DJ, Evans PC, Guzik T, Hoefer IE, Waltenberger J, Wojta J, Weber C (2021). Progress in cardiac research - from rebooting cardiac regeneration to a complete cell atlas of the heart. Cardiovasc Res. 2021 Jun 11:cvab200. doi: 10.1093/cvr/cvab200. Epub ahead of print. PMID: 34114614.
Egea V, Kessenbrock K, Lawson D, Bartelt A, Weber C, Ries C (2021). Let-7f miRNA regulates SDF-1α- and hypoxia-promoted migration of mesenchymal stem cells and attenuates mammary tumor growth upon exosomal release. Cell Death Dis. 2021 May 20;12(6):516. doi: 10.1038/s41419-021-03789-3. PMID: 34016957.
Evans P, Wojta J, Hoefer IE, Waltenberger J, Guzik T, Badimon L, Weber C (2021). THE YEAR IN BASIC VASCULAR BIOLOGY RESEARCH: FROM MECHANORECEPTORS AND NETS TO SMARTPHONE DATA AND OMICS. Cardiovasc Res. 2021 Mar 21:cvab105. doi: 10.1093/cvr/cvab105. Epub ahead of print. PMID: 33744925.
Gencer S, Evans BR, van der Vorst EPC, Döring Y, Weber C (2021). Inflammatory Chemokines in Atherosclerosis. Cells. 2021 Jan 25;10(2):226. doi: 10.3390/cells10020226. PMID: 33503867.
Gencer S, Döring Y, Jansen Y, Bayasgalan S, Schengel O, Müller M, Peters LJF, Weber C, van der Vorst EPC (2021). Adipocyte-Specific ACKR3 Regulates Lipid Levels in Adipose Tissue. Biomedicines. 2021 Apr 6;9(4):394. doi: 10.3390/biomedicines9040394. PMID: 33917642; PMCID: PMC8067615.
He YY, Xie XM, Zhang HD, Ye J, Gencer S, van der Vorst EPC, Döring Y, Weber C, Pang XB, Jing ZC, Yan Y, Han ZY (2021). Identification of Hypoxia Induced Metabolism Associated Genes in Pulmonary Hypertension. Front Pharmacol. 2021 Nov 5;12:753727. doi: 10.3389/fphar.2021.753727. PMID: 34803695; PMCID: PMC8602807.
Henderson JM, Weber C, Santovito D (2021). Beyond Self-Recycling: Cell-Specific Role of Autophagy in Atherosclerosis. Cells. 2021 Mar 11;10(3):625. doi: 10.3390/cells10030625. PMID: 33799835; PMCID: PMC7998923.
Hettwer J, Hinterdobler J, Miritsch B, Deutsch MA, Li X, Mauersberger C, Moggio A, Braster Q, Gram H, Robertson AAB, Cooper MA, Groß O, Krane M, Weber C, Koenig W, Soehnlein O, Adamstein NH, Ridker P, Schunkert H, Libby P, Kessler T, Sager HB (2021). Interleukin-1β suppression dampens inflammatory leukocyte production and uptake in atherosclerosis. Cardiovasc Res. 2021 Oct 28:cvab337. doi: 10.1093/cvr/cvab337. Epub ahead of print. PMID: 34718444.
Hinterdobler J, Schott S, Jin H, Meesmann A, Steinsiek AL, Zimmermann AS, Wobst J, Müller P, Mauersberger C, Vilne B, Baecklund A, Chen CS, Moggio A, Braster Q, Molitor M, Krane M, Kempf WE, Ladwig KH, Hristov M, Hulsmans M, Hilgendorf I, Weber C, Wenzel P, Scheiermann C, Maegdefessel L, Soehnlein O, Libby P, Nahrendorf M, Schunkert H, Kessler T, Sager HB (2021). Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis. Eur Heart J. 2021 Jul 19:ehab371. doi: 10.1093/eurheartj/ehab371. Epub ahead of print. PMID: 34279021.
Lacy M, Bürger C, Shami A, Ahmadsei M, Winkels H, Nitz K, van Tiel CM, Seijkens TTP, Kusters PJH, Karshovka E, Prange KHM, Wu Y, Brouns SLN, Unterlugauer S, Kuijpers MJE, Reiche ME, Steffens S, Edsfeldt A, Megens RTA, Heemskerk JWM, Goncalves I, Weber C, Gerdes N, Atzler D, Lutgens E (2021). Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease. Nat Commun. 2021 Jun 18;12(1):3754. doi: 10.1038/s41467-021-23909-z. PMID: 34145241.
Natarelli L, Parca L, Mazza T, Weber C, Virgili F, Fratantonio D (2021). MicroRNAs and Long Non-Coding RNAs as Potential Candidates to Target Specific Motifs of SARS-CoV-2. Noncoding RNA. 2021 Feb 18;7(1):14. doi: 10.3390/ncrna7010014. PMID: 33670580; PMCID: PMC7931055.
Natarelli L, Virgili F, Weber C (2021). SARS-CoV-2, Cardiovascular Diseases, and Noncoding RNAs: A Connected Triad. Int J Mol Sci. 2021 Nov 12;22(22):12243. doi: 10.3390/ijms222212243. PMID: 34830125; PMCID: PMC8620514.
Santovito D, Toto L, De Nardis V, Marcantonio P, D'Aloisio R, Mastropasqua A, De Cesare D, Bucci M, Paganelli C, Natarelli L, Weber C, Consoli A, Mastropasqua R, Cipollone F (2021). Plasma microRNA signature associated with retinopathy in patients with type 2 diabetes. Sci Rep. 2021 Feb 18;11(1):4136. doi: 10.1038/s41598-021-83047-w. PMID: 33602976.
Santovito D, Weber C (2021). Not all myocardial infarctions are created equal: The potential of circulating microRNAs to discern coronary artery dissection. EBioMedicine. 2021 May 6;67:103366. doi: 10.1016/j.ebiom.2021.103366. Epub ahead of print. PMID: 33965874.
Sundararaman SS, Peters LJF, Jansen Y, Gencer S, Yan Y, Nazir S, Bonnin Marquez A, Kahles F, Lehrke M, Biessen EAL, Jankowski J, Weber C, Döring Y, van der Vorst EPC (2021). Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe-/- mice. Sci Rep. 2021 May 17;11(1):10409. doi: 10.1038/s41598-021-89893-y. PMID: 34001955; PMCID: PMC8128899.
van der Vorst EPC, Pepe MAA, Peters LJF, Haberbosch M, Jansen Y, Nauman R, Stathopoulos GT, Weber C, Bidzhekov K (2021). Transcriptome signature of miRNA-26b KO mouse model suggests novel targets. BMC Genom Data. 2021 Jun 30;22(1):23. doi: 10.1186/s12863-021-00976-1. PMID: 34193044; PMCID: PMC8243710.
von Hundelshausen P, Lorenz R, Siess W, Weber C (2021). Vaccine-induced immune thrombotic thrombocytopenia (VITT): targeting pathomechanisms with Bruton tyrosine kinase inhibitors. Thromb Haemost. 2021 Apr 13. doi: 10.1055/a-1481-3039. Epub ahead of print. PMID: 33851389.
Yan Y, Thakur M, van der Vorst EPC, Weber C, Döring Y (2021). Targeting the chemokine network in atherosclerosis. Atherosclerosis. 2021 Jun 29:S0021-9150(21)01197-7. doi: 10.1016/j.atherosclerosis.2021.06.912. Epub ahead of print. PMID: 34247863.

2020

Alexander Y, Osto E, Schmidt-Trucksäss A, Shechter M, Trifunovic D, Duncker DJ, Aboyans V, Bäck M, Badimon L, Cosentino F, De Carlo M, Weber C, Wilkinson F, Bochaton-Piallat ML, Evans PC (2020). Endothelial function in cardiovascular precision medicine: a position paper on behalf of the european society of cardiology. Cardiovasc Res. 2020 Apr 13. pii: cvaa085. doi: 10.1093/cvr/cvaa085. [Epub ahead of print]
Bartelt A, Weber C (2020). Mitochondrial Ejection for Cardiac Protection: The Macrophage Connection. Cell Metab. 2020 Oct 6;32(4):512-513. doi: 10.1016/j.cmet.2020.09.014. PMID: 33027673.
Döring Y, Jansen Y, Cimen I, Aslani M, Gencer S, Peters LJF, Duchene J, Weber C, van der Vorst EPC. B-Cell-Specific CXCR4 Protects Against Atherosclerosis Development and Increases Plasma IgM Levels. Circ Res. 2020 Mar 13;126(6):787-788. doi: 10.1161/CIRCRESAHA.119.316142. Epub 2020 Feb 5. PMID: 32078474.
Döring Y, Noels H, van der Vorst E, Weber C (2020). Seeing is repairing: how imaging-based timely interference with CXCR4 could improve repair after myocardial infarction. Eur Heart J. 2020 Sep 11:ehaa625. doi: 10.1093/eurheartj/ehaa625. Epub ahead of print. PMID: 32918455.
Eckardt V, Miller MC, Blanchet X, Duan R, Leberzammer J, Duchene J, Soehnlein O, Megens RT, Ludwig AK, Dregni A, Faussner A, Wichapong K, Ippel H, Dijkgraaf I, Kaltner H, Döring Y, Bidzhekov K, Hackeng TM, Weber C, Gabius HJ, von Hundelshausen P, Mayo KH (2020). Chemokines and galectins form heterodimers to modulate inflammation. EMBO Rep. 2020 Feb 21:e47852. doi: 10.15252/embr.201947852. [Epub ahead of print]
Evans PC, Ed Rainger G, Mason JC, Guzik TJ, Osto E, Stamataki Z, Neil D, Hoefer IE, Fragiadaki M, Waltenberger J, Weber C, Bochaton-Piallat ML, Bäck M (2020). Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science. Cardiovasc Res. 2020;cvaa230. doi:10.1093/cvr/cvaa230 [published online ahead of print, 2020 Aug 4]
Gencer S, Lacy M, Atzler D, van der Vorst EPC, Döring Y, Weber C (2020). Immunoinflammatory, Thrombohaemostatic, and Cardiovascular Mechanisms in COVID-19. Thromb Haemost. 2020 Oct 29. doi: 10.1055/s-0040-1718735. Epub ahead of print. PMID: 33124029.
Hamid SM, Citir M, Terzi EM, Cimen I, Yildirim Z, Dogan AE, Kocaturk B, Onat UI, Arditi M, Weber C, Traynor-Kaplan A, Schultz C, Erbay E (2020). Inositol-requiring enzyme-1 regulates phosphoinositide signaling lipids and macrophage growth. EMBO Rep. 2020 Nov 2:e51462. doi: 10.15252/embr.202051462. Epub ahead of print. PMID: 33140520.
Kontos C, El Bounkari O, Krammer C, Sinitski D, Hille K, Zan C, Yan G, Wang S, Gao Y, Brandhofer M, Megens RTA, Hoffmann A, Pauli J, Asare Y, Gerra S, Bourilhon P, Leng L, Eckstein HH, Kempf WE, Pelisek J, Gokce O, Maegdefessel L, Bucala R, Dichgans M, Weber C, Kapurniotu A, Bernhagen J (2020). Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting. Nat Commun. 2020 Nov 25;11(1):5981. doi: 10.1038/s41467-020-19764-z. PMID: 33239628.
Krammer C, Kontos C, Dewor M, Hille K, Dalla Volta B, El Bounkari O, Taş K, Sinitski D, Brandhofer M, Megens RTA, Weber C, Schultz JR, Bernhagen J, Kapurniotu A (2020). A MIF-derived cyclopeptide that inhibits MIF binding and atherogenic signaling via the chemokine receptor CXCR2. Chembiochem. 2020 Oct 30. doi: 10.1002/cbic.202000574. Epub ahead of print. PMID: 33125165.
Peters LJF, Biessen EAL, Hohl M, Weber C, van der Vorst EPC, Santovito D (2020). Small Things Matter: Relevance of MicroRNAs in Cardiovascular Disease. Front Physiol. 2020;11:793. Published 2020 Jul 7. doi:10.3389/fphys.2020.00793
Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourão A, Blanchet X, Wichapong K, Aslani M, Brunßen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen MJAP, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, Hundelshausen PV, Steffens S, Duchêne J, Megens RTA, Sattler M, Weber C (2020). Autophagy unleashes noncanonical microRNA functions. Autophagy. 2020 Oct 15:1-3. doi: 10.1080/15548627.2020.1830523. Epub ahead of print. PMID: 33054575.
Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourão A, Blanchet X, Wichapong K, Aslani M, Brunßen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen MJAP, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, von Hundelshausen P, Steffens S, Duchêne J, Megens RTA, Sattler M, Weber C (2020). Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis. Sci Transl Med. 2020;12(546):eaaz2294. doi:10.1126/scitranslmed.aaz2294

2019

Tilstam PV, Soppert J, Hemmers C, Harlacher E, Döring Y, van der Vorst EPC, Schulte C, Alampour-Rajabi S, Theelen W, Asare Y, de Winther MPJ, Lawrence T, Bernhagen J, Schober A, Zernecke A, Jankowski J, Weber C, Noels H (2019). Non-activatable mutant of inhibitor of kappa B kinase α (IKKα) exerts vascular site-specific effects on atherosclerosis in Apoe-deficient mice. Atherosclerosis. 2019 Nov 2;292:23-30. doi: 10.1016/j.atherosclerosis.2019.10.023. [Epub ahead of print]
Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, Habenicht AJR (2019). ApoE attenuates unresolvable inflammation by complex formation with activated C1q. Nat Med. 2019 Jan 28. doi: 10.1038/s41591-018-0336-8. [Epub ahead of print]

2018

Lacy M, Kontos C, Brandhofer M, Hille K, Gröning S, Sinitski D, Bourilhon P, Rosenberg E, Krammer C, Thavayogarajah T, Pantouris G, Bakou M, Weber C, Lolis E, Bernhagen J, Kapurniotu A (2018). Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4. Sci Rep. 2018 Mar 26;8(1):5171. doi: 10.1038/s41598-018-23554-5.
Schmitz C, Noels H, El Bounkari O, Straussfeld E, Megens RTA, Sternkopf M, Alampour-Rajabi S, Krammer C, Tilstam PV, Gerdes N, Bürger C, Kapurniotu A, Bucala R, Jankowski J, Weber C, Bernhagen J (2018). Mif-deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis. FASEB J. 2018 Mar 15:fj201800058R. doi: 10.1096/fj.201800058R. [Epub ahead of print]

Weber, Christian

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