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Simons, Mikael

  • Feiten AF, Dahm K, Schlepckow K, van Lengerich B, Suh JH, Reifschneider A, Wefers B, Bartos LM, Wind-Mark K, de Weerd L, Ulas T, De-Domenico E, Grundschöttel P, Paulusch S, Tast B, Honda T, Müller SA, Becker M, Khalin I, Ricci A, Liesz A, Brunner B, Krenner C, Buschmann K, Nuscher B, Spieth L, Junker N, Berghoff SA, Davis SS, Neher JJ, Wurst W, Plesnila N, Lewcock JW, Simons M, Lichtenthaler SF, Di Paolo G, Brendel M, Capell A, Monroe KM, Schultze JL, Haass C. TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism. Nat Commun. 2026 Jan 24. doi: 10.1038/s41467-026-68706-8. Epub ahead of print. PMID: 41580393.
  • Gnörich J, Kusche-Palenga J, Palleis C, Neubauer A, Frontzkowski L, Jäck A, Kling A, Bauer T, Eyob H, Probst K, Roemer-Cassiano SN, Bernhardt AM, Katzdobler S, Marth L, Zaganjori M, Hopfner F, Zwergal A, Häckert J, Rullmann M, Sabri O, Barthel H, Stöcklein S, Werner RA, Simons M, Levin J, Herms J, Franzmeier N, Höglinger GU, Brendel M; German Imaging Initiative for Tauopathies (GII4T). Longitudinal monitoring of tau aggregation in progressive supranuclear palsy with [18F]PI-2620 PET. Alzheimers Dement. 2026 Feb;22(2):e71195. doi: 10.1002/alz.71195. PMID: 41736364; PMCID: PMC12932912.

  • Androvic P, Schifferer M, Perez Anderson K, Cantuti-Castelvetri L, Jiang H, Ji H, Liu L, Gouna G, Berghoff SA, Besson-Girard S, Knoferle J, Simons M, Gokce O (2023). Spatial Transcriptomics-correlated Electron Microscopy maps transcriptional and ultrastructural responses to brain injury. Nat Commun. 2023 Jul 11;14(1):4115. doi: 10.1038/s41467-023-39447-9. PMID: 37433806; PMCID: PMC10336148.
  • Bernhardt AM, Tiedt S, Teupser D, Dichgans M, Meyer B, Gempt J, Kuhn PH, Simons M, Palleis C, Weidinger E, Nübling G, Holdt L, Hönikl L, Gasperi C, Giesbertz P, Müller SA, Breimann S, Lichtenthaler SF, Kuster B, Mann M, Imhof A, Barth T, Hauck SM, Zetterberg H, Otto M, Weichert W, Hemmer B, Levin J (2023). A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases. EBioMedicine. 2023 Feb 4;89:104456. doi: 10.1016/j.ebiom.2023.104456. Epub ahead of print. PMID: 36745974; PMCID: PMC9931915.
  • Dawkins E, Derks RJE, Schifferer M, Trambauer J, Winkler E, Simons M, Paquet D, Giera M, Kamp F, Steiner H (2023). Membrane lipid remodeling modulates γ-secretase processivity. J Biol Chem. 2023 Feb 15:103027. doi: 10.1016/j.jbc.2023.103027. Epub ahead of print. PMID: 36805335.
  • Depp C, Sun T, Sasmita AO, Spieth L, Berghoff SA, Nazarenko T, Overhoff K, Steixner-Kumar AA, Subramanian S, Arinrad S, Ruhwedel T, Möbius W, Göbbels S, Saher G, Werner HB, Damkou A, Zampar S, Wirths O, Thalmann M, Simons M, Saito T, Saido T, Krueger-Burg D, Kawaguchi R, Willem M, Haass C, Geschwind D, Ehrenreich H, Stassart R, Nave KA (2023). Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease. Nature. 2023 May 31. doi: 10.1038/s41586-023-06120-6. Epub ahead of print. PMID: 37258678.
  • Djannatian M, Radha S, Weikert U, Safaiyan S, Wrede C, Deichsel C, Kislinger G, Rhomberg A, Ruhwedel T, Campbell DS, van Ham T, Schmid B, Hegermann J, Möbius W, Schifferer M, Simons M (2023). Myelination generates aberrant ultrastructure that is resolved by microglia. J Cell Biol. 2023 Mar 6;222(3):e202204010. doi: 10.1083/jcb.202204010. Epub 2023 Jan 13. PMID: 36637807; PMCID: PMC9856851.
  • Finze A, Biechele G, Rauchmann BS, Franzmeier N, Palleis C, Katzdobler S, Weidinger E, Guersel S, Schuster S, Harris S, Schmitt J, Beyer L, Gnörich J, Lindner S, Albert NL, Wetzel CH, Rupprecht R, Rominger A, Danek A, Burow L, Kurz C, Tato M, Utecht J, Papazov B, Zaganjori M, Trappmann LK, Goldhardt O, Grimmer T, Haeckert J, Janowitz D, Buerger K, Keeser D, Stoecklein S, Dietrich O, Morenas-Rodriguez E, Barthel H, Sabri O, Bartenstein P, Simons M, Haass C, Höglinger GU, Levin J, Perneczky R, Brendel M (2023). Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies. Mol Psychiatry. 2023 Jul 26. doi: 10.1038/s41380-023-02188-8. Epub ahead of print. PMID: 37495886.
  • Groh J, Abdelwahab T, Kattimani Y, Hörner M, Loserth S, Gudi V, Adalbert R, Imdahl F, Saliba AE, Coleman M, Stangel M, Simons M, Martini R (2023). Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects. Nat Commun. 2023 Oct 30;14(1):6911. doi: 10.1038/s41467-023-42570-2. PMID: 37903797; PMCID: PMC10616105.
  • Kolabas ZI, Kuemmerle LB, Perneczky R, Förstera B, Ulukaya S, Ali M, Kapoor S, Bartos LM, Büttner M, Caliskan OS, Rong Z, Mai H, Höher L, Jeridi D, Molbay M, Khalin I, Deligiannis IK, Negwer M, Roberts K, Simats A, Carofiglio O, Todorov MI, Horvath I, Ozturk F, Hummel S, Biechele G, Zatcepin A, Unterrainer M, Gnörich J, Roodselaar J, Shrouder J, Khosravani P, Tast B, Richter L, Díaz-Marugán L, Kaltenecker D, Lux L, Chen Y, Zhao S, Rauchmann BS, Sterr M, Kunze I, Stanic K, Kan VWY, Besson-Girard S, Katzdobler S, Palleis C, Schädler J, Paetzold JC, Liebscher S, Hauser AE, Gokce O, Lickert H, Steinke H, Benakis C, Braun C, Martinez-Jimenez CP, Buerger K, Albert NL, Höglinger G, Levin J, Haass C, Kopczak A, Dichgans M, Havla J, Kümpfel T, Kerschensteiner M, Schifferer M, Simons M, Liesz A, Krahmer N, Bayraktar OA, Franzmeier N, Plesnila N, Erener S, Puelles VG, Delbridge C, Bhatia HS, Hellal F, Elsner M, Bechmann I, Ondruschka B, Brendel M, Theis FJ, Erturk A (2023). Distinct molecular profiles of skull bone marrow in health and neurological disorders. Cell. 2023 Aug 3:S0092-8674(23)00742-0. doi: 10.1016/j.cell.2023.07.009. Epub ahead of print. PMID: 37562402
  • Simons M, Levin J, Dichgans M (2023). Tipping points in neurodegeneration. Neuron. 2023 Jun 21:S0896-6273(23)00433-6. doi: 10.1016/j.neuron.2023.05.031. Epub ahead of print. PMID: 37385247.
  • Ziegler KA, Ahles A, Dueck A, Esfandyari D, Pichler P, Weber K, Kotschi S, Bartelt A, Sinicina I, Graw M, Leonhardt H, Weckbach LT, Massberg S, Schifferer M, Simons M, Hoeher L, Luo J, Ertürk A, Schiattarella GG, Sassi Y, Misgeld T Engelhardt S (2023). Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease. Science. 2023 Jul 21;381(6655):285-290. doi: 10.1126/science.abn6366. Epub 2023 Jul 20. PMID: 37471539

  • Arends M, Weber M, Papan C, Damm M, Surma MA, Spiegel C, Djannatian M, Li S, Connell L, Johannes L, Schifferer M, Klose C, Simons M (2022). Ganglioside lipidomics of CNS myelination using direct infusion shotgun mass spectrometry. iScience. 2022 Oct 10;25(11):105323. doi: 10.1016/j.isci.2022.105323. PMID: 36310581; PMCID: PMC9615322.
  • Bosch-Queralt M, Tiwari V, Damkou A, Vaculčiaková L, Alexopoulos I, Simons M (2022). A fluorescence microscopy-based protocol for volumetric measurement of lysolecithin lesion-associated de- and re-myelination in mouse brain. STAR Protoc. 2022 Jan 29;3(1):101141. doi: 10.1016/j.xpro.2022.101141. PMID: 35141565; PMCID: PMC8810560.
  • Cantuti-Castelvetri L, Gokce O, Simons M (2022). Reparative inflammation in multiple sclerosis. Semin Immunol. 2022 Jun 21:101630. doi: 10.1016/j.smim.2022.101630. Epub ahead of print. PMID: 35750551.
  • Franklin RJM, Simons M (2022). CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities. Neuron. 2022 Oct 6:S0896-6273(22)00862-5. doi: 10.1016/j.neuron.2022.09.023. Epub ahead of print. PMID: 36228613.
  • Franzmeier N, Brendel M, Beyer L, Slemann L, Kovacs GG, Arzberger T, Kurz C, Respondek G, Lukic MJ, Biel D, Rubinski A, Frontzkowski L, Hummel S, Müller A, Finze A, Palleis C, Joseph E, Weidinger E, Katzdobler S, Song M, Biechele G, Kern M, Scheifele M, Rauchmann BS, Perneczky R, Rullman M, Patt M, Schildan A, Barthel H, Sabri O, Rumpf JJ, Schroeter ML, Classen J, Villemagne V, Seibyl J, Stephens AW, Lee EB, Coughlin DG, Giese A, Grossman M, McMillan CT, Gelpi E, Molina-Porcel L, Compta Y, van Swieten JC, Laat LD, Troakes C, Al-Sarraj S, Robinson JL, Xie SX, Irwin DJ, Roeber S, Herms J, Simons M, Bartenstein P, Lee VM, Trojanowski JQ, Levin J, Höglinger G, Ewers M (2022). Tau deposition patterns are associated with functional connectivity in primary tauopathies. Nat Commun. 2022 Mar 15;13(1):1362. doi: 10.1038/s41467-022-28896-3. PMID: 35292638; PMCID: PMC8924216
  • Kaya T, Mattugini N, Liu L, Ji H, Cantuti-Castelvetri L, Wu J, Schifferer M, Groh J, Martini R, Besson-Girard S, Kaji S, Liesz A, Gokce O, Simons M (2022). CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging. Nat Neurosci. 2022 Nov;25(11):1446-1457. doi: 10.1038/s41593-022-01183-6. Epub 2022 Oct 24. PMID: 36280798; PMCID: PMC9630119.
  • Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Brône B, Brown GC, Butovsky O, Carson MJ, Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de Strooper B, Denes A, Eggen BJL, Eyo U, Galea E, Garel S, Ginhoux F, Glass CK, Gokce O, Gomez-Nicola D, González B, Gordon S, Graeber MB, Greenhalgh AD, Gressens P, Greter M, Gutmann DH, Haass C, Heneka MT, Heppner FL, Hong S, Hume DA, Jung S, Kettenmann H, Kipnis J, Koyama R, Lemke G, Lynch M, Majewska A, Malcangio M, Malm T, Mancuso R, Masuda T, Matteoli M, McColl BW, Miron VE, Molofsky AV, Monje M, Mracsko E, Nadjar A, Neher JJ, Neniskyte U, Neumann H, Noda M, Peng B, Peri F, Perry VH, Popovich PG, Pridans C, Priller J, Prinz M, Ragozzino D, Ransohoff RM, Salter MW, Schaefer A, Schafer DP, Schwartz M, Simons M, Smith CJ, Streit WJ, Tay TL, Tsai LH, Verkhratsky A, von Bernhardi R, Wake H, Wittamer V, Wolf SA, Wu LJ, Wyss-Coray T (2022). Microglia states and nomenclature: A field at its crossroads. Neuron. 2022 Nov 2;110(21):3458-3483. doi: 10.1016/j.neuron.2022.10.020. PMID: 36327895.
  • Vöglein J, Franzmeier N, Morris JC, Dieterich M, McDade E, Simons M, Preische O, Hofmann A, Hassenstab J, Benzinger TL, Fagan A, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal JP, Salloway S, Xiong C, Karch CM, Cairns N, Perrin RJ, Day G, Martins R, Sanchez-Valle R, Mori H, Shimada H, Ikeuchi T, Suzuki K, Schofield PR, Masters CL, Goate A, Buckles V, Fox NC, Chrem P, Allegri R, Ringman JM, Yakushev I, Laske C, Jucker M, Höglinger G, Bateman RJ, Danek A, Levin J, Dominantly Inherited Alzheimer Network (2022). Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease. Alzheimers Dement. 2022 May 24. doi: 10.1002/alz.12684. Epub ahead of print. PMID: 35609137.