Liesz, Arthur

Berghoff SA, Spieth L, Vitale S, Schlaphoff L, Zirngibl M, Junker N, Dean AC, Liu L, Damkou A, Roth S, Hurler CA, Hosang L, Perez Anderson K, Besson-Girard S, Reich M, Feiten A, Huber L, Müller C, Kislinger G, Dinkel L, Nkeh YB, Groh J, Williams A, Liesz A, Schifferer M, Saher G, Nave KA, Jäkel S, Tahirovic S, Giera M, Gokce O, Simons M. Chronic progressive demyelination induces a microglial state with lysosomal dysfunction. Nat Neurosci. 2026 Oct 26. doi: 10.1038/s41593-026-02489-5. Epub ahead of print. PMID: 42934349.

Chen W, Wang X, Huang T, Li Y, Chen C, Zhang Y, Xie W, Tang D, Fan Q, Pang R, Yin J, Sparwasser T, Wang Z, Liesz A, Gan Y, Yu W, Ginhoux F, Li P. Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6ChighLy6Glow monocytes after stroke. J Exp Med. 2026 Apr 6;223(4):e20242025. doi: 10.1084/jem.20242025. Epub 2026 Mar 18. PMID: 41848599.
Delgado Jiménez R, Ruggles A, Adedokun MA, Sorbie A, Fink D, Laudani S, Simats A, He Y, Pahl V, Díaz-Marugán L, Voss M, Singh K, Lledós M, Carofiglio O, Melton P, Pinkham K, Ricci A, Roth S, Sadler R, Khayat S, Mousavi SM, Tsaktanis T, Tobinski AM, Walter C, Ohnmacht C, Huehn J, Herkel J, Carambia A, Klotz L, Gelderblom M, Rothhammer V, Regen T, Bernhagen J, Gigl M, Zimmermann M, Fernandez-Cadenas I, Hirt L, Delacher M, Liesz A, Benakis C. Gut microbiota primes stroke severity via the AHR in intestinal dendritic cells. Cell. 2026 Sep 29:S0092-8674(26)01115-3. doi: 10.1016/j.cell.2026.09.013. Epub ahead of print. PMID: 42810339.
Feiten AF, Dahm K, Schlepckow K, van Lengerich B, Suh JH, Reifschneider A, Wefers B, Bartos LM, Wind-Mark K, de Weerd L, Ulas T, De-Domenico E, Grundschöttel P, Paulusch S, Tast B, Honda T, Müller SA, Becker M, Khalin I, Ricci A, Liesz A, Brunner B, Krenner C, Buschmann K, Nuscher B, Spieth L, Junker N, Berghoff SA, Davis SS, Neher JJ, Wurst W, Plesnila N, Lewcock JW, Simons M, Lichtenthaler SF, Di Paolo G, Brendel M, Capell A, Monroe KM, Schultze JL, Haass C. TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism. Nat Commun. 2026 Jan 24. doi: 10.1038/s41467-026-68706-8. Epub ahead of print. PMID: 41580393.
Liesz A. Trained Immunity in Interorgan Communication and Vascular Inflammation. Arterioscler Thromb Vasc Biol. 2026 Jan 22. doi: 10.1161/ATVBAHA.125.323130. Epub ahead of print. PMID: 41568457.
Llovera G, Heindl S, Varga DP, Lenart N, Kallabis S, Göb V, Stegner D, Escaig R, Nicolai L, Franzmeier N, Meissner F, Denes A, Liesz A. Blocking microglial reactivity via purinergic receptors prevents subacute cognitive deficits after TIA. EMBO Mol Med. 2026 Mar 20. doi: 10.1038/s44321-026-00397-6. Epub ahead of print. PMID: 41862768.
Tiedt S, Vlegels N, Dimitriadis K, Li W, Jickling GC, McCullough LD, Liesz A, Lo EH, Hill MD. A roadmap towards clinical use of molecular biomarkers in acute ischaemic stroke. Nat Rev Neurol. 2026 Oct 6. doi: 10.1038/s41582-026-01270-3. Epub ahead of print. PMID: 42839011.
Zhang S, Liesz A. Trained immunity in acute and chronic neurological diseases. Elife. 2026 Jan 15;15:e106037. doi: 10.7554/eLife.106037. PMID: 41537429; PMCID: PMC12807454.
Zhang Y, Chen Y, Cheng Y, Li R, Chen W, Li Y, Fan Q, Zhou Y, Huang T, Xie W, Guo Y, Liesz A, Wan J, Ginhoux F, Li P. Serotonin signaling enhances phagocytosis by brain macrophages through Htr2b and alleviates brain injury after stroke. Nat Neurosci. 2026 Oct 28. doi: 10.1038/s41593-026-02482-y. Epub ahead of print. PMID: 42951997.

Asare Y, Yan G, Schlegl C, Prestel M, van der Vorst EPC, Teunissen AJP, Aronova A, Tosato F, Naser N, Caputo J, Prevot G, Azzun A, Wefers B, Wurst W, Schneider M, Forne I, Bidzhekov K, Naumann R, van der Laan SW, Brandhofer M, Cao J, Roth S, Malik R, Tiedt S, Mulder WJM, Imhof A, Liesz A, Weber C, Bernhagen J, Dichgans M. A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis. Immunity. 2025 Jan 22:S1074-7613(25)00026-3. doi: 10.1016/j.immuni.2025.01.003. Epub ahead of print. PMID: 39879983.
Fekete R, Simats A, Bíró E, Pósfai B, Cserép C, Schwarcz AD, Szabadits E, Környei Z, Tóth K, Fichó E, Szalma J, Vida S, Kellermayer A, Dávid C, Acsády L, Kontra L, Silvestre-Roig C, Moldvay J, Fillinger J, Csikász-Nagy A, Hortobágyi T, Liesz A, Benkő S, Dénes Á. Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19. Nat Neurosci. 2025 Mar;28(3):558-576. doi: 10.1038/s41593-025-01871-z. Epub 2025 Mar 6. PMID: 40050441.
Gomez-Diaz C, Greulich W, Wefers B, Wang M, Bolsega S, Effern M, Varga DP, Han Z, Chen M, Bérouti M, Leonardi N, Schillinger U, Holzmann B, Liesz A, Roers A, Hölzel M, Basic M, Wurst W, Hornung V. RNase T2 restricts TLR13-mediated autoinflammation in vivo. J Exp Med. 2025 Mar 3;222(3):e20241424. doi: 10.1084/jem.20241424. Epub 2025 Jan 24. PMID: 39853306; PMCID: PMC11758920.
Huang T, Xie W, Guo Y, Li Y, Yin J, Jin X, Ma Y, Zhang Y, Huang D, Chen C, Wang X, Zhu Z, Gan Y, Liesz A, Yu W, Yuan J, Li P. St3gal5-mediated sialylation of glyco-CD177 on neutrophils restricts neuroinflammation following CNS injury. Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2426187122. doi: 10.1073/pnas.2426187122. Epub 2025 Apr 17. PMID: 40244680; PMCID: PMC12037025.

Luo J, Molbay M, Chen Y, Horvath I, Kadletz K, Kick B, Zhao S, Al-Maskari R, Singh I, Ali M, Bhatia HS, Minde DP, Negwer M, Hoeher L, Calandra GM, Groschup B, Su J, Kimna C, Rong Z, Galensowske N, Todorov MI, Jeridi D, Ohn TL, Roth S, Simats A, Singh V, Khalin I, Pan C, Arús BA, Bruns OT, Zeidler R, Liesz A, Protzer U, Plesnila N, Ussar S, Hellal F, Paetzold J, Elsner M, Dietz H, Erturk A. Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning. Nat Biotechnol. 2025 Jan 14. doi: 10.1038/s41587-024-02528-1. Epub ahead of print. PMID: 39809933.
Todorov-Völgyi K, González-Gallego J, Müller SA, Todorov MI, Seker FB, Frerich S, Cernilogar FM, Schröger L, Malik R, Cao J, Llovera G, Roth S, Schillinger U, Schifferer M, Reyahi A, Crusius D, Pedro LD, Simons M, Carlsson P, Ertürk A, Liesz A, Schotta G, Plesnila N, Lichtenthaler SF, Paquet D, Dichgans M. The stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling. Nat Neurosci. 2025 Dec 15. doi: 10.1038/s41593-025-02136-5. Epub ahead of print. PMID: 41398477.

Cao J, Roth S, Zhang S, Kopczak A, Mami S, Asare Y, Georgakis MK, Messerer D, Horn A, Shemer R, Jacqmarcq C, Picot A, Green JP, Schlegl C, Li X, Tomas L, Dutsch A, Liman TG, Endres M, Wernsdorf SR, Fürle C, Carofiglio O, Zhu J, Brough D; DEMDAS Study Group; Hornung V, Dichgans M, Vivien D, Schulz C, Dor Y, Tiedt S, Sager HB, Grosse GM, Liesz A. DNA-sensing inflammasomes cause recurrent atherosclerotic stroke. Nature. 2024 Aug 7. doi: 10.1038/s41586-024-07803-4. Epub ahead of print. PMID: 39112714.
Dinkel L, Hummel S, Zenatti V, Malara M, Tillmann Y, Colombo A, Monasor LS, Suh JH, Logan T, Roth S, Paeger L, Hoffelner P, Bludau O, Schmidt A, Müller SA, Schifferer M, Nuscher B, Njavro JR, Prestel M, Bartos LM, Wind-Mark K, Slemann L, Hoermann L, Kunte ST, Gnörich J, Lindner S, Simons M, Herms J, Paquet D, Lichtenthaler SF, Bartenstein P, Franzmeier N, Liesz A, Grosche A, Bremova-Ertl T, Catarino C, Beblo S, Bergner C, Schneider SA, Strupp M, Di Paolo G, Brendel M, Tahirovic S. Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease. Sci Transl Med. 2024 Dec 4;16(776):eadl4616. doi: 10.1126/scitranslmed.adl4616. Epub 2024 Dec 4. PMID: 39630885.
Gao B, Shi K, Pan Y, Ge S, Liu Y, Yan J, Liesz A, Meisel A, Qu Y, Zhao X, Shi FD. Multicentre prospective, randomised open-label, endpoint-blinded study to evaluate the safety and efficacy of propranolol for the prevention of stroke-associated pneumonia in patients with intracerebral haemorrhage (PROCHASE): rationale and design. Stroke Vasc Neurol. 2024 Dec 31:svn-2024-003630. doi: 10.1136/svn-2024-003630. Epub ahead of print. PMID: 39740854.
Geiseler SJ, Hadzic A, Lambertus M, Forbord KM, Sajedi G, Liesz A, Morland C. L-Lactate Treatment at 24 h and 48 h after Acute Experimental Stroke Is Neuroprotective via Activation of the L-Lactate Receptor HCA1. Int J Mol Sci. 2024 Jan 19;25(2):1232. doi: 10.3390/ijms25021232. PMID: 38279234; PMCID: PMC10816130.
Groschup B, Calandra GM, Raitmayr C, Shrouder J, Llovera G, Zaki AG, Burgstaller S, Bischof H, Eroglu E, Liesz A, Malli R, Filser S, Plesnila N. Probing intracellular potassium dynamics in neurons with the genetically encoded sensor lc-LysM GEPII 1.0 in vitro and in vivo. Sci Rep. 2024 Jun 14;14(1):13753. doi: 10.1038/s41598-024-62993-1. PMID: 38877089; PMCID: PMC11178854.
Kedia S, Ji H, Feng R, Androvic P, Spieth L, Liu L, Franz J, Zdiarstek H, Anderson KP, Kaboglu C, Liu Q, Mattugini N, Cherif F, Prtvar D, Cantuti-Castelvetri L, Liesz A, Schifferer M, Stadelmann C, Tahirovic S, Gokce O, Simons M. T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis. Nat Neurosci. 2024 Jun 27. doi: 10.1038/s41593-024-01682-8. Epub ahead of print. PMID: 38937583.
Li R, Huang T, Zhou J, Liu X, Li G, Zhang Y, Guo Y, Li F, Li Y, Liesz A, Li P, Wang Z, Wan J. Mef2c Exacerbates Neuron Necroptosis via Modulating Alternative Splicing of Cflar in Ischemic Stroke With Hyperlipidemia. CNS Neurosci Ther. 2024 Dec;30(12):e70144. doi: 10.1111/cns.70144. PMID: 39648651; PMCID: PMC11625962.
Llovera G, Langhauser F, Isla Cainzos S, Hoppen M, Abberger H, Mohamud Yusuf A, Mencl S, Heindl S, Ricci A, Haupeltshofer S, Kuchenbecker-Pöls L, Gunzer M, Hansen W, Hermann DM, Gelderblom M, Schmidt-Pogoda A, Minnerup J, Kleinschnitz C, Magnus T, Liesz A. Stroke of Consistency: Streamlining Multicenter Protocols for Enhanced Reproducibility of Infarct Volumes in Preclinical Stroke Research. Stroke. 2024 Oct;55(10):2522-2527. doi: 10.1161/STROKEAHA.124.047232. Epub 2024 Sep 24. PMID: 39315830.
Simats A, Sager H, Liesz A. Heart brain axis in health and disease: role of innate and adaptive immunity. Cardiovasc Res. 2024 Aug 24:cvae185. doi: 10.1093/cvr/cvae185. Epub ahead of print. PMID: 39180327.
Simats A, Zhang S, Messerer D, Chong F, Beşkardeş S, Chivukula AS, Cao J, Besson-Girard S, Montellano FA, Morbach C, Carofiglio O, Ricci A, Roth S, Llovera G, Singh R, Chen Y, Filser S, Plesnila N, Braun C, Spitzer H, Gokce O, Dichgans M, Heuschmann PU, Hatakeyama K, Beltrán E, Clauss S, Bonev B, Schulz C, Liesz A. Innate immune memory after brain injury drives inflammatory cardiac dysfunction. Cell. 2024 Jul 12:S0092-8674(24)00702-5. doi: 10.1016/j.cell.2024.06.028. Epub ahead of print. PMID: 39043180.
Smith EE, Biessels GJ, Gao V, Gottesman RF, Liesz A, Parikh NS, Iadecola C. Systemic determinants of brain health in ageing. Nat Rev Neurol. 2024 Oct 7. doi: 10.1038/s41582-024-01016-z. Epub ahead of print. PMID: 39375564.
Zatcepin A, Gnörich J, Rauchmann BS, Bartos LM, Wagner S, Franzmeier N, Malpetti M, Xiang X, Shi Y, Parhizkar S, Grosch M, Wind-Mark K, Kunte ST, Beyer L, Meyer C, Brösamle D, Wendeln AC, Osei-Sarpong C, Heindl S, Liesz A, Stoecklein S, Biechele G, Finze A, Eckenweber F, Lindner S, Rominger A, Bartenstein P, Willem M, Tahirovic S, Herms J, Buerger K, Simons M, Haass C, Rupprecht R, Riemenschneider MJ, Albert NL, Beyer M, Neher JJ, Paeger L, Levin J, Höglinger GU, Perneczky R, Ziegler SI, Brendel M. Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer's disease. Mol Neurodegener. 2024 Sep 5;19(1):64. doi: 10.1186/s13024-024-00752-6. PMID: 39238030; PMCID: PMC11375924.
Zhou Y, Wang X, Yin W, Li Y, Guo Y, Chen C, Boltze J, Liesz A, Sparwasser T, Wen D, Yu W, Li P. Perioperative stroke deteriorates white matter integrity by enhancing cytotoxic CD8+ T-cell activation. CNS Neurosci Ther. 2024 Jul;30(7):e14747. doi: 10.1111/cns.14747. PMID: 38973085; PMCID: PMC11227991.

Geiseler SJ, Phan KD, Brox C, Nguyen TD, Tartanoglu C, Doosje HL,. Christiansen CL, Liesz A, Morland C. Pre-stroke exercise does not reduce. atrophy in healthy young adult mice. Neurosci Lett. 2023 Aug 19:137447. doi: 10.1016/j.neulet.2023.137447. Epub ahead of print. PMID: 37604388.
Green JP, El-Sharkawy LY, Roth S, Zhu J, Cao J, Leach AG, Liesz A, CFreeman S, Brough D (2023). Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome. iScience. 2023 Apr 27;26(5):106758. doi: 10.1016/j.isci.2023.106758. PMID: 37216118; PMCID: PMC10193008.
Kolabas ZI, Kuemmerle LB, Perneczky R, Förstera B, Ulukaya S, Ali M, Kapoor S, Bartos LM, Büttner M, Caliskan OS, Rong Z, Mai H, Höher L, Jeridi D, Molbay M, Khalin I, Deligiannis IK, Negwer M, Roberts K, Simats A, Carofiglio O, Todorov MI, Horvath I, Ozturk F, Hummel S, Biechele G, Zatcepin A, Unterrainer M, Gnörich J, Roodselaar J, Shrouder J, Khosravani P, Tast B, Richter L, Díaz-Marugán L, Kaltenecker D, Lux L, Chen Y, Zhao S, Rauchmann BS, Sterr M, Kunze I, Stanic K, Kan VWY, Besson-Girard S, Katzdobler S, Palleis C, Schädler J, Paetzold JC, Liebscher S, Hauser AE, Gokce O, Lickert H, Steinke H, Benakis C, Braun C, Martinez-Jimenez CP, Buerger K, Albert NL, Höglinger G, Levin J, Haass C, Kopczak A, Dichgans M, Havla J, Kümpfel T, Kerschensteiner M, Schifferer M, Simons M, Liesz A, Krahmer N, Bayraktar OA, Franzmeier N, Plesnila N, Erener S, Puelles VG, Delbridge C, Bhatia HS, Hellal F, Elsner M, Bechmann I, Ondruschka B, Brendel M, Theis FJ, Erturk A (2023). Distinct molecular profiles of skull bone marrow in health and neurological disorders. Cell. 2023 Aug 3:S0092-8674(23)00742-0. doi: 10.1016/j.cell.2023.07.009. Epub ahead of print. PMID: 37562402
Magnus T, Liesz A (2023). Unveiling the immunopathology of stroke: a comprehensive view on brain-immune interaction. Semin Immunopathol. 2023 May;45(3):279-280. doi: 10.1007/s00281-023-00995-3. PMID: 37335353; PMCID: PMC10279564.
Riemenschneider H, Simonetti F, Sheth U, Katona E, Roth S, Hutten S, Farny D, Michaelsen M, Nuscher B, Schmidt MK, Flatley A, Schepers A, Gruijs da Silva LA, Zhou Q, Klopstock T, Liesz A, Arzberger T, Herms J, Feederle R, Gendron TF, Dormann D, Edbauer D (2023). Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo. Acta Neuropathol Commun. 2023 Jul 11;11(1):112. doi: 10.1186/s40478-023-01592-z. PMID: 37434215; PMCID: PMC10334564.
Ricci A, Liesz A (2023). A tale of two cells: Regulatory T cell-microglia cross-talk in the ischemic brain. Sci Transl Med. 2023 Nov 8;15(721):eadj0052. doi: 10.1126/scitranslmed.adj0052. Epub 2023 Nov 8. PMID: 37939163.
Roth S, Wernsdorf SR, Liesz A (2023). The role of circulating cell-free DNA as an inflammatory mediator after stroke. Semin Immunopathol. 2023 May 22. doi: 10.1007/s00281-023-00993-5. Epub ahead of print. PMID: 37212886.
Sienel RI, Mamrak U, Biller J, Roth S, Zellner A, Parakaw T, Khambata RS, Liesz A, Haffner C, Ahluwalia A, Seker BF, Plesnila N. Inhaled nitric oxide suppresses neuroinflammation in experimental ischemic stroke. J Neuroinflammation. 2023 Dec 15;20(1):301. doi: 10.1186/s12974-023-02988-3. PMID: 38102677; PMCID: PMC10725028.
Shrouder JJ, Calandra GM, Filser S, Varga DP, Besson-Girard S, Mamrak U, Dorok M, Bulut-Impraim B, Seker FB, Gesierich B, Laredo F, Wehn AC, Khalin I, Bayer P, Liesz A, Gokce O, Plesnila N (2023). Continued dysfunction of capillary pericytes promotes no-reflow after experimental stroke in vivo. Brain. 2023 Dec 28:awad401. doi: 10.1093/brain/awad401. Epub ahead of print. PMID: 38153327.
Xie W, Simats A, Guo Y, Huang T, Sun X, Chen W, Lin Y, Wang X, Lai Z, Yu W, Liesz A, Li P (2023). Perspective Review of Myeloid Immune Cell Responses and Poststroke Immunosuppression. Stroke. 2023 Apr 6. doi: 10.1161/STROKEAHA.122.042075. Epub ahead of print. PMID: 37021568

Benakis C, Liesz A (2022). The gut-brain axis in ischemic stroke: its relevance in pathology and as a therapeutic target. Neurol Res Pract. 2022 Nov 14;4(1):57. doi: 10.1186/s42466-022-00222-8. PMID: 36401322; PMCID: PMC9673423.
Benakis C, Simats A, Tritschler S, Heindl S, Besson-Girard S, Llovera G, Pinkham K, Kolz A, Ricci A, Theis FJ, Bittner S, Gökce Ö, Peters A, Liesz A (2022). T cells modulate the microglial response to brain ischemia. Elife. 2022 Dec 13;11:e82031. doi: 10.7554/eLife.82031. PMID: 36512388; PMCID: PMC9747154.
Kaya T, Mattugini N, Liu L, Ji H, Cantuti-Castelvetri L, Wu J, Schifferer M, Groh J, Martini R, Besson-Girard S, Kaji S, Liesz A, Gokce O, Simons M (2022). CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging. Nat Neurosci. 2022 Nov;25(11):1446-1457. doi: 10.1038/s41593-022-01183-6. Epub 2022 Oct 24. PMID: 36280798; PMCID: PMC9630119.
Li T, Liesz A (2022). Immunity in Stroke: The Next Frontier. Thromb Haemost. 2022 Jun 10. doi: 10.1055/s-0042-1748890. Epub ahead of print. PMID: 35688450.
Reifschneider A, Robinson S, van Lengerich B, Gnörich J, Logan T, Heindl S, Vogt MA, Weidinger E, Riedl L, Wind K, Zatcepin A, Pesämaa I, Haberl S, Nuscher B, Kleinberger G, Klimmt J, Götzl JK, Liesz A, Bürger K, Brendel M, Levin J, Diehl-Schmid J, Suh J, Di Paolo G, Lewcock JW, Monroe KM, Paquet D, Capell A, Haass C (2022). Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. EMBO J. 2022 Jan 12:e109108. doi: 10.15252/embj.2021109108. Epub ahead of print. PMID: 35019161.
Simats A, Liesz A (2022). Systemic inflammation after stroke: implications for post-stroke comorbidities. EMBO Mol Med. 2022 Aug 15:e16269. doi: 10.15252/emmm.202216269. Epub ahead of print. PMID: 35971650.
Wilmes M, Pinto Espinoza C, Ludewig P, Stabernack J, Liesz A, Nicke A, Gelderblom M, Gerloff C, Falzoni S, Tolosa E, Di Virgilio F, Rissiek B, Plesnila N, Koch-Nolte F, Magnus T (2022). Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions. J Neuroinflammation. 2022 Oct 12;19(1):256. doi: 10.1186/s12974-022-02601-z. PMID: 36224611; PMCID: PMC9559872.
Zatcepin A, Heindl S, Schillinger U, Kaiser L, Lindner S, Bartenstein P, Kopczak A, Liesz A, Brendel M, Ziegler SI (2022). Reduced Acquisition Time [18F]GE-180 PET Scanning Protocol Replaces Gold-Standard Dynamic Acquisition in a Mouse Ischemic Stroke Model. Front Med (Lausanne). 2022 Feb 10;9:830020. doi: 10.3389/fmed.2022.830020. PMID: 35223925; PMCID: PMC8866959.

Aswendt M, Green C, Sadler R, Llovera G, Dzikowski L, Heindl S, Gomez de Agüero M, Diedenhofen M, Vogel S, Wieters F, Wiedermann D, Liesz A, Hoehn M (2021). The gut microbiota modulates brain network connectivity under physiological conditions and after acute brain ischemia. iScience. 2021 Sep 9;24(10):103095. doi: 10.1016/j.isci.2021.103095. PMID: 34622150; PMCID: PMC8479691.
Colombo AV, Sadler RK, Llovera G, Singh V, Roth S, Heindl S, Sebastian Monasor L, Verhoeven A, Peters F, Parhizkar S, Kamp F, Gomez de Aguero M, MacPherson AJ, Winkler E, Herms J, Benakis C, Dichgans M, Steiner H, Giera M, Haass C, Tahirovic S, Liesz A (2021). Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition. Elife. 2021 Apr 13;10:e59826. doi: 10.7554/eLife.59826. PMID: 33845942.
Heindl S, Ricci A, Carofiglio O, Zhou Q, Arzberger T, Lenart N, Franzmeier N, Hortobagyi T, Nelson PT, Stowe AM, Denes A, Edbauer D, Liesz A (2021). Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies. J Exp Med. 2021 Aug 2;218(8):e20202411. doi: 10.1084/jem.20202411. Epub 2021 May 26. PMID: 34037669.
Hermann DM, Liesz A, Dzyubenko E (2021). Implications of immune responses for stroke injury and recovery. Brain Behav Immun. 2021 May 20:S0889-1591(21)00217-8. doi: 10.1016/j.bbi.2021.05.020. Epub ahead of print. PMID: 34023355.
Llovera G, Pinkham K, Liesz A (2021). Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis. J Vis Exp. 2021 May 6;(171). doi: 10.3791/62536. PMID: 34028443.
Llovera G, Simats A, Liesz A (2021). Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery. J Vis Exp. 2021 May 24;(171). doi: 10.3791/62573. PMID: 34096920.
Roth S, Cao J, Singh V, Tiedt S, Hundeshagen G, Li T, Boehme JD, Chauhan D, Zhu J, Ricci A, Gorka O, Asare Y, Yang J, Lopez MS, Rehberg M, Bruder D, Zhang S, Groß O, Dichgans M, Hornung V, Liesz A (2021). Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade. Immunity. 2021 Mar 1:S1074-7613(21)00070-4. doi: 10.1016/j.immuni.2021.02.004. Epub ahead of print. PMID: 33667383.
Schafflick D, Wolbert J, Heming M, Thomas C, Hartlehnert M, Börsch AL, Ricci A, Martín-Salamanca S, Li X, Lu IN, Pawlak M, Minnerup J, Strecker JK, Seidenbecher T, Meuth SG, Hidalgo A, Liesz A, Wiendl H, Meyer Zu Horste G (2021). Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges. Nat Neurosci. 2021 Jul 12. doi: 10.1038/s41593-021-00880-y. Epub ahead of print. PMID: 34253922.
Zhang Y, Liesz A, Li (2021). Coming to the Rescue: Regulatory T Cells for Promoting Recovery After Ischemic Stroke. Stroke. 2021 Dec;52(12):e837-e841. doi: 10.1161/STROKEAHA.121.036072. Epub 2021 Nov 22. PMID: 34807742.
Zhu J, Cao J, Liesz A, Roth S (2021). A macrophage-T cell coculture model for severe tissue injury-induced T cell death. STAR Protoc. 2021 Dec 1;2(4):100983. doi: 10.1016/j.xpro.2021.100983. PMID: 34927092; PMCID: PMC8646263.

Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RT, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M (2020). Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability. Circ Res. 2020;10.1161/CIRCRESAHA.120.316743. doi:10.1161/CIRCRESAHA.120.316743 [published online ahead of print, 2020 Jun 17].
Roth S, Yang J, Cramer JV, Malik R, Liesz A (2020). Detection of cytokine-induced sickness behavior after ischemic stroke by an optimized behavioral assessment battery. Brain Behav Immun. 2020 Nov 14:S0889-1591(20)32392-8. doi: 10.1016/j.bbi.2020.11.016. Epub ahead of print. PMID: 33197540.
Sebastian Monasor L, Müller SA, Colombo AV, Tanrioever G, König J, Roth S, Liesz A, Berghofer A, Piechotta A, Prestel M, Saito T, Saido TC, Herms J, Willem M, Haass C, Lichtenthaler SF. Tahirovic S (2020). Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models. Elife. 2020;9:e54083. Published 2020 Jun 8. doi:10.7554/eLife.54083

Benakis C, Martin-Gallausiaux C, Trezzi JP, Melton P, Liesz A, Wilmes P (2019). The microbiome-gut-brain axis in acute and chronic brain diseases. Curr Opin Neurobiol. 2019 Dec 5;61:1-9. doi: 10.1016/j.conb.2019.11.009. [Epub ahead of print]
Cramer JV, Gesierich B, Roth S, Dichgans M, Düring M, Liesz A (2019). In vivo widefield calcium imaging of the mouse cortex for analysis of network connectivity in health and brain disease. Neuroimage. 2019 Jun 7;199:570-584. doi: 10.1016/j.neuroimage.2019.06.014. [Epub ahead of print]
Cserép C, Pósfai B, Lénárt N, Fekete R, László ZI, Lele Z, Orsolits B, Molnár G, Heindl S, Schwarcz AD, Ujvári K, Környei Z, Tóth K, Szabadits E, Sperlágh B, Baranyi M, Csiba L, Hortobágyi T, Maglóczky Z, Martinecz B, Szabó G, Erdélyi F, Szipőcs R, Tamkun MM, Gesierich B, Duering M, Katona I, Liesz A, Tamás G, Dénes Á (2019). Microglia monitor and protect neuronal function via specialized somatic purinergic junctions. Science. 2019 Dec 12. pii: eaax6752. doi: 10.1126/science.aax6752. [Epub ahead of print]
Liesz A (2019). The vascular side of Alzheimer's disease. Science. 2019 Jul 19;365(6450):223-224. doi: 10.1126/science.aay2720.
Sadler R, Cramer JV, Heindl S, Kostidis S, Betz D, Zuurbier KR, Northoff BH, Heijink M, Goldberg MP, Plautz EJ, Roth S, Malik R, Dichgans M, Holdt LM, Benakis C, Giera M, Stowe AM, Liesz A (2019). Short-chain fatty acids improve post-stroke recovery via immunological mechanisms. J Neurosci. 2019 Dec 30. pii: 1359-19. doi: 10.1523/JNEUROSCI.1359-19.2019. [Epub ahead of print]
Zhou Q, Mareljic N, Michaelsen M, Parhizkar S, Heindl S, Nuscher B, Farny D, Czuppa M, Schludi C, Graf A, Krebs S, Blum H, Feederle R, Roth S, Haass C, Arzberger T, Liesz A, Edbauer D (2019). Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model. EMBO Mol Med. 2019 Dec 20:e10919. doi: 10.15252/emmm.201910919. [Epub ahead of print]

Benakis C, Llovera G, Liesz A (2018). The meningeal and choroidal infiltration routes for leukocytes in stroke. Ther Adv Neurol Disord. 2018 Jun 18;11:1756286418783708. doi: 10.1177/1756286418783708. eCollection 2018.
Cai R, Pan C, Ghasemigharagoz A, Todorov MI, Förstera B, Zhao S, Bhatia HS, Parra-Damas A, Mrowka L, Theodorou D, Rempfler M, Xavier ALR, Kress BT, Benakis C, Steinke H, Liebscher S, Bechmann I, Liesz A , Menze B, Kerschensteiner M, Nedergaard M, Ertürk A (2018). Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull–meninges connections. Nat Neurosci. 2018 Dec 31. doi: 10.1038/s41593-018-0301-3. [Epub ahead of print]
Cramer JV, Benakis C, Liesz A (2018). T cells in the post-ischemic brain: Troopers or paramedics? J Neuroimmunol. 2018 Nov 13;326:33-37. doi: 10.1016/j.jneuroim.2018.11.006. [Epub ahead of print]
Heindl S, Gesierich B, Benakis C, Llovera G, Duering M, Liesz A (2018). Automated Morphological Analysis of Microglia After Stroke. Front Cell Neurosci. 2018 Apr 19;12:106. doi: 10.3389/fncel.2018.00106. eCollection 2018
Roth S, Singh V, Tiedt S, Schindler L, Huber G, Geerlof A, Antoine DJ, Anfray A, Orset C, Gauberti M, Fournier A, Holdt LM, Harris HE, Engelhardt B, Bianchi ME, Vivien D, Haffner C, Bernhagen J, Dichgans M, Liesz A (2018). Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke. Sci Transl Med. 2018 Mar 14;10(432). pii: eaao1313. doi: 10.1126/scitranslmed.aao1313.
Singh V, Sadler R, Heindl S, Llovera G, Roth S, Benakis C, Liesz A (2018). The gut microbiome primes a cerebroprotective immune response after stroke. J Cereb Blood Flow Metab. 2018 Jan 1:271678X18780130. doi: 10.1177/0271678X18780130. [Epub ahead of print]

Kumar V, Fleming T, Terjung S, Gorzelanny C, Gebhardt C, Agrawal R, Mall MA, Ranzinger J, Zeier M, Madhusudhan T, Ranjan S, Isermann B, Liesz A, Deshpande D, Häring HU, Biswas SK, Reynolds PR, Hammes HP, Peperkok R, Angel P, Herzig S, Nawroth PP (2017). Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair. Nucleic Acids Res. 2017 Aug 9. doi: 10.1093/nar/gkx705. [Epub ahead of print]
Llovera G, Benakis C, Enzmann G, Cai R, Arzberger T, Ghasemigharagoz A, Mao X, Malik R, Lazarevic I, Liebscher S, Ertürk A, Meissner L, Vivien D, Haffner C, Plesnila N, Montaner J, Engelhardt B, Liesz A (2017). The choroid plexus is a key cerebral invasion route for T cells after stroke. Acta Neuropathol. 2017 Jul 31. doi: 10.1007/s00401-017-1758-y. [Epub ahead of print]
Sadler R, Singh V, Benakis C, Garzetti D, Lopez DB, Stecher B, Anrather J, Liesz A (2017). Microbiota differences between commercial breeders impacts the post-stroke immune response. Brain Behav Immun. 2017 Mar 24. pii: S0889-1591(17)30101-0. doi: 10.1016/j.bbi.2017.03.011. [Epub ahead of print]
Tiedt S, Prestel M, Malik R, Schieferdecker N, Düring M, Kautzky V, Stoycheva I, Böck J, Northoff BH, Klein M, Dorn F, Krohn K, Teupser D, Liesz A, Plesnila N, Holdt LM, Dichgans M (2017). RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke. Circ Res. 2017 Jul 19. pii: CIRCRESAHA.117.311572. doi: 10.1161/CIRCRESAHA.117.311572. [Epub ahead of print]

Daria A, Colombo A, Llovera G, Hampel H, Willem M, Liesz A, Haass C, Tahirovic S (2016). Young microglia restore amyloid plaque clearance of aged microglia. EMBO J. 2016 Dec 21. pii: e201694591. doi: 10.15252/embj.201694591. [Epub ahead of print]
Ertürk A, Mentz S, Stout EE, Hedehus M, Dominguez SL, Neumaier L, Krammer F, Llovera G, Srinivasan K, Hansen DV, Liesz A, Scearce-Levie KA, Sheng M (2016). Interfering with the Chronic Immune Response Rescues Chronic Degeneration After Traumatic Brain Injury. J Neurosci. 2016 Sep 21;36(38):9962-75. doi: 10.1523/JNEUROSCI.1898-15.2016.
Friedländer F, Bohmann F, Brunkhorst M, Chae JH, Devraj K, Köhler Y, Kraft P, Kuhn H, Lucaciu A, Luger S, Pfeilschifter W, Sadler R, Liesz A, Scholtyschik K, Stolz L, Vutukuri R, Brunkhorst R (2016). Reliability of infarct volumetry: Its relevance and the improvement by a software-assisted approach. J Cereb Blood Flow Metab. 2016 Dec 1. pii: 0271678X16681311. [Epub ahead of print]
Liesz A, Kleinschnitz C (2016). Regulatory T cells in post-stroke immune homeostasis. Transl Stroke Res. 2016 Mar 31. [Epub ahead of print]
Llovera G, Liesz A (2016). The next step in translational research: Lessons learned from the first preclinical randomized controlled trial. J Neurochem. 2016 Mar 10. doi: 10.1111/jnc.13516. [Epub ahead of print]
Lourbopoulos A, Mamrak U, Roth S, Balbi M, Shrouder J, Liesz A, Hellal F, Plesnila N (2016). Inadequate food and water intake determine mortality following stroke in mice. J Cereb Blood Flow Metab. 2016 Jul 22. pii: 0271678X16660986. [Epub ahead of print]
Roth S, Liesz A. (2016). Stroke research at the crossroads – where are we heading? Swiss Medical Weekly. 2016 July 11. 146:w14329. DOI: 10.4414/smw.2016.14329. eCollection 2016.
Singh V, Roth S, Llovera G, Sadler R, Garzetti D, Stecher B, Dichgans M, Liesz A. (2016). Microbiota dysbiosis controls the neuroinflammatory response after stroke. Journal Neuroscience. 2016 July 13. 36(28):7428-40. DOI: 10.1523/JNEUROSCI.1114-16.2016.
Xiang X, Werner G, Bohrmann B, Liesz A, Mazaheri F, Capell A, Feederle R, Knuesel I, Kleinberger G, Haass C. (2016). TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance. EMBO Molecular Medicine. 2016 July 8. pii: e201606370. DOI: 10.15252/emmm.201606370. [Epub ahead of print]

Liesz A, Dalpke A, Mracsko E, Antoine DJ, Roth S, Zhou W, Yang H, Na SY, Akhisaroglu M, Fleming T, Eigenbrod T, Nawroth PP, Tracey KJ, Veltkamp R (2015). DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury. J Neurosci. 2015 Jan 14;35(2):583-98. doi: 10.1523/JNEUROSCI. 2439-14.2015.
Liesz A, Hu X, Kleinschnitz C, Offner H (2015). Functional Role of Regulatory Lymphocytes in Stroke: Facts and Controversies. Stroke. 2015 Mar 19. pii: STROKEAHA.114.008608. [Epub ahead of print]
Liesz A, Roth S, Zorn M, Sun L, Hofmann K, Veltkamp R (2015). Acquired immunoglobulin G deficiency in stroke patients and experimental brain ischemia. Exp Neurol. 2015 May 7;271:46-52. doi: 10.1016/j.expneurol.2015.04.021. [Epub ahead of print]
Liesz A, Kleinschnitz C (2015). Editorial: Mechanisms of neuroinflammation and inflammatory neurodegeneration in acute brain injury. Front Cell Neurosci. 2015 Aug 5;9:300. doi: 10.3389/fncel.2015.00300. eCollection 2015.
Llovera G, Hofmann K, Roth S, Salas-Pérdomo A, Ferrer-Ferrer M, Perego C, Zanier ER, Mamrak U, Rex A, Party H, Agin V, Fauchon C, Orset C, Haelewyn B, De Simoni MG, Dirnagl U, Grittner U, Planas AM, Plesnila N, Vivien D, Liesz A (2015). Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia. Sci Transl Med. 2015 Aug 5;7(299):299ra121. doi: 10.1126/scitranslmed.aaa9853.
Singh V, Roth S, Veltkamp R, Liesz A (2015). HMGB1 as a key mediator of immune mechanisms in ischemic stroke. Antioxid Redox Signal. 2015 Oct 22. [Epub ahead of print]

Liesz A, Bauer A, Hoheisel JD, Veltkamp R (2014). Intracerebral Interleukin-10 injection modulates post-ischemic neuroinflammation: An experimental microarray study. Neurosci Lett. 2014 Jul 11. pii: S0304-3940(14)00559-X. doi: 10.1016/j.neulet.2014.07.003. [Epub ahead of print]
Llovera G, Roth S, Plesnila N, Veltkamp R, Liesz A (2014). Modeling stroke in mice: permanent coagulation of the distal middle cerebral artery. J Vis Exp. 2014 Jul 31;(89). doi: 10.3791/51729.
Mracsko E, Liesz A, Stojanovic A, Lou WP, Osswald M, Zhou W, Karcher S, Winkler F, Martin-Villalba A, Cerwenka A, Veltkamp R (2014). Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke. J Neurosci. 2014 Dec 10;34(50):16784-95. doi: 10.1523/JNEUROSCI.1867-14.2014.
Mracsko E, Liesz A, Karcher S, Zorn M, Bari F, Veltkamp R (2014). Differential effects of sympathetic nervous system and hypothalamic-pituitary-adrenal axis on systemic immune cells after severe experimental stroke. Brain Behav Immun. 2014 Jun 2. pii: S0889-1591(14)00137-8. doi: 10.1016/j.bbi.2014.05.015. [Epub ahead of print]
Mracsko E, Javidi E, Na SY, Kahn A, Liesz A, Veltkamp R (2014). Leukocyte Invasion of the Brain After Experimental Intracerebral Hemorrhage in Mice. Stroke. 2014 Jun 10. pii: STROKEAHA.114.005801. [Epub ahead of print]
Na SY, Mracsko E, Liesz A, Hünig T, Veltkamp R (2014). Amplification of Regulatory T Cells Using a CD28 Superagonist Reduces Brain Damage After Ischemic Stroke in Mice. Stroke. 2014 Nov 6. pii: STROKEAHA.114.007756. [Epub ahead of print]

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