Lichtenthaler, Stefan

Askin B, Kilic C, Cordero Gómez C, Duong SL, Domingues-Baquero A, Goihl A, Nalbach K, Petushi J, Grundschöttel P, Wagner J, Thomas V, Lamberty J, Withers E, Huber H, Huebschmann S, Semenova E, Turko P, Newman AG, Diez L, Beyer M, De Domenico E, Körtvelyessy P, Reinhold D, Schneider A, Neher JJ, Ulas T, Lichtenthaler SF, Rost BR, Schmitz D, Prüss H, Wegmann S. IgLON5 autoimmune antibodies activate Tau via neuronal hyperactivity. Sci Adv. 2026 May 15;12(20):eaec2042. doi: 10.1126/sciadv.aec2042. Epub 2026 May 13. PMID: 42127169; PMCID: PMC13170660.
Feiten AF, Dahm K, Schlepckow K, van Lengerich B, Suh JH, Reifschneider A, Wefers B, Bartos LM, Wind-Mark K, de Weerd L, Ulas T, De-Domenico E, Grundschöttel P, Paulusch S, Tast B, Honda T, Müller SA, Becker M, Khalin I, Ricci A, Liesz A, Brunner B, Krenner C, Buschmann K, Nuscher B, Spieth L, Junker N, Berghoff SA, Davis SS, Neher JJ, Wurst W, Plesnila N, Lewcock JW, Simons M, Lichtenthaler SF, Di Paolo G, Brendel M, Capell A, Monroe KM, Schultze JL, Haass C. TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism. Nat Commun. 2026 Jan 24. doi: 10.1038/s41467-026-68706-8. Epub ahead of print. PMID: 41580393.
Heger LM, Gubinelli F, Huber AJ, Cardona-Alberich A, Rovere M, Matti U, Müller SA, Nagaraja SR, Jaschkowitz L, Schifferer M, Wurst W, Lichtenthaler SF, Behrends C, Sambandan S, Burbulla LF. VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1-linked Parkinson's neurons. Sci Adv. 2026 Feb 13;12(7):eadz5645. doi: 10.1126/sciadv.adz5645. Epub 2026 Feb 11. PMID: 41671379; PMCID: PMC12893317.
Tsai WY, Giesbertz P, Breimann S, Lichtenthaler S, Frishman D. Multi-platform integration of brain and CSF proteomes reveals biomarker panels for Alzheimer's disease. Brief Bioinform. 2026 Jan 7;27(1):bbag012. doi: 10.1093/bib/bbag012. PMID: 41608987; PMCID: PMC12853123.

Bhattacharya D, da Silva-Buttkus P, Nalbach K, Cheng L, Garrett L, Irmler M, Kislinger G, Werner G, Rodde R, Lengger C, Beckers J, Zimprich A, Hölter SM, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Wefers B, Wurst W, Brill MS, Schifferer M, Lichtenthaler SF, Behrends C. Neuropathy-associated Tecpr2 mutation knock-in mice reveal endolysosomal loss of function phenotypes in neurons and microglia. Cell Death Dis. 2025 Oct 31;16(1):775. doi: 10.1038/s41419-025-08168-w. PMID: 41173829; PMCID: PMC12578842.
Breimann S, Kamp F, Basset G, Abou-Ajram C, Güner G, Yanagida K, Okochi M, Müller SA, Lichtenthaler SF, Langosch D, Frishman D, Steiner H. Charting γ-secretase substrates by explainable AI. Nat Commun. 2025 Jul 1;16(1):5428. doi: 10.1038/s41467-025-60638-z. PMID: 40593564; PMCID: PMC12219630.
Distler U, Yoo HB, Kardell O, Hein D, Sielaff M, Scherer M, Jozefowicz AM, Leps C, Gomez-Zepeda D, von Toerne C, Merl-Pham J, Barth TK, Tüshaus J, Giesbertz P, Müller T, Kliewer G, Aljakouch K, Helm B, Unger H, Frey DL, Helm D, Schwarzmüller L, Popp O, Qin D, Wudy SI, Sinn LR, Mergner J, Ludwig C, Imhof A, Kuster B, Lichtenthaler SF, Krijgsveld J, Klingmüller U, Mertins P, Coscia F, Ralser M, Mülleder M, Hauck SM, Tenzer S. Multicenter evaluation of label-free quantification in human plasma on a high dynamic range benchmark set. Nat Commun. 2025 Oct 2;16(1):8774. doi: 10.1038/s41467-025-64501-z. PMID: 41038884; PMCID: PMC12491457.
Franke BU, Kummer K, Rose-John S, Lichtenthaler SF, Kress M. Shedding new light on BACE1-mediated modulation of IL-6 signaling: Implications for neural activity and synaptic plasticity in mice. Cytokine. 2025 Jun;190:156925. doi: 10.1016/j.cyto.2025.156925. Epub 2025 Apr 3. PMID: 40184913.
González-Gallego J, Todorov-Völgyi K, Müller SA, Antesberger S, Todorov MI, Malik R, Grimalt-Mirada R, Gonçalves CC, Schifferer M, Kislinger G, Weisheit I, Lindner B, Crusius D, Kroeger J, Borri M, Erturk A, Nelson M, Misgeld T, Lichtenthaler SF, Dichgans M, Paquet D. A fully iPS-cell-derived 3D model of the human blood-brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions. Nat Neurosci. 2025 Dec 15. doi: 10.1038/s41593-025-02123-w. Epub ahead of print. PMID: 41398476.
Guilbaud L, Roger K, Schmidt A, Chhuon C, Breimann S, Lipecka J, Dreux S, Müller SA, Zérah M, Larghero J, Jouannic JM, Lichtenthaler SF, Guerrera IC. Molecular insights into myelomeningocele via proteomic analysis of amniotic fluid. J Proteomics. 2025 Jan 6;313:105372. doi: 10.1016/j.jprot.2024.105372. Epub ahead of print. PMID: 39778765.
Heininger H, Feng X, Altunkaya A, Zheng F, Stockinger F, Wefers B, Müller SA, Giesbertz P, Tschirner SK, Shqau D, Adelsberger H, Ponomarenko A, Fenzl T, Alzheimer C, Lichtenthaler SF, Huth T. BACE1 regulates sleep-wake cycle through both enzymatic and non-enzymatic actions. EMBO Rep. 2025 Nov 20. doi: 10.1038/s44319-025-00604-4. Epub ahead of print. PMID: 41266616.
Jocher G, Ozcelik G, Müller SA, Hsia HE, Lastra Osua M, Hofmann LI, Aßfalg M, Dinkel L, Feng X, Schlepckow K, Willem M, Haass C, Tahirovic S, Blobel CP, Lichtenthaler SF. The late-onset Alzheimer's disease risk factor RHBDF2 is a modifier of microglial TREM2 proteolysis. Life Sci Alliance. 2025 Mar 13;8(5):e202403080. doi: 10.26508/lsa.202403080. PMID: 40081988; PMCID: PMC11909414.
Kardell O, Gronauer T, von Toerne C, Merl-Pham J, König AC, Barth TK, Mergner J, Ludwig C, Tüshaus J, Giesbertz P, Breimann S, Schweizer L, Müller T, Kliewer G, Distler U, Gomez-Zepeda D, Popp O, Qin D, Teupser D, Cox J, Imhof A, Küster B, Lichtenthaler SF, Krijgsveld J, Tenzer S, Mertins P, Coscia F, Hauck SM. Multicenter Longitudinal Quality Assessment of MS-Based Proteomics in Plasma and Serum. J Proteome Res. 2025 Feb 7. doi: 10.1021/acs.jproteome.4c00644. Epub ahead of print. PMID: 39918541.
Lourbopoulos A, Müller SA, Jocher G, Wick M, Plesnila N, Lichtenthaler SF. An Improved Method for Sampling and Quantitative Protein Analytics of Cerebrospinal Fluid of Individual Mice. Mol Cell Proteomics. 2025 Mar 27;24(5):100958. doi: 10.1016/j.mcpro.2025.100958. Epub ahead of print. PMID: 40157722.
Takalo M, Jeskanen H, Rolova T, Kervinen I, Hellén M, Heikkinen S, Koivisto H, Jokivarsi K, Müller SA, Koivumäki EM, Mäkinen P, Juopperi SP, Willman RM, Sinisalo R, Hoffmann D, Jäntti H, Peitz M, Fließbach K, Kuulasmaa T, Natunen T, Kemppainen S, Poutiainen P, Leinonen V, Malm T, Martiskainen H, Ramirez A, Haapasalo A, Lichtenthaler SF, Tanila H, Haass C, Rinne J, Koistinaho J, Hiltunen M. The protective PLCγ2-P522R variant mitigates Alzheimer's disease-associated pathologies by enhancing beneficial microglial functions. J Neuroinflammation. 2025 Mar 5;22(1):64. doi: 10.1186/s12974-025-03387-6. PMID: 40038760; PMCID: PMC11881468.
Todorov-Völgyi K, González-Gallego J, Müller SA, Todorov MI, Seker FB, Frerich S, Cernilogar FM, Schröger L, Malik R, Cao J, Llovera G, Roth S, Schillinger U, Schifferer M, Reyahi A, Crusius D, Pedro LD, Simons M, Carlsson P, Ertürk A, Liesz A, Schotta G, Plesnila N, Lichtenthaler SF, Paquet D, Dichgans M. The stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling. Nat Neurosci. 2025 Dec 15. doi: 10.1038/s41593-025-02136-5. Epub ahead of print. PMID: 41398477
Tschirner SK, Schmidt A, Ito M, Hyakkoku K, Yoshimura A, Müller SA, Horiguchi N, Lichtenthaler SF. Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non-Human Primates. Proteomics. 2025 Nov 27:e70082. doi: 10.1002/pmic.70082. Epub ahead of print. PMID: 41310967.

Aßfalg M, Güner G, Müller SA, Breimann S, Langosch D, Muhle-Goll C, Frishman D, Steiner H, Lichtenthaler SF. Cleavage efficiency of the intramembrane protease γ-secretase is reduced by the palmitoylation of a substrate's transmembrane domain. FASEB J. 2024 Feb;38(2):e23442. doi:10.1096/fj.202302152R. PMID: 38275103.
Beaufort N, Ingendahl L, Merdanovic M, Schmidt A, Podlesainski D, Richter T, Neumann T, Kuszner M, Vetter IR, Stege P, Burston SG, Filipovic A, Ruiz-Blanco YB, Bravo-Rodriguez K, Mieres-Perez J, Beuck C, Uebel S, Zobawa M, Schillinger J, Malik R, Todorov-Völgyi K, Rey J, Roberti A, Hagemeier B, Wefers B, Müller SA, Wurst W, Sanchez-Garcia E, Zimmermann A, Hu XY, Clausen T, Huber R, Lichtenthaler SF, Schmuck C, Giese M, Kaiser M, Ehrmann M, Dichgans M. Rational correction of pathogenic conformational defects in HTRA1. Nat Commun. 2024 Jul 16;15(1):5944. doi: 10.1038/s41467-024-49982-8. PMID: 39013852; PMCID: PMC11252331.
Bonelli S, Lo Pinto M, Ye Y, Mueller SA, Lichtenthaler SF, Scilabra SD. Proteomic characterization of ubiquitin carboxyl-terminal hydrolase 19 deficient cells reveals a role for USP19 in secretion of lysosomal proteins. Mol Cell Proteomics. 2024 Oct 8:100854. doi: 10.1016/j.mcpro.2024.100854. Epub ahead of print. PMID: 39389361.
Calligaris M, Spanò DP, Bonelli S, Müller SA, Carcione C, D'apolito D, Amico G, Miele M, Di Bella M, Zito G, Nuti E, Rossello A, Blobel CP, Lichtenthaler SF, Scilabra SD. iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I. Cell Mol Life Sci. 2024 Apr 4;81(1):163. doi: 10.1007/s00018-024-05201-7. PMID: 38570362; PMCID: PMC10991058.
Calligaris M, Spanò DP, Puccio MC, Müller SA, Bonelli S, Lo Pinto M, Zito G, Blobel CP, Lichtenthaler SF, Troeberg L, Scilabra SD. Development of a Proteomic Workflow for the Identification of Heparan Sulphate Proteoglycan-Binding Substrates of ADAM17. Proteomics. 2024 Sep 24:e202400076. doi: 10.1002/pmic.202400076. Epub ahead of print. PMID: 39318062.
Dinkel L, Hummel S, Zenatti V, Malara M, Tillmann Y, Colombo A, Monasor LS, Suh JH, Logan T, Roth S, Paeger L, Hoffelner P, Bludau O, Schmidt A, Müller SA, Schifferer M, Nuscher B, Njavro JR, Prestel M, Bartos LM, Wind-Mark K, Slemann L, Hoermann L, Kunte ST, Gnörich J, Lindner S, Simons M, Herms J, Paquet D, Lichtenthaler SF, Bartenstein P, Franzmeier N, Liesz A, Grosche A, Bremova-Ertl T, Catarino C, Beblo S, Bergner C, Schneider SA, Strupp M, Di Paolo G, Brendel M, Tahirovic S. Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease. Sci Transl Med. 2024 Dec 4;16(776):eadl4616. doi: 10.1126/scitranslmed.adl4616. Epub 2024 Dec 4. PMID: 39630885.
Gallwitz L, Bleibaum F, Voss M, Schweizer M, Spengler K, Winter D, Zöphel F, Müller S, Lichtenthaler S, Damme M, Saftig P. Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis. Cell Mol Life Sci. 2024 May 22;81(1):227. doi: 10.1007/s00018-024-05274-4. PMID: 38775843; PMCID: PMC11111660.
Marvian AT, Strauss T, Tang Q, Tuck BJ, Keeling S, Rüdiger D, Mirzazadeh Dizaji N, Mohammad-Beigi H, Nuscher B, Chakraborty P, Sutherland DS, McEwan WA, Köglsperger T, Zahler S, Zweckstetter M, Lichtenthaler SF, Wurst W, Schwarz S, Höglinger G. Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons. Mol Neurodegener. 2024 Dec 31;19(1):100. doi: 10.1186/s13024-024-00786-w. PMID: 39736627; PMCID: PMC11686972.
Schmidt A, Hrupka B, van Bebber F, Sunil Kumar S, Feng X, Tschirner SK, Aßfalg M, Müller SA, Hilger LS, Hofmann LI, Pigoni M, Jocher G, Voytyuk I, Self EL, Ito M, Hyakkoku K, Yoshimura A, Horiguchi N, Feederle R, De Strooper B, Schulte-Merker S, Lammert E, Moechars D, Schmid B, Lichtenthaler SF. The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling. J Clin Invest. 2024 Jun 18:e170550. doi: 10.1172/JCI170550. Epub ahead of print. PMID: 38888964.
Song F, Kovac V, Mohammadi B, Littau JL, Scharfenberg F, Matamoros Angles A, Vanni I, Shafiq M, Orge L, Galliciotti G, Djakkani S, Linsenmeier L, Černilec M, Hartman K, Jung S, Tatzelt J, Neumann JE, Damme M, Tschirner SK, Lichtenthaler SF, Ricklefs FL, Sauvigny T, Schmitz M, Zerr I, Puig B, Tolosa E, Ferrer I, Magnus T, Rupnik MS, Sepulveda-Falla D, Matschke J, Šmid LM, Bresjanac M, Andreoletti O, Krasemann S, Foliaki ST, Nonno R, Becker-Pauly C, Monzo C, Crozet C, Haigh CL, Glatzel M, Curin Serbec V, Altmeppen HC. Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases. Acta Neuropathol. 2024 Jul 9;148(1):2. doi: 10.1007/s00401-024-02763-5. PMID: 38980441; PMCID: PMC11233397.
Todorov-Völgyi K, González-Gallego J, Müller SA, Beaufort N, Malik R, Schifferer M, Todorov MI, Crusius D, Robinson S, Schmidt A, Körbelin J, Bareyre F, Ertürk A, Haass C, Simons M, Paquet D, Lichtenthaler SF, Dichgans M. Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging. Nat Aging. 2024 Mar 22. doi: 10.1038/s43587-024-00598-z. Epub ahead of print. PMID: 38519806.
Yasa S, Butz ES, Colombo A, Chandrachud U, Montore L, Tschirner S, Prestel M, Sheridan SD, Müller SA, Groh J, Lichtenthaler SF, Tahirovic S, Cotman SL. Loss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover. Commun Biol. 2024 Oct 22;7(1):1373. doi: 10.1038/s42003-024-07057-w. PMID: 39438652; PMCID: PMC11496662.
Yoshida F, Nagatomo R, Utsunomiya S, Kimura M, Shun S, Kono R, Kato Y, Nao Y, Maeda K, Koyama R, Ikegaya Y, Lichtenthaler SF, Takatori S, Takemoto H, Ogawa K, Ito G, Tomita T. Soluble form of Lingo2, an autism spectrum disorder-associated molecule, functions as an excitatory synapse organizer in neurons. Transl Psychiatry. 2024 Oct 23;14(1):448. doi: 10.1038/s41398-024-03167-5. PMID: 39443477; PMCID: PMC11500186.

Amin A, Badenes M, Tüshaus J, de Carvalho É, Burbridge E, Faísca P, Trávníčková K, Barros A, Carobbio S, Domingos PM, Vidal-Puig A, Moita LF, Maguire S, Stříšovský K, Ortega FJ, Fernández-Real JM, Lichtenthaler SF, Adrain C (2023). Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis. Mol Metab. 2023 Apr 28:101731. doi: 10.1016/j.molmet.2023.101731. Epub ahead of print. PMID: 37121509.
Bartos LM, Kirchleitner SV, Kolabas ZI, Quach S, Beck A, Lorenz J, Blobner J, Mueller SA, Ulukaya S, Hoeher L, Horvath I, Wind-Mark K, Holzgreve A, Ruf VC, Gold L, Kunze LH, Kunte ST, Beumers P, Park HE, Antons M, Zatcepin A, Briel N, Hoermann L, Schaefer R, Messerer D, Bartenstein P, Riemenschneider MJ, Lindner S, Ziegler S, Herms J, Lichtenthaler SF, Ertürk A, Tonn JC, von Baumgarten L, Albert NL, Brendel M (2023). Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution. Sci Adv. 2023 Oct 27;9(43):eadi8986. doi: 10.1126/sciadv.adi8986. Epub 2023 Oct 27. PMID: 37889970; PMCID: PMC10610915.
Bernhardt AM, Tiedt S, Teupser D, Dichgans M, Meyer B, Gempt J, Kuhn PH, Simons M, Palleis C, Weidinger E, Nübling G, Holdt L, Hönikl L, Gasperi C, Giesbertz P, Müller SA, Breimann S, Lichtenthaler SF, Kuster B, Mann M, Imhof A, Barth T, Hauck SM, Zetterberg H, Otto M, Weichert W, Hemmer B, Levin J (2023). A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases. EBioMedicine. 2023 Feb 4;89:104456. doi: 10.1016/j.ebiom.2023.104456. Epub ahead of print. PMID: 36745974; PMCID: PMC9931915.
Calligaris M, Yang CY, Bonelli S, Spanò DP, Müller SA, Lichtenthaler SF, Troeberg L, Scilabra SD (2023). Identification of membrane proteins regulated by ADAM15 by SUSPECS proteomics. Front Mol Biosci. 2023 Jun 14;10:1162504. doi: 10.3389/fmolb.2023.1162504. PMID: 37388246; PMCID: PMC10304831.
Kardell O, von Toerne C, Merl-Pham J, König AC, Blindert M, Barth TK, Mergner J, Ludwig C, Tüshaus J, Eckert S, Müller SA, Breimann S, Giesbertz P, Bernhardt AM, Schweizer L, Albrecht V, Teupser D, Imhof A, Kuster B, Lichtenthaler SF, Mann M, Cox J, Hauck SM. Multicenter Collaborative Study to Optimize Mass Spectrometry Workflows of Clinical Specimens. J Proteome Res. 2023 Nov 28. doi: 10.1021/acs.jproteome.3c00473. Epub ahead of print. PMID: 38015820.
Liu S, Heumüller SE, Hossinger A, Müller SA, Buravlova O, Lichtenthaler SF, Denner P, Vorberg IM (2023). Reactivated endogenous retroviruses promote protein aggregate spreading. Nat Commun. 2023 Aug 18;14(1):5034. doi: 10.1038/s41467-023-40632-z. PMID: 37596282; PMCID: PMC10439213.
Müller SA, Shmueli MD, Feng X, Tüshaus J, Schumacher N, Clark R, Smith BE, Chi A, Rose-John S, Kennedy ME, Lichtenthaler SF (2023). The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130. Mol Neurodegener. 2023 Feb 21;18(1):13. doi: 10.1186/s13024-023-00596-6. PMID: 36810097; PMCID: PMC9942414.
Nalbach K, Schifferer M, Bhattacharya D, Ho-Xuan H, Tseng W, Williams LA, Stolz A, Lichtenthaler SF, Elazar Z, Behrends C (2023). Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2. Nat Commun. 2023 Feb 16;14(1):870. doi: 10.1038/s41467-023-36553-6. PMID: 36797266; PMCID: PMC9935918.
Overby M, Serrano-Rodriguez A, Dadras S, Christiansen AK, Ozcelik G, Lichtenthaler SF, Weick JP, Müller HK (2023). Neuron-specific gene NSG1 binds to and positively regulates sortilin ectodomain shedding via a metalloproteinase-dependent mechanism. J Biol Chem. 2023 Nov 8;299(12):105446. doi: 10.1016/j.jbc.2023.105446. Epub ahead of print. PMID: 37949230.
Pesämaa I, Müller SA, Robinson S, Darcher A, Paquet D, Zetterberg H, Lichtenthaler SF, Haass C (2023). A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer's disease patients from controls. Mol Neurodegener. 2023 Sep 29;18(1):70. doi: 10.1186/s13024-023-00657-w. PMID: 37775827; PMCID: PMC10543321.

Pratsch K, Unemura C, Ito M, Lichtenthaler SF, Horiguchi N, Herms J (2023). New Highly Selective BACE1 Inhibitors and Their Effects on Dendritic Spine Density In Vivo. Int J Mol Sci. 2023 Jul 31;24(15):12283. doi: 10.3390/ijms241512283. PMID: 37569661; PMCID: PMC10418759.
Rabinowitsch AI, Maretzky T, Weskamp G, Haxaire C, Tueshaus J, Lichtenthaler SF, Monette S, Blobel CP (2023). Analysis of the function of ADAM17 in iRhom2-curly-bare (cub) and Tylosis with Oesophageal Cancer (TOC) mutant mice. J Cell Sci. 2023 Jun 7:jcs.260910. doi: 10.1242/jcs.260910. Epub ahead of print. PMID: 37282854.
Tai YH, Engels D, Locatelli G, Emmanouilidis I, Fecher C, Theodorou D, Müller SA, Licht-Mayer S, Kreutzfeldt M, Wagner I, de Mello NP, Gkotzamani SN, Trovò L, Kendirli A, Aljović A, Breckwoldt MO, Naumann R, Bareyre FM, Perocchi F, Mahad D, Merkler D, Lichtenthaler SF, Kerschensteiner M, Misgeld T (2023). Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions. Nat Metab. 2023 Jul 10. doi: 10.1038/s42255-023-00838-3. Epub ahead of print. PMID: 37430025.
Werner NT, Högel P, Güner G, Stelzer W, Wozny M, Aßfalg M, Lichtenthaler SF, Steiner H, Langosch D (2023). Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase. Commun Biol. 2023 Feb 15;6(1):177. doi: 10.1038/s42003-023-04470-5. PMID: 36792683; PMCID: PMC9931712.

Bhatia HS, Brunner AD, Öztürk F, Kapoor S, Rong Z, Mai H, Thielert M, Ali M, Al-Maskari R, Paetzold JC, Kofler F, Todorov MI, Molbay M, Kolabas ZI, Negwer M, Hoeher L, Steinke H, Dima A, Gupta B, Kaltenecker D, Caliskan ÖS, Brandt D, Krahmer N, Müller S, Lichtenthaler SF, Hellal F, Bechmann I, Menze B, Theis F, Mann M, Ertürk A (2022). Spatial proteomics in three-dimensional intact specimens. Cell. 2022 Dec 22;185(26):5040-5058.e19. doi: 10.1016/j.cell.2022.11.021. PMID: 36563667.
Eninger T, Müller SA, Bacioglu M, Schweighauser M, Lambert M, Maia LF, Neher JJ, Hornfeck SM, Obermüller U, Kleinberger G, Haass C, , Kahle PJ, Staufenbiel M, Ping L, Duong DM, Levey AI, Seyfried NT, Lichtenthaler SF, Jucker M, Kaeser SA (2022). Signatures of glial activity can be detected in the CSF proteome. Proc Natl Acad Sci U S A. 2022 Jun 14;119(24):e2119804119. doi: 10.1073/pnas.2119804119. Epub 2022 Jun 6. PMID: 35666874; PMCID: PMC9214531.
Güner G, Aßfalg M, Zhao K, Dreyer T, Lahiri S, Lo Y, Slivinschi BI, Imhof A, Jocher G, Strohm L, Behrends C, Langosch D, Bronger H, Nimsky C, Bartsch JW, Riddell SR, Steiner H, Lichtenthaler SF (2022). Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activity. EMBO Mol Med. 2022 Sep 7:e16084. doi: 10.15252/emmm.202216084. Epub ahead of print. PMID: 36069059.
Jocher G, Grass V, Tschirner SK, Riepler L, Breimann S, Kaya T, Oelsner M, Hamad MS, Hofmann LI, Blobel CP, Schmidt-Weber CB, Gokce O, Jakwerth CA, Trimpert J, Kimpel J, Pichlmair A, Lichtenthaler SF (2022). ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion. EMBO Rep. 2022 Jun 7;23(6):e54305. doi: 10.15252/embr.202154305. Epub 2022 May 8. PMID: 35527514.
Papadopoulou AA, Stelzer W, Silber M, Schlosser C, Spitz C, Haug-Kröper M, Straub T, Müller SA, Lichtenthaler SF, Muhle-Goll C, Langosch D, Fluhrer R (2022). Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage. Sci Rep. 2022 Dec 5;12(1):20987. doi: 10.1038/s41598-022-24772-8. PMID: 36470941; PMCID: PMC9722940.
Rother C, Uhlmann RE, Müller SA, Schelle J, Skodras A, Obermüller U, Häsler LM, Lambert M, Baumann F, Xu Y, Bergmann C, Salvadori G, Loos M, Brzak I, Shimshek D, Neumann U; Dominantly Inherited Alzheimer Network, Walker LC, Schultz SA, Chhatwal JP, Kaeser SA, Lichtenthaler SF, Staufenbiel M, Jucker M (2022). Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae. Nat Commun. 2022 Nov 28;13(1):7333. doi: 10.1038/s41467-022-34538-5. PMID: 36443293; PMCID: PMC9705543.
Rudan Njavro J, Vukicevic M, Fiorini E, Dinkel L, Müller SA, Berghofer A, Bordier C, Kozlov S, Halle A, Buschmann K, Capell A, Giudici C, Willem M, Feederle R, Lichtenthaler SF, Babolin C, Montanari P, Pfeifer A, Kosco-Vilbois M, Tahirovic S (2022). Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model. Cells. 2022 Dec 24;12(1):79. doi: 10.3390/cells12010079. PMID: 36611872; PMCID: PMC9818422.
Schneider MF, Müller V, Müller SA, Lichtenthaler SF, Becker PB, Scheuermann JC (2022). LncRNA RUS shapes the gene expression program towards neurogenesis. Life Sci Alliance. 2022 Jun 10;5(10):e202201504. doi: 10.26508/lsa.202201504. PMID: 35688487.
Yang CY, Bonelli S, Calligaris M, Carreca AP, Müller SA, Lichtenthaler SF, Troeberg L, Scilabra SD (2022). Quantitative Proteomics Reveals That ADAM15 Can Have Proteolytic-Independent Functions in the Steady State. Membranes (Basel). 2022 May 31;12(6):578. doi: 10.3390/membranes12060578. PMID: 35736286; PMCID: PMC9227920.

Boehmer DFR, Formisano S, de Oliveira Mann CC, Mueller SA, Kluge M, Metzger P, Rohlfs M, Hörth C, Kocheise L, Lichtenthaler SF, Hopfner KP, Endres S, Rothenfusser S, Friedel CC, Duewell P, Schnurr M, Koenig LM (2021). OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis. Sci Immunol. 2021 Jul 16;6(61):eabe2550. doi: 10.1126/sciimmunol.abe2550. PMID: 34272227.
Carreca AP, Pravatà VM, D'Apolito D, Bonelli S, Calligaris M, Monaca E, Müller SA, Lichtenthaler SF, Scilabra SD (2021). Quantitative Proteomics Reveals Changes Induced by TIMP-3 on Cell Membrane Composition and Novel Metalloprotease Substrates. Int J Mol Sci. 2021 Feb 27;22(5):2392. doi: 10.3390/ijms22052392. PMID: 33673623.
Colombo A, Dinkel L, Müller SA, Sebastian Monasor L, Schifferer M, Cantuti-Castelvetri L, König J, Vidatic L, Bremova-Ertl T, Lieberman AP, Hecimovic S, Simons M, Lichtenthaler SF, Strupp M, Schneider SA, Tahirovic S (2021). Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia. Nat Commun. 2021 Feb 24;12(1):1158. doi: 10.1038/s41467-021-21428-5. PMID: 33627648.
Dominko K, Rastija A, Sobocanec S, Vidatic L, Meglaj S, Lovincic Babic A, Hutter-Paier B, Colombo AV, Lichtenthaler SF, Tahirovic S, Hecimovic S (2021). Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation. Int J Mol Sci. 2021 Dec 9;22(24):13256. doi: 10.3390/ijms222413256. PMID: 34948052; PMCID: PMC8705785.
Lichtenthaler SF, Tschirner SK, Steiner H (2021). Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2. Curr Opin Neurobiol. 2021 Oct 21;72:101-110. doi: 10.1016/j.conb.2021.09.003. Epub ahead of print. PMID: 34689040.
Liu S, Hossinger A, Heumüller SE, Hornberger A, Buravlova O, Konstantoulea K, Müller SA, Paulsen L, Rousseau F, Schymkowitz J, Lichtenthaler SF, Neumann M, Denner P, Vorberg IM (2021). Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions. Nat Commun. 2021 Oct 19;12(1):5739. doi: 10.1038/s41467-021-25855-2. PMID: 34667166; PMCID: PMC8526834.
Lora J, Weskamp G, Li TM, Maretzky T, Shola DTN, Monette S, Lichtenthaler SF, Lu TT, Yang C, Blobel CP (2021). Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype. J Biol Chem. 2021 May 3:100733. doi: 10.1016/j.jbc.2021.100733. Epub ahead of print. PMID: 33957124.
Macrini C, Gerhards R, Winklmeier S, Bergmann L, Mader S, Spadaro M, Vural A, Smolle M, Hohlfeld R, Kümpfel T, Lichtenthaler SF, Franquelim HG, Jenne D, Meinl E (2021). Features of MOG required for recognition by patients with MOG antibody-associated disorders. Brain. 2021 Mar 11:awab105. doi: 10.1093/brain/awab105. Epub ahead of print. PMID: 33704436.
Martín-de-Saavedra MD, Dos Santos M, Culotta L, Varea O, Spielman BP, Parnell E, Forrest MP, Gao R, Yoon S, McCoig E, Jalloul HA, Myczek K, Khalatyan N, Hall EA, Turk LS, Sanz-Clemente A, Comoletti D, Lichtenthaler SF, Burgdorf JS, Barbolina MV, Savas JN, Penzes P (2021). Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2. Neuron. 2021 Dec 16:S0896-6273(21)00986-7. doi: 10.1016/j.neuron.2021.11.025. Epub ahead of print. PMID: 34921780.
McDade E, Voytyuk I, Aisen P, Bateman RJ, Carrillo MC, De Strooper B, Haass C, Reiman EM, Sperling R, Tariot PN, Yan R, Masters CL, Vassar R, Lichtenthaler SF (2021). The case for low-level BACE1 inhibition for the prevention of Alzheimer disease. Nat Rev Neurol. 2021 Sep 21. doi: 10.1038/s41582-021-00545-1. Epub ahead of print. PMID: 34548654.
Nash A, Gijsen HJM, Hrupka BJ, Teng KS, Lichtenthaler SF, Takeshima H, Gunnersen JM, Munro KM (2021). BACE inhibitor treatment of mice induces hyperactivity in a Seizure-related gene 6 family dependent manner without altering learning and memory. Sci Rep. 2021 Jul 23;11(1):15084. doi: 10.1038/s41598-021-94369-0. PMID: 34302009; PMCID: PMC8302682.
Ong-Pålsson E, Njavro JR, Wilson Y, Pigoni M, Schmidt A, Müller SA, Meyer M, Hartmann J, Busche MA, Gunnersen JM, Munro KM, Lichtenthaler SF (2021). The β-Secretase Substrate Seizure 6-Like Protein (SEZ6L) Controls Motor Functions in Mice. Mol Neurobiol. 2021 Dec 27. doi: 10.1007/s12035-021-02660-y. Epub ahead of print. PMID: 34958451.
Pagnon de la Vega M, Giedraitis V, Michno W, Kilander L, Güner G, Zielinski M, Löwenmark M, Brundin R, Danfors T, Söderberg L, Alafuzoff I, Nilsson LNG, Erlandsson A, Willbold D, Müller SA, Schröder GF, Hanrieder J, Lichtenthaler SF, Lannfelt L, Sehlin D, Ingelsson M (2021). The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid β fibril formation. Sci Transl Med. 2021 Aug 11;13(606):eabc6184. doi: 10.1126/scitranslmed.abc6184. PMID: 34380771.
Penkert H, Bertrand A, Tiwari V, Breimann S, Müller SA, Jordan PM, Gerl MJ, Klose C, Cantuti-Castelvetri L, Bosch-Queralt M, Levental I, Lichtenthaler SF, Werz O, Simons M (2021). Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery. Cell Rep. 2021 Oct 26;37(4):109898. doi: 10.1016/j.celrep.2021.109898. PMID: 34706241.
Sachs M, Wetzel S, Reichelt J, Sachs W, Schebsdat L, Zielinski S, Seipold L, Heintz L, Müller SA, Kretz O, Lindenmeyer M, Wiech T, Huber TB, Lüllmann-Rauch R, Lichtenthaler SF, Saftig P, Meyer-Schwesinger C (2021). ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage. J Am Soc Nephrol. 2021 Mar 30:ASN.2020081213. doi: 10.1681/ASN.2020081213. Epub ahead of print. PMID: 33785583.
Tüshaus J, Müller SA, Shrouder J, Arends M, Simons M, Plesnila N, Blobel CP, Lichtenthaler SF (2021). The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system. FASEB J. 2021 Nov;35(11):e21962. doi: 10.1096/fj.202100936R. PMID: 34613632.

Brouwers B, Coppola I, Vints K, Dislich B, Jouvet N, Van Lommel L, Segers C, Gounko NV, Thorrez L, Schuit F, Lichtenthaler SF, Estall JL, Declercq J, Ramos-Molina B, Creemers JWM (2020). Loss of Furin in β cells Induces an mTORC1-ATF4 Anabolic Pathway that Leads to β cell Dysfunction. Diabetes. 2020 Dec 4:db200474. doi: 10.2337/db20-0474. Epub ahead of print. PMID: 33277337.
Cunha MI, Su M, Cantuti-Castelvetri L, Müller SA, Schifferer M, Djannatian M, Alexopoulos I, van der Meer F, Winkler A, van Ham TJ, Schmid B, Lichtenthaler SF, Stadelmann C, Simons M (2020). Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis. J Exp Med. 2020 May 4;217(5). pii: e20191390. doi: 10.1084/jem.20191390.
Fang R, Haxaire C, Otero M, Lessard S, Weskamp G, McIlwain DR, Mak TW, Lichtenthaler SF, Blobel CP (2020). Role of iRhoms 1 and 2 in Endochondral Ossification. Int J Mol Sci. 2020 Nov 19;21(22):8732. doi: 10.3390/ijms21228732. PMID: 33227998; PMCID: PMC7699240.
Gerhards R, Pfeffer LK, Lorenz J, Starost L, Nowack L, Thaler FS, Schlüter M, Rübsamen H, Macrini C, Winklmeier S, Mader S, Bronge M, Grönlund H, Feederle R, Hsia HE, Lichtenthaler SF, Merl-Pham J, Hauck SM, Kuhlmann T, Bauer IJ, Beltran E, Gerdes LA, Mezydlo A, Bar-Or A, Banwell B, Khademi M, Olsson T, Hohlfeld R, Lassmann H, Kümpfel T, Kawakami N, Meinl E (2020). Oligodendrocyte myelin glycoprotein as a novel target for pathogenic autoimmunity in the CNS. Acta Neuropathol Commun. 2020 Nov 30;8(1):207. doi: 10.1186/s40478-020-01086-2. PMID: 33256847; PMCID: PMC7706210.
Güner G, Lichtenthaler SF (2020). The substrate repertoire of γ-secretase/presenilin. Semin Cell Dev Biol. 2020;S1084-9521(20)30003-3. doi:10.1016/j.semcdb.2020.05.019 [published online ahead of print, 2020 Jun 29]
Koo CZ, Harrison N, Noy PJ, Szyroka J, Matthews AL, Hsia HE, Müller SA, Tüshaus J, Goulding J, Willis K, Apicella C, Cragoe B, Davis E, Keles M, Malinova A, McFarlane TA, Morrison PR, Nguyen HTH, Sykes MC, Ahmed H, Di Maio A, Seipold L, Saftig P, Cull E, Pliotas C, Rubinstein E, Poulter NS, Briddon SJ, Holliday ND, Lichtenthaler SF, Tomlinson MG (2020). The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex. J Biol Chem. 2020 Feb 28. pii: jbc.RA120.012601. doi: 10.1074/jbc.RA120.012601. [Epub ahead of print]
Kumar R, Tang Q, Müller SA, Gao P, Mahlstedt D, Zampagni S, Tan Y, Klingl A, Bötzel K, Lichtenthaler SF, Höglinger GU, Koeglsperger T (2020). Fibroblast Growth Factor 2-Mediated Regulation of Neuronal Exosome Release Depends on VAMP3/Cellubrevin in Hippocampal Neurons. Adv Sci (Weinh). 2020 Jan 28;7(6):1902372. doi: 10.1002/advs.201902372. eCollection 2020 Mar.
Kumar R, Donakonda S, Müller SA, Lichtenthaler SF, Bötzel K, Höglinger GU, Koeglsperger T (2020). Basic Fibroblast Growth Factor 2-Induced Proteome Changes Endorse Lewy Body Pathology in Hippocampal Neurons. iScience. 2020;23(8):101349. doi:10.1016/j.isci.2020.101349 [published online ahead of print, 2020 Jul 9]
Lichtenthaler SF, Meinl E (2020). To cut or not to cut: New rules for proteolytic shedding of membrane proteins. J Biol Chem. 2020;295(35):12353-12354. doi:10.1074/jbc.H120.015304
Pigoni M, Hsia HE, Hartmann J, Rudan Njavro J, Shmueli MD, Müller SA, Güner G, Tüshaus J, Kuhn PH, Kumar R, Gao P, Tran ML, Ramazanov B, Blank B, Hipgrave Ederveen AL, Von Blume J, Mulle C, Gunnersen JM, Wuhrer M, Rammes G, Busche MA, Koeglsperger T, Lichtenthaler SF (2020). Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3. EMBO J. 2020;e103457. doi:10.15252/embj.2019103457 [published online ahead of print, 2020 Jun 22].
Sebastian Monasor L, Müller SA, Colombo AV, Tanrioever G, König J, Roth S, Liesz A, Berghofer A, Piechotta A, Prestel M, Saito T, Saido TC, Herms J, Willem M, Haass C, Lichtenthaler SF. Tahirovic S (2020). Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models. Elife. 2020;9:e54083. Published 2020 Jun 8. doi:10.7554/eLife.54083
Tüshaus J, Müller SA, Kataka ES, Zaucha J, Sebastian Monasor L, Su M, Güner G, Jocher G, Tahirovic S, Frishman D, Simons M, Lichtenthaler SF (2020). An optimized quantitative proteomics method establishes the cell type-resolved mouse brain secretome. EMBO J. 2020 Sep 21:e105693. doi: 10.15252/embj.2020105693. Epub ahead of print. PMID: 32954517.
Tüshaus J, Kataka ES, Zaucha J, Frishman D, Müller SA, Lichtenthaler SF (2020). Neuronal Differentiation of LUHMES Cells Induces Substantial Changes of the Proteome. Proteomics. 2020 Sep 19:e2000174. doi: 10.1002/pmic.202000174. Epub ahead of print. PMID: 32951307.
Weskamp G, Tüshaus J, Li D, Feederle R, Maretzky T, Swendeman S, Falck-Pedersen E, McIlwain DR, Mak TW, Salmon JE, Lichtenthaler SF, Blobel CP (2020). ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1). J Biol Chem. 2020 Feb 14. pii: jbc.RA119.011136. doi: 10.1074/jbc.RA119.011136. [Epub ahead of print]
Yang CY, Chanalaris A, Bonelli S, McClurg O, Hiles GL, Cates AL, Zarebska JM, Vincent TL, Day ML, Müller SA, Lichtenthaler SF, Nagase H, Scilabra SD, Troeberg L (2020). Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage. Osteoarthr Cartil Open. 2020 Dec;2(4):100128. doi: 10.1016/j.ocarto.2020.100128. PMID: 33381768; PMCID: PMC7762825.

Bartels M, Weckbecker D, Kuhn PH, Ryazanov S, Leonov A, Griesinger C, Lichtenthaler SF, Bötzel K, Giese A (2019). Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression. Sci Rep. 2019 Jun 24;9(1):9100. doi: 10.1038/s41598-019-45298-6.
Brummer T, Müller SA, Pan-Montojo F, Yoshida F, Fellgiebel A, Tomita T, Endres K, Lichtenthaler SF (2019). NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease. EMBO Mol Med. 2019 Mar 4. pii: e9695. doi: 10.15252/emmm.201809695. [Epub ahead of print]
Fang WS, Sun DY, Yang S, Cheng C, Moschke K, Li T, Sun S, Lichtenthaler SF, Huang J, Wang Y (2019). Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR. Bioorg Chem. 2019 Sep 13;92:103253. doi: 10.1016/j.bioorg.2019.103253. [Epub ahead of print]
Fecher C, Trovò L, Müller SA, Snaidero N, Wettmarshausen J, Heink S, Ortiz O, Wagner I, Kühn R, Hartmann J, Karl RM, Konnerth A, Korn T, Wurst W, Merkler D, Lichtenthaler SF, Perocchi F, Misgeld T (2019). Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity. Nat Neurosci. 2019 Sep 9. doi: 10.1038/s41593-019-0479-z. [Epub ahead of print]
Höfling C, Shehabi E, Kuhn PH, Lichtenthaler SF, Hartlage-Rübsamen M, Roßner S (2019). Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer’s Disease. Front Neurosci. 2019 Feb 22;13:137. doi: 10.3389/fnins.2019.00137. eCollection 2019.
Hsia HE, Tüshaus J, Brummer T, Zheng Y, Scilabra SD, Lichtenthaler SF (2019). Functions of 'A disintegrin and metalloproteases (ADAMs)' in the mammalian nervous system. Cell Mol Life Sci. 2019 Jun 24. doi: 10.1007/s00018-019-03173-7. [Epub ahead of print]
Lichtenthaler SF, Güner G (2019). Pathology-linked protease caught in action. Science. 2019 Feb 15;363(6428):690-691. doi: 10.1126/science.aaw5547.
Montagna E, Crux S, Luckner M, Herber J, Colombo AV, Marinković P, Tahirovic S, Lichtenthaler SF, Wanner G, Müller UC, Sgobio C, Herms J (2019). In vivo Ca2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria. Glia. 2019 Jan 22. doi: 10.1002/glia.23584. [Epub ahead of print]
Nash A, Aumann TD, Pigoni M, Lichtenthaler SF, Takeshima H, Munro KM, Gunnersen JM (2019). Lack of Sez6 Family Proteins Impairs Motor Functions, Short-Term Memory, and Cognitive Flexibility and Alters Dendritic Spine Properties. Cereb Cortex. 2019 Nov 11. pii: bhz230. doi: 10.1093/cercor/bhz230. [Epub ahead of print]
Niemeyer J, Mentrup T, Heidasch R, Müller SA, Biswas U, Meyer R, Papadopoulou AA, Dederer V, Haug-Kröper M, Adamski V, Lüllmann-Rauch R, Bergmann M, Mayerhofer A, Saftig P, Wennemuth G, Jessberger R, Fluhrer R, Lichtenthaler SF, Lemberg MK, Schröder B (2019). The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban. EMBO Rep. 2019 Feb 7. pii: e46449. doi: 10.15252/embr.201846449. [Epub ahead of print]
Papadopoulou AA, Müller SA, Mentrup T, Shmueli MD, Niemeyer J, Haug-Kröper M, von Blume J, Mayerhofer A, Feederle R, Schröder B, Lichtenthaler SF, Fluhrer R (2019). Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins. EMBO Rep. 2019 Feb 7. pii: e46451. doi: 10.15252/embr.201846451. [Epub ahead of print]
Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Monasor LS, Tahirovic S, Herms J, Willem M, Pettkus N, Butovsky O, Bartenstein P, Edbauer D, Rominger A, Ertürk A, Grathwohl SA, Neher JJ, Holtzman DM, Meyer-Luehmann M, Haass C (2019). Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Nat Neurosci. 2019 Jan 7. doi: 10.1038/s41593-018-0296-9. [Epub ahead of print]
Peters F, Salihoglu H, Pratsch K, Herzog E, Pigoni M, Sgobio C, Lichtenthaler SF, Neumann U, Herms J (2019). Tau deletion reduces plaque-associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease. EMBO J. 2019 Nov 7:e2019102345. doi: 10.15252/embj.2019102345. [Epub ahead of print]
Riemschoss K, Arndt V, Bolognesi B, von Eisenhart-Rothe P, Liu S, Buravlova O, Duernberger Y, Paulsen L, Hornberger A, Hossinger A, Lorenzo-Gotor N, Hogl S, Müller SA, Tartaglia G, Lichtenthaler SF, Vorberg IM (2019). Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cells. Life Sci Alliance. 2019 Jul 2;2(4). pii: e201800280. doi: 10.26508/lsa.201800280. Print 2019 Aug.
Rudan Njavro J, Klotz J, Dislich B, Wanngren J, Shmueli MD, Herber J, Kuhn PH, Kumar R, Koeglsperger T, Conrad M, Wurst W, Feederle R, Vlachos A, Michalakis S, Jedlicka P, Müller SA, Lichtenthaler SF (2019). Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1. FASEB J. 2019 Dec 27. doi: 10.1096/fj.201902347R. [Epub ahead of print]
Scharfenberg F, Helbig A, Sammel M, Benzel J, Schlomann U, Peters F, Wichert R, Bettendorff M, Schmidt-Arras D, Rose-John S, Moali C, Lichtenthaler SF, Pietrzik CU, Bartsch JW, Tholey A, Becker-Pauly C (2019). Degradome of soluble ADAM10 and ADAM17 metalloproteases. Cell Mol Life Sci. 2019 Jun 17. doi: 10.1007/s00018-019-03184-4. [Epub ahead of print]
Yates SC, Groeneboom NE, Coello C, Lichtenthaler SF, Kuhn PH, Demuth HU, Hartlage-Rübsamen M, Roßner S, Leergaard T, Kreshuk A, Puchades MA, Bjaalie JG (2019). QUINT: Workflow for Quantification and Spatial Analysis of Features in Histological Images From Rodent Brain. Front Neuroinform. 2019 Dec 3;13:75. doi: 10.3389/fninf.2019.00075. eCollection 2019.

Abdullahi S, Jäkel M, Behrend SJ, Steiger K, Topping G, Krabbe T, Colombo A, Sandig V, Schiergens TS, Thasler WE, Werner J, Lichtenthaler SF, Schmid RM, Ebert O, Altomonte J (2018). A novel chimeric oncolytic virus vector for improved safety and efficacy in hepatocellular carcinoma. J Virol. 2018 Sep 19. pii: JVI.01386-18. doi: 10.1128/JVI.01386-18. [Epub ahead of print]
Blume T, Filser S, Jaworska A, Blain JF, Koenig G, Moschke K, Lichtenthaler SF, Herms J (2018). BACE1 Inhibitor MK-8931 Alters Formation but Not Stability of Dendritic Spines. Front Aging Neurosci. 2018 Jul 26;10:229. doi: 10.3389/fnagi.2018.00229. eCollection 2018.
Brummer T, Pigoni M, Rossello A, Wang H, Noy PJ, Tomlinson MG, Blobel CP, Lichtenthaler SF (2018). The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation. FASEB J. 2018 Feb 7:fj201700823RR. doi: 10.1096/fj.201700823RR. [Epub ahead of print]
Causevic M, Dominko K, Malnar M, Vidatic L, Cermak S, Pigoni M, Kuhn PH, Colombo A, Havas D, Flunkert S, McDonald J, Gunnersen JM, Hutter-Paier B, Tahirovic S, Windisch M, Krainc D, Lichtenthaler SF, Hecimovic S (2018). BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains. PLoS One. 2018 Jul 6;13(7):e0200344. doi: 10.1371/journal.pone.0200344. eCollection 2018.
Colombo A, Hsia HE, Wang M, Kuhn PH, Brill MS, Canevazzi P, Feederle R, Taveggia C, Misgeld T, Lichtenthaler SF (2018). Non-cell-autonomous function of DR6 in Schwann cell proliferation. EMBO J. 2018 Feb 19. pii: e97390. doi: 10.15252/embj.201797390. [Epub ahead of print]
Duernberger Y, Liu S, Riemschoss K, Paulsen L, Bester R, Kuhn PH, Schölling M, Lichtenthaler SF, Vorberg I. Prion Replication in the Mammalian Cytosol: Functional Regions within a Prion Domain Driving Induction, Propagation, and Inheritance. Mol Cell Biol. 2018 Jul 16;38(15):e00111-18. doi: 10.1128/MCB.00111-18. PMID: 29784771; PMCID: PMC6048315.
Hartlage-Rübsamen M, Bluhm A, Piechotta A, Linnert M, Rahfeld JU, Demuth HU, Lues I, Kuhn PH, Lichtenthaler SF, Roßner S, Höfling C (2018). Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation. Molecules. 2018 Apr 17;23(4). pii: E924. doi: 10.3390/molecules23040924.
Heiland T, Zeitschel U, Puchades MA, Kuhn PH, Lichtenthaler SF, Bjaalie JG, Hartlage-Rübsamen M, Roßner S, Höfling C (2018). Defined astrocytic expression of human amyloid precursor protein in Tg2576 mouse brain. Glia. 2018 Nov 28. doi: 10.1002/glia.23550. [Epub ahead of print]
Herber J, Njavro J, Feederle R, Schepers U, Müller U, Bräse S, Müller S, Lichtenthaler SF (2018). Click chemistry-mediated biotinylation reveals a function for the protease BACE1 in modulating the neuronal surface glycoproteome. Mol Cell Proteomics. 2018 May 1. pii: mcp.RA118.000608. doi: 10.1074/mcp.RA118.000608. [Epub ahead of print]
Lichtenthaler SF, Lemberg MK, Fluhrer R (2018). Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments. EMBO J. 2018 Jul 5. pii: e99456. doi: 10.15252/embj.201899456. [Epub ahead of print]
Meinl E, Thaler FS, Lichtenthaler SF (2018). Shedding of BAFF/APRIL Receptors Controls B Cells. Trends Immunol. 2018 Jul 30. pii: S1471-4906(18)30126-1. doi: 10.1016/j.it.2018.07.002. [Epub ahead of print]
Scilabra SD, Pigoni M, Pravatá V, Schätzl T, Müller SA, Troeberg L, Lichtenthaler SF (2018). Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor. Sci Rep. 2018 Oct 2;8(1):14697. doi: 10.1038/s41598-018-32910-4.
Voytyuk I, Mueller SA, Herber J, Snellinx A, Moechars D, van Loo G, Lichtenthaler SF, De Strooper B (2018). BACE2 distribution in major brain cell types and identification of novel substrates. Life Sci Alliance. 2018 Feb 15;1(1):e201800026. doi: 10.26508/lsa.201800026. eCollection 2018 Jan.
Zellner A, Scharrer E, Arzberger T, Oka C, Domenga-Denier V, Joutel A, Lichtenthaler SF, Müller SA, Dichgans M, Haffner C (2018). CADASIL brain vessels show a HTRA1 loss-of-function profile. Acta Neuropathol. 2018 May 3. doi: 10.1007/s00401-018-1853-8. [Epub ahead of print]

Baranger K, Bonnet AE, Girard SD, Paumier JM, García-González L, Elmanaa W, Bernard A, Charrat E, Stephan D, Bauer C, Moschke K, Lichtenthaler SF, Roman FS, Checler F, Khrestchatisky M, Rivera S (2017). MT5-MMP Promotes Alzheimer’s Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro. Front Mol Neurosci. 2017 Jan 10;9:163. doi: 10.3389/fnmol.2016.00163. eCollection 2016.
Bruch J, Xu H, Rösler TW, De Andrade A, Kuhn PH, Lichtenthaler SF, Arzberger T, Winklhofer KF, Müller U, Höglinger GU (2017). PERK activation mitigates tau pathology in vitro and in vivo. EMBO Mol Med. 2017 Feb 1. pii: e201606664. doi: 10.15252/emmm.201606664. [Epub ahead of print]
Schlepckow K, Kleinberger G, Fukumori A, Feederle R, Lichtenthaler SF, Steiner H, Haass C (2017). An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function. EMBO Mol Med. 2017 Aug 30. pii: e201707672. doi: 10.15252/emmm.201707672. [Epub ahead of print]
Serdaroglu A, Müller SA, Schepers U, Bräse S, Weichert W, Lichtenthaler SF, Kuhn PH. An optimised version of the secretome protein enrichment with click sugars (SPECS) method leads to enhanced coverage of the secretome. Proteomics. 2017 Mar;17(5). doi: 10.1002/pmic.201600423. Epub 2017 Jan 31. PMID: 27991726.

Barão S, Moechars D, Lichtenthaler SF, De Strooper B (2016). BACE1 physiological functions may limit its use as therapeutic target for Alzheimer's disease. Trends Neurosci. 2016 Jan 29. pii: S0166-2236(16)00004-7. doi: 10.1016/j.tins.2016.01.003. [Epub ahead of print]
Biella G, Federica F, Nardo E, Bernocchi O, Colombo A, Lichtenthaler SF, Forloni G, Albani (2016). Sirtuin 2 inhibition improves cognitive performance and acts on amyloid-β protein precursor processing in two alzheimer's disease mouse models. Journal of Alzheimer's Disease. 2016 June 30. DOI: 10.3233/JAD-151135. [Epub ahead of print]
Höfling C, Morawski M, Zeitschel U, Zanier ER, Moschke K, Serdaroglu A, Canneva F, von Hörsten S, De Simoni MG, Forloni G, Jäger C, Kremmer E, Roßner S, Lichtenthaler SF, Kuhn P (2016). Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodies. Aging Cell. 2016 Jul 29. doi: 10.1111/acel.12508. [Epub ahead of print]
Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn PH, Kremmer E, Giese A, Lichtenthaler SF, Haass C, Arzberger T, Steiner H (2016). Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease. EMBO Mol Med. 2016 Mar 17. pii: e201505952. doi: 10.15252/emmm.201505952. [Epub ahead of print]
Kuhn PH, Colombo AV, Schusser B, Dreymueller D, Wetzel S, Schepers U, Herber J, Ludwig A, Kremmer E, Montag D, Müller U, Schweizer M, Saftig P, Bräse S, Lichtenthaler SF (2016). Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. Elife. 2016 Jan 23;5. pii: e12748. doi: 10.7554/eLife.12748. [Epub ahead of print]
Müller SA, Scilabra SD, Lichtenthaler SF (2016). Proteomic Substrate Identification for Membrane Proteases in the Brain. Front Mol Neurosci. 2016 Oct 13;9:96. eCollection 2016.
Pigoni M, Wanngren J, Kuhn PH, Munro KM, Gunnersen JM, Takeshima H, Feederle R, Voytyuk I, De Strooper B, Levasseur MD, Hrupka BJ, Müller SA, Lichtenthaler SF (2016). Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons. Mol Neurodegener. 2016 Oct 5;11(1):67.
Pigoni M, Gunnersen JM, Lichtenthaler SF (2016). Seizure-6 proteins highlight BACE1 functions in neurobiology. Oncotarget. 2016 Dec 5. doi: 10.18632/oncotarget.13801. [Epub ahead of print]
Schönherr C, Bien J, Isbert S, Wichert R, Prox J, Altmeppen H, Kumar S, Walter J, Lichtenthaler SF, Weggen S, Glatzel M, Becker-Pauly C, Pietrzik CU (2016). Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site. Mol Neurodegener. 2016 Feb 19;11(1):19. doi: 10.1186/s13024-016-0084-5.
Scilabra SD, Yamamoto K, Pigoni M, Sakamoto K, Müller SA, Papadopoulou A, Lichtenthaler SF, Troeberg L, Nagase H, Kadomatsu K (2016). Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue. Matrix Biol. 2016 Jul 29. pii: S0945-053X(16)30132-9. doi: 10.1016/j.matbio.2016.07.004. [Epub ahead of print]
Zhu K, Xiang X, Filser S, Marinković P, Dorostkar MM, Crux S, Neumann U, Shimshek DR, Rammes G, Haass C, Lichtenthaler SF, Gunnersen JM, Herms J (2016). Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6. Biol Psychiatry. 2016 Dec 26. pii: S0006-3223(16)33157-2. doi: 10.1016/j.biopsych.2016.12.023. [Epub ahead of print]

Baranger K, Marchalant Y, Bonnet AE, Crouzin N, Carrete A, Paumier JM, Py NA, Bernard A, Bauer C, Charrat E, Moschke K, Seiki M, Vignes M, Lichtenthaler SF, Checler F, Khrestchatisky M, Rivera S (2015). MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease. Cell Mol Life Sci. 2015 Jul 23. [Epub ahead of print]
Dislich B, Wohlrab F, Bachhuber T, Mueller S, Kuhn PH, Hogl S, Meyer-Luehmann M, Lichtenthaler SF (2015). Label-free quantitative proteomics of mouse cerebrospinal fluid detects BACE1 protease substrates in vivo. Mol Cell Proteomics. 2015 Jul 2. pii: mcp.M114.041533. [Epub ahead of print]
Kuhn PH, Voss M, Haug-Kröper M, Schröder B, Schepers U, Bräse S, Haass C, Lichtenthaler SF, Fluhrer R (2015). Secretome analysis identifies novel signal peptide peptidase-like 3 (SPPL3) substrates and reveals a role of SPPL3 in multiple Golgi glycosylation pathways. Mol Cell Proteomics. 2015 Mar 31. pii: mcp.M115.048298. [Epub ahead of print]
Laurent SA, Hoffmann FS, Kuhn PH, Cheng Q, Chu Y, Schmidt-Supprian M, Hauck SM, Schuh E, Krumbholz M, Rübsamen H, Wanngren J, Khademi M, Olsson T, Alexander T, Hiepe F, Pfister HW, Weber F, Jenne D, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E (2015). γ-secretase directly sheds the survival receptor BCMA from plasma cells. Nat Commun. 2015 Jun 11;6:7333. doi: 10.1038/ncomms8333.
Li S, Dislich B, Brakebusch CH, Lichtenthaler SF, Brocker T (2015). Control of homeostasis and dendritic cell survival by the GTPase RhoA. Am J Med Genet B Neuropsychiatr Genet. 2015 Apr 2. doi: 10.1002/ajmg.b.32309. [Epub ahead of print]
Lichtenthaler SF, O'Hara BF, Blobel CP (2015). iRhoms in the brain - a new frontier? Cell Cycle. 2015 Aug 20:0. [Epub ahead of print]
Schulz AM, Stutte S, Hogl S, Luckashenak N, Dudziak D, Leroy C, Forné I, Imhof A, Müller SA, Brakebusch CH, Lichtenthaler SF, Brocker T (2015). Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells. J Cell Biol. 2015 Nov 9;211(3):553-67. doi: 10.1083/jcb.201503128.

Cox CJ, Choudhry F, Peacey E, Perkinton MS, Richardson JC, Howlett DR, Lichtenthaler SF, Francis PT, Williams RJ(2014). Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing. Neurobiol Aging. 2014 Jul 30. pii: S0197-4580(14)00501-6. doi: 10.1016/j.neurobiolaging.2014.07.032. [Epub ahead of print]
Hoffmann FS, Kuhn PH, Laurent SA, Hauck SM, Berer K, Wendlinger SA, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister HW, Alexander T, Hiepe F, Kümpfel T, Crawford HC, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E (2014). The Immunoregulator Soluble TACI Is Released by ADAM10 and Reflects B Cell Activation in Autoimmunity. J Immunol. 2014 Dec 10. pii: 1402070. [Epub ahead of print]
Vassar R, Kuhn PH, Haass C, Kennedy ME, Rajendran L, Wong PC, Lichtenthaler SF (2014). Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. J Neurochem. 2014 Mar 19. doi: 10.1111/jnc.12715. [Epub ahead of print]
Voss M, Künzel U, Higel F, Kuhn PH, Colombo A, Fukumori A, Haug-Kröper M, Klier B, Grammer G, Seidl A, Schröder B, Obst R, Steiner H, Lichtenthaler SF, Haass C, Fluhrer R (2014). Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation. EMBO J. 2014 Oct 29. pii: e201488375. [Epub ahead of print]

Fleck D, van Bebber F, Colombo A, Galante C, Schwenk BM, Rabe L, Hampel H, Novak B, Kremmer E, Tahirovic S, Edbauer D, Lichtenthaler SF, Schmid B, Willem M, Haass C (2013). Dual cleavage of Neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling. J Neuroscience 2013 33(18): 7856-7869; doi: 10.1523/JNEUROSCI.3372-12.2013
Hachmeister M, Bobowski KD, Hogl S, Dislich B, Fukumori A, Eggert C, Mack B, Kremling H, Sarrach S, Coscia F, Zimmermann W, Steiner H, Lichtenthaler SF, Gires O (2013). Regulated Intramembrane Proteolysis and Degradation of Murine Epithelial Cell Adhesion Molecule mEpCAM. PLoS One. 2013 Aug 29;8(8):e71836. doi: 10.1371/journal.pone.0071836.
Hofmann JP, Denner P, Nussbaum-Krammer C, Kuhn PH, Suhre MH, Scheibel T, Lichtenthaler SF, Schätzl HM, Bano D, Vorberg IM (2013). Cell-to-cell propagation of infectious cytosolic protein aggregates. Proc Natl Acad Sci U S A. 2013 Mar 18. [Epub ahead of print]
Hogl S, van Bebber F, Dislich B, Kuhn PH, Haass C, Schmid B, Lichtenthaler SF (2013). Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Proteomics. 2013 Mar 4. doi: 10.1002/pmic.201200582. [Epub ahead of print]
Ivankov DN, Bogatyreva NS, Hönigschmid P, Dislich B, Hogl S, Kuhn PH, Frishman D, Lichtenthaler SF (2013). QARIP: a web server for quantitative proteomic analysis of regulated intramembrane proteolysis. Nucleic Acids Res. 2013 May 31. [Epub ahead of print]
Kretner B, Fukumori A, Kuhn PH, Pérez-Revuelta BI, Lichtenthaler SF, Haass C, Steiner H (2013). Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase. J Neurochem. (2013) Dec 12. doi: 10.1111/jnc.12124. [Epub ahead of print]
Lichtenthaler SF (2013). iRHOM2 takes control of rheumatoid arthritis. J Clin Invest. 25:1-3 (2013)
Misgeld T, Lichtenthaler SF, Dichgans M (2013). Between new genetic discoveries and large randomized trials-neurological research in the era of systems medicine. EMBO Rep. 2013 May 14. doi: 10.1038/embor.2013.70. [Epub ahead of print]
Mueller-Rischart A-K, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, Peis R, Deinlein A, Schweimer C, Kuhn P-H, Lichtenthaler SF, Motori E, Hrelia S, Wurst W, Truembach D, Langer T, Krappmann D, Dittmar G, Tatzelt J, Winklhofer KF (2013). The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO. Molecular cell doi:10.1016/j.molcel.2013.01.036
Ohno M, Hiraoka Y, Lichtenthaler SF, Nishi K, Saijo S, Matsuoka T, Tomimoto H, Araki W, Takahashi R, Kita T, Kimura T, Nishi E (2013). Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model. Neurobiol Aging. 2013 Aug 15. pii: S0197-4580(13)00319-9. doi: 10.1016/j.neurobiolaging.2013.07.014. [Epub ahead of print]
Schmid B, Hruschaa A, Hogla S, Banzhaf-Strathmanna J, Strecker K, van der Zee J, Teucke M, Eimer S, Hegermann J, Kittelmann M, Kremmer E, Cruts M, Solchenberger B, Hasenkamp L, van Bebber F, Van Broeckhoven C, Edbauer D, Lichtenthaler SF, Haass C (2013). Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth. PNAS 2013 ; published ahead of print March 1, 2013, doi:10.1073/pnas.1218311110
Schwenk BM, Lang CM, Hogl S, Tahirovic S, Orozco D, Rentzsch K, Lichtenthaler SF, Hoogenraad CC, Capell A, Haass C, Edbauer D (2013). The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes. EMBO J. 2013 Dec 19. [Epub ahead of print]
Taverna M, Straub T, Hampel H, Rujescu D, Lichtenthaler SF (2013). A New Sandwich Immunoassay for Detection of the α-Secretase Cleaved, Soluble Amyloid-β Protein Precursor in Cerebrospinal Fluid and Serum. J Alzheimers Dis. 2013 Jul 23. [Epub ahead of print]

Page RM, Münch A, Horn T, Kuhn PH, Colombo A, Reiner O, Boutros M, Steiner H, Lichtenthaler SF, Haass C (2012). Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments. J Neurosci. 32(50):18204-14 (2012)
Voss M, Fukumori A, Kuhn PH, Künzel U, Klier B, Grammer G, Haug-Kröper M, Kremmer E, Lichtenthaler SF, Steiner H, Schröder B, Haass C, Fluhrer R (2012). Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3). J Biol Chem. 287(52):43401-9 (2012)

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