Korn, Thomas
Afzali AM, Nirschl L, Sie C, Pfaller M, Ulianov O, Hassler T, Federle C, Petrozziello E, Kalluri SR, Chen HH, Tyystjärvi S, Muschaweckh A, Lammens K, Delbridge C, Büttner A, Steiger K, Seyhan G, Ottersen OP, Öllinger R, Rad R, Jarosch S, Straub A, Mühlbauer A, Grassmann S, Hemmer B, Böttcher JP, Wagner I, Kreutzfeldt M, Merkler D, Pardàs IB, Schmidt Supprian M, Buchholz VR, Heink S, Busch DH, Klein L, Korn T. B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. Nature. 2024 Feb 21. doi: 10.1038/s41586-024-07079-8. Epub ahead of print. PMID: 38383779.
Baeten P, Hamad I, Hoeks C, Hiltensperger M, Van Wijmeersch B, Popescu V, Aly L, Somers V, Korn T, Kleinewietfeld M, Hellings N, Broux B. Rapamycin rescues loss-of-function in blood-brain barrier-interacting regulatory T cells. JCI Insight. 2024 Feb 22:e167457. doi: 10.1172/jci.insight.167457. Epub ahead of print. PMID: 38386413.
Chang Y, Bach L, Hasiuk M, Wen L, Elmzzahi T, Tsui C, Gutiérrez-Melo N, Steffen T, Utzschneider DT, Raj T, Jost PJ, Heink S, Cheng J, Burton OT, Zeiträg J, Alterauge D, Dahlström F, Becker JC, Kastl M, Symeonidis K, van Uelft M, Becker M, Reschke S, Krebs S, Blum H, Abdullah Z, Paeschke K, Ohnmacht C, Neumann C, Liston A, Meissner F, Korn T, Hasenauer J, Heissmeyer V, Beyer M, Kallies A, Jeker LT, Baumjohann D. TGF-β specifies TFH versus TH17 cell fates in murine CD4+ T cells through c-Maf. Sci Immunol. 2024 Mar;9(93):eadd4818. doi: 10.1126/sciimmunol.add4818. Epub 2024 Mar 1. PMID: 38427718.
- Gross CC, Schulte-Mecklenbeck A, Steinberg OV, Wirth T, Lauks S, Bittner S, Schindler P, Baranzini SE, Groppa S, Bellmann-Strobl J, Bünger N, Chien C, Dawin E, Eveslage M, Fleischer V, Gonzalez-Escamilla G, Gisevius B, Haas J, Kerschensteiner M, Kirstein L, Korsukewitz C, Lohmann L, Lünemann JD, Luessi F, Meyer Zu Hörste G, Motte J, Ruck T, Ruprecht K, Schwab N, Steffen F, Meuth SG, Paul F, Wildemann B, Kümpfel T, Gold R, Hahn T, Zipp F, Klotz L, Wiendl H; German Competence Network Multiple Sclerosis (KKNMS) [i.a. Hemmer B, Korn T]. Multiple sclerosis endophenotypes identified by high-dimensional blood signatures are associated with distinct disease trajectories. Sci Transl Med. 2024 Mar 27;16(740):eade8560. doi: 10.1126/scitranslmed.ade8560. Epub 2024 Mar 27. PMID: 38536936.
Kavaka V, Mutschler L, de la Rosa Del Val C, Eglseer K, Gómez Martínez AM, Flierl-Hecht A, Ertl-Wagner B, Keeser D, Mortazavi M, Seelos K, Zimmermann H, Haas J, Wildemann B, Kümpfel T, Dornmair K, Korn T, Hohlfeld R, Kerschensteiner M, Gerdes LA, Beltrán E. Twin study identifies early immunological and metabolic dysregulation of CD8+ T cells in multiple sclerosis. Sci Immunol. 2024 Sep 27;9(99):eadj8094. doi: 10.1126/sciimmunol.adj8094. Epub 2024 Sep 27. PMID: 39331727.
Wertheimer T, Zwicky P, Rindlisbacher L, Sparano C, Vermeer M, de Melo BMS, Haftmann C, Rückert T, Sethi A, Schärli S, Huber A, Ingelfinger F, Xu C, Kim D, Häne P, Fonseca da Silva A, Muschaweckh A, Nunez N, Krishnarajah S, Köhler N, Zeiser R, Oukka M, Korn T, Tugues S, Becher B. IL-23 stabilizes an effector Treg cell program in the tumor microenvironment. Nat Immunol. 2024 Feb 14. doi: 10.1038/s41590-024-01755-7. Epub ahead of print. PMID: 38356059.
- Wicklein R, Kreitner L, Wild A, Aly L, Rueckert D, Hemmer B, Korn T, Menten MJ, Knier B. Retinal small vessel pathology is associated with disease burden in multiple sclerosis. Mult Scler. 2024 May 15:13524585241247775. doi: 10.1177/13524585241247775. Epub ahead of print. PMID: 38751230.
Wolf E, Wicklein R, Aly L, Schmaderer C, Afzali AM, Mardin C, Korn T, Hemmer B, Hofauer B, Knier B. Optical coherence tomography angiography suggests different retinal pathologies in multiple sclerosis and Sjögren's syndrome. J Neurol. 2024 May 14. doi: 10.1007/s00415-024-12414-0. Epub ahead of print. PMID: 38743089.
- Bauer IJ, Fang P, Lämmle KF, Tyystjärvi S, Alterauge D, Baumjohann D, Yoon H, Korn T, Wekerle H, Kawakami N (2023). Visualizing the activation of encephalitogenic T cells in the ileal lamina propria by in vivo two-photon imaging. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2302697120. doi: 10.1073/pnas.2302697120. Epub 2023 Jul 19. PMID: 37467267.
- Bertram D, Tsaktanis T, Berthele A, Korn T (2023). The role of intrathecal free light chains kappa for the detection of autoimmune encephalitis in subacute onset neuropsychiatric syndromes. Sci Rep. 2023 Oct 11;13(1):17224. doi: 10.1038/s41598-023-44427-6. PMID: 37821561; PMCID: PMC10567819.
- Korn T (2023). Foxp3+ regulatory T cells in the central nervous system and other non-lymphoid tissues. Eur J Immunol. 2023 May 4:e2250227. doi: > 10.1002/eji.202250227. Epub ahead of print. PMID: 37143298.
- Linnerbauer M, Beyer T, Nirschl L, Farrenkopf D, Lößlein L, Vandrey O, Peter A, Tsaktanis T, Kebir H, Laplaud D, Oellinger R, Engleitner T, Alvarez JI, Rad R, Korn T, Hemmer B, Quintana FJ, Rothhammer V (2023). PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation. Nat Commun. 2023 Sep 9;14(1):5555. doi: 10.1038/s41467-023-40982-8. PMID: 37689786; PMCID: PMC10492803.
- Romahn EF, Wiltgen T, Bussas M, Aly L, Wicklein R, Noll C, Berthele A, Dehmelt V, Mardin C, Zimmer C, Korn T, Hemmer B, Kirschke JS, Mühlau M, Knier B. Association of retinal vessel pathology and brain atrophy in relapsing-remitting multiple sclerosis. Front Immunol. 2023 Nov 28;14:1284986. doi: 10.3389/fimmu.2023.1284986. PMID: 38090586; PMCID: PMC10715309.
- Schaller T, Ringen J, Fischer B, Bieler T, Perius K, Knopp T, Kommoss KS, Korn T, Heikenwälder M, Oelze M, Daiber A, Münzel T, Kramer D, Wenzel P, Wild J, Karbach S, Waisman A (2023). Reactive oxygen species produced by myeloid cells in psoriasis as a potential biofactor contributing to the development of vascular inflammation. Biofactors. 2023 May 4. doi: 10.1002/biof.1949. Epub ahead of print. PMID: 37139784.
- Scherer S, Oberle SG, Kanev K, Gerullis AK, Wu M, de Almeida GP, Puleston DJ, Baixauli F, Aly L, Greco A, Nizharadze T, Becker NB, Hoesslin MV, Donhauser LV, Berner J, Chu T, McNamara HA, Esencan Z, Roelli P, Wurmser C, Kleiter I, Vehreschild MJGT, Mayer CA, Knolle P, Klingenspor M, Fumagalli V, Iannacone M, Prlic M, Korn T, Pearce EL, Höfer T, Schulz AM, Zehn D (2023). Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development. Nat Immunol. 2023 Mar;24(3):501-515. doi: 10.1038/s41590-023-01436-x. Epub 2023 Feb 16. PMID: 36797499.
- Schmidt H, Raj T, O'Neill TJ, Muschaweckh A, Giesert F, Negraschus A, Hoefig KP, Behrens G, Esser L, Baumann C, Feederle R, Plaza-Sirvent C, Geerlof A, Gewies A, Isay SE, Ruland J, Schmitz I, Wurst W, Korn T, Krappmann D, Heissmeyer V (2023). Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity. Proc Natl Acad Sci U S A. 2023 Nov 28;120(48):e2309205120. doi: 10.1073/pnas.2309205120. Epub 2023 Nov 21. PMID: 37988467; PMCID: PMC10691344.
- Wauschkuhn J, Solorza Buenrostro G, Aly L, Asseyer S, Wicklein R, Hartberger JM, Ruprecht K, Mühlau M, Schmitz-Hübsch T, Chien C, Berthele A, Brandt AU, Korn T, Paul F, Hemmer B, Zimmermann HG, Knier B (2023). Retinal ganglion cell loss is associated with future disability worsening in early relapsing-remitting multiple sclerosis. Eur J Neurol. 2023 Jan 12. doi: 10.1111/ene.15681. Epub ahead of print. PMID: 36635219.
- Aly L, Noll C, Wicklein R, Wolf E, Romahn EF, Wauschkuhn J, Hosari S, Mardin C, Berthele A, Hemmer B, Korn T, Knier B (2022). Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2022 Mar 17;9(3):e1159. doi: 10.1212/NXI.0000000000001159. PMID: 35301260; PMCID: PMC8931743.
- Benkhoucha M, Tran NL, Breville G, Senoner I, Bradfield PF, Papayannopoulou T, Merkler D, Korn T, Lalive PH (2022). CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation. J Neuroinflammation. 2022 Apr 29;19(1):103. doi: 10.1186/s12974-022-02461-7. PMID: 35488271; PMCID: PMC9052663.
- Haimon Z, Frumer GR, Kim JS, Trzebanski S, Haffner-Krausz R, Ben-Dor S, Porat Z, Muschaweckh A, Chappell-Maor L, Boura-Halfon S, Korn T, Jung S (2022). Cognate microglia-T cell interactions shape the functional regulatory T cell pool in experimental autoimmune encephalomyelitis pathology. Nat Immunol. 2022 Dec;23(12):1749-1762. doi: 10.1038/s41590-022-01360-6. Epub 2022 Dec 1. PMID: 36456736.
- Kenney RC, Liu M, Hasanaj L, Joseph B, Al-Hassan AA, Balk LJ, Behbehani R, Brandt A, Calabresi PA, Frohman E, Frohman TC, Havla J, Hemmer B, Jiang H, Knier B, Korn T, Leocani L, Martinez-Lapiscina EH, Papadopoulou A, Paul F, Petzold A, Pisa M, Villoslada P, Zimmermann H, Thorpe LE, Ishikawa H, Schuman JS, Wollstein G, Chen Y, Saidha S, Galetta S, Balcer LJ (2022). The Role of OCT Criteria and Machine Learning in Multiple Sclerosis and Optic Neuritis Diagnosis. Neurology. 2022 Jun 28:10.1212/WNL.0000000000200883. doi: 10.1212/WNL.0000000000200883. Epub ahead of print. PMID: 35764402.
- Kenney R, Liu M, Hasanaj L, Joseph B, Al-Hassan AA, Balk L, Behbehani R, Brandt AU, Calabresi PA, Frohman EM, Frohman T, Havla J, Hemmer B, Jiang H, Knier B, Korn T, Leocani L, Martínez-Lapiscina EH, Papadopoulou A, Paul F, Petzold A, Pisa M, Villoslada P, Zimmermann H, Ishikawa H, Schuman JS, Wollstein G, Chen Y, Saidha S, Thorpe LE, Galetta SL, Balcer LJ, IMSVISUAL Consortium. (2022). Normative Data and Conversion Equation for Spectral-Domain Optical Coherence Tomography in an International Healthy Control Cohort. J Neuroophthalmol. 2022 Oct 18. doi: 10.1097/WNO.0000000000001717. Epub ahead of print. PMID: 36049213.
- Korn T (2022). CNS Treg cells have alternative functions but run on conventional fuel. Nat Immunol. 2022 Jun;23(6):818-819. doi: 10.1038/s41590-022-01201-6. PMID: 35618830.
- Lutz K, Musumeci A, Sie C, Dursun E, Winheim E, Bagnoli J, Ziegenhain C, Rausch L, Bergen V, Luecken MD, Oostendorp RAJ, Schraml BU, Theis FJ, Enard W, Korn T, Krug AB (2022). Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage. Nat Commun. 2022 Jun 16;13(1):3456. doi: 10.1038/s41467-022-31054-4. PMID: 35705536; PMCID: PMC9200809.
- Maisam Afzali A, Stüve L, Pfaller M, Aly L, Steiger K, Knier B, Korn T (2022). Aquaporin-4 prevents exaggerated astrocytosis and structural damage in retinal inflammation. J Mol Med (Berl). 2022 Jun;100(6):933-946. doi: 10.1007/s00109-022-02202-6. Epub 2022 May 10. PMID: 35536323; PMCID: PMC9166880.
- Mitsdoerffer M, Aly L, Barz M, Engleitner T, Sie C, Delbridge C, Lepennetier G, Öllinger R, Pfaller M, Wiestler B, Rad R, Meyer B, Knier B, Schmidt-Graf F, Gempt J, Korn T (2022). The glioblastoma multiforme tumor site promotes the commitment of tumor-infiltrating lymphocytes to the TH17 lineage in humans. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2206208119. doi: 10.1073/pnas.2206208119. Epub 2022 Aug 15. PMID: 35969754.
- Noll C, Hiltensperger M, Aly L, Wicklein R, Afzali AM, Mardin C, Gasperi C, Berthele A, Hemmer B, Korn T, Knier B (2022). Association of the retinal vasculature, intrathecal immunity, and disability in multiple sclerosis. Front Immunol. 2022 Nov 11;13:997043. doi: 10.3389/fimmu.2022.997043. PMID: 36439131; PMCID: PMC9695398.
- Sie C, Kant R, Peter C, Muschaweckh A, Pfaller M, Nirschl L, Moreno HD, Chadimová T, Lepennetier G, Kuhlmann T, Öllinger R, Engleitner T, Rad R, Korn T (2022). IL-24 intrinsically regulates Th17 cell pathogenicity in mice. J Exp Med. 2022 Aug 1;219(8):e20212443. doi: 10.1084/jem.20212443. Epub 2022 Jul 12. PMID: 35819408.
- Tuzlak S, Ginhoux F, Korn T, Becher B (2022). Reply to 'Comment on: Repositioning TH cell polarization from single cytokines to complex help'. Nat Immunol. 2022 Feb 21. doi: 10.1038/s41590-022-01142-0. Epub ahead of print. PMID: 35190719.
- Aly L, Strauß EM, Feucht N, Weiß I, Berthele A, Mitsdoerffer M, Haass C, Hemmer B, Maier M, Korn T, Knier B (2021). Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders. Mult Scler. 2021 Jul 14:13524585211028831. doi: 10.1177/13524585211028831. Epub ahead of print. PMID: 34259579.
- Gil-Pulido J, Amézaga N, Jorgacevic I, Manthey HD, Rösch M, Brand T, Cidlinsky P, Schäfer S, Beilhack A, Saliba AE, Lorenz K, Boon L, Prinz I, Waisman A, Korn T, Cochain C, Zernecke A (2021). Interleukin-23 receptor expressing γδ T cells locally promote early atherosclerotic lesion formation and plaque necrosis in mice. Cardiovasc Res. 2021 Dec 13:cvab359. doi: 10.1093/cvr/cvab359. Epub ahead of print. PMID: 34897380.
- Hiltensperger M, Beltrán E, Kant R, Tyystjärvi S, Lepennetier G, Domínguez Moreno H, Bauer IJ, Grassmann S, Jarosch S, Schober K, Buchholz VR, Kenet S, Gasperi C, Öllinger R, Rad R, Muschaweckh A, Sie C, Aly L, Knier B, Garg G, Afzali AM, Gerdes LA, Kümpfel T, Franzenburg S, Kawakami N, Hemmer B, Busch DH, Misgeld T, Dornmair K, Korn T (2021). Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity. Nat Immunol. 2021 Jun 7. doi: 10.1038/s41590-021-00948-8. Epub ahead of print. PMID: 34099917.
- Korn T, Hiltensperger M (2021). Role of IL-6 in the commitment of T cell subsets. Cytokine. 2021 Jul 26;146:155654. doi: 10.1016/j.cyto.2021.155654. Epub ahead of print. PMID: 34325116.
- Kurgyis Z, Vornholz L, Pechloff K, Kemény LV, Wartewig T, Muschaweckh A, Joshi A, Kranen K, Hartjes L, Möckel S, Steiger K, Hameister E, Volz T, Mellett M, French LE, Biedermann T, Korn T, Ruland J (2021). Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation. Sci Immunol. 2021 Nov 26;6(65):eabi4425. doi: 10.1126/sciimmunol.abi4425. Epub 2021 Nov 26. PMID: 34826258.
- Mitsdörffer M, Di Liberto G, Dötsch S, Sie C, Wagner I, Pfaller M, Kreutzfeldt M, Fräßle S, Aly L, Knier B, Busch DH, Merkler D, Korn T (2021). Formation and immunomodulatory function of meningeal B-cell aggregates in progressive CNS autoimmunity. Brain. 2021 Mar 9:awab093. doi: 10.1093/brain/awab093. Epub ahead of print. PMID: 33693558.
- Tuzlak S, Dejean AS, Iannacone M, Quintana FJ, Waisman A, Ginhoux F, Korn T, Becher B (2021). Repositioning TH cell polarization from single cytokines to complex help. Nat Immunol. 2021 Oct;22(10):1210-1217. doi: 10.1038/s41590-021-01009-w. Epub 2021 Sep 20. PMID: 34545250.
- Wicklein R, Heidegger S, Verbeek M, Eiz-Vesper B, Maecker-Kolhoff B, Kirschke JS, Page A, Korn T, Hemmer B, Deschauer M (2021). Combined Treatment With Pembrolizumab and Allogenic BK Virus-Specific T Cells in Progressive Multifocal Leukoencephalopathy: A Case Report. Neurol Neuroimmunol Neuroinflamm. 2021 Jul 20;8(5):e1042. doi: 10.1212/NXI.0000000000001042. PMID: 34285093; PMCID: PMC8293283.
- Aly L, Havla J, Lepennetier G, Andlauer TFM, Sie C, Strauß EM, Hoshi MM, Kümpfel T, Hiltensperger M, Mitsdoerffer M, Mühlau M, Zimmer C, Hemmer B, Korn T, Knier B (2020). Inner retinal layer thinning in radiologically isolated syndrome predicts conversion to multiple sclerosis. Eur J Neurol. 2020;10.1111/ene.14416. doi:10.1111/ene.14416 [published online ahead of print, 2020 Jun 26].
- Bartsch YC, Eschweiler S, Leliavski A, Lunding HB, Wagt S, Petry J, Lilienthal GM, Rahmöller J, de Haan N, Hölscher A, Erapaneedi R, Giannou AD, Aly L, Sato R, de Neef LA, Winkler A, Braumann D, Hobusch J, Kuhnigk K, Krémer V, Steinhaus M, Blanchard V, Gemoll T, Habermann JK, Collin M, Salinas G, Manz RA, Fukuyama H, Korn T, Waisman A, Yogev N, Huber S, Rabe B, Rose-John S, Busch H, Berberich-Siebelt F, Hölscher C, Wuhrer M, Ehlers M (2020). IgG Fc sialylation is regulated during the germinal center reaction upon immunization with different adjuvants. J Allergy Clin Immunol. 2020;S0091-6749(20)30728-4. doi:10.1016/j.jaci.2020.04.059 [published online ahead of print, 2020 May 20].
- Baumann T, Dunkel A, Schmid C, Schmitt S, Hiltensperger M, Lohr K, Laketa V, Donakonda S, Ahting U, Lorenz-Depiereux B, Heil JE, Schredelseker J, Simeoni L, Fecher C, Körber N, Bauer T, Hüser N, Hartmann D, Laschinger M, Eyerich K, Eyerich S, Anton M, Streeter M, Wang T, Schraven B, Spiegel D, Assaad F, Misgeld T, Zischka H, Murray PJ, Heine A, Heikenwälder M, Korn T, Dawid C, Hofmann T, Knolle PA, Höchst B (2020). Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal. Nat Immunol. 2020 May;21(5):555-566. doi: 10.1038/s41590-020-0666-9. Epub 2020 Apr 23.
- Dietrich M, Koska V, Hecker C, Göttle P, Hilla AM, Heskamp A, Lepka K, Issberner A, Hallenberger A, Baksmeier C, Steckel J, Balk L, Knier B, Korn T, Havla J, Martínez-Lapiscina EH, Solà-Valls N, Manogaran P, Olbert ED, Schippling S, Cruz-Herranz A, Yiu H, Button J, Caldito NG, von Gall C, Mausberg AK, Stettner M, Zimmermann HG, Paul F, Brandt AU, Küry P, Goebels N, Aktas O, Berndt C, Saidha S, Green AJ, Calabresi PA, Fischer D, Hartung HP, Albrecht P (2020). Protective effects of 4-aminopyridine in experimental optic neuritis and multiple sclerosis. Brain. 2020 Apr 15. pii: awaa062. doi: 10.1093/brain/awaa062. [Epub ahead of print]
- Heitmann H, Andlauer TFM, Korn T, Mühlau M, Henningsen P, Hemmer B, Ploner M (2020). Fatigue, depression, and pain in multiple sclerosis: How neuroinflammation translates into dysfunctional reward processing and anhedonic symptoms. Mult Scler. 2020 Nov 12:1352458520972279. doi: 10.1177/1352458520972279. Epub ahead of print. PMID: 33179588.
- Matthias J, Heink S, Picard FS, Zeiträg J, Kolz A, Chao YY, Soll D, de Almeida GP, Glasmacher E, Jacobsen ID, Riedel T, Peters A, Floess S, Huehn J, Baumjohann D, Huber M, Korn T, Zielinski CE (2020). Salt generates anti-inflammatory Th17 cells but amplifies their pathogenicity in pro-inflammatory cytokine microenvironments. J Clin Invest. 2020;137786. doi:10.1172/JCI137786 [published online ahead of print, 2020 Jun 2].
- Mufazalov IA, Andruszewski D, Schelmbauer C, Heink S, Blanfeld M, Masri J, Tang Y, Schüler R, Eich C, Wunderlich FT, Karbach SH, Bluestone JA, Korn T, Waisman A (2020). Cutting Edge: IL-6-Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression. J Immunol. 2020 Jan 10. pii: ji1900876. doi: 10.4049/jimmunol.1900876. [Epub ahead of print]
- Tsaktanis T, Beyer T, Nirschl L, Linnerbauer M, Grummel V, Bussas M, Tjon E, Mühlau M, Korn T, Hemmer B, Quintana FJ, Rothhammer V (2020). Aryl Hydrocarbon Receptor Plasma Agonist Activity Correlates With Disease Activity in Progressive MS. Neurol Neuroimmunol Neuroinflamm. 2020 Dec 24;8(2):e933. doi: 10.1212/NXI.0000000000000933. PMID: 33361385.
- Andreas N, Potthast M, Geiselhöringer AL, Garg G, de Jong R, Riewaldt J, Russkamp D, Riemann M, Girard JP, Blank S, Kretschmer K, Schmidt-Weber C, Korn T, Weih F, Ohnmacht C (2019). RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells. J Immunol. 2019 Oct 2. pii: ji1801530. doi: 10.4049/jimmunol.1801530. [Epub ahead of print]
- Balk LJ, Coric D, Knier B, Zimmermann HG, Behbehani R, Alroughani R, Martinez-Lapiscina EH, Brandt AU, Sánchez-Dalmau B, Vidal-Jordana A, Albrecht P, Koska V, Havla J, Pisa M, Nolan RC, Leocani L, Paul F, Aktas O, Montalban X, Balcer LJ, Villoslada P, Outteryck O, Korn T, Petzold A; IMSVISUAL consortium (2019). Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis; a longitudinal OCT study. Mult Scler J Exp Transl Clin. 2019 Sep 5;5(3):2055217319871582. doi: 10.1177/2055217319871582. eCollection 2019 Jul-Sep.
- Bittner S, Engel S, Lange C, Weber MS, Haghikia A, Luessi F, Korn T, Klotz L, Bayas A, Paul F, Heesen C, Stangel M, Wildemann B, Bergh FT, Tackenberg B, Trebst C, Warnke C, Linker R, Kerschensteiner M, Zettl U, Tumani H, Brück W, Meuth SG, Kümpfel T, Hemmer B, Wiendl H, Gold R, Zipp F (2019). [Article in German] [Diagnostics and treatment of tuberculosis under immunotherapy for multiple sclerosis : Current status and recommeExpression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer’s Disease. Nervenarzt. 2019 Jul 11. doi: 10.1007/s00115-019-0760-0. [Epub ahead of print]
- Fecher C, Trovò L, Müller SA, Snaidero N, Wettmarshausen J, Heink S, Ortiz O, Wagner I, Kühn R, Hartmann J, Karl RM, Konnerth A, Korn T, Wurst W, Merkler D, Lichtenthaler SF, Perocchi F, Misgeld T (2019). Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity. Nat Neurosci. 2019 Sep 9. doi: 10.1038/s41593-019-0479-z. [Epub ahead of print]
- Garg G, Muschaweckh A, Moreno H, Vasanthakumar A, Floess S, Lepennetier G, Oellinger R, Zhan Y, Regen T, Hiltensperger M, Peter C, Aly L, Knier B, Palam LR, Kapur R, Kaplan MH, Waisman A, Rad R, Schotta G, Huehn J, Kallies A, Korn T (2019). Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation. Cell Rep. 2019 Feb 12;26(7):1854-1868.e5. doi: 10.1016/j.celrep.2019.01.070.
- International Multiple Sclerosis Genetics Consortium [i.a. Hemmer B, Korn T] (2019). Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science. 2019 Sep 27;365(6460). pii: eaav7188. doi: 10.1126/science.aav7188.
- Korn T (2019). Stars Are Not in Outer Space: Astrocytes Respond to Environmental Cues. Cell. 2019 Jan 24;176(3):416-418. doi: 10.1016/j.cell.2018.12.025.
- Korn T, Muschaweckh A (2019). Stability and Maintenance of Foxp3+ Treg Cells in Non-lymphoid Microenvironments. Front Immunol. 2019 Nov 14;10:2634. doi: 10.3389/fimmu.2019.02634. eCollection 2019.
- Nolan RC, Liu M, Akhand O, Calabresi PA, Paul F, Petzold A, Balk L, Brandt AU, Martínez-Lapiscina EH, Saidha S, Villoslada P, Al-Hassan AA, Behbehani R, Frohman EM, Frohman T, Havla J, Hemmer B, Jiang H, Knier B, Korn T, Leocani L, Papadopoulou A, Pisa M, Zimmermann H, Galetta SL, Balcer LJ; IMSVISUAL Consortium (2019). Optimal Inter-Eye Difference Thresholds by OCT in MS: An International Study. Ann Neurol. 2019 Mar 9. doi: 10.1002/ana.25462. [Epub ahead of print]
- Sie C, Perez LG, Kreutzfeldt M, Potthast M, Ohnmacht C, Merkler D, Huber S, Krug A, Korn T (2019). Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on α4 Integrins. J Immunol. 2019 Aug 9. pii: ji1900468. doi: 10.4049/jimmunol.1900468. [Epub ahead of print]
- Steinbach K, Vincenti I, Egervari K, Kreutzfeldt M, van der Meer F, Page N, Klimek B, Rossitto-Borlat I, Di Liberto G, Muschaweckh A, Wagner I, Hammad K, Stadelmann C, Korn T, Hartley O, Pinschewer DD, Merkler D (2019). Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice. Sci Transl Med. 2019 Jun 26;11(498). pii: eaav5519. doi: 10.1126/scitranslmed.aav5519.
- Wuschek A, Grahl S, Pongratz V, Korn T, Kirschke J, Zimmer C, Hemmer B, Mühlau M (2019). CSF Protein Concentration Shows No Correlation With Brain Volume Measures. Front Neurol. 2019 May 3;10:463. doi: 10.3389/fneur.2019.00463. eCollection 2019.
- Aly L, Korn T (2018). Multiple sclerosis: is it all black and white in optical coherence tomography? Brain. 2018 Nov 1;141(11):3088-3091. doi: 10.1093/brain/awy269.
- Breuer J, Korpos E, Hannocks MJ, Schneider-Hohendorf T, Song J, Zondler L, Herich S, Flanagan K, Korn T, Zarbock A, Kuhlmann T, Sorokin L, Wiendl H, Schwab N (2018). Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus. J Neuroinflammation. 2018 Aug 22;15(1):236. doi: 10.1186/s12974-018-1276-4.
- Feucht N, Maier M, Lepennetier G, Pettenkofer M, Wetzlmair C, Daltrozzo T, Scherm P, Zimmer C, Hoshi MM, Hemmer B, Korn T, Knier B (2018). Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis. Mult Scler. 2018 Jan 1:1352458517750009. doi: 10.1177/1352458517750009. [Epub ahead of print]
- Garbers C, Heink S, Korn T, Rose-John S (2018). Interleukin-6: designing specific therapeutics for a complex cytokine. Nat Rev Drug Discov. 2018 May 4. doi: 10.1038/nrd.2018.45. [Epub ahead of print]
- Knier B, Hiltensperger M, Sie C, Aly L, Lepennetier G, Engleitner T, Garg G, Muschaweckh A, Mitsdörffer M, Koedel U, Höchst B, Knolle P, Gunzer M, Hemmer B, Rad R, Merkler D, Korn T (2018). Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity. Nat Immunol. 2018 Dec;19(12):1341-1351. doi: 10.1038/s41590-018-0237-5. Epub 2018 Oct 29.
- Zimmermann HG, Knier B, Oberwahrenbrock T, Behrens J, Pfuhl C, Aly L, Kaminski M, Hoshi MM, Specovius S, Giess RM, Scheel M, Mühlau M, Bellmann-Strobl J, Ruprecht K, Hemmer B, Korn T, Paul F, Brandt AU (2018). Association of Retinal Ganglion Cell Layer Thickness With Future Disease Activity in Patients With Clinically Isolated Syndrome. JAMA Neurol. 2018 Apr 23. doi: 10.1001/jamaneurol.2018.1011. [Epub ahead of print]
- Biberacher V, Schmidt P, Selter RC, Pernpeinter V, Kowarik MC, Knier B, Buck D, Hoshi MM, Korn T, Berthele A, Kirschke JS, Zimmer C, Hemmer B, Mühlau M (2017). Fatigue in multiple sclerosis: Associations with clinical, MRI and CSF parameters. Mult Scler. 2017 May 1:1352458517712078. doi: 10.1177/1352458517712078. [Epub ahead of print]
- Gelderblom M, Gallizioli M, Ludewig P, Thom V, Arunachalam P, Rissiek B, Bernreuther C, Glatzel M, Korn T, Arumugam TV, Sedlacik J, Gerloff C, Tolosa E, Planas AM, Magnus T (2017). IL-23 (Interleukin-23)-Producing Conventional Dendritic Cells Control the Detrimental IL-17 (Interleukin-17) Response in Stroke. Stroke. 2017 Dec 6. pii: STROKEAHA.117.019101. doi: 10.1161/STROKEAHA.117.019101. [Epub ahead of print]
- Hiltensperger M, Korn T (2017). The Interleukin (IL)-23/T helper (Th)17 Axis in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis. Cold Spring Harb Perspect Med. 2017 Nov 3. pii: a029637. doi: 10.1101/cshperspect.a029637. [Epub ahead of print]
- Knier B, Leppenetier G, Wetzlmair C, Aly L, Hoshi MM, Pernpeintner V, Biberacher V, Berthele A, Mühlau M, Zimmer C, Hemmer B, Korn T (2017). Association of Retinal Architecture, Intrathecal Immunity, and Clinical Course in Multiple Sclerosis. JAMA Neurol. 2017 May 1. doi: 10.1001/jamaneurol.2017.0377. [Epub ahead of print]
- Korn T, Kallies A (2017). T cell responses in the central nervous system. Nat Rev Immunol. 2017 Jan 31. doi: 10.1038/nri.2016.144. [Epub ahead of print]
- Korn T (2017). Disentangling the manifold functions of RORγt. Nat Immunol. 2017 Sep 19;18(10):1059-1060. doi: 10.1038/ni.3831.
- Korn T, Oukka M (2017). A BAFFling Association between Malaria Resistance and the Risk of Multiple Sclerosis. N Engl J Med. 2017 Apr 27;376(17):1680-1681. doi: 10.1056/NEJMe1700720.
- Muschaweckh A, Petermann F, Korn T (2017). IL-1b and IL-23 Promote Extrathymic Commitment of CD27+CD1222 gd T Cells to gdT17 Cells. J Immunol. 2017 Aug 30. pii: ji1700287. doi: 10.4049/jimmunol.1700287. [Epub ahead of print]
- Oertel FC, Kuchling J, Zimmermann H, Chien C, Schmidt F, Knier B, Bellmann-Strobl J, Korn T, Scheel M, Klistorner A, Ruprecht K, Paul F, Brandt AU (2017). Microstructural visual system changes in AQP4-antibody-seropositive NMOSD. Neurol Neuroimmunol Neuroinflamm. 2017 Feb 22;4(3):e334. doi: 10.1212/NXI.0000000000000334. eCollection 2017.
- Prajeeth CK, Kronisch J, Khorooshi R, Knier B, Toft-Hansen H, Gudi V, Floess S, Huehn J, Owens T, Korn T, Stangel M(2017). Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties. J Neuroinflammation. 2017 Oct 16;14(1):204. doi: 10.1186/s12974-017-0978-3.
- Vogel AL, Knier B, Lammens K, Kalluri SR, Kuhlmann T, Bennett JL, Korn T (2017). Deletional tolerance prevents AQP4 directed autoimmunity in mice. Eur J Immunol. 2017 Jan 5. doi: 10.1002/eji.201646855. [Epub ahead of print]
- Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T (2016). Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol. 2016 Nov 28. doi: 10.1038/ni.3632. [Epub ahead of print]
- Knier B, Schmidt P, Aly L, Buck D, Berthele A, Mühlau M, Zimmer C, Hemmer B, Korn T (2016). Retinal inner nuclear layer volume reflects response to immunotherapy in multiple sclerosis. Brain. 2016 Aug 30. pii: aww219. [Epub ahead of print]
- Muschaweckh A, Buchholz VR, Fellenzer A, Hessel C, König PA, Tao S, Tao R, Heikenwälder M, Busch DH, Korn T, Kastenmüller W, Drexler I, Gasteiger G (2016). Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells. J Exp Med. 2016 Nov 29. pii: jem.20160888. [Epub ahead of print]
- Penkert H, Delbridge C, Wantia N, Wiestler B, Korn T (2016). Fulminant central nervous system nocardiosis in a patient treated with alemtuzumab for relapsing-remitting multiple sclerosis. JAMA Neurol. 2016 Apr 4. doi: 10.1001/jamaneurol.2016.0146. [Epub ahead of print]
- Reinhardt A, Yevsa T, Worbs T, Lienenklaus S, Sandrock I, Oberdörfer L, Korn T, Weiss S, Förster R, Prinz I (2016). IL-23-dependent γδ T cells produce IL-17 and accumulate in enthesis, aortic valve, and ciliary body. Arthritis Rheumatol. 2016 Apr 25. doi: 10.1002/art.39732. [Epub ahead of print]
- Sie C, Korn T (2016). Dendritic cells in central nervous system autoimmunity. Semin Immunopathol. 2016 Nov 25. [Epub ahead of print]
- Steinbach K, Vincenti I, Kreutzfeldt M, Page N, Muschaweckh A, Wagner I, Drexler I, Pinschewer D, Korn T, Merkler(2016). Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection. Journal of Experimental Medicine. 2016 July 4. pii: jem.20151916. DOI: 10.1084/jem.20151916. [Epub ahead of print]
- Hemmer B, Kerschensteiner M, Korn T (2015). Role of the innate and adaptive immune responses in the course of multiple sclerosis. Lancet Neurol. 2015 Apr;14(4):406-419. doi: 10.1016/S1474-4422(14)70305-9.
- Kleinschnitz C, Linker RA, Magnus T, Korn T, Meuth SG; speakers at the 6’th NEUROWIND e.V. scientific meeting (2015). Report on the 6th scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Motzen, Germany, Oct. 31th - Nov. 2nd, 2014. Exp Transl Stroke Med. 2015 Jan 13;7:1. doi: 10.1186/s13231-014-0013-z. eCollection 2015
- Knier B, Berthele A, Buck D, Schmidt P, Zimmer C, Mühlau M, Hemmer B, Korn T (2015). Optical coherence tomography indicates disease activity prior to clinical onset of central nervous system demyelination. Mult Scler. 2015 Sep 11. pii: 1352458515604496. [Epub ahead of print]
- Kolber P, Luessi F, Meuth SG, Klotz L, Korn T, Trebst C, Tackenberg B, Kieseier B, Kümpfel T, Fleischer V, Tumani H, Wildemann B, Lang M, Flachenecker P, Meier U, Brück W, Limmroth V, Haghikia A, Hartung HP, Stangel M, Hohlfeld R, Hemmer B, Gold R, Wiendl H, Zipp F (2015). Current aspects of therapy conversion for multiple sclerosis [Article in German] Nervenarzt. 2015 Aug 13. [Epub ahead of print]
- Waisman A, Korn T (2015). B cells assume the command. Sci Transl Med. 2015 Oct 21;7(310):310fs42. doi: 10.1126/scitranslmed.aad2740.
- Gewies A, Gorka O, Bergmann H, Pechloff K, Petermann F, Jeltsch KM, Rudelius M, Kriegsmann M, Weichert W, Horsch M, Beckers J, Wurst W, Heikenwalder M, Korn T, Heissmeyer V, Ruland J (2014). Uncoupling malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation. Cell Rep. 2014 Nov 20;9(4):1292-305. doi: 10.1016/j.celrep.2014.10.044. Epub 2014 Nov 13.
- Heinemann C, Heink S, Petermann F, Vasanthakumar A, Rothhammer V, Doorduijn E, Mitsdoerffer M, Sie C, Prazeres da Costa O, Buch T, Hemmer B, Oukka M, Kallies A, Korn T (2014). IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4(+) T cells by inducing Blimp1. Nat Commun. 2014 May 6;5:3770. doi: 10.1038/ncomms4770.
- Knier B, Rothhammer V, Heink S, Puk O, Graw J, Hemmer B, Korn T (2014). Neutralizing IL-17 protects the optic nerve from autoimmune pathology and prevents retinal nerve fiber layer atrophy during experimental autoimmune encephalomyelitis. J Autoimmun. 2014 Oct 1. pii: S0896-8411(14)00132-2. doi: 10.1016/j.jaut.2014.09.003. [Epub ahead of print]
- Knier B, Hemmer B, Korn T (2014). Novel monoclonal antibodies for therapy of multiple sclerosis. Expert Opin Biol Ther. 2014 Feb 28. [Epub ahead of print]
- Rothhammer V, Muschaweckh A, Gasteiger G, Petermann F, Heink S, Busch DH, Heikenwälder M, Hemmer B, Drexler I, Korn T (2014). α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets. Acta Neuropathol Commun. 2014 Mar 7;2(1):27. doi: 10.1186/2051-5960-2-27.
- Schirmer L, Srivastava R, Kalluri SR, Böttinger S, Herwerth M, Carassiti D, Srivastava B, Gempt J, Schlegel J, Kuhlmann T, Korn T, Reynolds R, Hemmer B (2014). Differential loss of KIR4.1 immunoreactivity in multiple sclerosis lesions. Ann Neurol. 2014 Apr 29. doi: 10.1002/ana.24168. [Epub ahead of print]
- Sie C, Korn T, Mitsdoerffer M (2014). Th17 cells in central nervous system autoimmunity. Exp Neurol. 2014 Mar 27. pii: S0014-4886(14)00086-7. doi: 10.1016/j.expneurol.2014.03.009. [Epub ahead of print]
- Vahl JC, Drees C, Heger K, Heink S, Fischer JC, Nedjic J, Ohkura N, Morikawa H, Poeck H, Schallenberg S, Rieß D, Hein MY, Buch T, Polic B, Schönle A, Zeiser R, Schmitt-Gräff A, Kretschmer K, Klein L, Korn T, Sakaguchi S, Schmidt-Supprian M12 (2014). Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool. Immunity. 2014 Nov 6;41(5):722-736. doi: 10.1016/j.immuni.2014.10.012. [Epub ahead of print]
- International Multiple Sclerosis Genetics Consortium (IMSGC), Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, Fontaine B, Hemmer B, Martin C, Zipp F, D'Alfonso S, Martinelli-Boneschi F, Taylor B, Harbo HF, Kockum I, Hillert J, Olsson T, Ban M, Oksenberg JR, Hintzen R, Barcellos LF; Wellcome Trust Case Control Consortium 2 (WTCCC2); International IBD Genetics Consortium (IIBDGC), Agliardi C, Alfredsson L, Alizadeh M, Anderson C, Andrews R, Søndergaard HB, Baker A, Band G, Baranzini SE, Barizzone N, Barrett J, Bellenguez C, Bergamaschi L, Bernardinelli L, Berthele A, Biberacher V, Binder TM, Blackburn H, Bomfim IL, Brambilla P, Broadley S, Brochet B, Brundin L, Buck D, Butzkueven H, Caillier SJ, Camu W, Carpentier W, Cavalla P, Celius EG, Coman I, Comi G, Corrado L, Cosemans L, Cournu-Rebeix I, Cree BA, Cusi D, Damotte V, Defer G, Delgado SR, Deloukas P, di Sapio A, Dilthey AT, Donnelly P, Dubois B, Duddy M, Edkins S, Elovaara I, Esposito F, Evangelou N, Fiddes B, Field J, Franke A, Freeman C, Frohlich IY, Galimberti D, Gieger C, Gourraud PA, Graetz C, Graham A, Grummel V, Guaschino C, Hadjixenofontos A, Hakonarson H, Halfpenny C, Hall G, Hall P, Hamsten A, Harley J, Harrower T, Hawkins C, Hellenthal G, Hillier C, Hobart J, Hoshi M, Hunt SE, Jagodic M, Jelčić I, Jochim A, Kendall B, Kermode A, Kilpatrick T, Koivisto K, Konidari I, Korn T, Kronsbein H, Langford C, Larsson M, Lathrop M, Lebrun-Frenay C, Lechner-Scott J, Lee MH, Leone MA, Leppä V, Liberatore G, Lie BA, Lill CM, Lindén M, Link J, Luessi F, Lycke J, Macciardi F, Männistö S, Manrique CP, Martin R, Martinelli V, Mason D, Mazibrada G, McCabe C, Mero IL, Mescheriakova J, Moutsianas L, Myhr KM, Nagels G, Nicholas R, Nilsson P, Piehl F, Pirinen M, Price SE, Quach H, Reunanen M, Robberecht W, Robertson NP, Rodegher M, Rog D, Salvetti M, Schnetz-Boutaud NC, Sellebjerg F, Selter RC, Schaefer C, Shaunak S, Shen L, Shields S, Siffrin V, Slee M, Sorensen PS, Sorosina M, Sospedra M, Spurkland A, Strange A, Sundqvist E, Thijs V, Thorpe J, Ticca A, Tienari P, van Duijn C, Visser EM, Vucic S, Westerlind H, Wiley JS, Wilkins A, Wilson JF, Winkelmann J, Zajicek J, Zindler E, Haines JL, Pericak-Vance MA, Ivinson AJ, Stewart G, Hafler D, Hauser SL, Compston A, McVean G, De Jager P, Sawcer SJ, McCauley JL (2013). Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet. 2013 Sep 29. doi: 10.1038/ng.2770. [Epub ahead of print]
- Korn T (2013). Which type of inflammation can be controlled by Foxp3+ Tregs? Neuropathol. 2013 Sep 18. [Epub ahead of print]
- Mitsdoerffer M, Kuchroo V, Korn T (2013). Immunology of neuromyelitis optica: a T cell-B cell collaboration. Ann N Y Acad Sci. 2013 Apr;1283(1):57-66. doi: 10.1111/nyas.12118