Konnerth, Arthur
2024
- Zott B, Nästle L, Grienberger C, Unger F, Knauer MM, Wolf C, Keskin-Dargin A, Feuerbach A, Busche MA, Skerra A, Konnerth A. β-amyloid monomer scavenging by an anticalin protein prevents neuronal hyperactivity in mouse models of Alzheimer's Disease. Nat Commun. 2024 Jul 10;15(1):5819. doi: 10.1038/s41467-024-50153-y. PMID: 38987287; PMCID: PMC11237084.
2023
- Aggarwal A, Liu R, Chen Y, Ralowicz AJ, Bergerson SJ, Tomaska F, Mohar B, Hanson TL, Hasseman JP, Reep D, Tsegaye G, Yao P, Ji X, Kloos M, Walpita D, Patel R, Mohr MA, Tillberg PW; GENIE Project Team; Looger LL, Marvin JS, Hoppa MB, Konnerth A, Kleinfeld D, Schreiter ER, Podgorski K (2023). Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission. Nat Methods. 2023 May 4. doi: 10.1038/s41592-023-01863-6. Epub ahead of print. PMID: 37142767.
2022
- Qin H, Fu L, Jian T, Jin W, Liang M, Li J, Chen Q, Yang X, Du H, Liao X, Zhang K, Wang R, Liang S, Yao J, Hu B, Ren S, Zhang C, Wang Y, Hu Z, Jia H, Konnerth A, Chen X (2022). REM sleep-active hypothalamic neurons may contribute to hippocampal social-memory consolidation. Neuron. 2022 Oct 18:S0896-6273(22)00809-1. doi: 10.1016/j.neuron.2022.09.004. Epub ahead of print. PMID: 36272414.
- Zott B, Konnerth A (2022). Impairments of glutamatergic synaptic transmission in Alzheimer's disease. Semin Cell Dev Biol. 2022 Mar 22:S1084-9521(22)00080-5. doi: 10.1016/j.semcdb.2022.03.013. Epub ahead of print. PMID: 35337739.
2021
- Hartmann J, Chen-Engerer HJ, Konnerth A (2021). Where have all the Orais gone? Commentary on "Orai1 channels are essential for amplification of glutamate-evoked Ca2+ signals in dendritic spines to regulate working and associative memory". Cell Calcium. 2021 Feb 17;96:102372. doi: 10.1016/j.ceca.2021.102372. Epub ahead of print. PMID: 33640627.
- Song B, Kang CY, Han JH, Kano M, Konnerth A, Bae S (2021). In vivo genome editing in single mammalian brain neurons through CRISPR-Cas9 and cytosine base editors. Comput Struct Biotechnol J. 2021 Apr 25;19:2477-2485. doi: 10.1016/j.csbj.2021.04.051. PMID: 34025938; PMCID: PMC8113754.
- Unger F, Konnerth A, Zott B (2021). Population imaging of synaptically released glutamate in mouse hippocampal slices. STAR Protoc. 2021 Nov 9;2(4):100877. doi: 10.1016/j.xpro.2021.100877. PMID: 34816125; PMCID: PMC8591355.
- Zhang K, Förster R, He W, Liao X, Li J, Yang C, Qin H, Wang M, Ding R, Li R, Jian T, Wang Y, Zhang J, Yang Z, Jin W, Zhang Y, Qin S, Lu Y, Chen T, Stobart J, Weber B, Adelsberger H, Konnerth A, Chen X (2021). Fear learning induces α7-nicotinic acetylcholine receptor-mediated astrocytic responsiveness that is required for memory persistence. Nat Neurosci. 2021 Nov 15. doi: 10.1038/s41593-021-00949-8. Epub ahead of print. PMID: 34782794.
2020
- Wang M, Liao X, Li R, Liang S, Ding R, Li J, Zhang J, He W, Liu K, Pan J, Zhao Z, Li T, Zhang K, Li X, Lyu J, Zhou Z, Varga Z, Mi Y, Zhou Y, Yan J, Zeng S, Liu JK, Konnerth A, Nelken I, Jia H, Chen X (2020). Single-neuron representation of learned complex sounds in the auditory cortex. Nat Commun. 2020;11(1):4361. Published 2020 Aug 31. doi:10.1038/s41467-020-18142-z
2019
- Birkner A, Konnerth A (2019). Deep Two-Photon Imaging In Vivo with a Red-Shifted Calcium Indicator. Methods Mol Biol. 2019;1929:15-26. doi: 10.1007/978-1-4939-9030-6_2.
- Chen-Engerer HJ, Hartmann J, Karl RM, Yang J, Feske S, Konnerth A (2019). Two types of functionally distinct Ca2+ stores in hippocampal neurons. Nat Commun. 2019 Jul 19;10(1):3223. doi: 10.1038/s41467-019-11207-8.
- Dana H, Sun Y, Mohar B, Hulse BK, Kerlin AM, Hasseman JP, Tsegaye G, Tsang A, Wong A, Patel R, Macklin JJ, Chen Y, Konnerth A, Jayaraman V, Looger LL, Schreiter ER, Svoboda K, Kim DS (2019). High-performance calcium sensors for imaging activity in neuronal populations and microcompartments. Nat Methods. 2019 Jul;16(7):649-657. doi: 10.1038/s41592-019-0435-6. Epub 2019 Jun 17.
- Fecher C, Trovò L, Müller SA, Snaidero N, Wettmarshausen J, Heink S, Ortiz O, Wagner I, Kühn R, Hartmann J, Karl RM, Konnerth A, Korn T, Wurst W, Merkler D, Lichtenthaler SF, Perocchi F, Misgeld T (2019). Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity. Nat Neurosci. 2019 Sep 9. doi: 10.1038/s41593-019-0479-z. [Epub ahead of print]
- Hammelmann V, Stieglitz MS, Hülle H, Le Meur K, Kass J, Brümmer M, Gruner C, Rötzer RD, Fenske S, Hartmann J, Zott B, Lüthi A, Spahn S, Moser M, Isbrandt D, Ludwig A, Konnerth A, Wahl-Schott C, Biel M (2019). Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures. JCI Insight. 2019 May 2;4(9). pii: 126418. doi: 10.1172/jci.insight.126418. eCollection 2019 May 2.
- Tischbirek CH, Noda T, Tohmi M, Birkner A, Nelken I, Konnerth A (2019). In Vivo Functional Mapping of a Cortical Column at Single-Neuron Resolution. Cell Rep. 2019 Apr 30;27(5):1319-1326.e5. doi: 10.1016/j.celrep.2019.04.007.
- Zott B, Simon MM, Hong W, Unger F, Chen-Engerer HJ, Frosch MP, Sakmann B, Walsh DM, Konnerth A (2019). A vicious cycle of β amyloid-dependent neuronal hyperactivation. Science. 2019 Aug 9;365(6453):559-565. doi: 10.1126/science.aay0198.
2018
- Qin H, Fu L, Hu B, Liao X, Lu J, He W, Liang S, Zhang K, Li R, Yao J, Yan J, Chen H, Jia H, Zott B, Konnerth A, Chen X (2018). A Visual-Cue-Dependent Memory Circuit for Place Navigation. Neuron. 2018 Jun 5. pii: S0896-6273(18)30419-7. doi: 10.1016/j.neuron.2018.05.021. [Epub ahead of print]
- Zott B, Busche MA, Sperling RA, Konnerth A (2018). What Happens with the Circuit in Alzheimer's Disease in Mice and Humans? Annu Rev Neurosci. 2018 Jul 8;41:277-297. doi: 10.1146/annurev-neuro-080317-061725.
2017
- Keskin AD, Kekuš M, Adelsberger H, Neumann U, Shimshek DR, Song B, Zott B, Peng T, Förstl H, Staufenbiel M, Nelken I, Sakmann B, Konnerth A, Busche MA (2017). BACE inhibition-dependent repair of Alzheimer’s pathophysiology. Proc Natl Acad Sci U S A. 2017 Jul 24. pii: 201708106. doi: 10.1073/pnas.1708106114. [Epub ahead of print]
2016
- Birkner A, Tischbirek CH, Konnerth A. (2016). Improved deep two-photon calcium imaging in vivo Cell Calcium. 2016 Dec 21. pii: S0143-4160(16)30215-9. doi: 10.1016/j.ceca.2016.12.005. [Epub ahead of print]
- Busche MA, Konnerth A (2016). Impairments of neural circuit function in Alzheimer’s disease. Philosophilcal Transactions of the Royal Society B Biological Sciences. 2016 August 5. 371(1700). pii: 20150429. DOI: 10.1098/rstb.2015.0429.
- Tischbirek CH, Birkner A, Konnerth A (2016). In vivo deep two-photon imaging of neural circuits with the fluorescent Ca2+ indicator Cal-590. J Physiol. 2016 Dec 20. doi: 10.1113/JP272790. [Epub ahead of print]: e201694085. [Epub ahead of print]
2015
- Busche MA, Konnerth A (2015). Neuronal hyperactivity - A key defect in Alzheimer's disease? Bioessays. 2015 Mar 14. doi: 10.1002/bies.201500004. [Epub ahead of print]
- Busche MA, Kekuš M, Adelsberger H, Noda T, Förstl H, Nelken I, Konnerth A (2015). Rescue of long-range circuit dysfunction in Alzheimer's disease models. Nat Neurosci. 2015 Nov;18(11):1623-30. doi: 10.1038/nn.4137. Epub 2015 Oct 12.
- Busche MA, Grienberger C, Keskin AD, Song B, Neumann U, Staufenbiel M, Förstl H, Konnerth A (2015). Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models. Nat Neurosci. 2015 Nov 9. doi: 10.1038/nn.4163. [Epub ahead of print]
- Hartmann J, Konnerth A (2015). TRPC3-dependent synaptic transmission in central mammalian neurons. J Mol Med (Berl). 2015 Jun 5. [Epub ahead of print]
- Tischbirek C, Birkner A, Jia H, Sakmann B, Konnerth A (2015). Deep two-photon brain imaging with a red-shifted fluorometric Ca2+ indicator. Proc Natl Acad Sci U S A. 2015 Aug 24. pii: 201514209. [Epub ahead of print]
- Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C (2015). η-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature. 2015 Aug 31. doi: 10.1038/nature14864. [Epub ahead of print]
2014
- Grienberger C, Chen X, Konnerth A (2014). NMDA Receptor-Dependent Multidendrite Ca2+ Spikes Required for Hippocampal Burst Firing In Vivo. Neuron. 2014 Feb 18. pii: S0896-6273(14)00019-1. doi: 10.1016/j.neuron.2014.01.014. [Epub ahead of print]
- Grienberger C, Chen X, Konnerth A (2014). Dendritic function in vivo. Trends Neurosci. 2014 Nov 25. pii: S0166-2236(14)00199-4. doi: 10.1016/j.tins.2014.11.002. [Epub ahead of print]
- Hartmann J, Karl RM, Alexander RP, Adelsberger H, Brill MS, Rühlmann C, Ansel A, Sakimura K, Baba Y, Kurosaki T, Misgeld T, Konnerth A (2014). STIM1 Controls Neuronal Ca(2+) Signaling, mGluR1-Dependent Synaptic Transmission, and Cerebellar Motor Behavior. Neuron. 2014 May 7;82(3):635-44. doi: 10.1016/j.neuron.2014.03.027.
- Jia H, Varga Z, Sakmann B, Konnerth A (2014). Linear integration of spine Ca2+ signals in layer 4 cortical neurons in vivo. Proc Natl Acad Sci U S A. 2014 Jun 9. pii: 201408525. [Epub ahead of print]
- Kleele T, Marinković P, Williams PR, Stern S, Weigand EE, Engerer P, Naumann R, Hartmann J, Karl RM, Bradke F, Bishop D, Herms J, Konnerth A, Kerschensteiner M, Godinho L, Misgeld T (2014). An assay to image neuronal microtubule dynamics in mice. Nat Commun. 2014 Sep 12;5:4827. doi: 10.1038/ncomms5827
2013
- Adelsberger H, Zainos A, Alvarez M, Romo R, Konnerth A (2013). Local domains of motor cortical activity revealed by fiber-optic calcium recordings in behaving nonhuman primates. Proc Natl Acad Sci U S A. 2013 Dec 16. [Epub ahead of print]
- Chen X, Rochefort NL, Sakmann B, Konnerth A (2013). Reactivation of the Same Synapses during Spontaneous Up States and Sensory Stimuli. Cell Rep 2013 Jun 26. pii: S2211-1247(13)00275-1. doi: 10.1016/j.celrep.2013.05.042. [Epub ahead of print]
- Hill DN, Varga Z, Jia H, Sakmann B, Konnerth A (2013). Multibranch activity in basal and tuft dendrites during firing of layer 5 cortical neurons in vivo. Proc Natl Acad Sci U S A. 2013 Jul 31. [Epub ahead of print]
- Stroh A, Adelsberger H, Groh A, Rühlmann C, Fischer S, Schierloh A, Deisseroth K, Konnerth A (2013). Making waves: initiation and propagation of corticothalamic ca(2+) waves in vivo. Neuron. 2013 Mar 20;77(6):1136-50. doi: 10.1016/j.neuron.2013.01.031