Jäkel, Sarah
2025
- Salazar Campos JM, Burbulla LF, Jäkel S. Are oligodendrocytes bystanders or drivers of Parkinson's disease pathology? PLoS Biol. 2025 Jan 8;23(1):e3002977. doi: 10.1371/journal.pbio.3002977. PMID: 39777410; PMCID: PMC11709285.
- Roemer-Cassiano SN, Wagner F, Evangelista L, Rauchmann BS, Dehsarvi A, Steward A, Dewenter A, Biel D, Zhu Z, Pescoller J, Gross M, Perneczky R, Malpetti M, Ewers M, Schöll M, Dichgans M, Höglinger GU, Brendel M, Jäkel S, Franzmeier N. Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer's disease. Sci Transl Med. 2025 Jan 22;17(782):eadp2564. doi: 10.1126/scitranslmed.adp2564. Epub 2025 Jan 22. PMID: 39841807.
2024
- Hurler CA, Liebscher S, Arzberger T, Jäkel S. Impact of fixation duration on messenger RNA detectability in human formalin-fixed paraffin-embedded brain tissue. Brain Commun. 2024 Nov 28;6(6):fcae430. doi: 10.1093/braincomms/fcae430. PMID: 39659968; PMCID: PMC11630792.
- Kaji S, Berghoff SA, Spieth L, Schlaphoff L, Sasmita AO, Vitale S, Büschgens L, Kedia S, Zirngibl M, Nazarenko T, Damkou A, Hosang L, Depp C, Kamp F, Scholz P, Ewers D, Giera M, Ischebeck T, Wurst W, Wefers B, Schifferer M, Willem M, Nave KA, Haass C, Arzberger T, Jäkel S, Wirths O, Saher G, Simons M. Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis. Immunity. 2024 Oct 9:S1074-7613(24)00458-8. doi: 10.1016/j.immuni.2024.09.014. Epub ahead of print. PMID: 39419029.
Macnair W, Calini D, Agirre E, Bryois J, Jäkel S, Smith RS, Kukanja P, Stokar-Regenscheit N, Ott V, Foo LC, Collin L, Schippling S, Urich E, Nutma E, Marzin M, Ansaloni F, Amor S, Magliozzi R, Heidari E, Robinson MD, Ffrench-Constant C, Castelo-Branco G, Williams A, Malhotra D. snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses. Neuron. 2024 Dec 20:S0896-6273(24)00873-0. doi: 10.1016/j.neuron.2024.11.016. Epub ahead of print. PMID: 39708806.
- Sasmita AO, Depp C, Nazarenko T, Sun T, Siems SB, Ong EC, Nkeh YB, Böhler C, Yu X, Bues B, Evangelista L, Mao S, Morgado B, Wu Z, Ruhwedel T, Subramanian S, Börensen F, Overhoff K, Spieth L, Berghoff SA, Sadleir KR, Vassar R, Eggert S, Goebbels S, Saito T, Saido T, Saher G, Möbius W, Castelo-Branco G, Klafki HW, Wirths O, Wiltfang J, Jäkel S, Yan R, Nave KA. Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice. Nat Neurosci. 2024 Aug 5. doi: 10.1038/s41593-024-01730-3. Epub ahead of print. PMID: 39103558.
2023
- Seeker LA, Bestard-Cuche N, Jäkel S, Kazakou NL, Bøstrand SMK, Wagstaff LJ, Cholewa-Waclaw J, Kilpatrick AM, Van Bruggen D, Kabbe M, Baldivia Pohl F, Moslehi Z, Henderson NC, Vallejos CA, La Manno G, Castelo-Branco G, Williams A. Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function. Acta Neuropathol Commun. 2023 May 22;11(1):84. doi: 10.1186/s40478-023-01568-z. PMID: 37217978; PMCID: PMC10204264.