Hohlfeld, Reinhard

2024

2022

Correale J, Hohlfeld R, Baranzini SE (2022). The role of the gut microbiota in multiple sclerosis. Nat Rev Neurol. 2022 Aug 5. doi: 10.1038/s41582-022-00697-8. Epub ahead of print. PMID: 35931825.
Havla J, Hohlfeld R (2022). Antibody Therapies for Progressive Multiple Sclerosis and for Promoting Repair. Neurotherapeutics. 2022 Mar 14. doi: 10.1007/s13311-022-01214-x. Epub ahead of print. PMID: 35289375.
Hohlfeld R, Liblau RS (2022). Toward identification of personalized immunological profiles in multiple sclerosis. Sci Adv. 2022 Apr 29;8(17):eabq4849. doi: 10.1126/sciadv.abq4849. Epub 2022 Apr 27. PMID: 35476442.
Ingelfinger F, Gerdes LA, Kavaka V, Krishnarajah S, Friebel E, Galli E, Zwicky P, Furrer R, Peukert C, Dutertre CA, Eglseer KM, Ginhoux F, Flierl-Hecht A, Kümpfel T, De Feo D, Schreiner B, Mundt S, Kerschensteiner M, Hohlfeld R, Beltrán E, Becher B (2022). Twin study reveals non-heritable immune perturbations in multiple sclerosis. Nature. 2022 Mar;603(7899):152-158. doi: 10.1038/s41586-022-04419-4. Epub 2022 Feb 16. PMID: 35173329.
Schneider-Hohendorf T, Gerdes LA, Pignolet B, Gittelman R, Ostkamp P, Rubelt F, Raposo C, Tackenberg B, Riepenhausen M, Janoschka C, Wünsch C, Bucciarelli F, Flierl-Hecht A, Beltrán E, Kümpfel T, Anslinger K, Gross CC, Chapman H, Kaplan I, Brassat D, Wekerle H, Kerschensteiner M, Klotz L, Lünemann JD, Hohlfeld R, Liblau R, Wiendl H, Schwab N (2022). Broader Epstein-Barr virus-specific T cell receptor repertoire in patients with multiple sclerosis. J Exp Med. 2022 Nov 7;219(11):e20220650. doi: 10.1084/jem.20220650. Epub 2022 Sep 1. PMID: 36048016; PMCID: PMC9437111.35468638.

2021

Brändle SM, Cerina M, Weber S, Held K, Menke AF, Alcalá C, Gebert D, Herrmann AM, Pellkofer H, Gerdes LA, Bittner S, Leypoldt F, Teegen B, Komorowski L, Kümpfel T, Hohlfeld R, Meuth SG, Casanova B, Melzer N, Beltrán E, Dornmair K (2021). Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABAA receptor encephalitis. Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e1916337118. doi: 10.1073/pnas.1916337118. PMID: 33619082.
Dangond F, Donnelly A, Hohlfeld R, Gourzis PLubetzki C, Kohlhaas S, Leocani L, Ciccarelli O, Stankoff B, Sormani MP, Chataway J, Bozzoli F, Cucca F, Melton L, Coetzee T, Salvetti M (2021). Facing the urgency of therapies for progressive MS - a Progressive MS Alliance proposal. Nat Rev Neurol. 2021 Jan 22. doi: 10.1038/s41582-020-00446-9. Epub ahead of print. PMID: 33483719.
Havla J, Schultz Y, Zimmermann H, Hohlfeld R, Danek A, Kümpfel T (2021). First manifestation of multiple sclerosis after immunization with the Pfizer-BioNTech COVID-19 vaccine. J Neurol. 2021 Jun 11:1–4. doi: 10.1007/s00415-021-10648-w. Epub ahead of print. PMID: 34115170; PMCID: PMC8193159.
Hohlfeld R (2021). Correcting gut dysbiosis can ameliorate inflammation and promote remyelination in multiple sclerosis - Commentary. Mult Scler. 2021 May 28:13524585211018990. doi: 10.1177/13524585211018990. Epub ahead of print. PMID: 34047222.
Hohlfeld R (2021). Multiple sclerosis meets systems immunology. Lancet Neurol. 2021 Nov;20(11):887-888. doi: 10.1016/S1474-4422(21)00325-2. PMID: 34687627.
Hohlfeld R (2021). Mesenchymal stem cells for multiple sclerosis: hype or hope? Lancet Neurol. 2021 Nov;20(11):881-882. doi: 10.1016/S1474-4422(21)00324-0. PMID: 34687621.
Kappos L, Fox RJ, Burcklen M, Freedman MS, Havrdová EK, Hennessy B, Hohlfeld R, Lublin F, Montalban X, Pozzilli C, Scherz T, D'Ambrosio D, Linscheid P, Vaclavkova A, Pirozek-Lawniczek M, Kracker H, Sprenger T (2021). Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study: A Randomized Clinical Trial. JAMA Neurol. 2021 Mar 29. doi: 10.1001/jamaneurol.2021.0405. Epub ahead of print. PMID: 33779698.
Macrini C, Gerhards R, Winklmeier S, Bergmann L, Mader S, Spadaro M, Vural A, Smolle M, Hohlfeld R, Kümpfel T, Lichtenthaler SF, Franquelim HG, Jenne D, Meinl E (2021). Features of MOG required for recognition by patients with MOG antibody-associated disorders. Brain. 2021 Mar 11:awab105. doi: 10.1093/brain/awab105. Epub ahead of print. PMID: 33704436.
Meinl E, Hohlfeld R (2021). CD20+ T cells as pathogenic players and therapeutic targets in MS. Ann Neurol. 2021 Sep 29. doi: 10.1002/ana.26232. Epub ahead of print. PMID: 34585761.
Mortazavi M, Hizarci Ö, Gerdes LA, Havla J, Kümpfel T, Hohlfeld R, Stöcklein S, Keeser D, Ertl-Wagner B (2021). Multiple sclerosis and subclinical neuropathology in healthy individuals with familial risk: A scoping review of MRI studies. Neuroimage Clin. 2021 Jun 18;31:102734. doi: 10.1016/j.nicl.2021.102734. Epub ahead of print. PMID: 34171607; PMCID: PMC8234346.
Ostkamp P, Salmen A, Pignolet B, Görlich D, Andlauer TFM, Schulte-Mecklenbeck A, Gonzalez-Escamilla G, Bucciarelli F, Gennero I, Breuer J, Antony G, Schneider-Hohendorf T, Mykicki N, Bayas A, Then Bergh F, Bittner S, Hartung HP, Friese MA, Linker RA, Luessi F, Lehmann-Horn K, Mühlau M, Paul F, Stangel M, Tackenberg B, Tumani H, Warnke C, Weber F, Wildemann B, Zettl UK, Ziemann U, Müller-Myhsok B, Kümpfel T, Klotz L, Meuth SG, Zipp F, Hemmer B, Hohlfeld R, Brassat D, Gold R, Gross CC, Lukas C, Groppa S, Loser K, Wiendl H, Schwab N; German Competence Network Multiple Sclerosis (KKNMS) and the BIONAT Network (2021). Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2018457118. doi: 10.1073/pnas.2018457118. PMID: 33376202.
Thompson AJ, Carroll W, Ciccarelli O, Comi G, Cross A, Donnelly A, Feinstein A, Fox RJ, Helme A, Hohlfeld R, Hyde R, Kanellis P, Landsman D, Lubetzki C, Marrie RA, Morahan J, Montalban X, Musch B, Rawlings S, Salvetti M, Sellebjerg F, Sincock C, Smith KE, Strum J, Zaratin P, Coetzee T (2021). Charting a global research strategy for progressive MS-An international progressive MS Alliance proposal. Mult Scler. 2021 Dec 1:13524585211059766. doi: 10.1177/13524585211059766. Epub ahead of print. PMID: 34850641.

2020

Bracher A, Alcalá C, Ferrer J, Melzer N, Hohlfeld R, Casanova B, Beltrán E, Dornmair K (2020). An expanded parenchymal CD8+ T cell clone in GABAA receptor encephalitis. Ann Clin Transl Neurol. 2020 Jan 14. doi: 10.1002/acn3.50974. [Epub ahead of print]
Comi G, Bar-Or A, Lassmann H, Uccelli A, Hartung HP, Montalban X, Sørensen PS, Hohlfeld R, Hauser SL; Expert Panel of the 27th Annual Meeting of the European Charcot Foundation. Role of B Cells in Multiple Sclerosis and Related Disorders. Ann Neurol. 2021 Jan;89(1):13-23. doi: 10.1002/ana.25927. Epub 2020 Nov 4. PMID: 33091175; PMCID: PMC8007167.
Gerdes LA, Janoschka C, Eveslage M, Mannig B, Wirth T, Schulte-Mecklenbeck A, Lauks S, Glau L, Gross CC, Tolosa E, Flierl-Hecht A, Ertl-Wagner B, Barkhof F, Meuth SG, Kümpfel T, Wiendl H, Hohlfeld R, Klotz L (2020). Immune signatures of prodromal multiple sclerosis in monozygotic twins. Proc Natl Acad Sci U S A. 2020;202003339. doi:10.1073/pnas.2003339117 [published online ahead of print, 2020 Aug 17]
Gerhards R, Pfeffer LK, Lorenz J, Starost L, Nowack L, Thaler FS, Schlüter M, Rübsamen H, Macrini C, Winklmeier S, Mader S, Bronge M, Grönlund H, Feederle R, Hsia HE, Lichtenthaler SF, Merl-Pham J, Hauck SM, Kuhlmann T, Bauer IJ, Beltran E, Gerdes LA, Mezydlo A, Bar-Or A, Banwell B, Khademi M, Olsson T, Hohlfeld R, Lassmann H, Kümpfel T, Kawakami N, Meinl E (2020). Oligodendrocyte myelin glycoprotein as a novel target for pathogenic autoimmunity in the CNS. Acta Neuropathol Commun. 2020 Nov 30;8(1):207. doi: 10.1186/s40478-020-01086-2. PMID: 33256847; PMCID: PMC7706210.
Hohlfeld R, Beltran E, Gerdes LA, Dornmair K (2020). Tissue-resident CD8+ memory T cells in multiple sclerosis. Brain. 2020 Dec 13:awaa352. doi: 10.1093/brain/awaa352. Epub ahead of print. PMID: 33313699.
Penkert H, Lauber C, Gerl MJ, Klose C, Damm M, Fitzner D, Flierl-Hecht A, Kümpfel T, Kerschensteiner M, Hohlfeld R, Gerdes LA, Simons M (2020). Plasma lipidomics of monozygotic twins discordant for multiple sclerosis. Ann Clin Transl Neurol. 2020 Nov 7. doi: 10.1002/acn3.51216. Epub ahead of print. PMID: 33159711.

2019

Beltrán E, Gerdes LA, Hansen J, Flierl-Hecht A, Krebs S, Blum H, Ertl-Wagner B, Barkhof F, Kümpfel T, Hohlfeld R, Dornmair K (2019). Early adaptive immune activation detected in monozygotic twins with prodromal multiple sclerosis. J Clin Invest. 2019 Sep 30. pii: 128475. doi: 10.1172/JCI128475. [Epub ahead of print]
Förster M, Küry P, Aktas O, Warnke C, Havla J, Hohlfeld R, Mares J, Hartung HP, Kremer D (2019). Managing Risks with Immune Therapies in Multiple Sclerosis. Drug Saf. 2019 Jan 3. doi: 10.1007/s40264-018-0782-8. [Epub ahead of print]
Hohlfeld R. Immune checkpoint blockade for treating progressive multifocal leukoencephalopathy. Lancet Neurol. 2019 Jul;18(7):623-624. doi: 10.1016/S1474-4422(19)30183-8. Epub 2019 May 16. PMID: 31104991.
Hohlfeld R (2019). Immune dysbalance in childhood multiple sclerosis: a ‘chicken or the egg’ conundrum. Brain. 2019 Mar 1;142(3):490-492. doi: 10.1093/brain/awz008.
Klotz L, Havla J, Schwab N, Hohlfeld R, Barnett M, Reddel S, Wiendl H (2019). Risks and risk management in modern multiple sclerosis immunotherapeutic treatment. Ther Adv Neurol Disord. 2019 Apr 1;12:1756286419836571. doi: 10.1177/1756286419836571. eCollection 2019.
Konjevic Sabolek M, Held K, Beltrán E, Niedl AG, Meinl E, Hohlfeld R, Lassmann H, Dornmair K (2019). Communication of CD8+ T cells with mononuclear phagocytes in multiple sclerosis. Ann Clin Transl Neurol. 2019 Jul;6(7):1151-1164. doi: 10.1002/acn3.783. Epub 2019 Jun 14.
Marti Fernandez I, Macrini C, Krumbholz M, Hensbergen PJ, Hipgrave Ederveen AL, Winklmeier S, Vural A, Kurne A, Jenne D, Kamp F, Gerdes LA, Hohlfeld R, Wuhrer M, Kümpfel T, Meinl E (2019). The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients. Front Immunol. 2019 Jun 11;10:1189. doi: 10.3389/fimmu.2019.01189. eCollection 2019.
Oertel FC, Outteryck O, Knier B, Zimmermann H, Borisow N, Bellmann-Strobl J, Blaschek A, Jarius S, Reindl M, Ruprecht K, Meinl E, Hohlfeld R, Paul F, Brandt AU, Kümpfel T, Havla J (2019). Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study. J Neuroinflammation. 2019 Jul 25;16(1):154. doi: 10.1186/s12974-019-1521-5.
Souren NY, Gerdes LA, Lutsik P, Gasparoni G, Beltrán E, Salhab A, Kümpfel T, Weichenhan D, Plass C, Hohlfeld R, Walter J (2019). DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis. Nat Commun. 2019 May 7;10(1):2094. doi: 10.1038/s41467-019-09984-3.
Thaler FS, Thaller AL, Biljecki M, Schuh E, Winklmeier S, Mahler CF, Gerhards R, Völk S, Schnorfeil F, Subklewe M, Hohlfeld R, Kümpfel T, Meinl E (2019). Abundant GAD-reactive B cells in GAD-antibody-associated neurological disorders. Ann Neurol. 2019 Jan 11. doi: 10.1002/ana.25414. [Epub ahead of print]
Winklmeier S, Schlüter M, Spadaro M, Thaler FS, Vural A, Gerhards R, Macrini C, Mader S, Kurne A, Inan B, Karabudak R, Özbay FG, Esendagli G, Hohlfeld R, Kümpfel T, Meinl E (2019). Identification of circulating MOG-specific B cells in patients with MOG antibodies. Neurol Neuroimmunol Neuroinflamm. 2019 Oct 14;6(6):625. doi: 10.1212/NXI.0000000000000625. Print 2019 Nov.

2018

Graetz C, Gröger A, Luessi F, Salmen A, Zöller D, Schultz J, Siller N, Fleischer V, Bellenberg B, Berthele A, Biberacher V, Havla J, Hecker M, Hohlfeld R, Infante-Duarte C, Kirschke JS, Kümpfel T, Linker R, Paul F, Pfeuffer S, Sämann P, Toenges G, Weber F, Zettl UK, Jahn-Eimermacher A, Antony G, Groppa S, Wiendl H, Hemmer B, Mühlau M, Lukas C, Gold R, Lill CM, Zipp F (2018). Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis. Mult Scler. 2018 Mar 1:1352458518763541. doi: 10.1177/1352458518763541. [Epub ahead of print]
Spadaro M, Winklmeier S, Beltrán E, Macrini C, Höftberger R, Schuh E, Thaler FS, Gerdes LA, Laurent S, Gerhards R, Brändle S, Dornmair K, Breithaupt C, Krumbholz M, Moser M, Kirshnamoorthy G, Kamp F, Jenne D, Hohlfeld R, Kümpfel T, Lassmann H, Kawakami N, Meinl E (2018). Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein. Ann Neurol. 2018 Jul 16. doi: 10.1002/ana.25291. [Epub ahead of print]

2017

Berer K, Gerdes LA, Cekanaviciute E, Jia X, Xiao L, Xia Z, Liu C, Klotz L, Stauffer U, Baranzini SE, Kümpfel T, Hohlfeld R, Krishnamoorthy G, Wekerle H (2017). Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A. 2017 Sep 11. pii: 201711233. doi: 10.1073/pnas.1711233114. [Epub ahead of print]
Hohlfeld R, Steinman L (2017). T Cell-Transfer Experimental Autoimmune Encephalomyelitis: Pillar of Multiple Sclerosis and Autoimmunity. J Immunol. 2017 May 1;198(9):3381-3383. doi: 10.4049/jimmunol.1700346.
Hohlfeld R, Meinl E (2017). Ocrelizumab in multiple sclerosis: markers and mechanisms. Lancet Neurol. 2017 Apr;16(4):259-261. doi: 10.1016/S1474-4422(17)30048-0.
Hohlfeld R, Havla J, Kümpfel T (2017). Patient-to-patient transmission of natalizumab-associated PML? Mult Scler. 2017 Mar 1:1352458517701316. doi: 10.1177/1352458517701316. [Epub ahead of print]
Hohlfeld R (2017). Stop inflammation and you stop neurodegeneration in MS - Commentary. Mult Scler. 2017 Apr 1:1352458517707587. doi: 10.1177/1352458517707587. [Epub ahead of print]
Hohlfeld R (2017). B-cells as therapeutic targets in neuro-inflammatory diseases. Clin Immunol. 2017 Jul 21. pii: S1521-6616(17)30529-6. doi: 10.1016/j.clim.2017.07.013. [Epub ahead of print]
Kyratsous NI, Bauer IJ, Zhang G, Pesic M, Bartholomäus I, Mues M, Fang P, Wörner M, Everts S, Ellwart JW, Watt JM, Potter BVL, Hohlfeld R, Wekerle H, Kawakami N (2017). Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy. Proc Natl Acad Sci U S A. 2017 Jul 17. pii: 201701806. doi: 10.1073/pnas.1701806114. [Epub ahead of print]
Meinl I, Havla J, Hohlfeld R, Kümpfel T (2017). Recurrence of disease activity during pregnancy after cessation of fingolimod in multiple sclerosis. Mult Scler. 2017 Sep 1:1352458517731913. doi: 10.1177/1352458517731913. [Epub ahead of print]
Schuh E, Musumeci A, Thaler FS, Laurent S, Ellwart JW, Hohlfeld R, Krug A, Meinl E (2017). Human Plasmacytoid Dendritic Cells Display and Shed B Cell Maturation Antigen upon TLR Engagement. J Immunol. 2017 Mar 10. pii: 1601746. doi: 10.4049/jimmunol.1601746. [Epub ahead of print]
Yshii LM, Hohlfeld R, Liblau RS (2017). Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives. Nat Rev Neurol. 2017 Dec;13(12):755-763. doi: 10.1038/nrneurol.2017.144. Epub 2017 Nov 6.

2016

Brändle S M, Obermeier B, Senel M, Bruder J, Mentele R, Khademi M, Olsson T, Hayrettin T, Kristoferitsch W, Lottspeich F, Wekerle H, Hohlfeld R, Dornmair K (2016). Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins. Proceedings of the National Academy of Sciences of the United States of America. 2016 June 20. pii: 201522730. DOI: 10.1073/pnas.1522730113. [Epub ahead of print]
Gerdes L A, Held K, Beltran E, Berking C, Prinz J C, Junker A, Tietze J K, Ertl-Wagner B, Straube A, Kümpfel T, Dornmair K, Hohlfeld R (2016). CTLA-4 as immunological checkpoint in the development of multiple sclerosis. Annals of Neurology. 2016 June 28. DOI: 10.1002/ana.24715. [Epub ahead of print]
Gross C C, Schulte-Mecklenbeck A, Rünzi A, Kuhlmann T, Posevitz-Fejfár A, Schwab N, Schneider-Hohendorf T, Herich S, Held K, Konjevic M, Hartwig M, Dornmair K, Hohlfeld R, Ziemssen T, Klotz L, Meuth S G, Wiendl H (2016). Impaired NK-mediated regulation of T cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation. Proceedings of the National Academy of Sciences. 2016 May 9. pii: 201524924. DOI: 10.1073/pnas.1524924113. [Epub ahead of print]
Havla J, Kümpfel T, Schinner R, Spadaro M, Schuh E, Meinl E, Hohlfeld R, Outteryck O (2016). Myelin-oligodendrocyte-glycoprotein (MOG) autoantibodies as potential markers of severe optic neuritis and subclinical retinal axonal degeneration. J Neurol. 2016 Nov 14. [Epub ahead of print]
Havla J, Warnke C, Derfuss T, Kappos L, Hartung HP, Hohlfeld R (2016). Interdisciplinary Risk Management in the Treatment of Multiple Sclerosis. Dtsch Arztebl Int. 2016 Dec 26;113(51-52):879-886. doi: 10.3238/arztebl.2016.0879.
Hohlfeld R, Kümpfel T (2016). Alemtuzumab and multiple sclerosis: Another note of caution. JAMA Neurol. 2016 Apr 4. doi: 10.1001/jamaneurol.2016.0259. [Epub ahead of print]
Hohlfeld R, Kerschensteiner M (2016). Antiglutamatergic therapy for multiple sclerosis? Lancet Neurol. 2016 Sep;15(10):1003-4. doi: 10.1016/S1474-4422(16)30163-6. Epub 2016 Aug 8.
Hohlfeld R, Schulze-Koops H (2016). Cytotoxic T cells go awry in inclusion body myositis. Brain. 2016 May. 139(Pt 5):1312-4. DOI: 10.1093/brain/aww053
Ingrisch M, Sourbron S, Herberich S, Schneider MJ, Kümpfel T, Hohlfeld R, Reiser MF, Ertl-Wagner B (2016). Dynamic Contrast-Enhanced Magnetic Resonance Imaging Suggests Normal Perfusion in Normal-Appearing White Matter in Multiple Sclerosis. Invest Radiol. 2016 Aug 19. [Epub ahead of print]
Rühl G, Niedl A, Parronov A, Siewert K, Pinkert S, Kalemanov M, Friese M A, Attfield K E, Antes I, Hohlfeld R, Dornmair K (2016). Multiple sclerosis - Molecular mimicry of an antimyelin HLA class I restricted T-cell receptor. Neurology Neuroimmunology Neuroinflammation. 2016 May 17. 3(4):e241. DOI: 10.1212/NXI.0000000000000241. eCollection 2016.
Schuh E, Berer K, Mulazzani M, Feil K, Meinl I, Lahm H, Krane M, Lange R, Pfannes K, Subklewe M, Gürkov R, Bradl M, Hohlfeld R, Kümpfel T, Meinl E, Krumbholz M (2016). Features of human CD3+CD20+ T cells Journal of Immunology. 2016 July 13. DOI: 10.4049/jimmunol.1600089. pii: 1600089. [Epub ahead of print]
Souren NY, Gerdes LA, Kümpfel T, Lutsik P, Klopstock T, Hohlfeld R, Walter J (2016). Mitochondrial DNA variation and heteroplasmy in monozygotic twins clinically discordant for multiple sclerosis. Hum Mutat. 2016 Apr 27. doi: 10.1002/humu.23003. [Epub ahead of print]
Spadaro M, Gerdes LA, Krumbholz M, Ertl-Wagner B, Thaler FS, Schuh E, Metz I, Blaschek A, Dick A, Brück W, Hohlfeld R, Meinl E, Kümpfel (2016). Autoantibodies to MOG in a distinct subgroup of adult multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2016 Jun 30;3(5):e257. doi: 10.1212/NXI.0000000000000257. eCollection 2016.

2015

Held K, Bhonsle-Deeng L, Siewert K, Sato W, Beltrán E, Schmidt S, Rühl G, Ng JK, Engerer P, Moser M, Klinkert WE, Babbe H, Misgeld T, Wekerle H, Laplaud DA, Hohlfeld R, Dornmair K (2015). αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features. Neurol Neuroimmunol Neuroinflamm. 2015 May 7;2(4):e107. doi: 10.1212/NXI.0000000000000107. eCollection 2015.
Held K, Beltrán E, Moser M, Hohlfeld R, Dornmair K (2015). T-cell receptor repertoire of human peripheral CD161hiTRAV1-2+ MAIT cells revealed by next generation sequencing and single cell analysis. Hum Immunol. 2015 Sep 14. pii: S0198-8859(15)00439-5. doi: 10.1016/j.humimm.2015.09.002. [Epub ahead of print]
Hoffmann FS, Hofereiter J, Rübsamen H, Melms J, Schwarz S, Faber H, Weber P, Pütz B, Loleit V, Weber F, Hohlfeld R, Meinl E, Krumbholz M (2015). Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation. 2015 Sep 30;12(1):184. doi: 10.1186/s12974-015-0393-6.
Hohlfeld R, Wekerle H (2015). Multiple sclerosis and microbiota: From genome to metagenome? [Article in German] Nervenarzt. 2015 Jun 24. [Epub ahead of print]
Hohlfeld R, Dornmair K, Meinl E, Wekerle H (2015). The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets. Lancet Neurol. 2015 Dec 23. pii: S1474-4422(15)00334-8. doi: 10.1016/S1474-4422(15)00334-8. [Epub ahead of print]
Hohlfeld R, Dornmair K, Meinl E, Wekerle H (2015). The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research. Lancet Neurol. 2015 Dec 23. pii: S1474-4422(15)00313-0. doi: 10.1016/S1474-4422(15)00313-0. [Epub ahead of print]
Kappos L, O'Connor P, Radue EW, Polman C, Hohlfeld R, Selmaj K, Ritter S, Schlosshauer R, von Rosenstiel P, Zhang-Auberson L, Francis G (2015). Long-term effects of fingolimod in multiple sclerosis: The randomized FREEDOMS extension trial. Neurology. 2015 Mar 20. pii: 10.1212/WNL.0000000000001462. [Epub ahead of print]
Kolber P, Luessi F, Meuth SG, Klotz L, Korn T, Trebst C, Tackenberg B, Kieseier B, Kümpfel T, Fleischer V, Tumani H, Wildemann B, Lang M, Flachenecker P, Meier U, Brück W, Limmroth V, Haghikia A, Hartung HP, Stangel M, Hohlfeld R, Hemmer B, Gold R, Wiendl H, Zipp F (2015). Current aspects of therapy conversion for multiple sclerosis [Article in German] Nervenarzt. 2015 Aug 13. [Epub ahead of print]
Laurent SA, Hoffmann FS, Kuhn PH, Cheng Q, Chu Y, Schmidt-Supprian M, Hauck SM, Schuh E, Krumbholz M, Rübsamen H, Wanngren J, Khademi M, Olsson T, Alexander T, Hiepe F, Pfister HW, Weber F, Jenne D, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E (2015). γ-secretase directly sheds the survival receptor BCMA from plasma cells. Nat Commun. 2015 Jun 11;6:7333. doi: 10.1038/ncomms8333.
Schuh E, Lohse P, Ertl-Wagner B, Witt M, Krumbholz M, Frankenberger M, Gerdes LA, Hohlfeld R, Kümpfel T (2015). Expanding spectrum of neurologic manifestations in patients with NLRP3 low-penetrance mutations. Neurol Neuroimmunol Neuroinflamm. 2015 May 14;2(4):e109. doi: 10.1212/NXI.0000000000000109. eCollection 2015.
Schwab N, Schneider-Hohendorf T, Pignolet B, Spadaro M, Görlich D, Meinl I, Windhagen S, Tackenberg B, Breuer J, Cantó E, Kümpfel T, Hohlfeld R, Siffrin V, Luessi F, Posevitz-Fejfár A, Montalban X, Meuth SG, Zipp F, Gold R, Du Pasquier RA, Kleinschnitz C, Jacobi A, Comabella M, Bertolotto A, Brassat D, Wiendl H (2015). PML risk stratification using anti-JCV antibody index and L-selectin. Mult Scler. 2015 Oct 2. pii: 1352458515607651. [Epub ahead of print]
Spadaro M, Gerdes LA, Mayer MC, Ertl-Wagner B, Laurent S, Krumbholz M, Breithaupt C, Högen T, Straube A, Giese A, Hohlfeld R, Lassmann H, Meinl E, Kümpfel T (2015). Histopathology and clinical course of MOG-antibody-associated encephalomyelitis. Ann Clin Transl Neurol. 2015 Mar;2(3):295-301. doi: 10.1002/acn3.164. Epub 2015 Jan 14
Wuhrer M, Selman MH, McDonnell LA, Kümpfel T, Derfuss T, Khademi M, Olsson T, Hohlfeld R, Meinl E, Krumbholz M(2015). Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid. J Neuroinflammation. 2015 Dec 18;12(1):235. doi: 10.1186/s12974-015-0450-1.

2014

Beltrán E, Obermeier B, Moser M, Coret F, Simó-Castelló M, Boscá I, Pérez-Miralles F, Villar LM, Senel M, Tumani H, Hohlfeld R, Casanova B, Dornmair K (2014). Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation. Brain. 2014 Jul 23. pii: awu205. [Epub ahead of print]
Hoepner R, Havla J, Eienbröker C, Tackenberg B, Hellwig K, Meinl I, Hohlfeld R, Gold R, Kümpfel T, Kleiter I (2014). Predictors for multiple sclerosis relapses after switching from natalizumab to fingolimod. Mult Scler. 2014 May 19. pii: 1352458514533398. [Epub ahead of print]
Hoffmann FS, Kuhn PH, Laurent SA, Hauck SM, Berer K, Wendlinger SA, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister HW, Alexander T, Hiepe F, Kümpfel T, Crawford HC, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E (2014). The Immunoregulator Soluble TACI Is Released by ADAM10 and Reflects B Cell Activation in Autoimmunity. J Immunol. 2014 Dec 10. pii: 1402070. [Epub ahead of print]
Mohan H, Friese A, Albrecht S, Krumbholz M, Elliott CL, Arthur A, Menon R, Farina C, Junker A, Stadelmann C, Barnett SC, Huitinga I, Wekerle H, Hohlfeld R, Lassmann H, Kuhlmann T, Linington C, Meinl E (2014). Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination. Acta Neuropathol Commun. 2014 Dec 11;2(1):178. [Epub ahead of print]
Schuh E, Ertl-Wagner B, Lohse P, Wolf W, Mann JF, Lee-Kirsch MA, Hohlfeld R, Kümpfel T (2014). Multiple sclerosis-like lesions and type I interferon signature in a patient with RVCL. Neurol Neuroimmunol Neuroinflamm. 2014 Dec 23;2(1):e55. doi: 10.1212/NXI.0000000000000055. eCollection 2015.
Warnke C, von Geldern G, Markwerth P, Dehmel T, Hoepner R, Gold R, Pawlita M, Kümpfel T, Mäurer M, Stangel M, Wegner F, Hohlfeld R, Straeten V, Limmroth V, Weber T, Hermsen D, Kleinschnitz C, Hartung HP, Wattjes MP, Svenningson A, Major E, Olsson T, Kieseier BC, Adams O (2014). The CSF JCV antibody index for diagnosis of natalizumab-associated PML. Ann Neurol. 2014 Apr 11. doi: 10.1002/ana.24153. [Epub ahead of print]
Warnke C, Stettner M, Lehmensiek V, Dehmel T, Mausberg AK, von Geldern G, Gold R, Kümpfel T, Hohlfeld R, Mäurer M, Stangel M, Straeten V, Limmroth V, Weber T, Kleinschnitz C, Wattjes MP, Svenningsson A, Olsson T, Hartung HP, Hermsen D, Tumani H, Adams O, Kieseier BC (2014). Natalizumab exerts a suppressive effect on surrogates of B cell function in blood and CSF. Mult Scler. 2014 Nov 12. pii: 1352458514556296. [Epub ahead of print]

2013

Haghikia A, Hohlfeld R, Gold R, Fugger L (2013). Therapies for multiple sclerosis: translational achievements and outstanding needs. Trends Mol Med. 2013 Apr 9. pii: S1471-4914(13)00044-0. doi: 10.1016/j.molmed.2013.03.004. [Epub ahead of print]
Havla J, Hohlfeld R, Kümpfel T (2013). Unusual natalizumab-associated progressive multifocal leukoencephalopathy starting in the brainstem. J Neurol. 2013 Nov 26. [Epub ahead of print]
Hohlfeld R, Stüve O (2013). A bird's-eye view of T cells during natalizumab therapy. Neurology. 2013 Sep 18. [Epub ahead of print]
Hohlfeld R (2013). Natalizumab-induced PML: can the beast be tamed? J Neurol Neurosurg Psychiatry. 2013 Mar 9. [Epub ahead of print]
Mayer MC, Breithaupt C, Reindl M, Schanda K, Rostásy K, Berger T, Dale RC, Brilot F, Olsson T, Jenne D, Pröbstel AK, Dornmair K, Wekerle H, Hohlfeld R, Banwell B, Bar-Or A, Meinl E (2013). Distinction and Temporal Stability of Conformational Epitopes on Myelin Oligodendrocyte Glycoprotein Recognized by Patients with Different Inflammatory Central Nervous System Diseases. J Immunol. 2013 Sep 6. [Epub ahead of print]
Tienari PJ, Hohlfeld R. TNFRSF1A in multiple sclerosis: a tale of soluble receptors and signaling cascades. Neurology. 2013 Nov 26;81(22):1886-8. doi: 10.1212/01.wnl.0000436624.56026.eb. Epub 2013 Oct 30. PMID: 24174591.

2012

Hohlfeld, Reinhard

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