Gerdes, Lisa Ann
Ho S, Wong HK, Shqau D, Winklmeier S, Grobe-Einsler M, Rostasy K, Kümpfel T, Thaler FS, Brimberg L, Schneider MA, Muley T, Vural A, Seifert-Held T, Endmayr V, Höftberger R, Faber J, Klopstock T, Frahm S, Gerdes LA, Meinl E, Mader S. Synaptophysin autoantibodies mediate synaptic dysfunction in cerebelar ataxia. Cell Rep Med. 2026 May 18:102822. doi: 10.1016/j.xcrm.2026.102822. Epub ahead of print. PMID: 42155449.
de la Rosa C, Kendirli A, Baygün S, Bauernschmitt F, Thomann AS, Kisioglu I, Beckmann D, Carpentier Solorio Y, Pfaffenstaller V, Tai YH, Mehraein N, Sanchez P, Spieth L, Gerdes LA, Beltran E, Dornmair K, Simons M, Peters A, Schmidt-Supprian M, Kerschensteiner M. In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation. Nat Neurosci. 2025 Dec 4. doi: 10.1038/s41593-025-02151-6. Epub ahead of print. PMID: 41345278.
- Engels D, Flierl-Hecht A, Shalaginova G, Rek S, Keeser D, Reinhard MA, Padberg F, Kümpfel T, Gerdes LA. Multiple sclerosis twin study reveals distinct genetic, disease-specific, and psychometric impact on coping with critical life events. J Neurol Sci. 2025 Jan 2;469:123381. doi: 10.1016/j.jns.2024.123381. Epub ahead of print. PMID: 39798189.
- Ullrich Gavilanes EM, Bartos LM, Gernert JA, Carral CA, Ruiz Navarro D, Havla J, Gerdes LA, Gnörich JS, Kunze LH, Dorneich JS, Pakula V, Tagnin L, Zimmermann H, Seelos K, Franzmeier N, Frontzkowski L, Pedrosa de Barros N, Ribbens A, Zwergal RM, Zwergal A, Vollmar C, Remi J, Picon C, Reynolds R, Merkler D, Wattjes MP, Kümpfel T, Brendel M, Kerschensteiner M. SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis. Sci Transl Med. 2025 Oct;17(818):eadt5585. doi: 10.1126/scitranslmed.adt5585. Epub 2025 Oct 1. PMID: 41032626.
Yoon H, Gerdes LA, Beigel F, Sun Y, Kövilein J, Wang J, Kuhlmann T, Flierl-Hecht A, Haller D, Hohlfeld R, Baranzini SE, Wekerle H, Peters A. Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study. Proc Natl Acad Sci U S A. 2025 May 6;122(18):e2419689122. doi: 10.1073/pnas.2419689122. Epub 2025 Apr 21. PMID: 40258140.
- Huth A, Ayoub I, Barateau L, Gerdes LA, Severac D, Krebs S, Blum H, Tumani H, Haas J, Wildemann B, Kümpfel T, Beltrán E, Liblau RS, Dauvilliers Y, Dornmair K. Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy. J Autoimmun. 2024 Apr 24;146:103234. doi: 10.1016/j.jaut.2024.103234. Epub ahead of print. PMID: 38663202.
- Ingelfinger F, Kuiper KL, Ulutekin C, Rindlisbacher L, Mundt S, Gerdes LA, Smolders J, van Luijn MM, Becher B. Twin study dissects CXCR3+ memory B cells as non-heritable feature in multiple sclerosis. Med. 2024 Mar 18:S2666-6340(24)00085-0. doi: 10.1016/j.medj.2024.02.013. Epub ahead of print. PMID: 38531361.
Kavaka V, Mutschler L, de la Rosa Del Val C, Eglseer K, Gómez Martínez AM, Flierl-Hecht A, Ertl-Wagner B, Keeser D, Mortazavi M, Seelos K, Zimmermann H, Haas J, Wildemann B, Kümpfel T, Dornmair K, Korn T, Hohlfeld R, Kerschensteiner M, Gerdes LA, Beltrán E. Twin study identifies early immunological and metabolic dysregulation of CD8+ T cells in multiple sclerosis. Sci Immunol. 2024 Sep 27;9(99):eadj8094. doi: 10.1126/sciimmunol.adj8094. Epub 2024 Sep 27. PMID: 39331727.
- Mortazavi M, Gerdes LA, Hizarci Ö, Kümpfel T, Anslinger K, Padberg F, Stöcklein S, Keeser D, Ertl-Wagner B. Impact of adult-onset multiple sclerosis on MRI-based intracranial volume: A study in clinically discordant monozygotic twins. Neuroimage Clin. 2024 Mar 22;42:103597. doi: 10.1016/j.nicl.2024.103597. Epub ahead of print. PMID: 38522363; PMCID: PMC10981084.
Peters A, Gerdes LA, Wekerle H. Multiple sclerosis and the intestine: Chasing the microbial offender. Immunol Rev. 2024 May 29. doi: 10.1111/imr.13357. Epub ahead of print. PMID: 38809041.
- Agrafiotis A, Dizerens R, Vincenti I, Wagner I, Kuhn R, Shlesinger D, Manero-Carranza M, Cotet TS, Hong KL, Page N, Fonta N, Shammas G, Mariotte A, Piccinno M, Kreutzfeldt M, Gruntz B, Ehling R, Genovese A, Pedrioli A, Dounas A, Franzenburg S, Tumani H, Kümpfel T, Kavaka V, Gerdes LA, Dornmair K, Beltrán E, Oxenius A, Reddy ST, Merkler D, Yermanos A (2023). Persistent virus-specific and clonally expanded antibody-secreting cells respond to induced self-antigen in the CNS. Acta Neuropathol. 2023 Jan 25. doi: 10.1007/s00401-023-02537-5. Epub ahead of print. PMID: 36695896
- Engels D, Mader S, Förderreuther S, Reindl M, Havla J, Meinl E, Kümpfel T, Gerdes LA (2023). MOG-IgG-associated bilateral optic neuritis in temporal relation to monkeypox vaccination. Ann Neurol. 2023 Apr 23. doi: 10.1002/ana.26664. Epub ahead of print. PMID: 37089005.
- Ingelfinger F, Beltrán E, Gerdes LA, Becher B. Single-cell multiomics in neuroinflammation. Curr Opin Immunol. 2022 Jun;76:102180. doi: 10.1016/j.coi.2022.102180. Epub 2022 Apr 21. PMID: 35462278.
- Ingelfinger F, Gerdes LA, Kavaka V, Krishnarajah S, Friebel E, Galli E, Zwicky P, Furrer R, Peukert C, Dutertre CA, Eglseer KM, Ginhoux F, Flierl-Hecht A, Kümpfel T, De Feo D, Schreiner B, Mundt S, Kerschensteiner M, Hohlfeld R, Beltrán E, Becher B (2022). Twin study reveals non-heritable immune perturbations in multiple sclerosis. Nature. 2022 Mar;603(7899):152-158. doi: 10.1038/s41586-022-04419-4. Epub 2022 Feb 16. PMID: 35173329.
- Schneider-Hohendorf T, Gerdes LA, Pignolet B, Gittelman R, Ostkamp P, Rubelt F, Raposo C, Tackenberg B, Riepenhausen M, Janoschka C, Wünsch C, Bucciarelli F, Flierl-Hecht A, Beltrán E, Kümpfel T, Anslinger K, Gross CC, Chapman H, Kaplan I, Brassat D, Wekerle H, Kerschensteiner M, Klotz L, Lünemann JD, Hohlfeld R, Liblau R, Wiendl H, Schwab N (2022). Broader Epstein-Barr virus-specific T cell receptor repertoire in patients with multiple sclerosis. J Exp Med. 2022 Nov 7;219(11):e20220650. doi: 10.1084/jem.20220650. Epub 2022 Sep 1. PMID: 36048016; PMCID: PMC9437111.35468638.
- Brändle SM, Cerina M, Weber S, Held K, Menke AF, Alcalá C, Gebert D, Herrmann AM, Pellkofer H, Gerdes LA, Bittner S, Leypoldt F, Teegen B, Komorowski L, Kümpfel T, Hohlfeld R, Meuth SG, Casanova B, Melzer N, Beltrán E, Dornmair K (2021). Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABAA receptor encephalitis. Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e1916337118. doi: 10.1073/pnas.1916337118. PMID: 33619082.
- Hiltensperger M, Beltrán E, Kant R, Tyystjärvi S, Lepennetier G, Domínguez Moreno H, Bauer IJ, Grassmann S, Jarosch S, Schober K, Buchholz VR, Kenet S, Gasperi C, Öllinger R, Rad R, Muschaweckh A, Sie C, Aly L, Knier B, Garg G, Afzali AM, Gerdes LA, Kümpfel T, Franzenburg S, Kawakami N, Hemmer B, Busch DH, Misgeld T, Dornmair K, Korn T (2021). Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity. Nat Immunol. 2021 Jun 7. doi: 10.1038/s41590-021-00948-8. Epub ahead of print. PMID: 34099917.
- Mortazavi M, Hizarci Ö, Gerdes LA, Havla J, Kümpfel T, Hohlfeld R, Stöcklein S, Keeser D, Ertl-Wagner B (2021). Multiple sclerosis and subclinical neuropathology in healthy individuals with familial risk: A scoping review of MRI studies. Neuroimage Clin. 2021 Jun 18;31:102734. doi: 10.1016/j.nicl.2021.102734. Epub ahead of print. PMID: 34171607; PMCID: PMC8234346.
- Mulazzani E, Wagner D, Havla J, Schlüter M, Meinl I, Gerdes LA, Kümpfel T. Neurological phenotypes in patients with NLRP3-, MEFV-, and TNFRSF1A low-penetrance variants. J Neuroinflammation. 2020 Jun 20;17(1):196. doi: 10.1186/s12974-020-01867-5. PMID: 32563262; PMCID: PMC7306142.