Feederle, Regina
Laposchan S, Riedel E, Flatley A, Pasquero S, Feederle R, Lee CY. Development of motif-specific monoclonal antibodies for global protein citrullination detection with minimal cross-reactivity to homocitrullination. Cell Rep Methods. 2026 Mar 27:101345. doi: 10.1016/j.crmeth.2026.101345. Epub ahead of print. PMID: 41903541.
O'Neill TJ, Graß C, Gewies A, Coelho S, Gehring T, Seeholzer T, Holdt LM, Flatley A, Feederle R, Staal J, Beyaert R, Giesert F, Wurst W, Kutukculer N, Naumann R, Krappmann D. MALT1 alternative splicing-A molecular rheostat for balancing immune activation and homeostasis. Sci Adv. 2026 Aug 14;12(33):eaeh2835. doi: 10.1126/sciadv.aeh2835. Epub 2026 Aug 12. PMID: 42585341; PMCID: PMC13464629.
- Ware K, Peter J, Yazell J, Thapa C, Taranov A, Bedolla A, Distel C, Lammich S, Feederle R, Sülzen A, Liddelow S, Roskin K, Luo Y. Inhibition of TGF-β signaling in microglia stimulates hippocampal adult neurogenesis and reduces anxiety-like behavior in adult mice. Nat Commun. 2026 Feb 9;17(1):1440. doi: 10.1038/s41467-026-68885-4. PMID: 41663429; PMCID: PMC12886940.
- Wong HK, Ho S, Yu Q, Given KS, Shqau D, Baier S, Winklmeier S, Rübsamen H, Kendirli A, Schanda K, Oswald E, Bräuer K, Thaler FS, Gerdes LA, Feederle R, Kerschensteiner M, Reindl M, Khademi M, Piehl F, Olsson T, Bennett JL, Kümpfel T, Kawakami N, Bradl M, Meinl E, Mader S. Antibodies against MLC1 found in patients with NMOSD-like disease mediate astrocytopathy in rodent models. Sci Transl Med. 2026 Aug 26;18(864):eady0403. doi: 10.1126/scitranslmed.ady0403. Epub 2026 Aug 26. PMID: 42647595.
- Hornung S, Vogl DP, Naltsas D, Dalla Volta B, Ballmann M, Marcon B, Syed MMK, Wu Y, Spanopoulou A, Feederle R, Heidrich L, Bernhagen J, Koeglsperger T, Höglinger GU, Rammes G, Lashuel HA, Kapurniotu A. Multi-Targeting Macrocyclic Peptides as Nanomolar Inhibitors of Self- and Cross-Seeded Amyloid Self-Assembly of α-Synuclein. Angew Chem Int Ed Engl. 2025 Jan 17:e202422834. doi: 10.1002/anie.202422834. Epub ahead of print. PMID: 39822034.
- Held S, Erck C, Kemppainen S, Bleibaum F, Giridhar NJ, Feederle R, Krenner C, Juopperi SP, Calliari A, Mentrup T, Schröder B, Dickson DW, Rauramaa T, Petrucelli L, Prudencio M, Hiltunen M, Lüningschrör P, Capell A, Damme M. Physiological shedding and C-terminal proteolytic processing of TMEM106B. Cell Rep. 2024 Dec 21;44(1):115107. doi: 10.1016/j.celrep.2024.115107. Epub ahead of print. PMID: 39709600.
- Keipert S, Gaudry MJ, Kutschke M, Keuper M, Dela Rosa MAS, Cheng Y, Monroy Kuhn JM, Laterveer R, Cotrim CA, Giere P, Perocchi F, Feederle R, Crichton PG, Lutter D, Jastroch M. Two-stage evolution of mammalian adipose tissue thermogenesis. Science. 2024 Jun 7;384(6700):1111-1117. doi: 10.1126/science.adg1947. Epub 2024 Jun 6. PMID: 38843333.
Schmidt A, Hrupka B, van Bebber F, Sunil Kumar S, Feng X, Tschirner SK, Aßfalg M, Müller SA, Hilger LS, Hofmann LI, Pigoni M, Jocher G, Voytyuk I, Self EL, Ito M, Hyakkoku K, Yoshimura A, Horiguchi N, Feederle R, De Strooper B, Schulte-Merker S, Lammert E, Moechars D, Schmid B, Lichtenthaler SF. The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling. J Clin Invest. 2024 Jun 18:e170550. doi: 10.1172/JCI170550. Epub ahead of print. PMID: 38888964.
- Xu M, Ito-Kureha T, Kang HS, Chernev A, Raj T, Hoefig KP, Hohn C, Giesert F, Wang Y, Pan W, Ziętara N, Straub T, Feederle R, Daniel C, Adler B, König J, Feske S, Tsokos GC, Wurst W, Urlaub H, Sattler M, Kisielow J, Wulczyn FG, Łyszkiewicz M, Heissmeyer V. The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression. Nat Commun. 2024 Mar 11;15(1):2194. doi: 10.1038/s41467-024-46371-z. PMID: 38467629; PMCID: PMC10928157.
- Fichtner ML, Rübsamen H, Smolle M, Schaller J, Feederle R, Bültmann A, Kümpfel T, Schneider P, Thaler FS, Meinl E (2023). Features of Isoforms of Human Soluble TACI. J Immunol. 2023 Jun 5:ji2101107. doi: 10.4049/jimmunol.2101107. Epub ahead of print. PMID: 37272840.
- Riemenschneider H, Simonetti F, Sheth U, Katona E, Roth S, Hutten S, Farny D, Michaelsen M, Nuscher B, Schmidt MK, Flatley A, Schepers A, Gruijs da Silva LA, Zhou Q, Klopstock T, Liesz A, Arzberger T, Herms J, Feederle R, Gendron TF, Dormann D, Edbauer D (2023). Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo. Acta Neuropathol Commun. 2023 Jul 11;11(1):112. doi: 10.1186/s40478-023-01592-z. PMID: 37434215; PMCID: PMC10334564.
- Schmidt H, Raj T, O'Neill TJ, Muschaweckh A, Giesert F, Negraschus A, Hoefig KP, Behrens G, Esser L, Baumann C, Feederle R, Plaza-Sirvent C, Geerlof A, Gewies A, Isay SE, Ruland J, Schmitz I, Wurst W, Korn T, Krappmann D, Heissmeyer V (2023). Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity. Proc Natl Acad Sci U S A. 2023 Nov 28;120(48):e2309205120. doi: 10.1073/pnas.2309205120. Epub 2023 Nov 21. PMID: 37988467; PMCID: PMC10691344.
- Spiller L, Manjula R, Leissing F, Basquin J, Bourilhon P, Sinitski D, Brandhofer M, Levecque S, Gerra S, Sabelleck B, Zhang L, Feederle R, Flatley A, Hoffmann A, Panstruga R, Bernhagen J, Lolis E (2023). Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells. Sci Signal. 2023 Nov 21;16(812):eadg2621. doi: 10.1126/scisignal.adg2621. Epub 2023 Nov 21. PMID: 37988455.
- Morenas-Rodríguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suárez-Calvet M, Fagan AM, Schultz S, Gordon BA, Benzinger TLS, Hassenstab J, McDade E, Feederle R, Karch CM, Schlepckow K, Morris JC, Kleinberger G, Nellgard B, Vöglein J, Blennow K, Zetterberg H, Ewers M, Jucker M, Levin J, Bateman RJ, Haass C; Dominantly Inherited Alzheimer Network (2022). Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study. Lancet Neurol. 2022 Apr;21(4):329-341. doi: 10.1016/S1474-4422(22)00027-8. PMID: 35305339; PMCID: PMC8926925.
- O'Neill AC, Uzbas F, Antognolli G, Merino F, Draganova K, Jäck A, Zhang S, Pedini G, Schessner JP, Cramer K, Schepers A, Metzger F, Esgleas M, Smialowski P, Guerrini R, Falk S, Feederle R, Freytag S, Wang Z, Bahlo M, Jungmann R, Bagni C, Borner GHH, Robertson SP, Hauck SM, Götz M (2022). Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity. Science. 2022 Jun 17;376(6599):eabf9088. doi: 10.1126/science.abf9088. Epub 2022 Jun 17. PMID: 35709258.
- Rudan Njavro J, Vukicevic M, Fiorini E, Dinkel L, Müller SA, Berghofer A, Bordier C, Kozlov S, Halle A, Buschmann K, Capell A, Giudici C, Willem M, Feederle R, Lichtenthaler SF, Babolin C, Montanari P, Pfeifer A, Kosco-Vilbois M, Tahirovic S (2022). Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model. Cells. 2022 Dec 24;12(1):79. doi: 10.3390/cells12010079. PMID: 36611872; PMCID: PMC9818422.
- Gruner K, Leissing F, Sinitski D, Thieron H, Axstmann C, Baumgarten K, Reinstädler A, Winkler P, Altmann M, Flatley A, Jaouannet M, Zienkiewicz K, Feussner I, Keller H, Coustau C, Falter-Braun P, Feederle R, Bernhagen J, Panstruga R (2021). Chemokine-like MDL proteins modulate flowering time and innate immunity in plants. J Biol Chem. 2021 Mar 30:100611. doi: 10.1016/j.jbc.2021.100611. Epub ahead of print. PMID: 33798552.
- Gerhards R, Pfeffer LK, Lorenz J, Starost L, Nowack L, Thaler FS, Schlüter M, Rübsamen H, Macrini C, Winklmeier S, Mader S, Bronge M, Grönlund H, Feederle R, Hsia HE, Lichtenthaler SF, Merl-Pham J, Hauck SM, Kuhlmann T, Bauer IJ, Beltran E, Gerdes LA, Mezydlo A, Bar-Or A, Banwell B, Khademi M, Olsson T, Hohlfeld R, Lassmann H, Kümpfel T, Kawakami N, Meinl E (2020). Oligodendrocyte myelin glycoprotein as a novel target for pathogenic autoimmunity in the CNS. Acta Neuropathol Commun. 2020 Nov 30;8(1):207. doi: 10.1186/s40478-020-01086-2. PMID: 33256847; PMCID: PMC7706210.
- Schlepckow K, Monroe KM, Kleinberger G, Cantuti-Castelvetri L, Parhizkar S, Xia D, Willem M, Werner G, Pettkus N, Brunner B, Sülzen A, Nuscher B, Hampel H, Xiang X, Feederle R, Tahirovic S, Park JI, Prorok R, Mahon C, Liang CC, Shi J, Kim DJ, Sabelström H, Huang F, Di Paolo G, Simons M, Lewcock JW, Haass C (2020). Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. EMBO Mol Med. 2020 Mar 10:e11227. doi: 10.15252/emmm.201911227. [Epub ahead of print]
- Weskamp G, Tüshaus J, Li D, Feederle R, Maretzky T, Swendeman S, Falck-Pedersen E, McIlwain DR, Mak TW, Salmon JE, Lichtenthaler SF, Blobel CP (2020). ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1). J Biol Chem. 2020 Feb 14. pii: jbc.RA119.011136. doi: 10.1074/jbc.RA119.011136. [Epub ahead of print]
- Gomes LA, Hipp SA, Rijal Upadhaya A, Balakrishnan K, Ospitalieri S, Koper MJ, Largo-Barrientos P, Uytterhoeven V, Reichwald J, Rabe S, Vandenberghe R, von Arnim CAF, Tousseyn T, Feederle R, Giudici C, Willem M, Staufenbiel M, Thal D (2019). Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein. Acta Neuropathol. 2019 Aug 14. doi: 10.1007/s00401-019-02053-5. [Epub ahead of print]
- Papadopoulou AA, Müller SA, Mentrup T, Shmueli MD, Niemeyer J, Haug-Kröper M, von Blume J, Mayerhofer A, Feederle R, Schröder B, Lichtenthaler SF, Fluhrer R (2019). Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins. EMBO Rep. 2019 Feb 7. pii: e46451. doi: 10.15252/embr.201846451. [Epub ahead of print]
- Rudan Njavro J, Klotz J, Dislich B, Wanngren J, Shmueli MD, Herber J, Kuhn PH, Kumar R, Koeglsperger T, Conrad M, Wurst W, Feederle R, Vlachos A, Michalakis S, Jedlicka P, Müller SA, Lichtenthaler SF (2019). Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1. FASEB J. 2019 Dec 27. doi: 10.1096/fj.201902347R. [Epub ahead of print]
- von Gamm M, Schaub A, Jones AN, Wolf C, Behrens G, Lichti J, Essig K, Macht A, Pircher J, Ehrlich A, Davari K, Chauhan D, Busch B, Wurst W, Feederle R, Feuchtinger A, Tschöp MH, Friedel CC, Hauck SM, Sattler M, Geerlof A, Hornung V, Heissmeyer V, Schulz C, Heikenwalder M, Glasmacher E (2019). Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3. J Exp Med. 2019 May 24. pii: jem.20181762. doi: 10.1084/jem.20181762. [Epub ahead of print]
- Zhou Q, Mareljic N, Michaelsen M, Parhizkar S, Heindl S, Nuscher B, Farny D, Czuppa M, Schludi C, Graf A, Krebs S, Blum H, Feederle R, Roth S, Haass C, Arzberger T, Liesz A, Edbauer D (2019). Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model. EMBO Mol Med. 2019 Dec 20:e10919. doi: 10.15252/emmm.201910919. [Epub ahead of print]
- Colombo A, Hsia HE, Wang M, Kuhn PH, Brill MS, Canevazzi P, Feederle R, Taveggia C, Misgeld T, Lichtenthaler SF (2018). Non-cell-autonomous function of DR6 in Schwann cell proliferation. EMBO J. 2018 Feb 19. pii: e97390. doi: 10.15252/embj.201797390. [Epub ahead of print]
- Frick P, Sellier C, Mackenzie IRA, Cheng CY, Tahraoui-Bories J, Martinat C, Pasterkamp RJ, Prudlo J, Edbauer D, Oulad-Abdelghani M, Feederle R, Charlet-Berguerand N, Neumann M (2018). Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers. Acta Neuropathol Commun. 2018 Aug 3;6(1):72. doi: 10.1186/s40478-018-0579-0.
- Herber J, Njavro J, Feederle R, Schepers U, Müller U, Bräse S, Müller S, Lichtenthaler SF (2018). Click chemistry-mediated biotinylation reveals a function for the protease BACE1 in modulating the neuronal surface glycoproteome. Mol Cell Proteomics. 2018 May 1. pii: mcp.RA118.000608. doi: 10.1074/mcp.RA118.000608. [Epub ahead of print]
- Kleinberger G, Brendel M, Mracsko E, Wefers B, Groeneweg L, Xiang X, Focke C, Deußing M, Suárez-Calvet M, Mazaheri F, Parhizkar S, Pettkus N, Wurst W, Feederle R, Bartenstein P, Mueggler T, Arzberger T, Knuesel I, Rominger A, Haass C (2017). The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. EMBO J. 2017 May 30. pii: e201796516. doi: 10.15252/embj.201796516. [Epub ahead of print]
- Lehmer C, Oeckl P, Weishaupt JH, Volk AE, Diehl-Schmid J, Schroeter ML, Lauer M, Kornhuber J, Levin J, Fassbender K, Landwehrmeyer B; German Consortium for Frontotemporal Lobar Degeneration, Schludi MH, Arzberger T, Kremmer E, Flatley A, Feederle R, Steinacker P, Weydt P, Ludolph AC, Edbauer D, Otto M (2017). Poly-GP in cerebrospinal fluid links C9orf72-associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD. EMBO Mol Med. 2017 Apr 13. pii: e201607486. doi: 10.15252/emmm.201607486. [Epub ahead of print]
- Schlepckow K, Kleinberger G, Fukumori A, Feederle R, Lichtenthaler SF, Steiner H, Haass C (2017). An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function. EMBO Mol Med. 2017 Aug 30. pii: e201707672. doi: 10.15252/emmm.201707672. [Epub ahead of print]
- Zhou Q, Lehmer C, Michaelsen M, Mori K, Alterauge D, Baumjohann D, Schludi MH, Greiling J, Farny D, Flatley A, Feederle R, May S, Schreiber F, Arzberger T, Kuhm C, Klopstock T, Hermann A, Haass C, Edbauer D (2017). Antibodies inhibit transmission and aggregation of C9orf72 poly-GA dipeptide repeat proteins. EMBO Mol Med. 2017 Mar 28. pii: e201607054. doi: 10.15252/emmm.201607054. [Epub ahead of print]
- Pigoni M, Wanngren J, Kuhn PH, Munro KM, Gunnersen JM, Takeshima H, Feederle R, Voytyuk I, De Strooper B, Levasseur MD, Hrupka BJ, Müller SA, Lichtenthaler SF (2016). Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons. Mol Neurodegener. 2016 Oct 5;11(1):67.
- Xiang X, Werner G, Bohrmann B, Liesz A, Mazaheri F, Capell A, Feederle R, Knuesel I, Kleinberger G, Haass C. (2016). TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance. EMBO Molecular Medicine. 2016 July 8. pii: e201606370. DOI: 10.15252/emmm.201606370. [Epub ahead of print]