Behrends, Christian

2024

Brenner D, Sieverding K, Srinidhi J, Zellner S, Secker C, Yilmaz R, Dyckow J, Amr S, Ponomarenko A, Tunaboylu E, Douahem Y, Schlag JS, Rodríguez Martínez L, Kislinger G, Niemann C, Nalbach K, Ruf WP, Uhl J, Hollenbeck J, Schirmer L, Catanese A, Lobsiger CS, Danzer KM, Yilmazer-Hanke D, Münch C, Koch P, Freischmidt A, Fetting M, Behrends C, Parlato R, Weishaupt JH. A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice. J Exp Med. 2024 May 6;221(5):e20221190. doi: 10.1084/jem.20221190. Epub 2024 Mar 22. PMID: 38517332; PMCID: PMC10959724.
Gahlot P, Kravic B, Rota G, van den Boom J, Levantovsky S, Schulze N, Maspero E, Polo S, Behrends C, Meyer H. Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH. Mol Cell. 2024 Mar 14:S1097-2765(24)00172-2. doi: 10.1016/j.molcel.2024.02.029. Epub ahead of print. PMID: 38503285.
Mukhopadhyay U, Levantovsky S, Carusone TM, Gharbi S, Stein F, Behrends C, Bhogaraju S. A ubiquitin-specific, proximity-based labeling approach for the identification of ubiquitin ligase substrates. Sci Adv. 2024 Aug 9;10(32):eadp3000. doi: 10.1126/sciadv.adp3000. Epub 2024 Aug 9. PMID: 39121224; PMCID: PMC11313854.
Wu J, Kislinger G, Duschek J, Durmaz AD, Wefers B, Feng R, Nalbach K, Wurst W, Behrends C, Schifferer M, Simons M. Nonvesicular lipid transfer drives myelin growth in the central nervous system. Nat Commun. 2024 Nov 11;15(1):9756. doi: 10.1038/s41467-024-53511-y. PMID: 39528474; PMCID: PMC11554831.

2023

Furthmann N, Bader V, Angersbach L, Blusch A, Goel S, Sánchez-Vicente A, Krause LJ, Chaban SA, Grover P, Trinkaus VA, van Well EM, Jaugstetter M, Tschulik K, Damgaard RB, Saft C, Ellrichmann G, Gold R, Koch A, Englert B, Westenberger A, Klein C, Jungbluth L, Sachse C, Behrends C, Glatzel M, Hartl FU, Nakamura K, Christine CW, Huang EJ, Tatzelt J, Winklhofer KF. NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62. Nat Commun. 2023 Dec 19;14(1):8368. doi: 10.1038/s41467-023-44033-0. PMID: 38114471; PMCID: PMC10730909.
Jülg J, Edbauer D, Behrends C (2023). C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains. EMBO Rep. 2023 Jun 15:e55895. doi: 10.15252/embr.202255895. Epub ahead of print. PMID: 37317656.
Nalbach K, Schifferer M, Bhattacharya D, Ho-Xuan H, Tseng W, Williams LA, Stolz A, Lichtenthaler SF, Elazar Z, Behrends C (2023). Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2. Nat Commun. 2023 Feb 16;14(1):870. doi: 10.1038/s41467-023-36553-6. PMID: 36797266; PMCID: PMC9935918.
Rogov VV, Nezis IP, Tsapras P, Zhang H, Dagdas Y, Noda NN, Nakatogawa H, Wirth M, Mouilleron S, McEwan DG, Behrends C, Deretic V, Elazar Z, Tooze SA, Dikic I, Lamark T, Johansen T. Atg8 family proteins, LIR/AIM motifs and other interaction modes. Autophagy Rep. 2023 Mar 19;2(1):27694127.2023.2188523. doi: 10.1080/27694127.2023.2188523. PMID: 38214012; PMCID: PMC7615515.
Tian Y, Milic J, Monasor LS, Chakraborty R, Wang S, Yuan Y, Asare Y, Behrends C, Tahirovic S, Bernhagen J (2023). The COP9 signalosome reduces neuroinflammation and attenuates ischemic neuronal stress in organotypic brain slice culture model. Cell Mol Life Sci. 2023 Aug 19;80(9):262. doi: 10.1007/s00018-023-04911-8. PMID: 37597109; PMCID: PMC10439869.

2022

Dormann D, Behrends C (2022). Only solid waste, please! Mol Cell. 2022 Apr 21;82(8):1408-1410. doi: 10.1016/j.molcel.2022.04.003. PMID: 35452612.
Güner G, Aßfalg M, Zhao K, Dreyer T, Lahiri S, Lo Y, Slivinschi BI, Imhof A, Jocher G, Strohm L, Behrends C, Langosch D, Bronger H, Nimsky C, Bartsch JW, Riddell SR, Steiner H, Lichtenthaler SF (2022). Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activity. EMBO Mol Med. 2022 Sep 7:e16084. doi: 10.15252/emmm.202216084. Epub ahead of print. PMID: 36069059.
Jia J, Wang F, Bhujabal Z, Peters R, Mudd M, Duque T, Allers L, Javed R, Salemi M, Behrends C, Phinney B, Johansen T, Deretic V (2022). Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage. J Cell Biol. 2022 Nov 7;221(11):e202207091. doi: 10.1083/jcb.202207091. Epub 2022 Sep 30. PMID: 36179369; PMCID: PMC9533235.
Jia J, Wang F, Bhujabal Z, Peters R, Mudd M, Duque T, Allers L, Javed R, Salemi M, Behrends C, Phinney B, Johansen T, Deretic V (2022). Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysosomal damage. Autophagy. 2022 Nov 29:1-3. doi: 10.1080/15548627.2022.2148900. Epub ahead of print. PMID: 36394332.
Kravić B, Bionda T, Siebert A, Gahlot P, Levantovsky S, Behrends C, Meyer H (2022). Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1. Mol Cell. 2022 Jun 28:S1097-2765(22)00577-9. doi: 10.1016/j.molcel.2022.06.012. Epub ahead of print. PMID: 35793674.
Schmitt D, Bozkurt S, Henning-Domres P, Huesmann H, Eimer S, Bindila L, Behrends C, Boyle E, Wilfling F, Tascher G, Münch C, Behl C, Kern A (2022). Lipid and protein content profiling of isolated native autophagic vesicles. EMBO Rep. 2022 Oct 10:e53065. doi: 10.15252/embr.202153065. Epub ahead of print. PMID: 36215690.
Schmitt D, Bozkurt S, Henning-Domres P, Huesmann H, Eimer S, Bindila L, Behrends C, Boyle E, Wilfling F, Tascher G, Münch C, Behl C, Kern A (2022). FACS-mediated isolation of native autophagic vesicles. Autophagy. 2022 Nov 29:1-2. doi: 10.1080/15548627.2022.2151188. Epub ahead of print. PMID: 36416088.
Sekar R, Motzler K, Kwon Y, Novikoff A, Jülg J, Najafi B, Wang S, Warnke AL, Seitz S, Hass D, Gancheva S, Kahl S, Yang B, Finan B, Schwarz K, Okun JG, Roden M, Blüher M, Müller TD, Krahmer N, Behrends C, Plettenburg O, Miaczynska M, Herzig S, Zeigerer A (2022). Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes. Cell Metab. 2022 Oct 9:S1550-4131(22)00412-0. doi: 10.1016/j.cmet.2022.09.022. Epub ahead of print. PMID: 36243006.
Siebert A, Gattringer V, Weishaupt JH, Behrends C (2022). ALS-linked loss of Cyclin-F function affects HSP90. Life Sci Alliance. 2022 Sep 16;5(12):e202101359. doi: 10.26508/lsa.202101359. PMID: 36114006; PMCID: PMC9481933.
Strohm L, Hu Z, Suk Y, Rühmkorf A, Sternburg E, Gattringer V, Riemenschneider H, Berutti R, Graf E, Weishaupt JH, Brill MS, Harbauer AB, Dormann D, Dengjel J, Edbauer D, Behrends C (2022). Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants. Life Sci Alliance. 2022 Jul 1;5(11):e202101327. doi: 10.26508/lsa.202101327. PMID: 35777956.
Williams LA, Gerber DJ, Elder A, Tseng WC, Baru V, Delaney-Busch N, Ambrosi C, Mahimkar G, Joshi V, Shah H, Harikrishnan K, Upadhyay H, Rajendran SH, Dhandapani A, Meier J, Ryan SJ, Lewarch C, Black L, Douville J, Cinquino S, Legakis H, Nalbach K, Behrends C, Sato A, Galluzzi L, Yu TW, Brown D, Agrawal S, Margulies D, Kopin A, Dempsey GT (2022). Developing antisense oligonucleotides for a TECPR2 mutation-induced, ultra-rare neurological disorder using patient-derived cellular models. Mol Ther Nucleic Acids. 2022 Jun 22;29:189-203. doi: 10.1016/j.omtn.2022.06.015. PMID: 35860385; PMCID: PMC9287140.
Zhou D, Borsa M, Puleston DJ, Zellner S, Capera J, Sanderson S, Schifferer M, Hester SS, Ge X, Fischer R, Jostins L, Behrends C*, Alsaleh G*, Simon AK* (2022). Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation. Nat Commun. 2022 Sep 2;13(1):5174. doi: 10.1038/s41467-022-32718-x. PMID: 36055998; PMCID: PMC9440129.

2021

Abudu YP, Shrestha BK, Zhang W, Palara A, Brenne HB, Larsen KB, Wolfson DL, Dumitriu G, Øie CI, Ahluwalia BS, Levy G, Behrends C, Tooze SA, Mouilleron S, Lamark T, Johansen T (2021). SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components. J Cell Biol. 2021 Aug 2;220(8):e202009092. doi: 10.1083/jcb.202009092. Epub 2021 May 26. PMID: 34037656.
Carinci M, Testa B, Bordi M, Milletti G, Bonora M, Antonucci L, Ferraina C, Carro M, Kumar M, Ceglie D, Eck F, Nardacci R, le Guerroué F, Petrini S, Soriano ME, Caruana I, Doria V, Manifava M, Peron C, Lambrughi M, Tiranti V, Behrends C, Papaleo E, Pinton P, Giorgi C, Ktistakis NT, Locatelli F, Nazio F, Cecconi F (2021). TFG binds LC3C to regulate ULK1 localization and autophagosome formation. EMBO J. 2021 May 1:e103563. doi: 10.15252/embj.2019103563. Epub ahead of print. PMID: 33932238.
Neuser S, Brechmann B, Heimer G, Brösse I, Schubert S, O'Grady L, Zech M, Srivastava S, Sweetser DA, Dincer Y, Mall V, Winkelmann J, Behrends C, Darras BT, Graham RJ, Jayakar P, Byrne B, El Bar-Aluma B, Haberman Y, Szeinberg A, Aldhalaan HM, Hashem M, Tenaiji AA, Ismayl O, Al Nuaimi AE, Maher K, Ibrahim S, Khan F, Houlden H, Ramakumaran VS, Pagnamenta AT, Posey JE, Lupski JR, Tan WH, ElGhazali G, Herman I, Muñoz T, Repetto GM, Seitz A, Krumbiegel M, Cecilia Poli M, Kini U, Efthymiou S, Meiler J, Maroofian R, Alkuraya FS, Jamra RA, Popp B, Ben-Zeev B, Ebrahimi-Fakhari D (2021). Clinical, neuroimaging and molecular spectrum of TECPR2-associated hereditary sensory and autonomic neuropathy with intellectual disability. Hum Mutat. 2021 Apr 13. doi: 10.1002/humu.24206. Epub ahead of print. PMID: 33847017.
Nguyen TN, Padman BS, Zellner S, Khuu G, Uoselis L, Lam WK, Skulsuppaisarn M, Lindblom RSJ, Watts EM, Behrends C, Lazarou M (2021). ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system. Mol Cell. 2021 Mar 25:S1097-2765(21)00169-6. doi: 10.1016/j.molcel.2021.03.001. Epub ahead of print. PMID: 33773106.
Tripathi-Giesgen I, Behrends C (2021). The ubiquitin ligation machinery in the defense against bacterial pathogens. EMBO Rep. 2021 Sep 13:e52864. doi: 10.15252/embr.202152864. Epub ahead of print. PMID: 34515402.
Zellner S, Schifferer M, Behrends C (2021). Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling. Mol Cell. 2021 Jan 28:S1097-2765(21)00009-5. doi: 10.1016/j.molcel.2021.01.009. Epub ahead of print. PMID: 33545068.
Zellner S, Nalbach K, Behrends C (2021). Autophagosome content profiling using proximity biotinylation proteomics coupled to protease digestion in mammalian cells. STAR Protoc. 2021 Apr 27;2(2):100506. doi: 10.1016/j.xpro.2021.100506. PMID: 33997820; PMCID: PMC8102175.
Zellner S, Behrends C (2021). Autophagosome content profiling reveals receptor-specific cargo candidates. Autophagy. 2021 Apr 5:1-3. doi: 10.1080/15548627.2021.1909410. Epub ahead of print. PMID: 33779494.

2020

Bhattacharya D, Behrends C (2020). When Separation Causes Activation: Biophysical Control of Bulk Autophagy Initiation. Mol Cell. 2020 Jan 22. pii: S1097-2765(19)30958-X. doi: 10.1016/j.molcel.2019.12.028. [Epub ahead of print]
Cai CZ, Yang C, Zhuang XX, Yuan NN, Wu MY, Tan JQ, Song JX, Cheung KH, Su H, Wang YT, Tang BS, Behrends C, Durairajan SSK, Yue Z, Li M, Lu JH (2020). NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation. Autophagy. 2020;1-19. doi:10.1080/15548627.2020.1760623 [published online ahead of print, 2020 Jun 16]
Eck F, Phuyal S, Smith MD, Kaulich M, Wilkinson S, Farhan H, Behrends C (2020). ACSL3 is a novel GABARAPL2 interactor that links ufmylation and lipid droplet biogenesis. J Cell Sci. 2020;jcs.243477. doi:10.1242/jcs.243477 [published online ahead of print, 2020 Aug 25]
Fraiberg M, Tamim-Yecheskel BC, Kokabi K, Subic N, Heimer G, Eck F, Nalbach K, Behrends C, Ben-Zeev B, Shatz O, Elazar Z (2020). Lysosomal targeting of autophagosomes by the TECPR domain of TECPR2. Autophagy. 2020 Nov 19. doi: 10.1080/15548627.2020.1852727. Epub ahead of print. PMID: 33213269.
Hiebel C, Stürner E, Hoffmeister M, Tascher G, Schwarz M, Nagel H, Behrends C, Münch C, Behl C (2020). BAG3 Proteomic Signature under Proteostasis Stress. Cells. 2020 Nov 4;9(11):E2416. doi: 10.3390/cells9112416. PMID: 33158300
Jia J, Bissa B, Brecht L, Allers L, Choi SW, Gu Y, Zbinden M, Burge MR, Timmins G, Hallows K, Behrends C, Deretic V (2020). AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System. Mol Cell. 2020 Jan 22. pii: S1097-2765(19)30958-X. doi: 10.1016/j.molcel.2019.12.028. [Epub ahead of print]
Jia J, Bissa B, Brecht L, Allers L, Choi SW, Gu Y, Zbinden M, Burge MR, Timmins G, Hallows K, Behrends C, Deretic V (2020). AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system. Autophagy. 2020;10.1080/15548627.2020.1788890. doi:10.1080/15548627.2020.1788890 [published online ahead of print, 2020 Jun 28]
Jülg J, Strohm L, Behrends C (2020). Canonical and non-canonical autophagy pathways in microglia. Mol Cell Biol. 2020 Nov 2:MCB.00389-20. doi: 10.1128/MCB.00389-20. Epub ahead of print. PMID: 33139495.
Sanwald JL, Poschmann G, Stühler K, Behrends C, Hoffmann S, Willbold D (2020). The GABARAP Co-Secretome Identified by APEX2-GABARAP Proximity Labelling of Extracellular Vesicles. Cells. 2020;9(6):E1468. Published 2020 Jun 16. doi:10.3390/cells9061468
Seitz S, Kwon Y, Hartleben G, Jülg J, Sekar R, Krahmer N, Najafi B, Loft A, Gancheva S, Stemmer K, Feuchtinger A, Hrabe de Angelis M, Müller TD, Mann M, Blüher M, Roden M, Berriel Diaz M, Behrends C, Gilleron J, Herzig S, Zeigerer A (2020). Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity. Nat Metab. 2019;1(10):1009-1026. doi:10.1038/s42255-019-0124-x
Tamim-Yecheskel BC, Fraiberg M, Kokabi K, Freud S, Shatz O, Marvaldi L, Subic N, Brenner O, Tsoory M, Eilam-Altstadter R, Biton I, Savidor A, Dezorella N, Heimer G, Behrends C, Ben-Zeev B, Elazar Z (2020). A tecpr2 knockout mouse exhibits age-dependent neuroaxonal dystrophyassociated with autophagosome accumulation. Autophagy. 2020 Nov 20. doi: 10.1080/15548627.2020.1852724. Epub ahead of print. PMID: 33218264.

2019

Centonze FG, Reiterer V, Nalbach K, Saito K, Pawlowski K, Behrends C, Farhan H (2019). LTK is an ER-resident receptor tyrosine kinase that regulates secretion. J Cell Biol. 2019 Jun 21. pii: jcb.201903068. doi: 10.1083/jcb.201903068. [Epub ahead of print]
Dannheisig DP, Beck E, Calzia E, Walther P, Behrends C, Pfister AS (2019). Loss of Peter Pan (PPAN) Affects Mitochondrial Homeostasis and Autophagic Flux. Cells. 2019 Aug 14;8(8). pii: E894. doi: 10.3390/cells8080894.
Deretic V, Prossnitz E, Burge M, Campen MJ, Cannon J, Liu KJ, Hall P, Sklar LA, Allers L, Mariscal L, Garcia SA, Baehrecke EH, Behrends C, Cecconi F, Codogno P, Chen GC, Elazar Z, Eskelinen EL, Fourie B, Gozuacik D, Hong W, Jo EK, Johansen T, Juhász G, Kimchi A, Ktistakis N, Kroemer G, Mizushima N, Münz C, Reggiori F, Rubinsztein D, Ryan K, Schroder K, Shen HM, Simonsen A, Tooze SA, Vaccaro M, Yoshimori T, Yu L, Zhang H, Klionsky DJ (2019). Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations. Autophagy. 2019 Jun 25. doi: 10.1080/15548627.2019.1634444. [Epub ahead of print]
Graab P, Bock C, Weiss K, Hirth A, Koller N, Braner M, Jung J, Loehr F, Tampé R, Behrends C, Abele R (2019). Lysosomal targeting of the ABC transporter TAPL is determined by membrane localized charged residues. J Biol Chem. 2019 Mar 15. pii: jbc.RA118.007071. doi: 10.1074/jbc.RA118.007071. [Epub ahead of print]
Grozdanov V, Bousset L, Hoffmeister M, Bliederhaeuser C, Meier C, Madiona K, Pieri L, Kiechle M, McLean PJ, Kassubek J, Behrends C, Ludolph AC, Weishaupt JH, Melki R, Danzer KM (2019). Increased immune activation by pathologic alpha-synuclein in Parkinson's Disease. Ann Neurol. 2019 Jul 25. doi: 10.1002/ana.25557. [Epub ahead of print]
Höllerhage M, Fussi N, Rösler TW, Wurst W, Behrends C, Höglinger GU (2019). Multiple molecular pathways stimulating macroautophagy protect from alpha-synuclein-induced toxicity in human neurons. Neuropharmacology. 2019 Feb 4;149:13-26. doi: 10.1016/j.neuropharm.2019.01.023. [Epub ahead of print]
Hoock SC, Ritter A, Steinhäuser K, Roth S, Behrends C, Oswald F, Solbach C, Louwen F, Kreis NN, Yuan J (2019). RITA modulates cell migration and invasion by affecting focal adhesion dynamics. Mol Oncol. 2019 Jul 28. doi: 10.1002/1878-0261.12551. [Epub ahead of print]
Ivanova S, Polajnar M, Narbona-Perez AJ, Hernandez-Alvarez MI, Frager P, Slobodnyuk K, Plana N, Nebreda AR, Palacin M, Gomis RR, Behrends C, Zorzano A (2019). Regulation of death receptor signaling by the autophagy protein TP53INP2. EMBO J. 2019 Apr 12. pii: e99300. doi: 10.15252/embj.201899300. [Epub ahead of print]
Klimek C, Jahnke R, Wördehoff J, Kathage B, Stadel D, Behrends C, Hergovich A, Höhfeld J (2019). The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy. Biochim Biophys Acta Mol Cell Res. 2019 Jul 18. pii: S0167-4889(19)30122-3. doi: 10.1016/j.bbamcr.2019.07.007. [Epub ahead of print]
Koerver L, Papadopoulos C, Liu B, Kravic B, Rota G, Brecht L, Veenendaal T, Polajnar M, Bluemke A, Ehrmann M, Klumperman J, Jäättelä M, Behrends C, Meyer H (2019). The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage. EMBO Rep. 2019 Aug 21:e48014. doi: 10.15252/embr.201948014. [Epub ahead of print]
Kravic B, Behrends C, Meyer H (2019). Regulation of lysosome integrity and lysophagy by the ubiquitin-conjugating enzyme UBE2QL1. Autophagy. 2019 Nov 6:1-2. doi: 10.1080/15548627.2019.1687217. [Epub ahead of print]
Martens S, Behrends C (2019). Molecular Mechanisms of Selective Autophagy. J Mol Biol. 2019 Dec 4. pii: S0022-2836(19)30674-6. doi: 10.1016/j.jmb.2019.11.010. [Epub ahead of print]
Seitz S, Kwon Y, Hartleben G, Jülg J, Sekar R, Krahmer N, Najafi B, Loft A, Gancheva S, Stemmer K, Feuchtinger A, Hrabě de Angelis M, Müller TD, Mann M, Blüher M, Roden M, Berriel Diaz M, Behrends C, Gilleron J, Herzig S, Zeigerer A (2019). Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity. Nat Metab. 2019:1:1009-1026. doi: 10.1038/s42255-019-0124-x
Strohm L, Behrends C (2019). Glia-specific autophagy dysfunction in ALS. Semin Cell Dev Biol. 2019 May 28. pii: S1084-9521(19)30020-5. doi: 10.1016/j.semcdb.2019.05.024. [Epub ahead of print]

2018

Deretic V, Prossnitz E, Burge M, Campen MJ, Cannon J, Liu KJ, Sklar LA, Allers L, Garcia SA, Baehrecke EH, Behrends C, Cecconi F, Codogno P, Chen GC, Elazar Z, Eskelinen EL, Fourie B, Gozuacik D, Hong W, Hotamisligi G, Jäättelä M, Jo EK, Johansen T, Juhász G, Kimchi A, Ktistakis N, Kroemer G, MIzushima N, Münz C, Reggiori F, Rubinsztein D, Ryan K, Schroder K, Simonsen A, Tooze S, Vaccaro M, Yoshimori T, Yu L, Zhang H, Klionsky DJ (2018). Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations. Autophagy. 2018 Jun 23. doi: 10.1080/15548627.2018.1465784. [Epub ahead of print]
Fussi N, Höllerhage M, Chakroun T, Nykänen NP, Rösler TW, Koeglsperger T, Wurst W, Behrends C, Höglinger GU (2018). Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy. Cell Death Dis. 2018 Jul 9;9(7):757. doi: 10.1038/s41419-018-0816-2.
Kolb J, Anders-Maurer M, Müller T, Hau AC, Grebbin BM, Kallenborn-Gerhardt W, Behrends C, Schulte D (2018). Arginine Methylation Regulates MEIS2 Nuclear Localization to Promote Neuronal Differentiation of Adult SVZ Progenitors. Stem Cell Reports. 2018 Apr 10;10(4):1184-1192. doi: 10.1016/j.stemcr.2018.03.010.
Meyer N, Zielke S, Michaelis JB, Linder B, Warnsmann V, Rakel S, Osiewacz HD, Fulda S, Mittelbronn M, Münch C, Behrends C, Kögel D (2018). AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. Autophagy. 2018 Jun 25. doi: 10.1080/15548627.2018.1476812. [Epub ahead of print]
Neuss S, Bartel Y, Born C, Weil S, Koch J, Behrends C, Hoffmeister M, Steinle A (2018). Cellular Mechanisms Controlling Surfacing of AICL Glycoproteins, Cognate Ligands of the Activating NK Receptor NKp80. J Immunol. 2018 Jul 6. pii: ji1800059. doi: 10.4049/jimmunol.1800059. [Epub ahead of print]
Nguyen TD, Shaid S, Vakhrusheva O, Koschade SE, Klann K, Thöken M, Baker F, Zhang J, Oellerich T, Sürün D, Derlet A, Haberbosch I, Eimer S, Osiewacz HD, Behrends C, Münch C, Dikic I, Brandts CH (2018). Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Blood. 2018 Nov 29. pii: blood-2018-02-833475. doi: 10.1182/blood-2018-02-833475. [Epub ahead of print]
Tuppi M, Kehrloesser S, Coutandin DW, Rossi V, Luh LM, Strubel A, Hötte K, Hoffmeister M, Schäfer B, De Oliveira T, Greten F, Stelzer EHK, Knapp S, De Felici M, Behrends C, Klinger FG, Dötsch V (2018). Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63. Nat Struct Mol Biol. 2018 Mar;25(3):261-269. doi: 10.1038/s41594-018-0035-7. Epub 2018 Feb 26.

2017

Aguilera-Gomez A, Zacharogianni M, van Oorschot MM, Genau H, Grond R, Veenendaal T, Sinsimer KS, Gavis EA, Behrends C, Rabouille C (2017). Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation. Cell Rep. 2017 Aug 29;20(9):2277. doi: 10.1016/j.celrep.2017.08.054.
Ilina EI, Armento A, Garea Sanchez L, Reichlmeir M, Braun Y, Penski C, Capper D, Sahm F, Jennewein L, Harter PN, Zukunft S, Fleming I, Schulte D, Le Guerroué F, Behrends C, Ronellenfitsch MW, Naumann U, Mittelbronn M (2017). Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux. Oncotarget. 2017 Jun 27. doi: 10.18632/oncotarget.18747. [Epub ahead of print]
Jung J, Nayak A, Schaeffer V, Starzetz T, Kirsch AK, Müller S, Dikic I, Mittelbronn M, Behrends C (2017). Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Elife. 2017 Feb 14;6. pii: e23063. doi: 10.7554/eLife.23063. [Epub ahead of print]
Jung J, Behrends C (2017). Protocol for Establishing a Multiplex Image-based Autophagy RNAi Screen in Cell Cultures. Bio Protoc. 2017 Sep 5;7(17):27982478. doi: 10.21769/BioProtoc.2540.
Jung J, Behrends C (2017). Multifaceted role of SMCR8 as autophagy regulator. Small GTPases. 2017 Jul 11:0. doi: 10.1080/21541248.2017.1346553. [Epub ahead of print]
Le Guerroué F, Eck F, Jung J, Starzetz T, Mittelbronn M, Kaulich M, Behrends C (2017). Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol Cell. 2017 Nov 16;68(4):786-796.e6. doi: 10.1016/j.molcel.2017.10.029.
Newman AC, Kemp AJ, Drabsch Y, Behrends C, Wilkinson S (2017). Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins. Nat Commun. 2017 Nov 16;8(1):1537. doi: 10.1038/s41467-017-00859-z.
Polajnar M, Dietz MS, Heilemann M, Behrends C (2017). Expanding the host cell ubiquitylation machinery targeting cytosolic Salmonella. EMBO Rep. 2017 Aug 6. pii: e201643851. doi: 10.15252/embr.201643851. [Epub ahead of print]
Smith MD, Harley ME, Kemp AJ, Wills J, Lee M, Arends M, von Kriegsheim A, Behrends C, Wilkinson S (2017). CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis. Dev Cell. 2017 Dec 27. pii: S1534-5807(17)30985-1. doi: 10.1016/j.devcel.2017.11.024. [Epub ahead of print]

2016

Behrends, Christian

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