Biochemist F. Ulrich Hartl, together with his colleague and geneticist Arthur L. Horwich, discovered that nascent proteins often do not fold spontaneously into their functional form. Proteins which assist the folding process, known as chaperones, are needed for this process. Both researchers now receive the HFSP Nakasone Prize 2022 of the Human Frontier Science Program for this fundamental and far-reaching discovery. F. Ulrich Hartl: " I am very honored to receive this award together with my early collaborator Art Horwich and look forward to the prize ceremony in Paris." The award honors scientists for their groundbreaking discoveries in areas of the life sciences.