News
 Dominik Paquet

Human model of blood-brain barrier

17 Dec 2025 | Press Release

Researchers at LMU University Hospital have created a functioning human blood-brain barrier from human stem cells in the laboratory - for the purpose of investigating pathological processes.

 Portrait Martin Dichgans
©Boris Schmalenberger

Stroke and dementia: combating loss of function in small vessels of the brain

17 Dec 2025 | Press Release

A new study identifies molecular factors that promote small vessel disease – and an active drug that can restore impaired vascular functions.

 Kerschensteiner Lab, LMU / BMC

In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation

4 Dec 2025 | News

A research team led by Martin Kerschensteiner has developed an experimental platform that helps uncover the signals that instruct immune cells in neuroinflammatory disease.

Research Spotlight

Using PET-imaging to detect cortical synapse loss in multiple sclerosis

9 Oct 2025 | Research Spotlight

The standard method for diagnosing multiple sclerosis (MS) is magnetic resonance imaging (MRI), which primarily identifies damage to the brain's white matter. However, synapse loss in gray matter is…

Podcast

57 Clusters of Excellence, 1 podcast. This episode of “Exzellent erklärt - Spitzenforschung für alle” focuses on our research with Thomas Misgeld and Anna-Sophia Wahl. Topics include research into common neurological diseases such as Alzheimer's, multiple sclerosis and stroke, the self-healing powers of the brain and the Cluster's interdisciplinary approach. Current advances in repair mechanisms, the importance of neuronal plasticity and the use of modern technologies such as AI for research are discussed.

  podcast cover exzellent erklärt #54

SyNergy is:

8
Partners
55
Members
27
Tandem projects
3229
Publications

The Cluster of Excellence SyNergy (Munich Cluster for Systems Neurology) investigates how complex neurological diseases such as Alzheimer's and Parkinson's Disease, stroke, or multiple sclerosis develop. Even though these diseases differ significantly in their clinical manifestations, overlapping mechanisms are involved in their development. Using systems neurology as a new interdisciplinary approach, researchers can better map the processes involved in neurovascular, neurodegenerative, and neuroimmunological diseases and develop approaches for novel therapies. The cluster has been funded by the German Research Foundation (DFG) since 2012.