Postdoctoral Researcher for in vivo brain imaging
Ludwig-Maximilians-Universität München is a leading research university in Europe. Since its founding in 1472 it has been committed to the highest international standards of excellence in research and teaching.
About us
Our research group led by Dr. Jonas Neher is interested in the molecular and cellular basis of aging and Alzheimer’s dementia, and has recently developed a particular interest in how amyloid aggregates contribute to the dysfunction of blood vessels in the brain. In particular, we have found that medin amyloid drives age-associated arterial stiffening and also promotes the aggregation of amyloid-β in the vasculature (see our recent publications in PNAS and Nature). In addition, we aim to understand how the immune system contributes to the development and progression of Alzheimer’s disease pathology (see e.g. our publication in Nature). We are an international lab of molecular and cellular biologists and are now looking for an imaging specialist to add another dimension to our research.
We offer a Post Doc position in our lab (level depending on experience) to study the functional impact of amyloid and inflammation on the brain’s vasculature. To this end, we want to apply in vivo imaging, either using 2-Photon imaging or a new system that combines high-frequency ultrasound and photoacoustics. The position and imaging system will be integrated in the larger imaging unit at the host institute, the Center for Stroke and Dementia (CSD) and the Munich Cluster for Systems Neurology (SyNergy).
Tasks & Responsibilities
We are looking for an experienced postdoctoral researcher to:
- Perform longitudinal in vivo imaging in animal models of Alzheimer’s disease and vascular amyloidosis
- Establish and optimize imaging on our new high-frequency ultrasound/photoacoustic system for the analysis of vascular function both inside and outside the brain
- Contribute to design and performance of imaging experiments in our research group
- Train other lab members to independently perform in vivo imaging experiments
- Present research results at national and international congresses
- Prepare research results for publication in international journals
Qualifications
- You have expertise in performing in vivo brain imaging of mice (e.g. 2-Photon), including cranial window surgeries
- You have a PhD degree in the field of life science or medicine and a strong interest in age-related brain diseases
- You have or would like to gain experience with high-frequency ultrasound/photoacoustic imaging for the analysis of neurovascular function and amyloid pathology
- You have experience with data analysis using Matlab, Python or other programming languages
- You are highly self-motivated and organized and are interested in developing your own research ideas
- You are a team player and enjoy working in a multi-disciplinary team
- You have excellent communication skills in English
Benefit
- You will become part of our interdisciplinary and international research group and will be integrated in the wider imaging and scientific community at the institutes that our group is affiliated with (i.e. the CSD and German Center for Neurodegenerative Diseases, DZNE) as well as the SyNergy Excellence Cluster. This provides interactions with leading scientists in the field, possibilities to develop novel collaborative research projects and access to state-of-the-art instrumentation and facilities. You will have freedom to develop your own research ideas and scientific career, and technical support will be made available to you.
- The institute is located at the Munich Campus Großhadern, which can be easily reached by public transport.
- The position is initially limited for three years, with a possibility of extension. Salary is determined by prior experience according to the German public sector pay scale TV-L.
- Also possible in a part-time capacity.
- People with disabilities who are equally as qualified as other applicants will receive preferential treatment.
Your Application
Please send your complete application (letter of motivation, CV including list of publications and addresses of two referees, degree certificates) in a single pdf (not exceeding 10MB) until September 30th, 2023 to Dr. Jonas Neher: Jonas.Neher@mail03.med.uni-muenchen.de.
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