Simons, Mikael
2024
- Biechele G, Rauchmann BS, Janowitz D, Buerger K, Franzmeier N, Weidinger E, Guersel S, Schuster S, Finze A, Harris S, Lindner S, Albert NL, Wetzel C, Rupprecht R, Rominger A, Palleis C, Katzdobler S, Burow L, Kurz C, Zaganjori M, Trappmann LK, Goldhardt O, Grimmer T, Haeckert J, Keeser D, Stoecklein S, Morenas-Rodriguez E, Bartenstein P, Levin J, Höglinger GU, Simons M, Perneczky R, Brendel M. Associations between sex, body mass index and the individual microglial response in Alzheimer's disease. J Neuroinflammation. 2024 Jan 23;21(1):30. doi:10.1186/s12974-024-03020-y. PMID: 38263017; PMCID: PMC10804830.
- Kedia S, Ji H, Feng R, Androvic P, Spieth L, Liu L, Franz J, Zdiarstek H, Anderson KP, Kaboglu C, Liu Q, Mattugini N, Cherif F, Prtvar D, Cantuti-Castelvetri L, Liesz A, Schifferer M, Stadelmann C, Tahirovic S, Gokce O, Simons M. T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis. Nat Neurosci. 2024 Jun 27. doi: 10.1038/s41593-024-01682-8. Epub ahead of print. PMID: 38937583.
- Reich M, Simon MJ, Polke B, Paris I, Werner G, Schrader C, Spieth L, Davis SS, Robinson S, de Melo GL, Schlaphoff L, Buschmann K, Berghoff S, Logan T, Nuscher B, de Weerd L, Edbauer D, Simons M, Suh JH, Sandmann T, Kariolis MS, DeVos SL, Lewcock JW, Paquet D, Capell A, Di Paolo G, Haass C. Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration. Sci Transl Med. 2024 Jun 5;16(750):eadj7308. doi: 10.1126/scitranslmed.adj7308. Epub 2024 Jun 5. PMID: 38838131.
- Simons M, Gibson EM, Nave KA. Oligodendrocytes: Myelination, Plasticity, and Axonal Support. Cold Spring Harb Perspect Biol. 2024 Apr 15:a041359. doi: 10.1101/cshperspect.a041359. Epub ahead of print. PMID: 38621824.
- Tiwari V, Prajapati B, Asare Y, Damkou A, Ji H, Liu L, Naser N, Gouna G, Leszczyńska KB, Mieczkowski J, Dichgans M, Wang Q, Kawaguchi R, Shi Z, Swarup V, Geschwind DH, Prinz M, Gokce O, Simons M. Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system. Immunity. 2024 Jul 19:S1074-7613(24)00348-0. doi: 10.1016/j.immuni.2024.07.001. Epub ahead of print. PMID: 39053462.
- Todorov-Völgyi K, González-Gallego J, Müller SA, Beaufort N, Malik R, Schifferer M, Todorov MI, Crusius D, Robinson S, Schmidt A, Körbelin J, Bareyre F, Ertürk A, Haass C, Simons M, Paquet D, Lichtenthaler SF, Dichgans M. Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging. Nat Aging. 2024 Mar 22. doi: 10.1038/s43587-024-00598-z. Epub ahead of print. PMID: 38519806.
2023
- Androvic P, Schifferer M, Perez Anderson K, Cantuti-Castelvetri L, Jiang H, Ji H, Liu L, Gouna G, Berghoff SA, Besson-Girard S, Knoferle J, Simons M, Gokce O (2023). Spatial Transcriptomics-correlated Electron Microscopy maps transcriptional and ultrastructural responses to brain injury. Nat Commun. 2023 Jul 11;14(1):4115. doi: 10.1038/s41467-023-39447-9. PMID: 37433806; PMCID: PMC10336148.
- Bernhardt AM, Tiedt S, Teupser D, Dichgans M, Meyer B, Gempt J, Kuhn PH, Simons M, Palleis C, Weidinger E, Nübling G, Holdt L, Hönikl L, Gasperi C, Giesbertz P, Müller SA, Breimann S, Lichtenthaler SF, Kuster B, Mann M, Imhof A, Barth T, Hauck SM, Zetterberg H, Otto M, Weichert W, Hemmer B, Levin J (2023). A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases. EBioMedicine. 2023 Feb 4;89:104456. doi: 10.1016/j.ebiom.2023.104456. Epub ahead of print. PMID: 36745974; PMCID: PMC9931915.
- Dawkins E, Derks RJE, Schifferer M, Trambauer J, Winkler E, Simons M, Paquet D, Giera M, Kamp F, Steiner H (2023). Membrane lipid remodeling modulates γ-secretase processivity. J Biol Chem. 2023 Feb 15:103027. doi: 10.1016/j.jbc.2023.103027. Epub ahead of print. PMID: 36805335.
- Depp C, Sun T, Sasmita AO, Spieth L, Berghoff SA, Nazarenko T, Overhoff K, Steixner-Kumar AA, Subramanian S, Arinrad S, Ruhwedel T, Möbius W, Göbbels S, Saher G, Werner HB, Damkou A, Zampar S, Wirths O, Thalmann M, Simons M, Saito T, Saido T, Krueger-Burg D, Kawaguchi R, Willem M, Haass C, Geschwind D, Ehrenreich H, Stassart R, Nave KA (2023). Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease. Nature. 2023 May 31. doi: 10.1038/s41586-023-06120-6. Epub ahead of print. PMID: 37258678.
- Djannatian M, Radha S, Weikert U, Safaiyan S, Wrede C, Deichsel C, Kislinger G, Rhomberg A, Ruhwedel T, Campbell DS, van Ham T, Schmid B, Hegermann J, Möbius W, Schifferer M, Simons M (2023). Myelination generates aberrant ultrastructure that is resolved by microglia. J Cell Biol. 2023 Mar 6;222(3):e202204010. doi: 10.1083/jcb.202204010. Epub 2023 Jan 13. PMID: 36637807; PMCID: PMC9856851.
- Finze A, Biechele G, Rauchmann BS, Franzmeier N, Palleis C, Katzdobler S, Weidinger E, Guersel S, Schuster S, Harris S, Schmitt J, Beyer L, Gnörich J, Lindner S, Albert NL, Wetzel CH, Rupprecht R, Rominger A, Danek A, Burow L, Kurz C, Tato M, Utecht J, Papazov B, Zaganjori M, Trappmann LK, Goldhardt O, Grimmer T, Haeckert J, Janowitz D, Buerger K, Keeser D, Stoecklein S, Dietrich O, Morenas-Rodriguez E, Barthel H, Sabri O, Bartenstein P, Simons M, Haass C, Höglinger GU, Levin J, Perneczky R, Brendel M (2023). Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies. Mol Psychiatry. 2023 Jul 26. doi: 10.1038/s41380-023-02188-8. Epub ahead of print. PMID: 37495886.
- Kolabas ZI, Kuemmerle LB, Perneczky R, Förstera B, Ulukaya S, Ali M, Kapoor S, Bartos LM, Büttner M, Caliskan OS, Rong Z, Mai H, Höher L, Jeridi D, Molbay M, Khalin I, Deligiannis IK, Negwer M, Roberts K, Simats A, Carofiglio O, Todorov MI, Horvath I, Ozturk F, Hummel S, Biechele G, Zatcepin A, Unterrainer M, Gnörich J, Roodselaar J, Shrouder J, Khosravani P, Tast B, Richter L, Díaz-Marugán L, Kaltenecker D, Lux L, Chen Y, Zhao S, Rauchmann BS, Sterr M, Kunze I, Stanic K, Kan VWY, Besson-Girard S, Katzdobler S, Palleis C, Schädler J, Paetzold JC, Liebscher S, Hauser AE, Gokce O, Lickert H, Steinke H, Benakis C, Braun C, Martinez-Jimenez CP, Buerger K, Albert NL, Höglinger G, Levin J, Haass C, Kopczak A, Dichgans M, Havla J, Kümpfel T, Kerschensteiner M, Schifferer M, Simons M, Liesz A, Krahmer N, Bayraktar OA, Franzmeier N, Plesnila N, Erener S, Puelles VG, Delbridge C, Bhatia HS, Hellal F, Elsner M, Bechmann I, Ondruschka B, Brendel M, Theis FJ, Erturk A (2023). Distinct molecular profiles of skull bone marrow in health and neurological disorders. Cell. 2023 Aug 3:S0092-8674(23)00742-0. doi: 10.1016/j.cell.2023.07.009. Epub ahead of print. PMID: 37562402
- Simons M, Levin J, Dichgans M (2023). Tipping points in neurodegeneration. Neuron. 2023 Jun 21:S0896-6273(23)00433-6. doi: 10.1016/j.neuron.2023.05.031. Epub ahead of print. PMID: 37385247.
- Ziegler KA, Ahles A, Dueck A, Esfandyari D, Pichler P, Weber K, Kotschi S, Bartelt A, Sinicina I, Graw M, Leonhardt H, Weckbach LT, Massberg S, Schifferer M, Simons M, Hoeher L, Luo J, Ertürk A, Schiattarella GG, Sassi Y, Misgeld T Engelhardt S (2023). Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease. Science. 2023 Jul 21;381(6655):285-290. doi: 10.1126/science.abn6366. Epub 2023 Jul 20. PMID: 37471539
2022
- Arends M, Weber M, Papan C, Damm M, Surma MA, Spiegel C, Djannatian M, Li S, Connell L, Johannes L, Schifferer M, Klose C, Simons M (2022). Ganglioside lipidomics of CNS myelination using direct infusion shotgun mass spectrometry. iScience. 2022 Oct 10;25(11):105323. doi: 10.1016/j.isci.2022.105323. PMID: 36310581; PMCID: PMC9615322.
- Bosch-Queralt M, Tiwari V, Damkou A, Vaculčiaková L, Alexopoulos I, Simons M (2022). A fluorescence microscopy-based protocol for volumetric measurement of lysolecithin lesion-associated de- and re-myelination in mouse brain. STAR Protoc. 2022 Jan 29;3(1):101141. doi: 10.1016/j.xpro.2022.101141. PMID: 35141565; PMCID: PMC8810560.
- Cantuti-Castelvetri L, Gokce O, Simons M (2022). Reparative inflammation in multiple sclerosis. Semin Immunol. 2022 Jun 21:101630. doi: 10.1016/j.smim.2022.101630. Epub ahead of print. PMID: 35750551.
- Franklin RJM, Simons M (2022). CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities. Neuron. 2022 Oct 6:S0896-6273(22)00862-5. doi: 10.1016/j.neuron.2022.09.023. Epub ahead of print. PMID: 36228613.
- Franzmeier N, Brendel M, Beyer L, Slemann L, Kovacs GG, Arzberger T, Kurz C, Respondek G, Lukic MJ, Biel D, Rubinski A, Frontzkowski L, Hummel S, Müller A, Finze A, Palleis C, Joseph E, Weidinger E, Katzdobler S, Song M, Biechele G, Kern M, Scheifele M, Rauchmann BS, Perneczky R, Rullman M, Patt M, Schildan A, Barthel H, Sabri O, Rumpf JJ, Schroeter ML, Classen J, Villemagne V, Seibyl J, Stephens AW, Lee EB, Coughlin DG, Giese A, Grossman M, McMillan CT, Gelpi E, Molina-Porcel L, Compta Y, van Swieten JC, Laat LD, Troakes C, Al-Sarraj S, Robinson JL, Xie SX, Irwin DJ, Roeber S, Herms J, Simons M, Bartenstein P, Lee VM, Trojanowski JQ, Levin J, Höglinger G, Ewers M (2022). Tau deposition patterns are associated with functional connectivity in primary tauopathies. Nat Commun. 2022 Mar 15;13(1):1362. doi: 10.1038/s41467-022-28896-3. PMID: 35292638; PMCID: PMC8924216
- Kaya T, Mattugini N, Liu L, Ji H, Cantuti-Castelvetri L, Wu J, Schifferer M, Groh J, Martini R, Besson-Girard S, Kaji S, Liesz A, Gokce O, Simons M (2022). CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging. Nat Neurosci. 2022 Nov;25(11):1446-1457. doi: 10.1038/s41593-022-01183-6. Epub 2022 Oct 24. PMID: 36280798; PMCID: PMC9630119.
- Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Brône B, Brown GC, Butovsky O, Carson MJ, Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de Strooper B, Denes A, Eggen BJL, Eyo U, Galea E, Garel S, Ginhoux F, Glass CK, Gokce O, Gomez-Nicola D, González B, Gordon S, Graeber MB, Greenhalgh AD, Gressens P, Greter M, Gutmann DH, Haass C, Heneka MT, Heppner FL, Hong S, Hume DA, Jung S, Kettenmann H, Kipnis J, Koyama R, Lemke G, Lynch M, Majewska A, Malcangio M, Malm T, Mancuso R, Masuda T, Matteoli M, McColl BW, Miron VE, Molofsky AV, Monje M, Mracsko E, Nadjar A, Neher JJ, Neniskyte U, Neumann H, Noda M, Peng B, Peri F, Perry VH, Popovich PG, Pridans C, Priller J, Prinz M, Ragozzino D, Ransohoff RM, Salter MW, Schaefer A, Schafer DP, Schwartz M, Simons M, Smith CJ, Streit WJ, Tay TL, Tsai LH, Verkhratsky A, von Bernhardi R, Wake H, Wittamer V, Wolf SA, Wu LJ, Wyss-Coray T (2022). Microglia states and nomenclature: A field at its crossroads. Neuron. 2022 Nov 2;110(21):3458-3483. doi: 10.1016/j.neuron.2022.10.020. PMID: 36327895.
- Vöglein J, Franzmeier N, Morris JC, Dieterich M, McDade E, Simons M, Preische O, Hofmann A, Hassenstab J, Benzinger TL, Fagan A, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal JP, Salloway S, Xiong C, Karch CM, Cairns N, Perrin RJ, Day G, Martins R, Sanchez-Valle R, Mori H, Shimada H, Ikeuchi T, Suzuki K, Schofield PR, Masters CL, Goate A, Buckles V, Fox NC, Chrem P, Allegri R, Ringman JM, Yakushev I, Laske C, Jucker M, Höglinger G, Bateman RJ, Danek A, Levin J, Dominantly Inherited Alzheimer Network (2022). Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease. Alzheimers Dement. 2022 May 24. doi: 10.1002/alz.12684. Epub ahead of print. PMID: 35609137.
2021
- Bosch-Queralt M, Cantuti-Castelvetri L, Damkou A, Schifferer M, Schlepckow K, Alexopoulos I, Lütjohann D, Klose C, Vaculčiaková L, Masuda T, Prinz M, Monroe KM, Di Paolo G, Lewcock JW, Haass C, Simons M (2021). Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination. Nat Metab. 2021 Feb;3(2):211-227. doi: 10.1038/s42255-021-00341-7. Epub 2021 Feb 18. PMID: 33619376.
- Colombo A, Dinkel L, Müller SA, Sebastian Monasor L, Schifferer M, Cantuti-Castelvetri L, König J, Vidatic L, Bremova-Ertl T, Lieberman AP, Hecimovic S, Simons M, Lichtenthaler SF, Strupp M, Schneider SA, Tahirovic S (2021). Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia. Nat Commun. 2021 Feb 24;12(1):1158. doi: 10.1038/s41467-021-21428-5. PMID: 33627648.
- Gouna G, Klose C, Bosch-Queralt M, Liu L, Gokce O, Schifferer M, Cantuti-Castelvetri L, Simons M (2021). TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination. J Exp Med. 2021 Oct 4;218(10):e20210227. doi: 10.1084/jem.20210227. Epub 2021 Aug 23. PMID: 34424266.
- Liu L, Besson-Girard S, Ji H, Gehring K, Bulut B, Kaya T, Usifo F, Simons M, Gokce O (2021). Dissociation of microdissected mouse brain tissue for artifact free single-cell RNA sequencing. STAR Protoc. 2021 Jun 10;2(2):100590. doi: 10.1016/j.xpro.2021.100590. PMID: 34159323; PMCID: PMC8196224.
- Penkert H, Bertrand A, Tiwari V, Breimann S, Müller SA, Jordan PM, Gerl MJ, Klose C, Cantuti-Castelvetri L, Bosch-Queralt M, Levental I, Lichtenthaler SF, Werz O, Simons M (2021). Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery. Cell Rep. 2021 Oct 26;37(4):109898. doi: 10.1016/j.celrep.2021.109898. PMID: 34706241.
- Rausch L, Lutz K, Schifferer M, inheim E, Gruber R, Oesterhaus EF, Rinke L, Hellmuth JC, Scherer C, Muenchhoff M, Mandel C, Bergwelt-Baildon M, Simons M, Straub T, Krug AB, Kranich J, Brocker T (2021). Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients. J Extracell Vesicles. 2021 Dec;10(14):e12173. doi: 10.1002/jev2.12173. PMID: 34854246; PMCID: PMC8636722.
- Safaiyan S, Besson-Girard S, Kaya T, Cantuti-Castelvetri L, Liu L, Ji H, Schifferer M, Gouna G, Usifo F, Kannaiyan N, Fitzner D, Xiang X, Rossner MJ, Brendel M, Gokce O, Simons M (2021). White matter aging drives microglial diversity. Neuron. 2021 Feb 11:S0896-6273(21)00073-8. doi: 10.1016/j.neuron.2021.01.027. Epub ahead of print. PMID: 33606969.
- Schmitt J, Palleis C, Sauerbeck J, Unterrainer M, Harris S, Prix C, Weidinger E, Katzdobler S, Wagemann O, Danek A, Beyer L, Rauchmann BS, Rominger A, Simons M, Bartenstein P, Perneczky R, Haass C, Levin J, Höglinger GU, Brendel M; German Imaging Initiative for Tauopathies (GII4T) (2021). Dual-Phase β-Amyloid PET Captures Neuronal Injury and Amyloidosis in Corticobasal Syndrome. Front Aging Neurosci. 2021 May 13;13:661284. doi: 10.3389/fnagi.2021.661284. PMID: 34054506; PMCID: PMC8155727.
- Tüshaus J, Müller SA, Shrouder J, Arends M, Simons M, Plesnila N, Blobel CP, Lichtenthaler SF (2021). The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system. FASEB J. 2021 Nov;35(11):e21962. doi: 10.1096/fj.202100936R. PMID: 34613632.
- Vöglein J, Levin J, Forbrig R, Liebig T, Dieterich M, Danek A (2021). Amphetamin induzierte zerebrale Vaskulitis – ein Fallbericht [Amphetamine-induced cerebral vasculitis-a case report]. Nervenarzt. 2021 Apr 29. German. doi: 10.1007/s00115-021-01125-w. Epub ahead of print. PMID: 33914110.
- Vöglein J, Kostova I, Arzberger T, Noachtar S, Dieterich M, Herms J, Schmitz P, Ruf V, Windl O, Roeber S, Simons M, Höglinger GU, Danek A, Giese A, Levin J (2021). Seizure prevalence in neurodegenerative diseases - a study of autopsy proven cases. Eur J Neurol. 2021 Sep 2. doi: 10.1111/ene.15089. Epub ahead of print. PMID: 34472165.PMC8161006.
2020
- Bader JM, Geyer PE, Müller JB, Strauss MT, Koch M, Leypoldt F, Koertvelyessy P, Bittner D, Schipke CG, Incesoy EI, Peters O, Deigendesch N, Simons M, Jensen MK, Zetterberg H, Mann M (2020). Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease. Mol Syst Biol. 2020;16(6):e9356. doi:10.15252/msb.20199356
- Berghoff SA, Spieth L, Sun T, Hosang L, Schlaphoff L, Depp C, Düking T, Winchenbach J, Neuber J, Ewers D, Scholz P, van der Meer F, Cantuti-Castelvetri L, Sasmita AO, Meschkat M, Ruhwedel T, Möbius W, Sankowski R, Prinz M, Huitinga I, Sereda MW, Odoardi F, Ischebeck T, Simons M, Tadelmann-Nessler C, Edgar JM, Nave KA, Saher G (2020). Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. Nat Neurosci. 2021 Jan;24(1):47-60. doi: 10.1038/s41593-020-00757-6. Epub 2020 Dec 21. PMID: 33349711.
- Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, Österlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu T, Hepojoki J, Vapalahti O, Stadelmann C, Balistreri G, Simons M (2020). Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science. 2020 Oct 20:eabd2985. doi: 10.1126/science.abd2985. Epub ahead of print. PMID: 33082293.
- Cunha MI, Su M, Cantuti-Castelvetri L, Müller SA, Schifferer M, Djannatian M, Alexopoulos I, van der Meer F, Winkler A, van Ham TJ, Schmid B, Lichtenthaler SF, Stadelmann C, Simons M (2020). Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis. J Exp Med. 2020 May 4;217(5). pii: e20191390. doi: 10.1084/jem.20191390.
- Fitzner D, Bader JM, Penkert H, Bergner CG, Su M, Weil MT, Surma MA, Mann M, Klose C, Simons M (2020). Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome. Cell Rep. 2020 Sep 15;32(11):108132. doi: 10.1016/j.celrep.2020.108132. PMID: 32937123.
- Kislinger G, Gnägi H, Kerschensteiner M, Simons M, Misgeld T, Schifferer M (2020). Multiscale ATUM-FIB Microscopy Enables Targeted Ultrastructural Analysis at Isotropic Resolution. iScience. 2020;23(7):101290. doi:10.1016/j.isci.2020.101290 [published online ahead of print, 2020 Jun 20]
- Kislinger G, Gnägi H, Kerschensteiner M, Simons M, Misgeld T (2020). ATUM-FIB microscopy for targeting and multiscale imaging of rare events in mouse cortex. STAR Protoc. 2020 Dec 16;1(3):100232. doi: 10.1016/j.xpro.2020.100232. PMID: 33377119; PMCID: PMC7757728.
- Kjell J, Götz M (2020). Filling the Gaps - A Call for Comprehensive Analysis of Extracellular Matrix of the Glial Scar in Region- and Injury-Specific Contexts. Front Cell Neurosci. 2020 Feb 20;14:32. doi: 10.3389/fncel.2020.00032. eCollection 2020.
- Kranich J, Chlis NK, Rausch L, Latha A, Schifferer M, Kurz T, Foltyn-Arfa Kia A, Simons M, Theis FJ, Brocker T (2020). In vivo identification of apoptotic and extracellular vesicle-bound live cells using image-based deep learning. J Extracell Vesicles. 2020 Jul 16;9(1):1792683. doi: 10.1080/20013078.2020.1792683. PMID: 32944180; PMCID: PMC7480589.
- Mondo E, Becker SC, Kautzman AG, Schifferer M, Baer CE, Chen J, Huang EJ, Simons M, Schafer DP (2020). A developmental analysis of juxtavascular microglia dynamics and interactions with the vasculature. J Neurosci. 2020;JN-RM-3006-19. doi:10.1523/JNEUROSCI.3006-19.2020 [published online ahead of print, 2020 Jul 13]
- Mukherjee C, Kling T, Russo B, Miebach K, Kess E, Schifferer M, Pedro LD, Weikert U, Fard MK, Kannaiyan N, Rossner M, Aicher ML, Goebbels S, Nave KA, Krämer-Albers EM, Schneider A, Simons M (2020). Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain. Cell Metab. 2020;S1550-4131(20)30300-4. doi:10.1016/j.cmet.2020.05.01 9[published online ahead of print, 2020 Jun 5]
- Penkert H, Lauber C, Gerl MJ, Klose C, Damm M, Fitzner D, Flierl-Hecht A, Kümpfel T, Kerschensteiner M, Hohlfeld R, Gerdes LA, Simons M (2020). Plasma lipidomics of monozygotic twins discordant for multiple sclerosis. Ann Clin Transl Neurol. 2020 Nov 7. doi: 10.1002/acn3.51216. Epub ahead of print. PMID: 33159711.
- Schlepckow K, Monroe KM, Kleinberger G, Cantuti-Castelvetri L, Parhizkar S, Xia D, Willem M, Werner G, Pettkus N, Brunner B, Sülzen A, Nuscher B, Hampel H, Xiang X, Feederle R, Tahirovic S, Park JI, Prorok R, Mahon C, Liang CC, Shi J, Kim DJ, Sabelström H, Huang F, Di Paolo G, Simons M, Lewcock JW, Haass C (2020). Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. EMBO Mol Med. 2020 Mar 10:e11227. doi: 10.15252/emmm.201911227. [Epub ahead of print]
- Tüshaus J, Müller SA, Kataka ES, Zaucha J, Sebastian Monasor L, Su M, Güner G, Jocher G, Tahirovic S, Frishman D, Simons M, Lichtenthaler SF (2020). An optimized quantitative proteomics method establishes the cell type-resolved mouse brain secretome. EMBO J. 2020 Sep 21:e105693. doi: 10.15252/embj.2020105693. Epub ahead of print. PMID: 32954517.
- Tüshaus J, Kataka ES, Zaucha J, Frishman D, Müller SA, Lichtenthaler SF (2020). Neuronal Differentiation of LUHMES Cells Induces Substantial Changes of the Proteome. Proteomics. 2020 Sep 19:e2000174. doi: 10.1002/pmic.202000174. Epub ahead of print. PMID: 32951307.
2019
- Djannatian M, Timmler S, Arends M, Luckner M, Weil MT, Alexopoulos I, Snaidero N, Schmid B, Misgeld T, Möbius W, Schifferer M, Peles E, Simons M (2019). Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS. Nat Commun. 2019 Oct 22;10(1):4794. doi: 10.1038/s41467-019-12789-z.
- Falkai P, Raabe F, Bogerts B, Schneider-Axmann T, Malchow B, Tatsch L, Huber V, Slapakova L, Dobrowolny H, Schmitz C, Cantuti-Castelvetri L, Simons M, Steiner J, Schmitt A (2019). Association between altered hippocampal oligodendrocyte number and neuronal circuit structures in schizophrenia: a postmortem analysis. Eur Arch Psychiatry Clin Neurosci. 2019 Sep 24. doi: 10.1007/s00406-019-01067-0. [Epub ahead of print]
- Papiol S, Keeser D, Hasan A, Schneider-Axmann T, Raabe F, Degenhardt F, Rossner MJ, Bickeböller H, Cantuti-Castelvetri L, Simons M, Wobrock T, Schmitt A, Malchow B, Falkai P (2019). Polygenic burden associated to oligodendrocyte precursor cells and radial glia influences the hippocampal volume changes induced by aerobic exercise in schizophrenia patients. Transl Psychiatry. 2019 Nov 11;9(1):284. doi: 10.1038/s41398-019-0618-z.
- Raabe FJ, Slapakova L, Rossner MJ, Cantuti-Castelvetri L, Simons M, Falkai PG, Schmitt A (2019). Oligodendrocytes as A New Therapeutic Target in Schizophrenia: From Histopathological Findings to Neuron-Oligodendrocyte Interaction. Cells. 2019 Nov 23;8(12). pii: E1496. doi: 10.3390/cells8121496.
- Schmitt A, Simons M, Cantuti-Castelvetri L, Falkai P (2019). A new role for oligodendrocytes and myelination in schizophrenia and affective disorders? Eur Arch Psychiatry Clin Neurosci. 2019 Jun;269(4):371-372. doi: 10.1007/s00406-019-01019-8.
- Stadelmann C, Timmler S, Barrantes-Freer A, Simons M (2019). Myelin in the Central Nervous System: Structure, Function, and Pathology. Physiol Rev. 2019 Jul 1;99(3):1381-1431. doi: 10.1152/physrev.00031.2018..
- Timmler S, Simons M (2019). Grey matter myelination. Glia. 2019 Mar 12. doi: 10.1002/glia.23614. [Epub ahead of print]
- Weil MT, Schulz-Ëberlin G, Mukherjee C, Kuo-Elsner WP, Schäfer I, Müller C, Simons M (2019). Isolation and Culture of Oligodendrocytes. Methods Mol Biol. 2019;1936:79-95. doi: 10.1007/978-1-4939-9072-6_5.
2018
- Cantuti-Castelvetri L, Fitzner D, Bosch-Queralt M, Weil MT, Su M, Sen P, Ruhwedel T, Mitkovski M, Trendelenburg G, Lütjohann D, Möbius W, Simons M (2018). Defective cholesterol clearance limits remyelination in the aged central nervous system. Science. 2018 Jan 4. pii: eaan4183. doi: 10.1126/science.aan4183. [Epub ahead of print]
- Dörr J, Wernecke KD, Würfel J, Bellmann-Strobl J, Siffrin V, Sättler MB, Simons M, Linsa A, Tumani H, Paul F (2018). Disease Modification in Multiple Sclerosis by Flupirtine-Results of a Randomized Placebo Controlled Phase II Trial. Front Neurol. 2018 Oct 9;9:842. doi: 10.3389/fneur.2018.00842. eCollection 2018.
- Duering M, Finsterwalder S, Baykara E, Tuladhar AM, Gesierich B, Konieczny MJ, Malik R, Franzmeier N, Ewers M, Jouvent E, Biessels GJ, Schmidt R, de Leeuw FE, Pasternak O, Dichgans M (2018). Free water determines diffusion alterations and clinical status in cerebral small vessel disease. Alzheimers Dement. 2018 Feb 1. pii: S1552-5260(18)30001-3. doi: 10.1016/j.jalz.2017.12.007. [Epub ahead of print]
- Hofweber M, Hutten S, Bourgeois B, Spreitzer E, Niedner-Boblenz A, Schifferer M, Ruepp MD, Simons M, Niessing D, Madl T, Dormann D (2018). Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation. Cell. 2018 Apr 19;173(3):706-719.e13. doi: 10.1016/j.cell.2018.03.004.
- Locatelli G, Theodorou D, Kendirli A, Jordão MJC, Staszewski O, Phulphagar K, Cantuti-Castelvetri L, Dagkalis A, Bessis A, Simons M, Meissner F, Prinz M, Kerschensteiner M (2018). Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model. Nat Neurosci. 2018 Aug 20. doi: 10.1038/s41593-018-0212-3. [Epub ahead of print]
- Page N, Klimek B, De Roo M, Steinbach K, Soldati H, Lemeille S, Wagner I, Kreutzfeldt M, Di Liberto G, Vincenti I, Lingner T, Salinas G, Brück W, Simons M, Murr R, Kaye J, Zehn D, Pinschewer DD, Merkler D (2018). Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells. Immunity. 2018 May 15;48(5):937-950.e8. doi: 10.1016/j.immuni.2018.04.005.
2017
- Dimou L, Simons M (2017). Diversity of oligodendrocytes and their progenitors. Curr Opin Neurobiol. 2017 Oct 24;47:73-79. doi: 10.1016/j.conb.2017.09.015. [Epub ahead of print]
- Fard MK, van der Meer F, Sánchez P, Cantuti-Castelvetri L, Mandad S, Jäkel S, Fornasiero EF, Schmitt S, Ehrlich M, Starost L, Kuhlmann T, Sergiou C, Schultz V, Wrzos C, Brück W, Urlaub H, Dimou L, Stadelmann C, Simons M (2017). BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions. Sci Transl Med. 2017 Dec 6;9(419). pii: eaam7816. doi: 10.1126/scitranslmed.aam7816.
- Snaidero N, Velte C, Myllykoski M, Raasakka A, Ignatev A, Werner HB, Erwig MS, Möbius W, Kursula P, Nave KA, Simons M (2017). Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin. Cell Rep. 2017 Jan 10;18(2):314-323. doi: 10.1016/j.celrep.2016.12.053.
- Snaidero N, Simons M (2017). The logistics of myelin biogenesis in the central nervous system. Glia. 2017 Feb 7. doi: 10.1002/glia.23116. [Epub ahead of print]
- Weil MT, Ruhwedel T, Möbius W, Simons M (2017). Intracerebral Injections and Ultrastructural Analysis of High-Pressure Frozen Brain Tissue. Curr Protoc Neurosci. 2017 Jan 3;78:2.27.1-2.27.18. doi: 10.1002/cpns.22.
2016
- Romanelli E, Merkler D, Mezydlo A, Weil MT, Weber MS, Nikić I, Potz S, Meinl E, Matznick FE, Kreutzfeldt M, Ghanem A, Conzelmann KK, Metz I, Brück W, Routh M, Simons M, Bishop D, Misgeld T, Kerschensteiner M (2016). Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model. Nat Commun. 2016 Nov 16;7:13275. doi: 10.1038/ncomms13275
- Safaiyan S, Kannaiyan N, Snaidero N, Brioschi S, Biber K, Yona S, Edinger A L, Jung S, Rossner M J, Simons M (2016). Age-related myelin degradation burdens the clearance function of microglia during aging Nature Neuroscience. 2016 June 13. DOI: 10.1038/nn.4325. [Epub ahead of print]
- Schneider A, Simons M (2016). Catching filopodia: Exosomes surf on fast highways to enter cells. J Cell Biol. 2016 Apr 25;213(2):143-5. doi: 10.1083/jcb.201604024. Epub 2016 Apr 25.
- Simons M, Winkler (2016). Editorial overview: Cellular neuroscience. Curr Opin Neurobiol. 2016 Aug;39:v-vii. doi: 10.1016/j.conb.2016.07.014.
- Weil M-T, Möbius W, Winkler A, Ruhwedel T, Wrzos C, Romanelli E, Bennett J L, Enz L, Goebels N, Nave K-A, Kerschensteiner M, Schaeren-Wiemers N, Stadelmann C, Simons M (2016). Loss of myelin basic protein function triggers myelin breakdown in models of demyelinating diseases. Cell Reports. 2016 June 22. pii: S2211-1247(16)30727-6. DOI: 10.1016/j.celrep.2016.06.008. [Epub ahead of print]