Hartl, Franz-Ulrich
2024
Cairo LV, Hong X, Müller MBD, Yuste-Checa P, Jagadeesan C, Bracher A, Park SH, Hayer-Hartl M, Hartl FU. Stress-dependent condensate formation regulated by the ubiquitin-related modifier Urm1. Cell. 2024 Jun 26:S0092-8674(24)00649-4. doi: 10.1016/j.cell.2024.06.009. Epub ahead of print. PMID: 38942013.
- Hipp MS, Hartl FU. Interplay of Proteostasis Capacity and ProteinAggregation: Implications for Cellular Function and Disease. J Mol Biol.2024 May 15:168615. doi: 10.1016/j.jmb.2024.168615. Epub ahead of print.PMID: 38759929.
- Kamps J, Yuste-Checa P, Mamashli F, Schmitz M, Georgina Herrera M, Margarida da Silva Correia S, Gogte K, Bader V, Zerr I, Hartl FU, Bracher A, Winklhofer KF, Tatzelt J. Regulated proteolysis induces aberrant phase transition of biomolecular condensates into aggregates; a protective role for the chaperone Clusterin. J Mol Biol. 2024 Oct 28:168839. doi: 10.1016/j.jmb.2024.168839 Epub ahead of print. PMID: 39476948.
- Krainer G, Jacquat RPB, Schneider MM, Welsh TJ, Fan J, Peter QAE, Andrzejewska EA, Šneiderienė G, Czekalska MA, Ausserwoeger H, Chai L, Arter WE, Saar KL, Herling TW, Franzmann TM, Kosmoliaptsis V, Alberti S, Hartl FU, Lee SF, Knowles TPJ. Single-molecule digital sizing of proteins in solution. Nat Commun. 2024 Sep 4;15(1):7740. doi: 10.1038/s41467-024-50825-9. PMID: 39231922; PMCID: PMC11375031.
2023
- Furthmann N, Bader V, Angersbach L, Blusch A, Goel S, Sánchez-Vicente A, Krause LJ, Chaban SA, Grover P, Trinkaus VA, van Well EM, Jaugstetter M, Tschulik K, Damgaard RB, Saft C, Ellrichmann G, Gold R, Koch A, Englert B, Westenberger A, Klein C, Jungbluth L, Sachse C, Behrends C, Glatzel M, Hartl FU, Nakamura K, Christine CW, Huang EJ, Tatzelt J, Winklhofer KF. NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62. Nat Commun. 2023 Dec 19;14(1):8368. doi: 10.1038/s41467-023-44033-0. PMID: 38114471; PMCID: PMC10730909.
- Müller MBD, Kasturi P, Jayaraj GG, Hartl FU (2023). Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control. Cell. 2023 Jun 13:S0092-8674(23)00587-1. doi: 10.1016/j.cell.2023.05.035. Epub ahead of print. PMID: 37339632.
- Saha I, Yuste-Checa P, Da Silva Padilha M, Guo Q, Körner R, Holthusen H, Trinkaus VA, Dudanova I, Fernández-Busnadiego R, Baumeister W, Sanders DW, Gautam S, Diamond MI, Hartl FU, Hipp MS (2023). The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system. Nat Commun. 2023 Feb 2;14(1):560. doi: 10.1038/s41467-023-36058-2. PMID: 36732333; PMCID: PMC9894937.
2022
- Gropp MHM, Klaips CL, Hartl FU (2022). Formation of toxic oligomers of polyQ-expanded Huntingtin by prion-mediated cross-seeding. Mol Cell. 2022 Oct 13:S1097-2765(22)00952-2. doi: 10.1016/j.molcel.2022.09.031. Epub ahead of print. PMID: 36272412.
- Riemenschneider H, Guo Q, Bader J, Frottin F, Farny D, Kleinberger G, Haass C, Mann M, Hartl FU, Baumeister W, Hipp MS, Meissner F, Fernández-Busnadiego R, Edbauer D (2022). Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons. EMBO Rep. 2022 Apr 19:e53890. doi: 10.15252/embr.202153890. Epub ahead of print. PMID: 35438230.
- Yuste-Checa P, Bracher A, Hartl FU (2022). The chaperone Clusterin in neurodegeneration-friend or foe? Bioessays. 2022 May 6:e2100287. doi: 10.1002/bies.202100287. Epub ahead of print. PMID: 35521968.
2021
- Schneider MM, Gautam S, Herling TW, Andrzejewska E, Krainer G, Miller AM, Trinkaus VA, Peter QAE, Ruggeri FS, Vendruscolo M, Bracher A, Dobson CM, Hartl FU (2021). The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends. Nat Commun. 2021 Oct 14;12(1):5999. doi: 10.1038/s41467-021-25966-w. PMID: 34650037.
- Sitron CS, Hartl FU (2021). A new way of D/Ealing with protein misfolding. Mol Cell. 2021 Oct 21;81(20):4114-4115. doi: 10.1016/j.molcel.2021.09.025. PMID: 34686313.
- Trinkaus VA, Riera-Tur I, Martínez-Sánchez A, Bäuerlein FJB, Guo Q, Arzberger T, Baumeister W, Dudanova I, Hipp MS, Hartl FU, Fernández-Busnadiego R (2021). In situ architecture of neuronal α-Synuclein inclusions. Nat Commun. 2021 Apr 14;12(1):2110. doi: 10.1038/s41467-021-22108-0. PMID: 33854052.
- Yuste-Checa P, Trinkaus VA, Riera-Tur I, Imamoglu R, Schaller TF, Wang H, Dudanova I, Hipp MS, Bracher A, Hartl FU (2021). The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model. Nat Commun. 2021 Aug 11;12(1):4863. doi: 10.1038/s41467-021-25060-1. PMID: 34381050.
2020
- Khosravi B, LaClair KD, Riemenschneider H, Zhou Q, Frottin F, Mareljic N, Czuppa M, Farny D, Hartmann H, Michaelsen M, Arzberger T, Hartl FU, Hipp MS, Edbauer D (2020). Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS/FTD. EMBO J. 2020 Mar 16:e102811. doi: 10.15252/embj.2019102811. [Epub ahead of print]
- Klaips CL, Gropp MHM, Hipp MS, Hartl FU (2020). Sis1 potentiates the stress response to protein aggregation and elevated temperature. Nat Commun. 2020 Dec 8;11(1):6271. doi: 10.1038/s41467-020-20000-x. PMID: 33293525; PMCID: PMC7722728.
2019
- Frottin F, Schueder F, Tiwary S, Gupta R, Körner R, Schlichthaerle T, Cox J, Jungmann R, Hartl FU, Hipp MS (2019). The nucleolus functions as a phase-separated protein quality control compartment. Science. 2019 Jul 11. pii: eaaw9157. doi: 10.1126/science.aaw9157. [Epub ahead of print]
- Hipp MS, Kasturi P, Hartl FU (2019). The proteostasis network and its decline in ageing. Nat Rev Mol Cell Biol. 2019 Feb 7. doi: 10.1038/s41580-019-0101-y. [Epub ahead of print]
- van Well EM, Bader V, Patra M, Sánchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, Trümbach D, Angersbach L, Showkat C, Sehr DA, Berlemann LA, Goldmann P, Clement AM, Behl C, Woerner AC, Saft C, Wurst W, Haass C, Ellrichmann G, Gold R, Dittmar G, Hipp MS, Hartl FU, Tatzelt J, Winklhofer KF (2019). A protein quality control pathway regulated by linear ubiquitination. EMBO J. 2019 Mar 18. pii: e100730. doi: 10.15252/embj.2018100730. [Epub ahead of print]
2018
- Gruber A, Hornburg D, Antonin M, Krahmer N, Collado J, Schaffer M, Zubaite G, Lüchtenborg C, Sachsenheimer T, Brügger B, Mann M, Baumeister W, Hartl FU, Hipp MS, Fernández-Busnadiego R (2018). Molecular and structural architecture of polyQ aggregates in yeast. Proc Natl Acad Sci U S A. 2018 Mar 26. pii: 201717978. doi: 10.1073/pnas.1717978115. [Epub ahead of print]
- Guo Q, Lehmer C, Martínez-Sánchez A, Rudack T, Beck F, Hartmann H, Pérez-Berlanga M, Frottin F, Hipp MS, Hartl FU, Edbauer D, Baumeister W, Fernández-Busnadiego R (2018). In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell. 2018 Feb 8;172(4):696-705.e12. doi: 10.1016/j.cell.2017.12.030. Epub 2018 Feb 1.
2017
- Bäuerlein FJB, Saha I, Mishra A, Kalemanov M, Martínez-Sánchez A, Klein R, Dudanova I, Hipp MS, Hartl FU, Baumeister W, Fernández-Busnadiego R (2017). In Situ Architecture and Cellular Interactions of PolyQ Inclusions. Cell. 2017 Sep 7. pii: S0092-8674(17)30934-0. doi: 10.1016/j.cell.2017.08.009. [Epub ahead of print]
- Hosp F, Gutiérrez-Ángel S, Schaefer MH, Cox J, Meissner F, Hipp MS, Hartl FU, Klein R, Dudanova I, Mann M (2017). Spatiotemporal Proteomic Profiling of Huntington's Disease Inclusions Reveals Widespread Loss of Protein Function. Cell Rep. 2017 Nov 21;21(8):2291-2303. doi: 10.1016/j.celrep.2017.10.097.
- Klaips CL, Jayaraj GG, Hartl FU (2017). Pathways of cellular proteostasis in aging and disease. J Cell Biol. 2017 Nov 10. pii: jcb.201709072. doi: 10.1083/jcb.201709072. [Epub ahead of print]
- Vincenz-Donnelly L, Holthusen H, Körner R, Hansen EC, Presto J, Johansson J, Sawarkar R, Hartl FU*, Hipp MS* (2017). High capacity of the endoplasmic reticulum to prevent secretion and aggregation of amyloidogenic proteins. EMBO J. 2017 Dec 15. pii: e201695841. doi: 10.15252/embj.201695841. [Epub ahead of print]
- Zheng J, Yang J, Choe YJ, Hao X, Cao X, Zhao Q, Zhang Y, Franssens V, Hartl FU, Nyström T, Winderickx J, Liu B (2017). Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1. Biochem Biophys Res Commun. 2017 Aug 29. pii: S0006-291X(17)31709-6. doi: 10.1016/j.bbrc.2017.08.126. [Epub ahead of print]
2016
- Choe YJ, Park SH, Hassemer T, Körner R, Vincenz-Donnelly L, Hayer-Hartl M, Hartl FU (2016). Failure of RQC machinery causes protein aggregation and proteotoxic stress. Nature. 2016 Mar 10;531(7593):191-5. doi: 10.1038/nature16973. Epub 2016 Feb 29.
- Kim YE, Hosp F, Frottin F, Ge H, Mann M, Hayer-Hartl M, Hartl FU (2016). Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors. Mol Cell. 2016 Aug 25. pii: S1097-2765(16)30375-6. doi: 10.1016/j.molcel.2016.07.022. [Epub ahead of print]
2015
- Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU (2015). Widespread Proteome Remodeling and Aggregation in Aging. C. elegans Cell. 2015 May 7;161(4):919-32. doi: 10.1016/j.cell.2015.03.032.
- Woerner AC, Frottin F, Hornburg D, Feng LR, Meissner F, Patra M, Tatzelt J, Mann M, Winklhofer KF, Hartl FU, Hipp MS(2015). Cytoplasmic protein aggregates interfere with nucleo-cytoplasmic transport of protein and RNA. Science. 2015 Dec 3. pii: aad2033. [Epub ahead of print]
2014
- Hipp MS, Park SH, Hartl FU (2014). Proteostasis impairment in protein-misfolding and -aggregation diseases. Trends Cell Biol. 2014 Jun 16. pii: S0962-8924(14)00086-5. doi: 10.1016/j.tcb.2014.05.003. [Epub ahead of print]
- Raychaudhuri S, Loew C, Körner R, Pinkert S, Theis M, Hayer-Hartl M, Buchholz F, Hartl FU (2014). Interplay of Acetyltransferase EP300 and the Proteasome System in Regulating Heat Shock Transcription Factor 1. Cell. 2014 Feb 27;156(5):975-85. doi: 10.1016/j.cell.2014.01.055.
- Ripaud L, Chumakova V, Antonin M, Hastie AR, Pinkert S, Körner R, Ruff KM, Pappu RV, Hornburg D, Mann M, Hartl FU, Hipp MS (2014). Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome. Proc Natl Acad Sci U S A. 2014 Dec 8. pii: 201421313. [Epub ahead of print]