Brendel, Matthias

2024

Bartos LM, Kunte ST, Wagner S, Beumers P, Schaefer R, Zatcepin A, Li Y, Griessl M, Hoermann L, Wind-Mark K, Bartenstein P, Tahirovic S, Ziegler S, Brendel M, Gnörich J. Astroglial glucose uptake determines brain FDG-PET alterations and metabolic connectivity during healthy aging in mice. Neuroimage. 2024 Sep 25;300:120860. doi: 10.1016/j.neuroimage.2024.120860. Epub ahead of print. PMID: 39332748.
Biechele G, Rauchmann BS, Janowitz D, Buerger K, Franzmeier N, Weidinger E, Guersel S, Schuster S, Finze A, Harris S, Lindner S, Albert NL, Wetzel C, Rupprecht R, Rominger A, Palleis C, Katzdobler S, Burow L, Kurz C, Zaganjori M, Trappmann LK, Goldhardt O, Grimmer T, Haeckert J, Keeser D, Stoecklein S, Morenas-Rodriguez E, Bartenstein P, Levin J, Höglinger GU, Simons M, Perneczky R, Brendel M. Associations between sex, body mass index and the individual microglial response in Alzheimer's disease. J Neuroinflammation. 2024 Jan 23;21(1):30. doi:10.1186/s12974-024-03020-y. PMID: 38263017; PMCID: PMC10804830.
Bischof GN, Brendel M, Barthel H, Theis H, Barbe M, Bartenstein P, Claasen J, Danek A, Höglinger G, Levin J, Marek K, Neumaier B, Palleis C, Patt M, Rullmann M, Saur D, Schroeter ML, Seibyl J, Song M, Stephens A, Sabri O, Drzezga A, van Eimeren T; German Imaging Initiative for Tauopathies. Improved Tau PET SUVR Quantification in 4-Repeat Tau Phenotypes with [18F]PI-2620. J Nucl Med. 2024 Apr 4:jnumed.123.265930. doi: 10.2967/jnumed.123.265930. Epub ahead of print. PMID: 38575191.
Brendel M, Guedj E, Yakushev I, Morbelli S, Höglinger GU, Tolboom N, Verger A, Albert NL, Cecchin D, Fernandez PA, Fraioli F, Traub-Weidinger T, Van Weehaeghe D, Barthel H. Neuroimaging biomarkers in the biological definition of Parkinson's disease and dementia with Lewy bodies - EANM position on current state, unmet needs and future perspectives. Eur J Nucl Med Mol Imaging. 2024 Jun 22. doi: 10.1007/s00259-024-06803-w. Epub ahead of print. PMID: 38907856.
Buchert R, Huppertz HJ, Wegner F, Berding G, Brendel M, Apostolova I, Buhmann C, Poetter-Nerger M, Dierks A, Katzdobler S, Klietz M, Levin J, Mahmoudi N, Rinscheid A, Quattrone A, Rogozinski S, Rumpf JJ, Schneider C, Stoecklein S, Spetsieris PG, Eidelberg D, Sabri O, Barthel H, Wattjes MP, Höglinger G; Alzheimer’s Disease Neuroimaging Initiative. Added value of FDG-PET for detection of progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 2024 Aug 8:jnnp-2024-333590. doi: 10.1136/jnnp-2024-333590. Epub ahead of print. PMID: 39107038.
Dilcher R, Wall S, Groß M, Katzdobler S, Wagemann O, Palleis C, Weidinger E, Fietzek U, Bernhardt A, Kurz C, Ferschmann C, Scheifele M, Zaganjori M, Gnörich J, Bürger K, Janowitz D, Rauchmann BS, Stöcklein S, Bartenstein P, Villemagne V, Seibyl J, Sabri O, Barthel H, Perneczky R, Schöberl F, Zwergal A, Höglinger GU, Levin J, Franzmeier N, Brendel M. Combining cerebrospinal fluid and PI-2620 tau-PET for biomarker-based stratification of Alzheimer's disease and 4R-tauopathies. Alzheimers Dement. 2024 Sep 12. doi: 10.1002/alz.14185. Epub ahead of print. PMID: 39263969.
Ferschmann C, Messerschmidt K, Gnörich J, Barthel H, Marek K, Palleis C, Katzdobler S, Stockbauer A, Fietzek U, Finze A, Biechele G, Rumpf JJ, Saur D, Schroeter ML, Rullmann M, Beyer L, Eckenweber F, Wall S, Schildan A, Patt M, Stephens A, Classen J, Bartenstein P, Seibyl J, Franzmeier N, Levin J, Höglinger GU, Sabri O, Brendel M, Scheifele M; German Imaging Initiative for Tauopathies (GII4T). Tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies. Eur J Nucl Med Mol Imaging. 2024 Feb 17. doi: 10.1007/s00259-024-06637-6. Epub ahead of print. PMID: 38366196.
Franzmeier N, Dehsarvi A, Steward A, Biel D, Dewenter A, Roemer SN, Wagner F, Groß M, Brendel M, Moscoso A, Arunachalam P, Blennow K, Zetterberg H, Ewers M, Schöll M. Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer's disease. Nat Commun. 2024 Jan 3;15(1):202. doi: 10.1038/s41467-023-44374-w. PMID: 38172114; PMCID: PMC10764818.
Gnörich J, Koehler M, Wind-Mark K, Klaus C, Zatcepin A, Palumbo G, Lalia M, Monasor LS, Beyer L, Eckenweber F, Scheifele M, Gildehaus FJ, von Ungern-Sternberg B, Barthel H, Sabri O, Bartenstein P, Herms J, Tahirovic S, Franzmeier N, Ziegler S, Brendel M. Towards multicenter β-amyloid PET imaging in mouse models: A triple scanner head-to-head comparison. Neuroimage. 2024 Jul 26;297:120748. doi: 10.1016/j.neuroimage.2024.120748. Epub ahead of print. PMID: 39069223.
Gold L, Barci E, Brendel M, Orth M, Cheng J, Kirchleitner SV, Bartos LM, Pötter D, Kirchner MA, Unterrainer LM, Kaiser L, Ziegler S, Weidner L, Riemenschneider MJ, Unterrainer M, Belka C, Tonn JC, Bartenstein P, Niyazi M, von Baumgarten L, Kälin RE, Glass R, Lauber K, Albert NL, Holzgreve A. The Traumatic Inoculation Process Affects TSPO Radioligand Uptake in Experimental Orthotopic Glioblastoma. Biomedicines. 2024 Jan 15;12(1):188. doi: 10.3390/biomedicines12010188. PMID: 38255293; PMCID: PMC10813339.
Hagen JM, Zacherl MJ, Brendel M, Clauß S, Kääb S, Bartenstein P, Todica A, Boening G, Fischer M. Quantitative assessment of cardiac 123iodo-metaiodobenzylguanidine SPECT/CT in patients with arrhythmogenic right ventricular cardiomyopathy: novel insight in disease monitoring. J Nucl Cardiol. 2024 Jul 13:101911. doi: 10.1016/j.nuclcard.2024.101911. Epub ahead of print. PMID: 39009215.

Heimer MM, Dikhtyar Y, Hoppe BF, Herr FL, Stüber AT, Burkard T, Zöller E, Fabritius MP, Unterrainer L, Adams L, Thurner A, Kaufmann D, Trzaska T, Kopp M, Hamer O, Maurer K, Ristow I, May MS, Tufman A, Spiro J, Brendel M, Ingrisch M, Ricke J, Cyran CC. Software-assisted structured reporting and semi-automated TNM classification for NSCLC staging in a multicenter proof of concept study. Insights Imaging. 2024 Oct 28;15(1):258. doi: 10.1186/s13244-024-01836-z. PMID: 39466506; PMCID: PMC11519274.
Kaiser L, Quach S, Zounek AJ, Wiestler B, Zatcepin A, Holzgreve A, Bollenbacher A, Bartos LM, Ruf VC, Böning G, Thon N, Herms J, Riemenschneider MJ, Stöcklein S, Brendel M, Rupprecht R, Tonn JC, Bartenstein P, von Baumgarten L, Ziegler S, Albert NL. Enhancing predictability of IDH mutation status in glioma patients at initial diagnosis: a comparative analysis of radiomics from MRI, [18F]FET PET, and TSPO PET. Eur J Nucl Med Mol Imaging. 2024 Feb 24. doi: 10.1007/s00259-024-06654-5. Epub ahead of print. PMID: 38396261.
Kunte SC, Wenter V, Toms J, Lindner S, Unterrainer M, Eilsberger F, Jurkschat K, Wängler C, Wängler B, Schirrmacher R, Tiling MW, Sheikh GT, Mehrens D, Brendel M, Rübenthaler J, Auernhammer CJ, Spitzweg C, Unterrainer LM, Holzgreve A. PET/CT imaging of differentiated and medullary thyroid carcinoma using the novel SSTR-targeting peptide [18F]SiTATE - first clinical experiences. Eur J Nucl Med Mol Imaging. 2024 Oct 15. doi: 10.1007/s00259-024-06944-y. Epub ahead of print. PMID: 39404789.
Liu FT, Lu JY, Li XY, Ge JJ, Sun YM, Yen TC, Jiao FY, Chen MJ, Zhao J, Yao RX, Tang G, Xu H, Lan XL, Lu J, Cui RX, Brendel M, Shi K, Guan YH, Rominger A, Wang J, Zuo CT; Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI). Visual reading for [18F]Florzolotau Tau PET scans in progressive supranuclear palsy. Eur J Nucl Med Mol Imaging. 2024 Oct 1. doi: 10.1007/s00259-024-06923-3. Epub ahead of print. PMID: 39352424.
Liubchenko G, Böning G, Zacherl M, Rumiantcev M, Unterrainer LM, Gildehaus FJ, Brendel M, Resch S, Bartenstein P, Ziegler SI, Delker A. Image-based dosimetry for [225Ac]Ac-PSMA-I&T therapy and the effect of daughter-specific pharmacokinetics. Eur J Nucl Med Mol Imaging. 2024 Mar 21. doi: 10.1007/s00259-024-06681-2. Epub ahead of print. PMID: 38512484.
Lopes L, Jiao F, Xue S, Pyka T, Krieger K, Ge J, Xu Q, Fahmi R, Spottiswoode B, Soliman A, Buchert R, Brendel M, Hong J, Guan Y, Bassetti CLA, Rominger A, Zuo C, Shi K, Wu P. Dopaminergic PET to SPECT domain adaptation: a cycle GAN translation approach. Eur J Nucl Med Mol Imaging. 2024 Nov 19. doi: 10.1007/s00259-024-06961-x. Epub ahead of print. PMID: 39557690.
Malpetti M, Franzmeier N, Brendel M. PET Imaging to Measure Neuroinflammation In Vivo. Methods Mol Biol. 2024;2785:177-193. doi: 10.1007/978-1-0716-3774-6_12. PMID: 38427195.
Malpetti M, Roemer SN, Harris S, Gross M, Gnörich J, Stephens A, Dewenter A, Steward A, Biel D, Dehsarvi A, Wagner F, Müller A, Koglin N, Weidinger E, Palleis C, Katzdobler S, Rupprecht R, Perneczky R, Rauchmann BS, Levin J, Höglinger GU, Brendel M, Franzmeier N. Neuroinflammation Parallels 18F-PI-2620 Positron Emission Tomography Patterns in Primary 4-Repeat Tauopathies. Mov Disord. 2024 Jul 18. doi: 10.1002/mds.29924. Epub ahead of print. PMID: 39022835.
Meindl M, Zatcepin A, Gnörich J, Scheifele M, Zaganjori M, Groß M, Lindner S, Schaefer R, Simmet M, Roemer S, Katzdobler S, Levin J, Höglinger G, Bischof AC, Barthel H, Sabri O, Bartenstein P, Saller T, Franzmeier N, Ziegler S, Brendel M. Assessment of [18F]PI-2620 Tau-PET Quantification via Non-Invasive Automatized Image Derived Input Function. Eur J Nucl Med Mol Imaging. 2024 May 8. doi: 10.1007/s00259-024-06741-7. Epub ahead of print. PMID: 38717592.
Palleis C, Franzmeier N, Weidinger E, Bernhardt AM, Katzdobler S, Wall S, Ferschmann C, Harris S, Schmitt J, Schuster S, Gnörich J, Finze A, Biechele G, Lindner S, Albert NL, Bartenstein P, Sabri O, Barthel H, Rupprecht R, Nuscher B, Stephens AW, Rauchmann BS, Perneczky R, Haass C, Brendel M, Levin J, Höglinger GU. Association of Neurofilament Light Chain, [18F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With β-Amyloid-Negative CBS. Neurology. 2024 Jan 9;102(1):e207901. doi: 10.1212/WNL.0000000000207901. Epub 2023 Dec 14. PMID: 38165362.
Roemer SN, Brendel M, Gnoerich J, Malpetti M, Zaganjori M, Quattrone A, Gross M, Steward A, Dewenter A, Wagner F, Dehsarvi A, Ferschmann C, Wall S, Palleis C, Rauchmann BS, Katzdobler S, Jaeck A, Stockbauer A, Fietzek UM, Bernhardt AM, Weidinger E, Zwergal A, Stoecklein S, Perneczky R, Barthel H, Sabri O, Levin J, Hoeglinger GU, Franzmeier N. Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies. Brain. 2024 Jun 6:awae174. doi: 10.1093/brain/awae174. Epub ahead of print. PMID: 38842726.
Ruch F, Gnörich J, Wind K, Köhler M, Zatcepin A, Wiedemann T, Gildehaus FJ, Lindner S, Boening G, von Ungern-Sternberg B, Beyer L, Herms J, Bartenstein P, Brendel M, Eckenweber F. Validity and value of metabolic connectivity in mouse models of β-amyloid and tauopathy. Neuroimage. 2024 Jan 6;286:120513. doi: 10.1016/j.neuroimage.2024.120513. Epub ahead of print. PMID: 38191101.
Shojaei M, Schaefer R, Schlepckow K, Kunze LH, Struebing FL, Brunner B, Willem M, Bartos LM, Feiten A, Palumbo G, Arzberger T, Bartenstein P, Parico GC, Xia D, Monroe KM, Haass C, Brendel M, Lindner S. PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies. Theranostics. 2024 Sep 30;14(16):6319-6336. doi: 10.7150/thno.97149. PMID: 39431020; PMCID: PMC11488106.
Shojaei M, Zhou Q, Palumbo G, Schaefer R, Kaskinoro J, Vehmaan-Kreula P, Bartenstein P, Brendel M, Edbauer D, Lindner S. Development and Preclinical Evaluation of a Copper-64-Labeled Antibody Targeting Glycine-Alanine Dipeptides for PET Imaging of C9orf72-Associated Amyotrophic Lateral Sclerosis/Frontotemporal Dementia. ACS Pharmacol Transl Sci. 2024 Apr 25;7(5):1404-1414. doi: 10.1021/acsptsci.4c00037. PMID: 38751620; PMCID: PMC11091963.
Traub-Weidinger T, Arbizu J, Barthel H, Boellaard R, Borgwardt L, Brendel M, Cecchin D, Chassoux F, Fraioli F, Garibotto V, Guedj E, Hammers A, Law I, Morbelli S, Tolboom N, Van Weehaeghe D, Verger A, Van Paesschen W, von Oertzen TJ, Zucchetta P, Semah F. EANM practice guidelines for an appropriate use of PET and SPECT for patients with epilepsy. Eur J Nucl Med Mol Imaging. 2024 Feb 23. doi: 10.1007/s00259-024-06656-3. Epub ahead of print. PMID: 38393374.
Van Weehaeghe D, Lapauw B, Fraioli F, Cecchin D, Verger A, Guedj E, Albert NL, Brendel M, Yakushev I, Barthel H, Traub-Weidinger T, Tolboom N, Giessen EV. EANM position on positron emission tomography in suspected functional pituitary neuroendocrine tumours. Eur J Nucl Med Mol Imaging. 2024 Apr 30. doi: 10.1007/s00259-024-06728-4. Epub ahead of print. PMID: 38687371.
Verger A, Cecchin D, Guedj E, Albert NL, Brendel M, Fraioli F, Tolboom N, Traub-Weidinger T, Yakushev I, Van Weehaeghe D, Fernandez PA, Garibotto V, Imbert L. EANM perspectives for CZT SPECT in brain applications. Eur J Nucl Med Mol Imaging. 2024 Jun 11. doi: 10.1007/s00259-024-06788-6. Epub ahead of print. PMID: 38858281.
Vinnakota JM, Biavasco F, Schwabenland M, Chhatbar C, Adams RC, Erny D, Duquesne S, El Khawanky N, Schmidt D, Fetsch V, Zähringer A, Salié H, Athanassopoulos D, Braun LM, Javorniczky NR, Ho JNHG, Kierdorf K, Marks R, Wäsch R, Simonetta F, Andrieux G, Pfeifer D, Monaco G, Capitini C, Fry TJ, Blank T, Blazar BR, Wagner E, Theobald M, Sommer C, Stelljes M, Reicherts C, Jeibmann A, Schittenhelm J, Monoranu CM, Rosenwald A, Kortüm M, Rasche L, Einsele H, Meyer PT, Brumberg J, Völkl S, Mackensen A, Coras R, von Bergwelt-Baildon M, Albert NL, Bartos LM, Brendel M, Holzgreve A, Mack M, Boerries M, Mackall CL, Duyster J, Henneke P, Priller J, Köhler N, Strübing F, Bengsch B, Ruella M, Subklewe M, von Baumgarten L, Gill S, Prinz M, Zeiser R. Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome. Nat Cancer. 2024 May 13. doi: 10.1038/s43018-024-00764-7. Epub ahead of print. PMID: 38741011.
Wehlte L, Walter J, Daisenberger L, Kuhnle F, Ingenerf M, Schmid-Tannwald C, Brendel M, Kauffmann-Guerrero D, Heinzerling L, Tufman A, Pfluger T, Völter F. The Association between the Body Mass Index, Chronic Obstructive Pulmonary Disease and SUV of the Non-Tumorous Lung in the Pretreatment [18F]FDG-PET/CT of Patients with Lung Cancer. Diagnostics (Basel). 2024 May 30;14(11):1139. doi: 10.3390/diagnostics14111139. PMID: 38893665; PMCID: PMC11171792.
Wuehr M, Peto D, Fietzek UM, Katzdobler S, Nübling G, Zaganjori M, Brendel M, Levin J, Höglinger GU, Zwergal A. Low-intensity vestibular noise stimulation improves postural symptoms in progressive supranuclear palsy. J Neurol. 2024 May 9. doi: 10.1007/s00415-024-12419-9. Epub ahead of print. PMID: 38722328.
Zatcepin A, Gnörich J, Rauchmann BS, Bartos LM, Wagner S, Franzmeier N, Malpetti M, Xiang X, Shi Y, Parhizkar S, Grosch M, Wind-Mark K, Kunte ST, Beyer L, Meyer C, Brösamle D, Wendeln AC, Osei-Sarpong C, Heindl S, Liesz A, Stoecklein S, Biechele G, Finze A, Eckenweber F, Lindner S, Rominger A, Bartenstein P, Willem M, Tahirovic S, Herms J, Buerger K, Simons M, Haass C, Rupprecht R, Riemenschneider MJ, Albert NL, Beyer M, Neher JJ, Paeger L, Levin J, Höglinger GU, Perneczky R, Ziegler SI, Brendel M. Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer's disease. Mol Neurodegener. 2024 Sep 5;19(1):64. doi: 10.1186/s13024-024-00752-6. PMID: 39238030; PMCID: PMC11375924.

2023

Albert NL, Nelwan DV, Fleischmann DF, Quach S, von Rohr K, Kaiser L, Teske N, Unterrainer LM, Bartos LM, Ruf VC, Brendel M, Riemenschneider MJ, Wetzel C, Herms J, Rupprecht R, Thon N, Tonn JC, Belka C, Bartenstein P, von Baumgarten L, Niyazi M, Unterrainer M, Holzgreve A (2023). Prognostic Value of TSPO PET Before Radiotherapy in Newly Diagnosed IDH-Wild-Type Glioblastoma. J Nucl Med. 2023 Aug 3:jnumed.122.265247. doi: 10.2967/jnumed.122.265247. Epub ahead of print. PMID: 37536737.
Ballweg A, Klaus C, Vogler L, Katzdobler S, Wind K, Zatcepin A, Ziegler SI, Secgin B, Eckenweber F, Bohr B, Bernhardt A, Fietzek U, Rauchmann BS, Stoecklein S, Quach S, Beyer L, Scheifele M, Simmet M, Joseph E, Lindner S, Berg I, Koglin N, Mueller A, Stephens AW, Bartenstein P, Tonn JC, Albert NL, Kümpfel T, Kerschensteiner M, Perneczky R, Levin J, Paeger L, Herms J, Brendel M (2023). [18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data. J Neuroinflammation. 2023 Mar 11;20(1):68. doi: 10.1186/s12974-023-02749-2. PMID: 36906584; PMCID: PMC10007845.
Bartos LM, Kirchleitner SV, Kolabas ZI, Quach S, Beck A, Lorenz J, Blobner J, Mueller SA, Ulukaya S, Hoeher L, Horvath I, Wind-Mark K, Holzgreve A, Ruf VC, Gold L, Kunze LH, Kunte ST, Beumers P, Park HE, Antons M, Zatcepin A, Briel N, Hoermann L, Schaefer R, Messerer D, Bartenstein P, Riemenschneider MJ, Lindner S, Ziegler S, Herms J, Lichtenthaler SF, Ertürk A, Tonn JC, von Baumgarten L, Albert NL, Brendel M (2023). Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution. Sci Adv. 2023 Oct 27;9(43):eadi8986. doi: 10.1126/sciadv.adi8986. Epub 2023 Oct 27. PMID: 37889970; PMCID: PMC10610915.
Biel D, Suárez-Calvet M, Hager P, Rubinski A, Dewenter A, Steward A, Roemer S, Ewers M, Haass C, Brendel M, Franzmeier N; Alzheimer's Disease Neuroimaging Initiative (ADNI) (2023). sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease. EMBO Mol Med. 2023 Jan 9:e16987. doi: 10.15252/emmm.202216987. Epub ahead of print. PMID: 36620941.
Buchert R, Wegner F, Huppertz HJ, Berding G, Brendel M, Apostolova I, Buhmann C, Dierks A, Katzdobler S, Klietz M, Levin J, Mahmoudi N, Rinscheid A, Rogozinski S, Rumpf JJ, Schneider C, Stöcklein S, Spetsieris PG, Eidelberg D, Wattjes MP, Sabri O, Barthel H, Höglinger G; Alzheimer's Disease Neuroimaging Initiative (2023). Automatic covariance pattern analysis outperforms visual reading of 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET) in variant progressive supranuclear palsy. Mov Disord. 2023 Sep 1. doi: 10.1002/mds.29581. Epub ahead of print. PMID: 37655363.
Bui VN, Unterrainer LM, Brendel M, Kunte SC, Holzgreve A, Allmendinger F, Bartenstein P, Klauschen F, Unterrainer M, Staehler M, Ledderose S (2023). PSMA-Expression Is Highly Associated with Histological Subtypes of Renal Cell Carcinoma: Potential Implications for Theranostic Approaches. Biomedicines. 2023 Nov 20;11(11):3095. doi: 10.3390/biomedicines11113095. PMID: 38002095; PMCID: PMC10668989.
Delker A, Schleske M, Liubchenko G, Berg I, Zacherl MJ, Brendel M, Gildehaus FJ, Rumiantcev M, Resch S, Hürkamp K, Wenter V, Unterrainer LM, Bartenstein P, Ziegler SI, Beyer L, Böning G (2023). Biodistribution and dosimetry for combined [177Lu]Lu-PSMA-I&T/[225Ac]Ac-PSMA-I&T therapy using multi-isotope quantitative SPECT imaging. Eur J Nucl Med Mol Imaging. 2023 Jan 11. doi: 10.1007/s00259-022-06092-1. Epub ahead of print. PMID: 36629878.
Finze A, Biechele G, Rauchmann BS, Franzmeier N, Palleis C, Katzdobler S, Weidinger E, Guersel S, Schuster S, Harris S, Schmitt J, Beyer L, Gnörich J, Lindner S, Albert NL, Wetzel CH, Rupprecht R, Rominger A, Danek A, Burow L, Kurz C, Tato M, Utecht J, Papazov B, Zaganjori M, Trappmann LK, Goldhardt O, Grimmer T, Haeckert J, Janowitz D, Buerger K, Keeser D, Stoecklein S, Dietrich O, Morenas-Rodriguez E, Barthel H, Sabri O, Bartenstein P, Simons M, Haass C, Höglinger GU, Levin J, Perneczky R, Brendel M (2023). Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies. Mol Psychiatry. 2023 Jul 26. doi: 10.1038/s41380-023-02188-8. Epub ahead of print. PMID: 37495886.
Gnörich J, Reifschneider A, Wind K, Zatcepin A, Kunte ST, Beumers P, Bartos LM, Wiedemann T, Grosch M, Xiang X, Fard MK, Ruch F, Werner G, Koehler M, Slemann L, Hummel S, Briel N, Blume T, Shi Y, Biechele G, Beyer L, Eckenweber F, Scheifele M, Bartenstein P, Albert NL, Herms J, Tahirovic S, Haass C, Capell A, Ziegler S, Brendel M (2023). Depletion and activation of microglia impact metabolic connectivity of the mouse brain. Neuroinflammation. 2023 Feb 24;20(1):47. doi: 10.1186/s12974-023-02735-8. PMID: 36829182; PMCID: PMC9951492.
Hong J, Lu J, Liu F, Wang M, Li X, Clement C, Lopes L, Brendel M, Rominger A, Yen TC, Guan Y, Tian M, Wang J, Zuo C, Shi K (2023); Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI). Uncovering distinct progression patterns of tau deposition in progressive supranuclear palsy using [18F]Florzolotau PET imaging and subtype/stage inference algorithm. EBioMedicine. 2023 Oct 13;97:104835. doi: 10.1016/j.ebiom.2023.104835. Epub ahead of print. PMID: 37839135; PMCID: PMC10590768.
Koeglsperger T, Rumpf SL, Schließer P, Struebing FL, Brendel M, Levin J, Trenkwalder C, Höglinger GU, Herms J (2023). Neuropathology of incidental Lewy body & prodromal Parkinson's disease. Mol Neurodegener. 2023 May 12;18(1):32. doi: 10.1186/s13024-023-00622-7. PMID: 37173733; PMCID: PMC10182593.
Kolabas ZI, Kuemmerle LB, Perneczky R, Förstera B, Ulukaya S, Ali M, Kapoor S, Bartos LM, Büttner M, Caliskan OS, Rong Z, Mai H, Höher L, Jeridi D, Molbay M, Khalin I, Deligiannis IK, Negwer M, Roberts K, Simats A, Carofiglio O, Todorov MI, Horvath I, Ozturk F, Hummel S, Biechele G, Zatcepin A, Unterrainer M, Gnörich J, Roodselaar J, Shrouder J, Khosravani P, Tast B, Richter L, Díaz-Marugán L, Kaltenecker D, Lux L, Chen Y, Zhao S, Rauchmann BS, Sterr M, Kunze I, Stanic K, Kan VWY, Besson-Girard S, Katzdobler S, Palleis C, Schädler J, Paetzold JC, Liebscher S, Hauser AE, Gokce O, Lickert H, Steinke H, Benakis C, Braun C, Martinez-Jimenez CP, Buerger K, Albert NL, Höglinger G, Levin J, Haass C, Kopczak A, Dichgans M, Havla J, Kümpfel T, Kerschensteiner M, Schifferer M, Simons M, Liesz A, Krahmer N, Bayraktar OA, Franzmeier N, Plesnila N, Erener S, Puelles VG, Delbridge C, Bhatia HS, Hellal F, Elsner M, Bechmann I, Ondruschka B, Brendel M, Theis FJ, Erturk A (2023). Distinct molecular profiles of skull bone marrow in health and neurological disorders. Cell. 2023 Aug 3:S0092-8674(23)00742-0. doi: 10.1016/j.cell.2023.07.009. Epub ahead of print. PMID: 37562402
Kunze LH, Ruch F, Biechele G, Eckenweber F, Wind-Mark K, Dinkel L, Feyen P, Bartenstein P, Ziegler S, Paeger L, Tahirovic S, Herms J, Brendel M (2023). Long-Term Pioglitazone Treatment Has No Significant Impact on Microglial Activation and Tau Pathology in P301S Mice. Int J Mol Sci. 2023 Jun 14;24(12):10106. doi: 10.3390/ijms241210106. PMID: 37373253; PMCID: PMC10298936.
Palleis C, Forbrig R, Lehner L, Quach S, Albert NL, Brendel M, Schöberl F, Straube A (2023). Lyme neuroborreliosis: An unusual case with extensive (peri)vasculitis of the middle cerebral artery. Eur J Neurol. 2023 Jan 13. doi: 10.1111/ene.15633. Epub ahead of print. PMID: 36636924.
Palumbo G, Kunze LH, Oos R, Wind-Mark K, Lindner S, von Ungern-Sternberg B, Bartenstein P, Ziegler S, Brendel M (2023). Longitudinal Studies on Alzheimer Disease Mouse Models with Multiple Tracer PET/CT: Application of Reduction and Refinement Principles in Daily Practice to Safeguard Animal Welfare during Progressive Aging. Animals (Basel). 2023 May 30;13(11):1812. doi: 10.3390/ani13111812. PMID: 37531139; PMCID: PMC10251952.
Rueb M, Rauen K, Koerte IK, Gersing A, Zetterberg H, Simrén J, Brendel M, Adorjan K. Traumatic Encephalopathy Syndrome and Tauopathy in a 19-Year-Old With Child Abuse. Neurotrauma Rep. 2023 Dec 26;4(1):857-862. doi: 10.1089/neur.2023.0078. PMID: 38156074; PMCID: PMC10754342.
Schönecker S, Palleis C, Franzmeier N, Katzdobler S, Ferschmann C, Schuster S, Finze A, Scheifele M, Prix C, Fietzek U, Weidinger E, Nübling G, Vöglein J, Patt M, Barthel H, Sabri O, Danek A, Höglinger GU, Brendel M, Levin J; for German Imaging Initiative for Tauopathies GII4T (2023). Symptomatology in 4-repeat tauopathies is associated with data-driven topology of [18F]-PI-2620 tau-PET signal. Neuroimage Clin. 2023 Apr 11;38:103402. doi: 10.1016/j.nicl.2023.103402. Epub ahead of print. PMID: 37087820.
Steward A, Biel D, Dewenter A, Roemer S, Wagner F, Dehsarvi A, Rathore S, Otero Svaldi D, Higgins I, Brendel M, Dichgans M, Shcherbinin S, Ewers M, Franzmeier N (2023). ApoE4 and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels. JAMA Neurol. 2023 Nov 6:e234038. doi: 10.1001/jamaneurol.2023.4038. Epub ahead of print. PMID: 37930695; PMCID: PMC10628846.
Stockbauer A, Beyer L, Huber M, Kreuzer A, Palleis C, Katzdobler S, Rauchmann BS, Morbelli S, Chincarini A, Bruffaerts R, Vandenberghe R, Kramberger MG, Trost M, Garibotto V, Nicastro N, Lathuilière A, Lemstra AW, van Berckel BNM, Pilotto A, Padovani A, Ochoa-Figueroa MA, Davidsson A, Camacho V, Peira E, Bauckneht M, Pardini M, Sambuceti G, Aarsland D, Nobili F, Gross M, Vöglein J, Perneczky R, Pogarell O, Buerger K, Franzmeier N, Danek A, Levin J, Höglinger GU, Bartenstein P, Cumming P, Rominger A, Brendel M (2023). Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission. Eur J Nucl Med Mol Imaging. 2023 Nov 16. doi: 10.1007/s00259-023-06493-w. Epub ahead of print. PMID: 37971501.
Tolboom N, Verger A, Albert NL, Brendel M, Cecchin D, Fernandez PA, Fraioli F, Guedj E, Herrmann K, Traub-Weidinger T, Morbelli S, Yakushev I, Zucchetta P, Barthel H, Van Weehaeghe D (2023). EANM position paper: theranostics in brain tumours-the present and the future. Eur J Nucl Med Mol Imaging. 2023 Sep 12. doi: 10.1007/s00259-023-06425-8. Epub ahead of print. PMID: 37698647.
Unterrainer M, Kunte SC, Unterrainer LM, Holzgreve A, Delker A, Lindner S, Beyer L, Brendel M, Kunz WG, Winkelmann M, Cyran CC, Ricke J, Jurkschat K, Wängler C, Wängler B, Schirrmacher R, Belka C, Niyazi M, Tonn JC, Bartenstein P, Albert NL (2023). Next-generation PET/CT imaging in meningioma-first clinical experiences using the novel SSTR-targeting peptide [18F]SiTATE. Eur J Nucl Med Mol Imaging. 2023 Jun 26. doi: 10.1007/s00259-023-06315-z. Epub ahead of print. PMID: 37358620.
van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park JI, Tatarakis D, Calvert M, Hummel S, Lianoglou S, Pizzo ME, Prorok R, Thomsen E, Bartos LM, Beumers P, Capell A, Davis SS, de Weerd L, Dugas JC, Duque J, Earr T, Gadkar K, Giese T, Gill A, Gnörich J, Ha C, Kannuswamy M, Kim DJ, Kunte ST, Kunze LH, Lac D, Lechtenberg K, Leung AW, Liang CC, Lopez I, McQuade P, Modi A, Torres VO, Nguyen HN, Pesämaa I, Propson N, Reich M, Robles-Colmenares Y, Schlepckow K, Slemann L, Solanoy H, Suh JH, Thorne RG, Vieira C, Wind-Mark K, Xiong K, Zuchero YJY, Diaz D, Dennis MS, Huang F, Scearce-Levie K, Watts RJ, Haass C, Lewcock JW, Di Paolo G, Brendel M, Sanchez PE, Monroe KM (2023). A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nat Neurosci. 2023 Jan 12. doi: 10.1038/s41593-022-01240-0. Epub ahead of print. PMID: 36635496.
Vogler L, Ballweg A, Bohr B, Briel N, Wind K, Antons M, Kunze LH, Gnörich J, Lindner S, Gildehaus FJ, Baumann K, Bartenstein P, Boening G, Ziegler SI, Levin J, Zwergal A, Höglinger GU, Herms J, Brendel M (2023). Assessment of synaptic loss in mouse models of β-amyloid and tau pathology using [18F]UCB-H PET imaging. Neuroimage Clin. 2023 Jul 26;39:103484. doi: 10.1016/j.nicl.2023.103484. Epub ahead of print. PMID: 37541098.
Wattjes MP, Huppertz HJ, Mahmoudi N, Stöcklein S, Rogozinski S, Wegner F, Klietz M, Apostolova I, Levin J, Katzdobler S, Buhmann C, Quattrone A, Berding G, Brendel M, Barthel H, Sabri O, Höglinger G, Buchert R (2023). Alzheimer's Disease Neuroimaging Initiative. Brain MRI in Progressive Supranuclear Palsy with Richardson's Syndrome and Variant Phenotypes. Mov Disord. 2023 Aug 6. doi: 10.1002/mds.29527. Epub ahead of print. PMID: 37545102.
Weidner L, Lorenz J, Quach S, Braun FK, Rothhammer-Hampl T, Ammer LM, Vollmann-Zwerenz A, Bartos LM, Dekorsy FJ, Holzgreve A, Kirchleitner SV, Thon N, Greve T, Ruf V, Herms J, Bader S, Milenkovic VM, von Baumgarten L, Menevse AN, Hussein A, Sax J, Wetzel CH, Rupprecht R, Proescholdt M, Schmidt NO, Beckhove P, Hau P, Tonn JC, Bartenstein P, Brendel M, Albert NL, Riemenschneider MJ (2023). Translocator protein (18kDA) (TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated macrophages. Acta Neuropathol Commun. 2023 Sep 11;11(1):147. doi: 10.1186/s40478-023-01651-5. PMID: 37697350; PMCID: PMC10496331.
Zatcepin A, Kopczak A, Holzgreve A, Hein S, Schindler A, Duering M, Kaiser L, Lindner S, Schidlowski M, Bartenstein P, Albert N, Brendel M, Ziegler Sl (2023). Machine learning-based approach reveals essential features for simplified TSPO PET quantification in ischemic stroke patients. Z Med Phys. 2023 Jan 20:S0939-3889(22)00128-3. doi: 10.1016/j.zemedi.2022.11.008. Epub ahead of print. PMID: 36682921.
Zounek AJ, Albert NL, Holzgreve A, Unterrainer M, Brosch-Lenz J, Lindner S, Bollenbacher A, Boening G, Rupprecht R, Brendel M, von Baumgarten L, Tonn JC, Bartenstein P, Ziegler S, Kaiser L (2023). Feasibility of radiomic feature harmonization for pooling of [18F]FET or [18F]GE-180 PET images of gliomas. Z Med Phys. 2023 Jan 27:S0939-3889(22)00138-6. doi: 10.1016/j.zemedi.2022.12.005. Epub ahead of print. PMID: 36710156.

2022

Antons M, Lindner M, Grosch M, Oos R, Palumbo G, Brendel M, Ziegler S, Bartenstein P, Dieterich M, Zwergal A(2022). Longitudinal [18]UCB-H/[18F]FDG imaging depicts complex patterns of structural and functional neuroplasticity following bilateral vestibular loss in the rat. Sci Rep. 2022 Apr 11;12(1):6049. doi: 10.1038/s41598-022-09936-w. PMID: 35411002; PMCID: PMC9001652.
Bartos LM, Kunte ST, Beumers P, Xiang X, Wind K, Ziegler S, Bartenstein P, Choi H, Lee DS, Haass C, von Baumgarten L, Tahirovic S, Albert NL, Lindner S, Brendel M (2022). Single cell radiotracer allocation via immunomagentic sorting (scRadiotracing) to disentangle PET signals at cellular resolution. J Nucl Med. 2022 May 19:jnumed.122.264171. doi: 10.2967/jnumed.122.264171. Epub ahead of print. PMID: 35589403.
Bartos LM, Kirchleitner SV, Blobner J, Wind K, Kunze LH, Holzgreve A, Gold L, Zatcepin A, Kolabas ZI, Ulukaya S, Weidner L, Quach S, Messerer D, Bartenstein P, Tonn JC, Riemenschneider MJ, Ziegler S, von Baumgarten L, Albert NL, Brendel M (2022). 18 kDa translocator protein positron emission tomography facilitates early and robust tumor detection in the immunocompetent SB28 glioblastoma mouse model. Front Med (Lausanne). 2022 Oct 17;9:992993. doi: 10.3389/fmed.2022.992993. PMID: 36325388; PMCID: PMC9621314.
Biel D, Luan Y, Brendel M, Hager P, Dewenter A, Moscoso A, Otero Svaldi D, Higgins IA, Pontecorvo M, Römer S, Steward A, Rubinski A, Zheng L, Schöll M, Shcherbinin S, Ewers M, Franzmeier N; Alzheimer’s Disease Neuroimaging Initiative (2022). Combining tau-PET and fMRI meta-analyses for patient-centered prediction of cognitive decline in Alzheimer's disease. Alzheimers Res Ther. 2022 Nov 7;14(1):166. doi: 10.1186/s13195-022-01105-5. PMID: 36345046; PMCID: PMC9639286.
Blume T, Deussing M, Biechele G, Peters F, Zott B, Schmidt C, Franzmeier N, Wind K, Eckenweber F, Sacher C, Shi Y, Ochs K, Kleinberger G, Xiang X, Focke C, Lindner S, Gildehaus FJ, Beyer L, von Ungern-Sternberg B, Bartenstein P, Baumann K, Adelsberger H, Rominger A, Cumming P, Willem M, Dorostkar MM, Herms J, Brendel M (2022). Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition. Front Aging Neurosci. 2022 Mar 30;14:854031. doi: 10.3389/fnagi.2022.854031. PMID: 35431893; PMCID: PMC9007038.
Blume T, Filser S, Sgobio C, Peters F, Neumann U, Shimshek D, Saito T, Saido TC, Brendel M, Herms J (2022). β-secretase inhibition prevents structural spine plasticity deficits in AppNL-G-F mice. Front Aging Neurosci. 2022 Jul 22;14:909586. doi: 10.3389/fnagi.2022.909586. PMID: 35936777; PMCID: PMC9354544.
Finze A, Wahl H, Janowitz D, Buerger K, Linn J, Rominger A, Stöcklein S, Bartenstein P, Wollenweber FA, Catak C, Brendel M (2022). Regional Associations of Cortical Superficial Siderosis and β-Amyloid-Positron-Emission-Tomography Positivity in Patients With Cerebral Amyloid Angiopathy. Front Aging Neurosci. 2022 Feb 3;13:786143. doi: 10.3389/fnagi.2021.786143. PMID: 35185518; PMCID: PMC8851392.
Franzmeier N, Brendel M, Beyer L, Slemann L, Kovacs GG, Arzberger T, Kurz C, Respondek G, Lukic MJ, Biel D, Rubinski A, Frontzkowski L, Hummel S, Müller A, Finze A, Palleis C, Joseph E, Weidinger E, Katzdobler S, Song M, Biechele G, Kern M, Scheifele M, Rauchmann BS, Perneczky R, Rullman M, Patt M, Schildan A, Barthel H, Sabri O, Rumpf JJ, Schroeter ML, Classen J, Villemagne V, Seibyl J, Stephens AW, Lee EB, Coughlin DG, Giese A, Grossman M, McMillan CT, Gelpi E, Molina-Porcel L, Compta Y, van Swieten JC, Laat LD, Troakes C, Al-Sarraj S, Robinson JL, Xie SX, Irwin DJ, Roeber S, Herms J, Simons M, Bartenstein P, Lee VM, Trojanowski JQ, Levin J, Höglinger G, Ewers M (2022). Tau deposition patterns are associated with functional connectivity in primary tauopathies. Nat Commun. 2022 Mar 15;13(1):1362. doi: 10.1038/s41467-022-28896-3. PMID: 35292638; PMCID: PMC8924216
Frontzkowski L, Ewers M, Brendel M, Biel D, Ossenkoppele R, Hager P, Steward A, Dewenter A, Römer S, Rubinski A, Buerger K, Janowitz D, Binette AP, Smith R, Strandberg O, Carlgren NM, Dichgans M, Hansson O, Franzmeier N (2022). Earlier Alzheimer's disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading. Nat Commun. 2022 Aug 20;13(1):4899. doi: 10.1038/s41467-022-32592-7. PMID: 35987901; PMCID: PMC9392750.
125. Katzdobler S, Nitschmann A, Barthel H, Bischof G, Beyer L, Marek K, Song M, Wagemann O, Palleis C, Weidinger E, Nack A, Fietzek U, Kurz C, Strupp M,Häckert J, Stapf T, Ferschmann C, Scheifele M, Eckenweber F, Biechele G, Franzmeier N, Dewenter A, Schönecker S, Saur D, Schroeter ML, Rumpf JJ, Rullmann M, Schildan A, Patt M, Stephens AW, van Eimeren T, Neumaier B, Drzezga A, Danek A, Classen J, Bürger K, Janowitz D, Rauchmann BS, Stöcklein S, Perneczky R, Schöberl F, Zwergal A, Höglinger GU, Bartenstein P, Villemagne V, Seibyl J, Sabri O, Levin J, Brendel M; German Imaging Initiative for Tauopathies (GII4T) (2022). Additive value of [18F]PI-2620 perfusion imaging in progressive supranuclear palsy and corticobasal syndrome. Eur J Nucl Med Mol Imaging. 2022 Sep 14. doi: 10.1007/s00259-022-05964-w. Epub ahead of print. PMID: 36102964.
142. Künze G, Kümpfel R, Rullmann M, Barthel H, Brendel M, Patt M, Sabri O (2022). Molecular Simulations Reveal Distinct Energetic and Kinetic Binding Properties of [18F]PI-2620 on Tau Filaments from 3R/4R and 4R Tauopathies. ACS Chem Neurosci. 2022 Jun 28. doi: 10.1021/acschemneuro.2c00291. Epub ahead of print. PMID: 35762647.
Messerschmidt K, Barthel H, Brendel M, Scherlach C, Hoffmann KT, Rauchmann BS, Rullmann M, Marek K, Villemagne VL, Rumpf JJ, Saur D, Schroeter ML, Schildan A, Patt M, Beyer L, Song M, Palleis C, Katzdobler S, Fietzek UM, Scherlach C, Hoffmann KT, Rauchmann BS, Rullmann M, Marek K, Villemagne VL, Rumpf JJ, Saur D, Schroeter ML, Schildan A, Patt M, Beyer L, Song M, Palleis C, Katzdobler S, Fietzek UM, Herms J, Boetzel K, Bartenstein P, Levin J, Seibyl JP, Höglinger G, Classen J, Sabri O (2022). 18F-PI-2620 Tau PET Improves the Imaging Diagnosis of Progressive Supranuclear Palsy. J Nucl Med. 2022 Apr 14:jnumed.121.262854. doi: 10.2967/jnumed.121.262854. Epub ahead of print. PMID: 35422444.
Pichet Binette A, Franzmeier N, Spotorno N, Ewers M, Brendel M, Biel D; Alzheimer’s Disease Neuroimaging Initiative; Strandberg O, Janelidze S, Palmqvist S, Mattsson-Carlgren N, Smith R, Stomrud E, Ossenkoppele R, Hansson O. Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer's disease. Nat Commun. 2022 Nov 4;13(1):6635. doi: 10.1038/s41467-022-34129-4. PMID: 36333294; PMCID: PMC9636262.
Rauchmann BS, Brendel M, Franzmeier N, Trappmann L, Ewers M, Palleis C, Weidinger E, Biechele G, Schuster S, Finze A, Eckenweber F, Rupprecht R, Rominger A, Goldhardt O, Grimmer T, Keeser D, Stoecklein S, Dietrich O, Bartenstein P, Levin J, Höglinger G, Perneczky R (2022). Microglial Activation and Connectivity in Alzheimer Disease and Aging. Ann Neurol. 2022 Aug 1. doi: 10.1002/ana.26465. Epub ahead of print. PMID: 36053756.
Reifschneider A, Robinson S, van Lengerich B, Gnörich J, Logan T, Heindl S, Vogt MA, Weidinger E, Riedl L, Wind K, Zatcepin A, Pesämaa I, Haberl S, Nuscher B, Kleinberger G, Klimmt J, Götzl JK, Liesz A, Bürger K, Brendel M, Levin J, Diehl-Schmid J, Suh J, Di Paolo G, Lewcock JW, Monroe KM, Paquet D, Capell A, Haass C (2022). Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. EMBO J. 2022 Jan 12:e109108. doi: 10.15252/embj.2021109108. Epub ahead of print. PMID: 35019161.
Rullmann M, Brendel M, Schroeter ML, Saur D, Levin J, Perneczky RG, Tiepolt S, Patt M, Mueller A, Villemagne VL, Classen J, Stephens AW, Sabri O, Barthel H, On Behalf Of The German Imaging Initiative For Tauopathies Gii T (2022). Multicenter 18F-PI-2620 PET for In Vivo Braak Staging of Tau Pathology in Alzheimer's Disease. Biomolecules. 2022 Mar 16;12(3):458. doi: 10.3390/biom12030458. PMID: 35327650; PMCID: PMC8946049.
Schuster S, Beyer L, Palleis C, Harris S, Schmitt J, Weidinger E, Prix C, Bötzel K, Danek A, Rauchmann BS, Stöcklein S, Lindner S, Unterrainer M, Albert NL, Mittlmeier LM, Wetzel C, Rupprecht R, Rominger A, Bartenstein P, Perneczky R, Levin J, Höglinger GU, Brendel M, Dekorsy FJ (2022). Impact of Partial Volume Correction on [18F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome. Brain Sci. 2022 Jan 31;12(2):204. doi: 10.3390/brainsci12020204. PMID: 35203967; PMCID: PMC8870519.
Shi Y, Cui M, Ochs K, Brendel M, Strübing FL, Briel N, Eckenweber F, Zou C, Banati RB, Liu GJ, Middleton RJ, Rupprecht R, Rudolph U, Zeilhofer HU, Rammes G, Herms J, Dorostkar MM (2022). Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO). Nat Neurosci. 2022 Mar;25(3):317-329. doi: 10.1038/s41593-022-01013-9. Epub 2022 Feb 28. PMID: 35228700.
Steward A, Biel D, Brendel M, Dewenter A, Roemer S, Rubinski A, Luan Y, Dichgans M, Ewers M, Franzmeier N; Alzheimer's Disease Neuroimaging Initiative (ADNI) (2022). Functional network segregation is associated with attenuated tau spreading in Alzheimer's disease. Alzheimers Dement. 2022 Nov 25. doi: 10.1002/alz.12867. Epub ahead of print. PMID: 36433865.
Unterrainer M, Mahler C, Schumacher AM, Ruf V, Blum B, Quach S, Brendel M, Rupprecht R, Bartenstein P, Kerschensteiner M, Kümpfel T, Albert NL (2022). Amino Acid Uptake, Glucose Metabolism, and Neuroinflammation in John Cunningham Virus Associated Progressive Multifocal Leukoencephalopathy. Clin Nucl Med. 2022 Feb 21. doi: 10.1097/RLU.0000000000004093. Epub ahead of print. PMID: 35195584.
Völter F, Beyer L, Eckenweber F, Scheifele M, Bui N, Patt M, Barthel H, Katzdobler S, Palleis C, Franzmeier N, Levin J, Perneczky R, Rauchmann BS, Sabri O, Hong J, Cumming P, Rominger A, Shi K, Bartenstein P, Brendel M (2022). Assessment of perfusion deficit with early phases of [18F]PI-2620 tau-PET versus [18F]flutemetamol-amyloid-PET recordings. Eur J Nucl Med Mol Imaging. 2022 Dec 27. doi: 10.1007/s00259-022-06087-y. Epub ahead of print. PMID: 36572740.
von Rohr K, Unterrainer M, Holzgreve A, Kirchner MA, Li Z, Unterrainer LM, Suchorska B, Brendel M, Tonn JC, Bartenstein P, Ziegler S, Albert NL, Kaiser L (2022). Can Radiomics Provide Additional Information in [18F]FET-Negative Gliomas? Cancers (Basel). 2022 Oct 5;14(19):4860. doi: 10.3390/cancers14194860. PMID: 36230783.
285. Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK, Lin CC, Davis S, Ha C, Leung AW, Nguyen H, Chau R, Yulyaningsih E, Lopez I, Solanoy H, Solanoy H, Masoud ST, Liang CC, Lin K, Astarita G, Khoury N, Zuchero JY, Thorne RG, Shen K, Miller S, Palop JJ, Garceau D, Sasner M, Whitesell JD, Harris JA, Hummel S, Gnörich J, Wind K, Kunze L, Zatcepin A, Brendel M, Willem M, Haass C, Barnett D, Zimmer TS, Orr AG, Scearce-Levie K, Lewcock JW, Di Paolo G, Sanchez PE (2022). Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia. Mol Neurodegener. 2022 Jun 11;17(1):41. doi: 10.1186/s13024-022-00547-7. PMID: 35690868; PMCID: PMC9188195.
Xiang X, Tahirovic S, Ziegler S, Haass C, Brendel M (2022). Response to Comment on "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases". Sci Transl Med. 2022 Aug 24;14(659):eabn5104. doi: 10.1126/scitranslmed.abn5104. Epub 2022 Aug 24. PMID: 36001676.
Zatcepin A, Heindl S, Schillinger U, Kaiser L, Lindner S, Bartenstein P, Kopczak A, Liesz A, Brendel M, Ziegler SI (2022). Reduced Acquisition Time [18F]GE-180 PET Scanning Protocol Replaces Gold-Standard Dynamic Acquisition in a Mouse Ischemic Stroke Model. Front Med (Lausanne). 2022 Feb 10;9:830020. doi: 10.3389/fmed.2022.830020. PMID: 35223925; PMCID: PMC8866959.

2021

Beyer L, Brendel M. Imaging of Tau Pathology in Neurodegenerative Diseases: An Update. Semin Nucl Med. 2021 May;51(3):253-263. doi: 10.1053/j.semnuclmed.2020.12.004. Epub 2020 Dec 20. PMID: 33353724.
Haeckert J, Brendel M, Beyer L, Barthel H, Sabri O, Hasan A, Perneczky R (2021). Effective Valproic Acid Treatment in a Patient With Delusional Parasitosis Due to Corticobasal Syndrome and Alzheimer Disease. J Clin Psychopharmacol. 2021 Mar 12. doi: 10.1097/JCP.0000000000001378. Epub ahead of print. PMID: 33734170.
Nuebling GS, Prix C, Brendel M, Beyer L, Wlasich E, Loosli SV, Barthel H, Sabri O, Bartenstein P, Vöglein J, Danek A, Rominger A, Edbauer D, Haass C, Levin J (2021). Low-degree trisomy 21 mosaicism promotes early-onset Alzheimer disease. Neurobiol Aging. 2021 Feb 28:S0197-4580(21)00076-2. doi: 10.1016/j.neurobiolaging.2021.02.021. Epub ahead of print. PMID: 33789815.
Song M, Scheifele M, Barthel H, van Eimeren T, Beyer L, Marek K, Eckenweber F, Palleis C, Kaiser L, Finze A, Kern M, Nitschmann A, Biechele G, Katzdobler S, Bischof G, Hammes J, Jessen F, Saur D, Schroeter ML, Rumpf JJ, Rullmann M, Schildan A, Patt M, Neumaier B, Stephens AW, Rauchmann BS, Perneczky R, Levin J, Classen J, Höglinger GU, Bartenstein P, Boening G, Ziegler S, Villemagne V, Drzezga A, Seibyl J, Sabri O, Brendel M; German Imaging Initiative for Tauopathies (GII4T) (2021). Feasibility of short imaging protocols for [18F]PI-2620 tau-PET in progressive supranuclear palsy. Eur J Nucl Med Mol Imaging. 2021 May 22. doi: 10.1007/s00259-021-05391-3. Epub ahead of print. PMID: 34021393.

Brendel, Matthias

Teilnehmende Universitäten

Partnerinstitute

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